| PRIMECAP MANAGEMENT CO/CA/ | 4,727,791 | $10,448 |
| MORGAN STANLEY | 4,160,469 | $9,195 |
| BlackRock, Inc. | 2,706,190 | $5,981 |
| VANGUARD GROUP INC | 2,540,535 | $5,615 |
| Soleus Capital Management, L.P. | 2,038,323 | $4,505 |
| ExodusPoint Capital Management, LP | 1,951,173 | $4,312 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 1,264,233 | $2,794 |
| DEUTSCHE BANK AG\ | 1,125,861 | $2,488 |
| GEODE CAPITAL MANAGEMENT, LLC | 906,521 | $2,004 |
| STATE STREET CORP | 821,217 | $1,815 |
| BRAIDWELL LP | 752,541 | $1,663 |
| BANK OF AMERICA CORP /DE/ | 727,799 | $1,608 |
| Parkman Healthcare Partners LLC | 727,781 | $1,608 |
| D. E. Shaw & Co., Inc. | 561,266 | $1,240 |
| Stonepine Capital Management, LLC | 486,400 | $1,075 |
| BARCLAYS PLC | 472,251 | $1,044 |
| JPMORGAN CHASE & CO | 426,779 | $943 |
| GSA CAPITAL PARTNERS LLP | 403,762 | $1 |
| GOLDMAN SACHS GROUP INC | 365,203 | $807 |
| ADAR1 Capital Management, LLC | 355,410 | $785 |
| NORTHERN TRUST CORP | 337,129 | $745 |
| RENAISSANCE TECHNOLOGIES LLC | 292,000 | $645 |
| Jefferies Financial Group Inc. | 285,110 | $630 |
| CFM WEALTH PARTNERS LLC | 264,039 | $584 |
| Birchview Capital, LP | 250,573 | $554 |
| KOTLER KEVIN | 200,000 | $442 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,440 | $419 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 184,903 | $409 |
| ACADIAN ASSET MANAGEMENT LLC | 178,033 | $0 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 174,774 | $386 |
| UBS Group AG | 171,596 | $379 |
| DIMENSIONAL FUND ADVISORS LP | 168,200 | $372 |
| JANE STREET GROUP, LLC | 164,971 | $365 |
| TWO SIGMA INVESTMENTS, LP | 132,770 | $293 |
| Schonfeld Strategic Advisors LLC | 120,693 | $267 |
| XTX Topco Ltd | 111,247 | $246 |
| ALGERT GLOBAL LLC | 99,712 | $0 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,179 | $206 |
| Bank of New York Mellon Corp | 92,787 | $205 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 85,000 | $188 |
| FMR LLC | 75,202 | $166 |
| Nuveen, LLC | 68,790 | $152 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 65,800 | $145 |
| Susquehanna Portfolio Strategies, LLC | 60,259 | $133 |
| AQR CAPITAL MANAGEMENT LLC | 58,919 | $130 |
| RHUMBLINE ADVISERS | 56,241 | $124 |
| ALLIANCEBERNSTEIN L.P. | 52,200 | $115 |
| PERKINS CAPITAL MANAGEMENT INC | 49,000 | $108 |
| Engineers Gate Manager LP | 48,169 | $106 |
| WELLS FARGO & COMPANY/MN | 47,580 | $105 |
| Banco BTG Pactual S.A. | 46,316 | $102 |
| CITADEL ADVISORS LLC | 45,257 | $100 |
| MERCER GLOBAL ADVISORS INC /ADV | 41,265 | $91 |
| Squarepoint Ops LLC | 41,251 | $91 |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | 40,000 | $88 |
| SIMPLEX TRADING, LLC | 34,518 | $76 |
| FNY Investment Advisers, LLC | 34,500 | $0 |
| Worth Venture Partners, LLC | 32,525 | $72 |
| Jain Global LLC | 30,566 | $68 |
| MILLENNIUM MANAGEMENT LLC | 29,531 | $65 |
| TUDOR INVESTMENT CORP ET AL | 22,912 | $51 |
| Verition Fund Management LLC | 22,043 | $49 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,884 | $0 |
| Creative Planning | 19,033 | $42 |
| Centiva Capital, LP | 18,545 | $41 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,953 | $40 |
| LAZARD ASSET MANAGEMENT LLC | 14,156 | $31 |
| REGATTA CAPITAL GROUP, LLC | 13,749 | $30 |
| OPAL CAPITAL LLC | 12,984 | $20 |
| INTECH INVESTMENT MANAGEMENT LLC | 12,805 | $28 |
| Russell Investments Group, Ltd. | 12,574 | $28 |
| Cerity Partners LLC | 12,364 | $27 |
| 49 WEALTH MANAGEMENT, LLC | 11,884 | $26 |
| HSBC HOLDINGS PLC | 11,522 | $26 |
| SG Americas Securities, LLC | 10,747 | $0 |
| Abel Hall, LLC | 10,654 | $24 |
| Invesco Ltd. | 10,573 | $23 |
| NINE MASTS CAPITAL Ltd | 10,106 | $22 |
| BNP PARIBAS ARBITRAGE, SA | 8,888 | $20 |
| Police & Firemen's Retirement System of New Jersey | 7,810 | $17 |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,914 | $15 |
| Tower Research Capital LLC (TRC) | 4,684 | $10 |
| CWM, LLC | 3,830 | $0 |
| Optiver Holding B.V. | 3,622 | $8 |
| Ameritas Investment Partners, Inc. | 3,617 | $8 |
| Legal & General Group Plc | 3,604 | $8 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,385 | $5 |
| GAMMA Investing LLC | 2,105 | $5 |
| OSAIC HOLDINGS, INC. | 1,445 | $3 |
| AMALGAMATED BANK | 1,215 | $0 |
| ROYAL BANK OF CANADA | 1,064 | $3 |
| AdvisorNet Financial, Inc | 1,000 | $2 |
| CITIGROUP INC | 875 | $2 |
| EverSource Wealth Advisors, LLC | 832 | $2 |
| Pinnacle Wealth Planning Services, Inc. | 695 | $2 |
| Fortitude Family Office, LLC | 592 | $1 |
| Parallel Advisors, LLC | 336 | $1 |
| Cornerstone Planning Group LLC | 288 | $1 |
| Sterling Capital Management LLC | 248 | $1 |
| NISA INVESTMENT ADVISORS, LLC | 214 | $0 |
| 11 other institutions | 480 | $1 |