NEWAMSTERDAM PHARMA COMPANY

Institution	Shares	Value ($000)
Logos Global Management LP	450,000	$15,786
Moody Aldrich Partners LLC	143,549	$5,036
AlphaCentric Advisors LLC	13,731	$482
Castle Hook Partners LP	1,085,008	$38,062
JTC Employer Solutions Trustee Ltd	75,500	$3
Mizuho Markets Cayman LP	47,879	$1,680
Persistent Asset Partners Ltd	3,948	$138
TWINBEECH CAPITAL LP	27,400	$961
Ensign Peak Advisors, Inc	549,511	$19,277
FOX RUN MANAGEMENT, L.L.C.	9,798	$344
Aquatic Capital Management LLC	45,989	$1,613
WINTON GROUP Ltd	28,665	$1,006
Centiva Capital, LP	80,000	$2,806
ALPS ADVISORS INC	92,902	$3,259
Jaffetilchin Investment Partners, LLC	9,218	$323
Walleye Capital LLC	96,261	$3,377
FIRST TRUST ADVISORS LP	279,701	$9,812
Jain Global LLC	47,584	$1,669
MILLENNIUM MANAGEMENT LLC	254,596	$8,931
JANE STREET GROUP, LLC	421,491	$14,786

Increased Positions (47)

Artia Global Partners LP

Value ($000) $17,678 (+219.0%) Shares 503,936 (+158.6%)

First Turn Management, LLC

Value ($000) $31,343 (+53.7%) Shares 893,473 (+24.6%)

Frazier Life Sciences Management, L.P.

Value ($000) $594,388 (+25.1%) Shares 16,943,774 (+1.4%)

Duquesne Family Office LLC

Value ($000) $108 (+96.9%) Shares 3,070,146 (+59.6%)

Lisanti Capital Growth, LLC

Value ($000) $6,294 (+366.4%) Shares 179,410 (+278.1%)

HealthInvest Partners AB

Value ($000) $6,912 (+1082.3%) Shares 197,036 (+1.8%)

MAVERICK CAPITAL LTD

Value ($000) $66,449 (+55.3%) Shares 1,894,226 (+25.9%)

XTX Topco Ltd

Value ($000) $4,823 (+2137.7%) Shares 137,492 (+1714.1%)

Nicholas Investment Partners, LP

Value ($000) $7,487 (+48.3%) Shares 213,419 (+20.2%)

GILDER GAGNON HOWE & CO LLC

Value ($000) $8,718 (+742.5%) Shares 248,528 (+583.1%)

HighVista Strategies LLC

Value ($000) $1,248 (+37.9%) Shares 35,586 (+11.8%)

KENNEDY CAPITAL MANAGEMENT LLC

Value ($000) $6,066 (+45.4%) Shares 172,931 (+17.9%)

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $176,564 (+54.4%) Shares 5,033,175 (+25.2%)

ADAR1 Capital Management, LLC

Value ($000) $4,161 (+27.9%) Shares 118,623 (+3.7%)

China Universal Asset Management Co., Ltd.

Value ($000) $929 (+65.4%) Shares 26,477 (+34.1%)

Bellevue Group AG

Value ($000) $1,275 (+206.8%) Shares 36,336 (+148.7%)

GOLDMAN SACHS GROUP INC

Value ($000) $60,536 (+141.7%) Shares 1,725,662 (+96.0%)

Virtus Investment Advisers, LLC

Value ($000) $251 (+62.8%) Shares 7,142 (+32.0%)

JANUS HENDERSON GROUP PLC

Value ($000) $82,300 (+36.8%) Shares 2,341,723 (+10.6%)

FMR LLC

Value ($000) $224,967 (+42.9%) Shares 6,412,984 (+15.9%)

Institution	Prev Shares	Curr Shares	Change
Artia Global Partners LP	194,838	503,936	+309,098 (+158.6%)
First Turn Management, LLC	716,971	893,473	+176,502 (+24.6%)
Frazier Life Sciences Management, L.P.	16,701,956	16,943,774	+241,818 (+1.4%)
Duquesne Family Office LLC	1,923,700	3,070,146	+1,146,446 (+59.6%)
Lisanti Capital Growth, LLC	47,445	179,410	+131,965 (+278.1%)
HealthInvest Partners AB	193,625	197,036	+3,411 (+1.8%)
MAVERICK CAPITAL LTD	1,504,747	1,894,226	+389,479 (+25.9%)
XTX Topco Ltd	7,579	137,492	+129,913 (+1714.1%)
Nicholas Investment Partners, LP	177,538	213,419	+35,881 (+20.2%)
GILDER GAGNON HOWE & CO LLC	36,384	248,528	+212,144 (+583.1%)
HighVista Strategies LLC	31,831	35,586	+3,755 (+11.8%)
KENNEDY CAPITAL MANAGEMENT LLC	146,715	172,931	+26,216 (+17.9%)
WELLINGTON MANAGEMENT GROUP LLP	4,020,126	5,033,175	+1,013,049 (+25.2%)
ADAR1 Capital Management, LLC	114,359	118,623	+4,264 (+3.7%)
China Universal Asset Management Co., Ltd.	19,742	26,477	+6,735 (+34.1%)
Bellevue Group AG	14,611	36,336	+21,725 (+148.7%)
GOLDMAN SACHS GROUP INC	880,552	1,725,662	+845,110 (+96.0%)
Virtus Investment Advisers, LLC	5,411	7,142	+1,731 (+32.0%)
JANUS HENDERSON GROUP PLC	2,117,075	2,341,723	+224,648 (+10.6%)
FMR LLC	5,535,293	6,412,984	+877,691 (+15.9%)

Decreased Positions (49)

Cormorant Asset Management, LP

Value ($000) $35,080 (-43.3%) Shares 1,000,000 (-54.0%)

Bain Capital Life Sciences Investors, LLC

Value ($000) $256,314 (-15.9%) Shares 7,306,566 (-31.8%)

Decheng Capital LLC

Value ($000) $20,769 (+11.1%) Shares 592,057 (-9.9%)

RA CAPITAL MANAGEMENT, L.P.

Value ($000) $335,021 (+16.2%) Shares 9,550,191 (-5.8%)

STEMPOINT CAPITAL LP

Value ($000) $2,565 (-40.1%) Shares 73,106 (-51.4%)

DCF Advisers, LLC

Value ($000) $5,634 (+13.0%) Shares 160,600 (-8.4%)

DEERFIELD MANAGEMENT COMPANY, L.P.

Value ($000) $146,101 (+20.4%) Shares 4,164,789 (-2.4%)

VIKING GLOBAL INVESTORS LP

Value ($000) $147,461 (-19.9%) Shares 4,203,567 (-35.1%)

Eversept Partners, LP

Value ($000) $14,763 (+6.2%) Shares 420,827 (-13.9%)

Ikarian Capital, LLC

Value ($000) $1,608 (-47.1%) Shares 45,830 (-57.1%)

Rock Springs Capital Management LP

Value ($000) $19,546 (+15.3%) Shares 557,194 (-6.5%)

CenterBook Partners LP

Value ($000) $423 (-78.9%) Shares 12,060 (-82.9%)

ADAGE CAPITAL PARTNERS GP, L.L.C.

Value ($000) $49,345 (-32.7%) Shares 1,406,631 (-45.4%)

Woodline Partners LP

Value ($000) $26,355 (-20.0%) Shares 751,270 (-35.1%)

Polar Capital Holdings Plc

Value ($000) $97,390 (+17.6%) Shares 2,776,222 (-4.7%)

Pictet Asset Management Holding SA

Value ($000) $26,174 (-28.8%) Shares 746,122 (-42.3%)

JENNISON ASSOCIATES LLC

Value ($000) $122,402 (+2.5%) Shares 3,489,221 (-16.9%)

TimesSquare Capital Management, LLC

Value ($000) $28,846 (+21.1%) Shares 822,300 (-1.8%)

ALLIANCEBERNSTEIN L.P.

Value ($000) $45,635 (-25.1%) Shares 1,300,875 (-39.3%)

Quarry LP

Value ($000) $105 (-46.2%) Shares 3,000 (-56.4%)

Institution	Prev Shares	Curr Shares	Change
Cormorant Asset Management, LP	2,175,000	1,000,000	-1,175,000 (-54.0%)
Bain Capital Life Sciences Investors, LLC	10,719,110	7,306,566	-3,412,544 (-31.8%)
Decheng Capital LLC	657,051	592,057	-64,994 (-9.9%)
RA CAPITAL MANAGEMENT, L.P.	10,138,938	9,550,191	-588,747 (-5.8%)
STEMPOINT CAPITAL LP	150,573	73,106	-77,467 (-51.4%)
DCF Advisers, LLC	175,250	160,600	-14,650 (-8.4%)
DEERFIELD MANAGEMENT COMPANY, L.P.	4,266,693	4,164,789	-101,904 (-2.4%)
VIKING GLOBAL INVESTORS LP	6,475,534	4,203,567	-2,271,967 (-35.1%)
Eversept Partners, LP	488,592	420,827	-67,765 (-13.9%)
Ikarian Capital, LLC	106,800	45,830	-60,970 (-57.1%)
Rock Springs Capital Management LP	595,929	557,194	-38,735 (-6.5%)
CenterBook Partners LP	70,613	12,060	-58,553 (-82.9%)
ADAGE CAPITAL PARTNERS GP, L.L.C.	2,576,631	1,406,631	-1,170,000 (-45.4%)
Woodline Partners LP	1,157,867	751,270	-406,597 (-35.1%)
Polar Capital Holdings Plc	2,911,634	2,776,222	-135,412 (-4.7%)
Pictet Asset Management Holding SA	1,292,150	746,122	-546,028 (-42.3%)
JENNISON ASSOCIATES LLC	4,198,554	3,489,221	-709,333 (-16.9%)
TimesSquare Capital Management, LLC	837,368	822,300	-15,068 (-1.8%)
ALLIANCEBERNSTEIN L.P.	2,141,778	1,300,875	-840,903 (-39.3%)
Quarry LP	6,875	3,000	-3,875 (-56.4%)

Exited Positions (9)

Saturn V Capital Management LP

Value ($000) $4,356 Shares 153,147

Siren, L.L.C.

Value ($000) $21,777 Shares 765,705

READYSTATE ASSET MANAGEMENT LP

Value ($000) $977 Shares 34,353

OMERS ADMINISTRATION Corp

Value ($000) $395 Shares 13,900

BANK OF MONTREAL /CAN/

Value ($000) $352 Shares 12,388

MATHER GROUP, LLC.

Value ($000) $28 Shares 1,000

SRS Capital Advisors, Inc.

Value ($000) $5 Shares 174

Clearstead Advisors, LLC

Value ($000) $3 Shares 88

SIMPLEX TRADING, LLC

Value ($000) $0 Shares 3,372

Institution	Prev Shares	Prev Value ($000)
Saturn V Capital Management LP	153,147	$4,356
Siren, L.L.C.	765,705	$21,777
READYSTATE ASSET MANAGEMENT LP	34,353	$977
OMERS ADMINISTRATION Corp	13,900	$395
BANK OF MONTREAL /CAN/	12,388	$352
MATHER GROUP, LLC.	1,000	$28
SRS Capital Advisors, Inc.	174	$5
Clearstead Advisors, LLC	88	$3
SIMPLEX TRADING, LLC	3,372	$0