| Frazier Life Sciences Management, L.P. | 16,943,774 | $594,388 |
| Capital World Investors | 9,984,000 | $350,239 |
| RA CAPITAL MANAGEMENT, L.P. | 9,550,191 | $335,021 |
| FCPM III SERVICES B.V. | 9,198,900 | $322,697 |
| Bain Capital Life Sciences Investors, LLC | 7,306,566 | $256,314 |
| FMR LLC | 6,412,984 | $224,967 |
| WELLINGTON MANAGEMENT GROUP LLP | 5,033,175 | $176,564 |
| VIKING GLOBAL INVESTORS LP | 4,203,567 | $147,461 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,164,789 | $146,101 |
| JENNISON ASSOCIATES LLC | 3,489,221 | $122,402 |
| Duquesne Family Office LLC | 3,070,146 | $108 |
| Medicxi Ventures Management (Jersey) Ltd | 2,869,565 | $100,664 |
| Polar Capital Holdings Plc | 2,776,222 | $97,390 |
| JANUS HENDERSON GROUP PLC | 2,341,723 | $82,300 |
| Capital International Investors | 2,062,535 | $72,354 |
| MAVERICK CAPITAL LTD | 1,894,226 | $66,449 |
| GOLDMAN SACHS GROUP INC | 1,725,662 | $60,536 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,406,631 | $49,345 |
| ALLIANCEBERNSTEIN L.P. | 1,300,875 | $45,635 |
| Castle Hook Partners LP | 1,085,008 | $38,062 |
| Cormorant Asset Management, LP | 1,000,000 | $35,080 |
| JPMORGAN CHASE & CO | 999,976 | $35,079 |
| UBS Group AG | 899,442 | $31,552 |
| First Turn Management, LLC | 893,473 | $31,343 |
| BlackRock, Inc. | 849,779 | $29,810 |
| TimesSquare Capital Management, LLC | 822,300 | $28,846 |
| FRANKLIN RESOURCES INC | 769,120 | $26,981 |
| Woodline Partners LP | 751,270 | $26,355 |
| Pictet Asset Management Holding SA | 746,122 | $26,174 |
| abrdn plc | 729,484 | $25,590 |
| CITADEL ADVISORS LLC | 635,247 | $22,284 |
| AMERICAN CENTURY COMPANIES INC | 603,401 | $21,167 |
| Decheng Capital LLC | 592,057 | $20,769 |
| Rock Springs Capital Management LP | 557,194 | $19,546 |
| Ensign Peak Advisors, Inc | 549,511 | $19,277 |
| MORGAN STANLEY | 532,803 | $18,691 |
| Artia Global Partners LP | 503,936 | $17,678 |
| BANK OF AMERICA CORP /DE/ | 459,391 | $16,115 |
| Logos Global Management LP | 450,000 | $15,786 |
| JANE STREET GROUP, LLC | 421,491 | $14,786 |
| Eversept Partners, LP | 420,827 | $14,763 |
| Handelsbanken Fonder AB | 415,800 | $15 |
| Bank of New York Mellon Corp | 391,827 | $13,745 |
| Slate Path Capital LP | 319,000 | $11,191 |
| ArrowMark Colorado Holdings LLC | 298,077 | $10,457 |
| FIRST TRUST ADVISORS LP | 279,701 | $9,812 |
| Affinity Asset Advisors, LLC | 275,000 | $9,647 |
| UBS ASSET MANAGEMENT AMERICAS INC | 265,199 | $9,303 |
| MILLENNIUM MANAGEMENT LLC | 254,596 | $8,931 |
| GILDER GAGNON HOWE & CO LLC | 248,528 | $8,718 |
| Nicholas Investment Partners, LP | 213,419 | $7,487 |
| LORD, ABBETT & CO. LLC | 200,638 | $7 |
| HealthInvest Partners AB | 197,036 | $6,912 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 195,635 | $6,863 |
| Lisanti Capital Growth, LLC | 179,410 | $6,294 |
| BNP Paribas Investment Partners S.A. | 177,016 | $6 |
| VANGUARD GROUP INC | 172,956 | $6,067 |
| KENNEDY CAPITAL MANAGEMENT LLC | 172,931 | $6,066 |
| DCF Advisers, LLC | 160,600 | $5,634 |
| AMERIPRISE FINANCIAL INC | 152,269 | $5,342 |
| Moody Aldrich Partners LLC | 143,549 | $5,036 |
| XTX Topco Ltd | 137,492 | $4,823 |
| DEUTSCHE BANK AG\ | 123,963 | $4,349 |
| ADAR1 Capital Management, LLC | 118,623 | $4,161 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 116,258 | $4 |
| GEODE CAPITAL MANAGEMENT, LLC | 102,395 | $3,590 |
| Walleye Capital LLC | 96,261 | $3,377 |
| ALPS ADVISORS INC | 92,902 | $3,259 |
| Swedbank AB | 90,900 | $3,189 |
| Swiss National Bank | 88,900 | $3,119 |
| Centiva Capital, LP | 80,000 | $2,806 |
| JTC Employer Solutions Trustee Ltd | 75,500 | $3 |
| STEMPOINT CAPITAL LP | 73,106 | $2,565 |
| Russell Investments Group, Ltd. | 71,282 | $2,501 |
| STATE STREET CORP | 68,523 | $2,404 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 63,302 | $2,221 |
| Lifetime Wealth Management P.C. | 59,250 | $2,078 |
| Mizuho Markets Cayman LP | 47,879 | $1,680 |
| Jain Global LLC | 47,584 | $1,669 |
| FRED ALGER MANAGEMENT, LLC | 47,535 | $1,668 |
| Aquatic Capital Management LLC | 45,989 | $1,613 |
| Ikarian Capital, LLC | 45,830 | $1,608 |
| SEI INVESTMENTS CO | 41,040 | $1,440 |
| Legal & General Group Plc | 40,951 | $1,437 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,276 | $1,413 |
| Bellevue Group AG | 36,336 | $1,275 |
| HighVista Strategies LLC | 35,586 | $1,248 |
| BOOTHBAY FUND MANAGEMENT, LLC | 33,919 | $1,190 |
| Knights of Columbus Asset Advisors LLC | 32,483 | $1,140 |
| Verition Fund Management LLC | 32,391 | $1,136 |
| NORTHERN TRUST CORP | 32,137 | $1,127 |
| Squarepoint Ops LLC | 30,819 | $1,081 |
| Ishara Investments LP | 30,000 | $1,052 |
| Voya Investment Management LLC | 28,875 | $1,013 |
| WINTON GROUP Ltd | 28,665 | $1,006 |
| TWINBEECH CAPITAL LP | 27,400 | $961 |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,680 | $936 |
| China Universal Asset Management Co., Ltd. | 26,477 | $929 |
| BNP PARIBAS ARBITRAGE, SA | 25,134 | $882 |
| ROYAL BANK OF CANADA | 24,084 | $846 |
| 82 other institutions | 560,187 | $19,577 |