GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q3 2018 (← Previous) (Next →)

Filing Date: Nov 14, 2018

Total Value ($000): $641,666 (100.0% shares, 0.0% debt)

Holdings (30)

BCRX BIOCRYST PHARMACEUTICALS 9.5%

Value ($000) $60,874 Shares 7,978,275 Est. Cost $5.12 Unrealized +31.2%

— ACCELERON PHARMA INC 8.2%

Value ($000) $52,524 Shares 917,767 Est. Cost $12348.62 Unrealized —

— ZAFGEN INC 6.2%

Value ($000) $39,645 Shares 3,391,385 Est. Cost $10.23 Unrealized —

IOVA IOVANCE BIOTHERAPEUTICS INC 6.1%

Value ($000) $39,334 Shares 3,496,340 Est. Cost $10.06 Unrealized +41.1%

UTHR UNITED THERAPEUTICS CORP DEL 6.0%

Value ($000) $38,364 Shares 300,000 Est. Cost $115.90 Unrealized +6.7%

KURA KURA ONCOLOGY INC 5.8%

Value ($000) $37,084 Shares 2,119,106 Est. Cost $11.71 Unrealized +63.8%

EXEL EXELIXIS INC 5.7%

Value ($000) $36,769 Shares 2,075,000 Est. Cost $23.28 Unrealized -16.2%

PTCT PTC THERAPEUTICS INC 5.3%

Value ($000) $33,721 Shares 717,458 Est. Cost $16.50 Unrealized +150.8%

— ENDOCYTE INC 4.4%

Value ($000) $28,524 Shares 1,606,100 Est. Cost $17.76 Unrealized —

VYGR VOYAGER THERAPEUTICS INC 4.1%

Value ($000) $26,488 Shares 1,400,000 Est. Cost $19.24 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 4.1%

Value ($000) $26,256 Shares 300,000 Est. Cost $99.37 Unrealized +1.2%

SVRA SAVARA INC 3.9%

Value ($000) $25,033 Shares 2,243,084 Est. Cost $11.29 Unrealized +1.9%

ACAD ACADIA PHARMACEUTICALS INC 3.9%

Value ($000) $24,831 Shares 1,196,098 Est. Cost $17.83 Unrealized -11.8%

— FOAMIX PHARMACEUTICALS LTD 3.6%

Value ($000) $23,094 Shares 4,030,268 Est. Cost $7.50 Unrealized —

— FIVE PRIME THERAPEUTICS INC 3.6%

Value ($000) $22,937 Shares 1,647,753 Est. Cost $9058.15 Unrealized —

CYTK CYTOKINETICS INC 3.3%

Value ($000) $21,470 Shares 2,179,688 Est. Cost $8.22 Unrealized -2.4%

— SPARK THERAPEUTICS INC 3.3%

Value ($000) $21,446 Shares 393,147 Est. Cost $16879.86 Unrealized —

ENTA ENANTA PHARMACEUTICALS INC 2.8%

Value ($000) $17,981 Shares 210,400 Est. Cost $100.17 Unrealized 0.0%

— MENLO THERAPEUTICS INC 2.0%

Value ($000) $12,848 Shares 1,304,407 Est. Cost $9.85 Unrealized —

TGTX TG THERAPEUTICS INC 1.7%

Value ($000) $10,920 Shares 1,950,000 Est. Cost $11.43 Unrealized 0.0%

PTGX PROTAGONIST THERAPEUTICS INC 1.6%

Value ($000) $10,109 Shares 982,449 Est. Cost $7.68 Unrealized +12.1%

ARGX ARGENX SE 1.5%

Value ($000) $9,788 Shares 129,060 Est. Cost $75.84 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 1.3%

Value ($000) $8,651 Shares 40,400 Est. Cost $250.94 Unrealized 0.0%

— INTRA CELLULAR THERAPIES INC 0.7%

Value ($000) $4,340 Shares 200,000 Est. Cost — Unrealized —

— ZYMEWORKS INC 0.6%

Value ($000) $3,799 Shares 241,970 Est. Cost $15.70 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.3%

Value ($000) $2,000 Shares 1,000,000 Est. Cost $2.00 Unrealized —

— ACER THERAPEUTICS INC 0.3%

Value ($000) $1,803 Shares 58,461 Est. Cost $30.84 Unrealized —

— SIERRA ONCOLOGY INC 0.1%

Value ($000) $834 Shares 490,843 Est. Cost $2070.00 Unrealized —

— STREAMLINE HEALTH SOLUTIONS 0.0%

Value ($000) $153 Shares 130,137 Est. Cost $6.45 Unrealized —

— CTI BIOPHARMA CORP 0.0%

Value ($000) $46 Shares 21,441 Est. Cost $3899.78 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BCRX	BIOCRYST PHARMACEUTICALS	7,978,275	$60,874	9.5%	$5.12	+31.2%	COM	09058V103
—	ACCELERON PHARMA INC	917,767	$52,524	8.2%	$12348.62	—	COM	00434H108
—	ZAFGEN INC	3,391,385	$39,645	6.2%	$10.23	—	COM	98885E103
IOVA	IOVANCE BIOTHERAPEUTICS INC	3,496,340	$39,334	6.1%	$10.06	+41.1%	COM	462260100
UTHR	UNITED THERAPEUTICS CORP DEL	300,000	$38,364	6.0%	$115.90	+6.7%	COM	91307C102
KURA	KURA ONCOLOGY INC	2,119,106	$37,084	5.8%	$11.71	+63.8%	COM	50127T109
EXEL	EXELIXIS INC	2,075,000	$36,769	5.7%	$23.28	-16.2%	COM	30161Q104
PTCT	PTC THERAPEUTICS INC	717,458	$33,721	5.3%	$16.50	+150.8%	COM	69366J200
—	ENDOCYTE INC	1,606,100	$28,524	4.4%	$17.76	—	COM	29269A102
VYGR	VOYAGER THERAPEUTICS INC	1,400,000	$26,488	4.1%	$19.24	—	COM	92915B106
ALNY	ALNYLAM PHARMACEUTICALS INC	300,000	$26,256	4.1%	$99.37	+1.2%	COM	02043Q107
SVRA	SAVARA INC	2,243,084	$25,033	3.9%	$11.29	+1.9%	COM	805111101
ACAD	ACADIA PHARMACEUTICALS INC	1,196,098	$24,831	3.9%	$17.83	-11.8%	COM	004225108
—	FOAMIX PHARMACEUTICALS LTD	4,030,268	$23,094	3.6%	$7.50	—	SHS	M46135105
—	FIVE PRIME THERAPEUTICS INC	1,647,753	$22,937	3.6%	$9058.15	—	COM	33830X104
CYTK	CYTOKINETICS INC	2,179,688	$21,470	3.3%	$8.22	-2.4%	COM	23282W605
—	SPARK THERAPEUTICS INC	393,147	$21,446	3.3%	$16879.86	—	COM	84652J103
ENTA	ENANTA PHARMACEUTICALS INC	210,400	$17,981	2.8%	$100.17	0.0%	COM	29251M106
—	MENLO THERAPEUTICS INC	1,304,407	$12,848	2.0%	$9.85	—	COM	586858102
TGTX	TG THERAPEUTICS INC	1,950,000	$10,920	1.7%	$11.43	0.0%	COM	88322Q108
PTGX	PROTAGONIST THERAPEUTICS INC	982,449	$10,109	1.6%	$7.68	+12.1%	COM	74366E102
ARGX	ARGENX SE	129,060	$9,788	1.5%	$75.84	—	SPONSORED ADR	04016X101
MDGL	MADRIGAL PHARMACEUTICALS INC	40,400	$8,651	1.3%	$250.94	0.0%	COM	558868105
—	INTRA CELLULAR THERAPIES INC	200,000	$4,340	0.7%	—	—	Put	46116X101
—	ZYMEWORKS INC	241,970	$3,799	0.6%	$15.70	—	COM	98985W102
—	SUNESIS PHARMACEUTICALS INC	1,000,000	$2,000	0.3%	$2.00	—	COM	867328700
—	ACER THERAPEUTICS INC	58,461	$1,803	0.3%	$30.84	—	COM	00444P108
—	SIERRA ONCOLOGY INC	490,843	$834	0.1%	$2070.00	—	COM	82640U107
—	STREAMLINE HEALTH SOLUTIONS	130,137	$153	0.0%	$6.45	—	COM	86323X106
—	CTI BIOPHARMA CORP	21,441	$46	0.0%	$3899.78	—	COM	12648L601