Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2018 (← Previous) (Next →)
Filing Date: Nov 14, 2018
Total Value: $3.74B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| NBIX | NEUROCRINE BIOSCIENCES INC | 4,777,254 | $587M | 15.7% | $122.95 * | $36.07 | +214.5% | COM | 64125C109 |
| FOLD | AMICUS THERAPEUTICS INC | 20,694,424 | $250M | 6.7% | $12.09 * | $5.74 | +143.8% | COM | 03152W109 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 5,148,910 | $196M | 5.2% | $38.00 | $30.05 | — | COM | 37890U108 |
| — | ZOGENIX INC | 3,807,632 | $189M | 5.0% | $49.60 | $15.83 | — | COM | 98978L204 |
| — | SOLID BIOSCIENCES INC | 3,927,222 | $185M | 5.0% | $47.18 | $7.50 | — | COM | 3422E1055 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 1,197,994 | $105M | 2.8% | $87.52 * | $67.14 | +49.8% | COM | 02043Q107 |
| — | ACCELERON PHARMA INC | 1,528,205 | $87.46M | 2.3% | $57.23 | $33.45 | — | COM | 00434H108 |
| — | LA JOLLA PHARMACEUTICAL CO | 4,313,611 | $86.83M | 2.3% | $20.13 | $27.07 | — | COM par $.0001 2 | 503459604 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 7,290,199 | $82.01M | 2.2% | $11.25 * | $9.50 | +49.4% | COM | 462260100 |
| ASND | ASCENDIS PHARMA A S | 1,072,647 | $76.01M | 2.0% | $70.86 | $65.49 | — | SPONSORED ADR | 04351P101 |
| CRNX | CRINETICS PHARMACEUTICALS INC | 2,587,953 | $74.14M | 2.0% | $28.65 * | $29.69 | 0.0% | COM | 22663K107 |
| — | BLUEPRINT MEDICINES CORP | 941,147 | $73.47M | 2.0% | $78.06 | $59.06 | — | COM | 09627Y109 |
| — | MYOKARDIA INC | 1,089,169 | $71.01M | 1.9% | $65.20 | $30.93 | — | COM | 62857M105 |
| — | DBV TECHNOLOGIES S A | 3,009,998 | $67.6M | 1.8% | $22.46 | $25.27 | — | SPONSORED ADR | 23306J101 |
| — | QUOTIENT LTD | 8,789,054 | $66.36M | 1.8% | $7.55 | $7.61 | — | SHS | G73268107 |
| — | DOVA PHARMACEUTICALS INC | 3,125,851 | $65.55M | 1.8% | $20.97 | $24.78 | — | COM | 25985T102 |
| MGTX | MEIRAGTX HOLDINGS PLC | 4,703,398 | $63.97M | 1.7% | $13.60 * | $13.41 | -19.4% | COM | G59665102 |
| — | ARENA PHARMACEUTICALS INC | 1,366,978 | $62.91M | 1.7% | $46.02 | $43.92 | — | COM NEW | 040047607 |
| MMSI | MERIT MED SYS INC | 994,198 | $61.09M | 1.6% | $61.45 * | $42.58 | +34.9% | COM | 589889104 |
| — | RETROPHIN INC | 3,212,871 | $60.48M | 1.6% | $18.83 | $16.07 | — | COM | 761299106 |
| — | CORIUM INTERNATIONAL INC | 6,357,133 | $60.46M | 1.6% | $9.51 | $6.41 | — | COM | 21887L107 |
| — | ALBIREO PHARMA INC | 1,704,330 | $56.17M | 1.5% | $32.96 | $24.69 | — | COM | 01345P106 |
| — | VERRICA PHARMACEUTICALS INC | 3,410,412 | $55.42M | 1.5% | $16.25 | $19.73 | — | COM | 92511W108 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,661,715 | $49.24M | 1.3% | $18.50 * | $18.00 | +26.6% | COM | 23284F105 |
| — | ATHENEX INC | 2,869,528 | $44.59M | 1.2% | $15.54 | $15.64 | — | COM | 04685N103 |
| — | KADMON HLDGS INC | 13,165,746 | $43.97M | 1.2% | $3.34 | $4.47 | — | COM | 48283N106 |
| — | ENDOCYTE INC REGISTERED SHS | 2,441,700 | $43.37M | 1.2% | $17.76 | $8.44 | — | COM | 29269A102 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $42.58M | 1.1% | $13.80 * | $6.64 | +22.3% | COM | 01438T106 |
| ARGX | ARGENX SE | 560,941 | $42.54M | 1.1% | $75.84 | $30.70 | — | SPONSORED ADR | 04016X101 |
| ISRG | INTUITIVE SURGICAL INC | 72,500 | $41.62M | 1.1% | $574.00 * | $148.81 | +19.3% | COM NEW | 46120E602 |
| ADMA | ADMA BIOLOGICS INC | 6,521,102 | $40.5M | 1.1% | $6.21 * | $4.10 | +40.6% | COM | 000899104 |
| — | BIOHAVEN PHARMACEUTICAL HLDG CO L | 990,943 | $37.21M | 1.0% | $37.55 | $25.06 | — | COM | G11196105 |
| RGNX | REGENXBIO INC | 470,672 | $35.54M | 1.0% | $75.50 * | $19.99 | +260.4% | COM | 75901B107 |
| QURE | UNIQURE NV | 972,831 | $35.4M | 0.9% | $36.39 * | $19.52 | +90.5% | SHS | N90064101 |
| VRAYQ | VIEWRAY INC REGISTERED SHS | 3,700,000 | $34.63M | 0.9% | $9.36 * | $9.80 | +0.3% | COM | 92672L107 |
| — | NEPTUNE WELLNESS SOLUTIONS I | 8,891,452 | $34.5M | 0.9% | $3.88 | $3.88 | — | COM | 64079L105 |
| XNCR | XENCOR INC | 828,095 | $32.27M | 0.9% | $38.97 * | $11.77 | +246.3% | COM | 98401F105 |
| — | INVITAE CORP | 1,861,100 | $31.14M | 0.8% | $16.73 | $8.88 | — | COM | 46185L103 |
| — | CYMABAY THERAPEUTICS INC | 2,742,821 | $30.39M | 0.8% | $11.08 | $8.36 | — | COM | 23257D103 |
| — | VBI VACCINES INC REGISTERED SHS | 9,665,843 | $23.39M | 0.6% | $2.42 | $3.58 | — | COM | 91822J103 |
| AKBA | AKEBIA THERAPEUTICS INC | 2,449,521 | $21.63M | 0.6% | $8.83 | $13.51 | -33.8% | COM | 00972D105 |
| AQST | AQUESTIVE THERAPEUTICS INC | 1,150,000 | $20.14M | 0.5% | $17.51 * | $16.48 | 0.0% | COM | 03843E104 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 664,186 | $19.37M | 0.5% | $29.17 * | $26.65 | +18.6% | COM | 76243J105 |
| — | FOAMIX PHARMACEUTICALS LTD | 3,107,424 | $17.81M | 0.5% | $5.73 | $6.39 | — | SHS | M46135105 |
| — | ZYMEWORKS INC | 1,123,890 | $16.91M | 0.5% | $15.05 | $10.53 | — | COM | 98985W102 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 168,939 | $15.99M | 0.4% | $94.66 * | $34.30 | +153.9% | COM | 450056106 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 635,000 | $15.3M | 0.4% | $24.10 * | $25.66 | 0.0% | COM | G31249108 |
| PRQR | PROQR THERAPEUTICS N.V. | 761,000 | $14.72M | 0.4% | $19.35 * | $10.63 | 0.0% | SHS EURO | N71542109 |
| — | MOTUS GI HOLDINGS INC REGISTERED SHS | 2,810,542 | $14.33M | 0.4% | $5.10 | $4.48 | — | COM | 62014P108 |
| LIVN | LIVANOVA PLC | 111,000 | $13.76M | 0.4% | $123.97 * | $117.94 | 0.0% | SHS | G5509L101 |
| — | SYNLOGIC INC | 942,852 | $13.4M | 0.4% | $14.21 | $16.39 | — | COM | 87166L100 |
| HUM | HUMANA INC | 35,000 | $11.85M | 0.3% | $338.51 * | $247.58 | +23.1% | COM | 444859102 |
| WVE | WAVE LIFE SCIENCES LTD | 234,019 | $11.7M | 0.3% | $50.00 * | $17.43 | +158.9% | COM | Y95308105 |
| — | PROTAGONIST THERAPEUTICS INC | 1,066,415 | $10.97M | 0.3% | $10.29 | $10.29 | — | COM | 4366E1029 |
| — | ABIOMED INC | 23,800 | $10.7M | 0.3% | $449.75 | $221.08 | — | COM | 003654100 |
| — | MOLECULAR TEMPLATES INC | 1,974,133 | $10.64M | 0.3% | $5.39 | $5.56 | — | COM | 608550109 |
| — | AMARIN CORP PLC | 610,200 | $9.928M | 0.3% | $16.27 | $16.27 | — | SPONS ADR NEW | 023111206 |
| — | THERAPEUTICSMD INC | 1,500,000 | $9.84M | 0.3% | $6.56 | $6.56 | — | COM | 88338N107 |
| — | MARINUS PHARMACEUTICALS INC | 907,732 | $9.077M | 0.2% | $10.00 | $5.87 | — | COM | 56854Q101 |
| — | ADAMAS PHARMACEUTICALS INC | 422,015 | $8.449M | 0.2% | $20.02 | $24.71 | — | COM | 00548A106 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $7.942M | 0.2% | $1.06 | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| — | TESARO INC | 200,000 | $7.802M | 0.2% | $39.01 | $41.74 | — | COM | 881569107 |
| CDNA | CAREDX INC | 260,676 | $7.521M | 0.2% | $28.85 * | $6.23 | +200.2% | COM | 14167L103 |
| ARWR | ARROWHEAD PHARMACEUTICALS INC | 365,445 | $7.006M | 0.2% | $19.17 * | $6.16 | +166.5% | COM | 04280A100 |
| — | EIDOS THERAPEUTICS INC | 686,922 | $6.855M | 0.2% | $9.98 | $20.34 | — | COM | 28249H104 |
| — | POLARITYTE INC | 336,818 | $6.433M | 0.2% | $19.10 | $19.10 | — | COM | 731094108 |
| EHTH | EHEALTH INC | 226,220 | $6.393M | 0.2% | $28.26 * | $26.55 | 0.0% | COM | 28238P109 |
| — | ONCOMED PHARMACEUTICALS INC | 2,620,897 | $5.556M | 0.1% | $2.12 | $4.27 | — | COM | 68234X102 |
| UROV | UROVANT SCIENCES LTD | 462,659 | $5.552M | 0.1% | $12.00 | $12.00 | — | SHS | G9381B108 |
| — | SIERRA ONCOLOGY INC | 3,200,000 | $5.44M | 0.1% | $1.70 | $2.12 | — | COM | 82640U107 |
| — | ABEONA THERAPEUTICS INC | 659,636 | $5.145M | 0.1% | $7.80 | $3.40 | — | W EXP 12/24/201 | 00289Y115 |
| — | TRANSLATE BIO INC | 500,000 | $5M | 0.1% | $10.00 | $12.65 | — | COM | 89374L104 |
| — | CLOVIS ONCOLOGY INC | 150,000 | $4.406M | 0.1% | $29.37 | $29.37 | — | COM | 189464100 |
| STIM | NEURONETICS INC | 135,500 | $4.345M | 0.1% | $32.07 * | $27.43 | +10.8% | COM | 64131A105 |
| — | ACHILLION PHARMACEUTICALS IN | 1,000,000 | $3.68M | 0.1% | $3.68 | $2.88 | — | COM | 00448Q201 |
| GERN | GERON CORP | 1,950,000 | $3.68M | 0.1% | $1.89 * | $3.82 | +14.2% | Put | 374163103 |
| — | XERIS PHARMACEUTICALS INC | 200,627 | $3.527M | 0.1% | $17.58 | $18.98 | — | COM | 98422L107 |
| EVH | EVOLENT HEALTH INC | 110,000 | $3.124M | 0.1% | $28.40 * | $20.72 | +15.1% | CL A | 30050B101 |
| — | ABEONA THERAPEUTICS INC | 240,459 | $3.078M | 0.1% | $12.80 | $13.00 | — | COM | 00289Y107 |
| — | NUVECTRA CORP | 135,000 | $2.967M | 0.1% | $21.98 | $13.02 | — | COM | 67075N108 |
| — | INVACARE CORP | 200,000 | $2.91M | 0.1% | $14.55 | $19.75 | — | COM | 461203101 |
| — | ALLENA PHARMACEUTICALS INC | 250,000 | $2.685M | 0.1% | $10.74 | $10.06 | — | COM | 018119107 |
| ARVN | ARVINAS INC | 125,000 | $2.109M | 0.1% | $16.87 * | $16.46 | 0.0% | COM | 04335A105 |
| — | VERU INC | 1,425,000 | $2.024M | 0.1% | $1.42 | $1.42 | — | COM | 92536C103 |
| — | ODONATE THERAPEUTICS INC | 100,000 | $1.941M | 0.1% | $19.41 | $25.00 | — | COM | 676079106 |
| — | EIGER BIOPHARMACEUTICALS INC REGISTERED SHS | 157,679 | $1.892M | 0.1% | $12.00 | $15.33 | — | COM | 28249U105 |
| — | KINIKSA PHARMACEUTICALS LTD | 53,169 | $1.356M | 0.0% | $25.50 | $17.35 | — | COM CL A | G5269C101 |
| — | TABULA RASA HEALTHCARE INC | 14,663 | $1.19M | 0.0% | $81.16 | $38.81 | — | COM | 873379101 |
| VKTX | VIKING THERAPEUTICS INC | 64,261 | $1.119M | 0.0% | $17.41 * | $11.90 | 0.0% | COM | 92686J106 |
| — | FIAT CHRYSLER AUTOMOBILES N. | 62,000 | $1.086M | 0.0% | $17.52 | $14.53 | — | COM | N31738102 |
| ONC | BEIGENE LTD | 5,700 | $982K | 0.0% | $172.28 | $103.51 | — | SPONSORED ADR | 07725L102 |
| — | ALLIQUA BIOMEDICAL INC | 423,394 | $961K | 0.0% | $2.27 | $1.81 | — | COM PAR | 019621309 |
| — | CAPITAL SR LIVING CORP | 100,173 | $946K | 0.0% | $9.44 | $18.29 | — | COM | 140475104 |
| PTCT | PTC THERAPEUTICS INC | 19,367 | $910K | 0.0% | $46.99 * | $25.34 | +63.3% | COM | 69366J200 |
| RACE | FERRARI N.V. | 6,200 | $849K | 0.0% | $136.94 * | $40.37 | +226.0% | COM | N3167Y103 |
| — | REATA PHARMACEUTICALS INC | 9,677 | $791K | 0.0% | $81.74 | $81.74 | — | COM | 75615P103 |
| — | G1 THERAPEUTICS INC | 14,055 | $735K | 0.0% | $52.29 | $43.47 | — | COM | 3621LQ109 |
| — | INTERCEPT PHARMACEUTICALS IN | 5,627 | $711K | 0.0% | $126.36 | $126.36 | — | COM | 45845P108 |
| — | HISTOGENICS CORP | 1,203,399 | $656K | 0.0% | $0.55 | $3.12 | — | COM | 43358V109 |
| — | MOMENTA PHARMACEUTICALS INC | 24,489 | $644K | 0.0% | $26.30 | $20.46 | — | COM | 60877T100 |
| NTRA | NATERA INC | 24,000 | $575K | 0.0% | $23.96 | $24.17 | 0.0% | COM | 632307104 |
| — | SENSEONICS HLDGS INC | 115,000 | $549K | 0.0% | $4.77 | $2.90 | — | COM | 81727U105 |
| BLFS | BIOLIFE SOLUTIONS INC | 29,376 | $514K | 0.0% | $17.50 * | $19.78 | 0.0% | COM | 09062W204 |
| — | ADAMIS PHARMACEUTICALS CORP | 137,500 | $481K | 0.0% | $3.50 | $3.50 | — | COM NEW | 00547W208 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 2,213 | $474K | 0.0% | $214.19 * | $57.12 | +339.3% | COM | 558868105 |
| — | PROTEON THERAPEUTICS INC | 240,488 | $469K | 0.0% | $1.95 | $8.74 | — | COM | 74371L109 |
| — | IMMUNOMEDICS INC | 21,335 | $444K | 0.0% | $20.81 | $20.81 | — | COM | 452907108 |
| — | PERNIX THERAPEUTICS HLDGS IN | 1,000,000 | $413K | 0.0% | $0.41 | $0.20 | — | DBCV 4.250% 4/0 | 71426VAK4 |
| VCEL | VERICEL CORP | 27,211 | $385K | 0.0% | $14.15 * | $8.27 | +41.8% | COM | 92346J108 |
| — | VACCINEX INC | 50,000 | $365K | 0.0% | $7.30 | $7.30 | — | COM | 918640103 |
| HCM | HUTCHISON CHINA MEDITECH LTD | 10,000 | $322K | 0.0% | $32.20 | $27.30 | — | SPONSORED ADR | 44842L103 |
| — | CASI PHARMACEUTICALS INC | 43,682 | $204K | 0.0% | $4.67 | $3.25 | — | COM | 14757U109 |
| — | ONCOSEC MED INC | 50,000 | $70,000 | 0.0% | $1.40 | $1.88 | — | COM | 68234L207 |
| — | SOLID BIOSCIENCES INC | 1,835 | $40,000 | 0.0% | $21.80 | $7.50 | — | Call | 3422E1055 |
| GERN | GERON CORP | 200,000 | $10,000 | 0.0% | $0.05 * | $3.82 | +14.2% | Call | 374163103 |
| — | ONCOBIOLOGICS INC | 420,875 | $6,000 | 0.0% | $0.01 | $0.01 | — | *W EXP 02/18/201 | 68235M113 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $4,000 | 0.0% | $1.00 | $1.50 | — | COM | 14070B101 |