Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2018 (← Previous) (Next →)
Filing Date: Feb 14, 2019
Total Value: $2.628B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| NBIX | NEUROCRINE BIOSCIENCES INC | 4,608,554 | $315M | 12.0% | $68.43 * | $36.07 | +165.6% | COM | 64125C109 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 5,425,726 | $223M | 8.5% | $41.05 | $30.61 | — | COM | 37890U108 |
| FOLD | AMICUS THERAPEUTICS INC | 20,724,424 | $192M | 7.3% | $9.25 * | $5.74 | +91.6% | COM | 03152W109 |
| — | ZOGENIX INC | 3,790,216 | $138M | 5.3% | $36.46 | $15.83 | — | COM | 98978L204 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 12,241,111 | $108M | 4.1% | $8.85 * | $9.56 | +0.9% | COM | 462260100 |
| — | SOLID BIOSCIENCES INC | 3,927,222 | $105M | 4.0% | $26.80 | $26.80 | — | COM | 83422E105 |
| CRNX | CRINETICS PHARMACEUTICALS INC | 2,587,953 | $77.61M | 3.0% | $29.99 * | $29.69 | -5.2% | COM | 22663K107 |
| — | QUOTIENT LTD | 10,789,054 | $66.03M | 2.5% | $6.12 | $7.33 | — | COM | G73268107 |
| — | AMARIN CORP PLC | 4,875,600 | $64.55M | 2.5% | $13.24 | $13.62 | — | SPONS ADR NEW | 023111206 |
| ASND | ASCENDIS PHARMA A S | 1,052,647 | $63.04M | 2.4% | $59.89 | $65.49 | — | SPONSORED ADR | 04351P101 |
| — | ARENA PHARMACEUTICALS INC | 1,430,171 | $55.6M | 2.1% | $38.88 | $43.70 | — | COM NEW | 040047607 |
| ARGX | ARGENX SE | 560,941 | $53.89M | 2.1% | $96.07 | $30.70 | — | SPONSORED ADR | 04016X101 |
| — | MYOKARDIA INC | 1,075,216 | $53.5M | 2.0% | $49.76 | $30.93 | — | COM | 62857M105 |
| MMSI | MERIT MEDICAL SYSTEMS INC | 949,198 | $52.18M | 2.0% | $54.97 * | $42.58 | +39.6% | COM | 589889104 |
| — | RETROPHIN INC | 3,342,038 | $49.78M | 1.9% | $14.90 | $16.02 | — | COM | 761299106 |
| MGTX | MEIRAGTX HOLDINGS PLC | 4,703,398 | $45.34M | 1.7% | $9.64 * | $13.41 | -5.9% | COM | G59665102 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,911,715 | $43.59M | 1.7% | $14.97 | $17.73 | -16.3% | COM | 23284F105 |
| — | BLUEPRINT MEDICINES CORP | 857,326 | $43.48M | 1.7% | $50.72 | $59.06 | — | COM | 09627Y109 |
| ALLO | ALLOGENE THERAPEUTICS INC | 1,543,790 | $41.57M | 1.6% | $26.93 | $26.57 | 0.0% | COM | 019770106 |
| — | LA JOLLA PHARMACEUTICAL CO | 4,313,611 | $41.02M | 1.6% | $9.51 | $27.07 | — | COM PAR $.0001 2 | 503459604 |
| — | ACCELERON PHARMA INC | 905,017 | $39.94M | 1.5% | $44.13 | $33.45 | — | COM | 00434H108 |
| — | ALBIREO PHARMA INC | 1,704,330 | $39.51M | 1.5% | $23.18 | $24.69 | — | COM | 01345P106 |
| — | VBI VACCINES INC | 23,951,556 | $38.32M | 1.5% | $1.60 | $2.40 | — | COM NEW | 91822J103 |
| — | ATHENEX INC | 5,096,022 | $32.55M | 1.2% | $6.39 | $11.60 | — | COM | 04685N103 |
| — | MOMENTA PHARMACEUTICALS INC | 2,825,000 | $31.13M | 1.2% | $11.02 | $11.10 | — | COM | 60877T100 |
| — | VERRICA PHARMACEUTICALS INC | 3,410,412 | $27.79M | 1.1% | $8.15 | $19.73 | — | COM | 92511W108 |
| — | KADMON HLDGS INC | 13,165,746 | $27.38M | 1.0% | $2.08 | $4.47 | — | COM | 48283N106 |
| RGNX | REGENXBIO INC | 645,726 | $26.89M | 1.0% | $41.65 * | $30.48 | +92.5% | COM | 75901B107 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $24.68M | 0.9% | $8.00 * | $6.64 | +54.4% | COM | 01438T106 |
| — | VAPOTHERM INC | 1,226,315 | $24.46M | 0.9% | $19.95 | $19.95 | — | COM | 922107107 |
| — | DOVA PHARMACEUTICALS INC | 3,125,851 | $23.69M | 0.9% | $7.58 | $24.78 | — | COM | 25985T102 |
| — | CONCERT PHARMACEUTICALS INC | 1,873,779 | $22.82M | 0.9% | $12.18 | $12.18 | — | COM | 206022105 |
| KOD | KODIAK SCIENCES INC | 3,135,199 | $22.26M | 0.8% | $7.10 * | $8.85 | 0.0% | COM | 50015M109 |
| VRAYQ | VIEWRAY INC | 3,905,650 | $21.71M | 0.8% | $5.56 * | $9.67 | -22.5% | COM | 92672L107 |
| — | INVITAE CORP | 1,863,406 | $20.61M | 0.8% | $11.06 | $8.88 | — | COM | 46185L103 |
| — | CYMABAY THERAPEUTICS INC | 2,462,821 | $19.38M | 0.7% | $7.87 | $8.36 | — | COM | 23257D103 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 262,241 | $18.46M | 0.7% | $70.40 * | $67.14 | +14.6% | COM | 02043Q107 |
| — | NEPTUNE WELLNESS SOLUTIONS I | 8,891,452 | $17.85M | 0.7% | $2.01 | $3.88 | — | COM | 64079L105 |
| — | CLEMENTIA PHARMACEUTICALS INC | 1,500,000 | $17.64M | 0.7% | $11.76 | $11.76 | — | COM | 185575107 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 614,242 | $15.88M | 0.6% | $25.85 * | $25.66 | -4.7% | COM | G31249108 |
| — | FOAMIX PHARMACEUTICALS LTD | 4,661,824 | $15.85M | 0.6% | $3.40 | $5.40 | — | SHS | M46135105 |
| ADMA | ADMA BIOLOGICS INC | 6,521,102 | $14.54M | 0.6% | $2.23 * | $4.10 | +20.9% | COM | 000899104 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 509,186 | $13.76M | 0.5% | $27.03 * | $26.65 | +3.7% | COM | 76243J105 |
| — | AQUESTIVE THERAPEUTICS INC | 2,113,400 | $13.31M | 0.5% | $6.30 | $6.30 | — | COM | 3843E1047 |
| — | SAGE THERAPEUTICS INC | 147,315 | $13.11M | 0.5% | $88.99 | $88.99 | — | COM | 78667J108 |
| — | MEI PHARMA INC | 4,400,440 | $11.62M | 0.4% | $2.64 | $2.64 | — | COM NEW | 55279B202 |
| PRQR | PROQR THERAPEUTICS N.V. | 722,523 | $11.25M | 0.4% | $15.57 * | $10.63 | +72.7% | SHS EURO | N71542109 |
| — | MARKER THERAPEUTICS INC | 2,000,000 | $11.1M | 0.4% | $5.55 | $5.55 | — | COM | 57055L107 |
| — | AXONICS MODULATION TECH INC | 751,000 | $10.94M | 0.4% | $14.56 | $14.56 | — | COM | 05465P101 |
| — | IMMUNOMEDICS INC | 700,000 | $10.5M | 0.4% | $15.00 | $15.18 | — | COM | 452907108 |
| — | MOTUS GI HOLDINGS INC | 3,210,542 | $9.984M | 0.4% | $3.11 | $4.31 | — | COM | 62014P108 |
| — | EDIOS THERAPEUTICS INC | 686,922 | $9.452M | 0.4% | $13.76 | $20.34 | — | COM | 28249H104 |
| — | PROTAGONIST THERAPEUTICS INC | 1,365,579 | $9.19M | 0.3% | $6.73 | $9.51 | — | COM | 4366E1029 |
| AKBA | AKEBIA THERAPEUTICS INC | 1,703,440 | $9.182M | 0.3% | $5.39 * | $13.51 | -42.1% | COM | 00972D105 |
| — | ORCHARD THERAPEUTICS PLC | 521,800 | $8.207M | 0.3% | $15.73 | $15.73 | — | ADS | 68570P101 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $7.383M | 0.3% | $0.98 | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 445,000 | $7.374M | 0.3% | $16.57 * | $17.11 | 0.0% | COM | 19459J104 |
| — | ZYMEWORKS INC | 573,890 | $7.196M | 0.3% | $12.54 | $10.53 | — | COM | 98985W102 |
| — | MOLECULAR TEMPLATES INC | 1,974,133 | $7.107M | 0.3% | $3.60 | $5.56 | — | COM | 608550109 |
| XNCR | XENCOR INC | 196,810 | $6.833M | 0.3% | $34.72 * | $11.77 | +211.6% | COM | 98401F105 |
| — | SYNLOGIC INC | 867,852 | $6.049M | 0.2% | $6.97 | $16.39 | — | COM | 87166L100 |
| QURE | UNIQURE NV | 220,707 | $5.946M | 0.2% | $26.94 * | $19.52 | +42.5% | SHS | N90064101 |
| — | THERAPEUTICSMD INC | 1,500,000 | $5.715M | 0.2% | $3.81 | $6.56 | — | COM | 88338N107 |
| — | DBV TECHNOLOGIES S A | 826,960 | $5.309M | 0.2% | $6.42 | $25.27 | — | SPONSORED ADR | 23306J101 |
| — | MIRATI THERAPEUTICS INC | 125,875 | $5.25M | 0.2% | $41.71 | $41.71 | — | COM | 60468T105 |
| UROV | UROVANT SCIENCES LTD | 625,359 | $3.915M | 0.1% | $6.26 | $10.51 | — | SHS | G9381B108 |
| ARWR | ARROWHEAD PHARMACEUTICALS INC | 300,000 | $3.582M | 0.1% | $11.94 * | $6.16 | +122.0% | COM | 04280A100 |
| RCKT | ROCKET PHARMACEUTICALS INC | 240,173 | $3.495M | 0.1% | $14.55 * | $16.60 | 0.0% | COM | 77313F106 |
| — | SIERRA ONCOLOGY INC | 2,666,190 | $3.413M | 0.1% | $1.28 | $2.12 | — | COM | 82640U107 |
| — | TRANSLATE BIO INC | 435,000 | $3.167M | 0.1% | $7.28 | $12.65 | — | COM | 89374L104 |
| TDOC | TELADOC HEALTH INC | 60,000 | $2.974M | 0.1% | $49.57 * | $61.19 | 0.0% | COM | 87918A105 |
| WVE | WAVE LIFE SCIENCES LTD | 59,498 | $2.501M | 0.1% | $42.04 * | $17.43 | +155.2% | SHS | Y95308105 |
| EHTH | EHEALTH INC | 55,021 | $2.113M | 0.1% | $38.40 * | $26.55 | +26.7% | COM | 28238P109 |
| PEN | PENUMBRA INC | 16,338 | $2.037M | 0.1% | $124.68 * | $133.93 | 0.0% | COM | 70975L107 |
| — | VERU INC | 1,425,000 | $1.853M | 0.1% | $1.30 | $1.42 | — | COM | 92536C103 |
| — | ACASTI PHARMA INC | 1,779,882 | $1.48M | 0.1% | $0.83 | $0.83 | — | CL A NEW | 00430K402 |
| — | EIGER BIOPHARMACEUTICALS INC | 139,890 | $1.421M | 0.1% | $10.16 | $15.33 | — | COM | 28249U105 |
| — | ONCOMED PHARMACEUTICALS INC | 1,719,111 | $1.284M | 0.0% | $0.75 | $4.27 | — | COM | 68234X102 |
| — | ABEONA THERAPEUTICS INC | 180,797 | $1.269M | 0.0% | $7.02 | $13.00 | — | COM | 00289Y107 |
| — | ABEONA THERAPEUTICS INC | 659,636 | $1.267M | 0.0% | $1.92 | $3.40 | — | W EXP12/24/201 | 00289Y115 |
| CDNA | CAREDX INC | 44,128 | $1.037M | 0.0% | $23.50 * | $6.23 | +312.1% | COM | 14167L103 |
| — | ADVERUM BIOTECHNOLOGIES INC | 300,000 | $960K | 0.0% | $3.20 | $3.20 | — | COM | 00773U108 |
| — | FIAT CHRYSLER AUTOMOBILES N. | 62,000 | $894K | 0.0% | $14.42 | $14.53 | — | SHS | N31738102 |
| — | INVACARE CORP | 200,000 | $860K | 0.0% | $4.30 | $19.75 | — | COM | 461203101 |
| — | ALLENA PHARMACEUTICALS INC | 132,300 | $704K | 0.0% | $5.32 | $10.06 | — | COM | 018119107 |
| — | PERNIX THERAPEUTICS HLDGS IN | 1,000,000 | $642K | 0.0% | $0.64 | $0.20 | — | DBCV 4,250% 4/0 | 71426VAK4 |
| RACE | FERRARI N.V. | 6,200 | $610K | 0.0% | $98.39 * | $40.37 | +178.2% | COM | N3167Y103 |
| VCEL | VERICEL CORP | 28,090 | $488K | 0.0% | $17.37 * | $8.48 | +76.4% | COM | 92346J108 |
| TNDM | TANDEM DIABETES CARE INC | 12,844 | $479K | 0.0% | $37.29 * | $35.31 | 0.0% | COM NEW | 875372203 |
| DXCM | DEXCOM INC | 3,733 | $442K | 0.0% | $118.40 * | $31.72 | 0.0% | COM | 252131107 |
| — | AMEDISYS INC | 3,672 | $422K | 0.0% | $114.92 | $114.92 | — | COM | 023436108 |
| GKOS | GLAUKOS CORP | 7,466 | $417K | 0.0% | $55.85 * | $60.12 | 0.0% | COM | 377322102 |
| — | ZOGENIX INC | 200,000 | $410K | 0.0% | $2.05 | $15.83 | — | Put | 98978L204 |
| STAA | STAAR SURGICAL CO | 12,953 | $405K | 0.0% | $31.27 * | $38.97 | 0.0% | COM PAR $ 0.01 | 852312305 |
| — | IMMUNOMEDICS INC | 200,000 | $308K | 0.0% | $1.54 | $15.18 | — | Call | 452907108 |
| SIBN | SI-BONE INC | 15,000 | $307K | 0.0% | $20.47 * | $18.92 | 0.0% | COM | 825704109 |
| — | ALLIQUA BIOMEDICAL INC | 114,730 | $214K | 0.0% | $1.87 | $1.81 | — | COM PAR | 019621309 |
| — | VACCINEX INC | 50,000 | $190K | 0.0% | $3.80 | $7.30 | — | COM | 918640103 |
| — | OUTLOOK THERAPEUTICS INC | 420,875 | $72,000 | 0.0% | $0.17 | $0.17 | — | *W EXP 02/18/201 | 69012T115 |
| — | ONCOSEC MEDICAL INC | 50,000 | $32,000 | 0.0% | $0.64 | $1.88 | — | COM | 68234L207 |
| — | SOLID BIOSCIENCES INC | 1,835 | $14,000 | 0.0% | $7.63 | $26.80 | — | Call | 83422E105 |