Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q2 2018 (← Previous) (Next →)
Filing Date: Nov 1, 2018
Total Value: $3.814B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| NBIX | NEUROCRINE BIOSCIENCES INC | 4,715,250 | $463M | 12.1% | $35.06 | +155.3% | COM | 64125C109 |
| FOLD | AMICUS THERAPEUTICS INC | 20,024,424 | $313M | 8.2% | $5.46 | +176.9% | COM | 03152W109 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 4,828,910 | $218M | 5.7% | $29.53 | — | COM | 37890U108 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 1,846,911 | $182M | 4.8% | $67.14 | +47.7% | COM | 02043Q107 |
| — | ZOGENIX INC | 3,970,357 | $175M | 4.6% | $15.83 | — | COM | 98978L204 |
| — | SOLID BIOSCIENCES INC | 3,927,222 | $140M | 3.7% | $7.50 | — | COM | 3422E1055 |
| — | LA JOLLA PHARMACEUTICAL CO | 4,313,611 | $126M | 3.3% | $27.07 | — | COM PAR $.0001 2 | 503459604 |
| — | BIOHAVEN PHARMACEUTICAL HOLDING CO L | 2,743,647 | $108M | 2.8% | $25.06 | — | COM | G11196105 |
| — | DOVA PHARMACEUTICALS INC | 3,125,851 | $93.53M | 2.5% | $24.78 | — | COM | 25985T102 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 5,852,202 | $74.91M | 2.0% | $8.35 | +75.1% | COM | 462260100 |
| — | ACCELERON PHARMA INC | 1,528,205 | $74.15M | 1.9% | $33.45 | — | COM | 00434H108 |
| ASND | ASCENDIS PHARMA A S | 1,072,647 | $71.35M | 1.9% | $65.49 | — | SPONSORED ADR | 04351P101 |
| — | VERRICA PHARMACEUTICALS INC | 3,410,412 | $67.29M | 1.8% | $19.73 | — | COM | 92511W108 |
| RGNX | REGENXBIO INC | 867,106 | $62.22M | 1.6% | $19.99 | +138.8% | COM | 75901B107 |
| — | BLUEPRINT MEDICINES CORP | 961,147 | $61.01M | 1.6% | $59.06 | — | COM | 09627Y109 |
| — | ALBIREO PHARMA INC | 1,704,330 | $60.5M | 1.6% | $24.69 | — | COM | 01345P106 |
| — | ALEXION PHARMACEUTICALS INC | 463,450 | $57.54M | 1.5% | $111.46 | — | COM | 015351109 |
| — | RETROPHIN INC | 3,212,871 | $57.39M | 1.5% | $16.07 | — | COM | 761299106 |
| MMSI | MERIT MED SYS INC | 1,082,013 | $55.4M | 1.5% | $42.58 | +16.4% | COM | 589889104 |
| QURE | UNIQURE NV | 1,444,628 | $54.61M | 1.4% | $19.52 | +64.0% | SHS | N90064101 |
| — | MYOKARDIA INC | 1,089,169 | $54.08M | 1.4% | $30.93 | — | COM | 62857M105 |
| MGTX | MEIRAGTX HOLDINGS PLC | 4,703,398 | $53.9M | 1.4% | $13.41 | 0.0% | COM | G59665102 |
| — | KADMON HLDGS INC | 13,165,746 | $52.53M | 1.4% | $4.47 | — | COM | 48283N106 |
| — | QUOTIENT LTD | 6,483,020 | $52.06M | 1.4% | $7.63 | — | SHS | G73268107 |
| — | CORIUM INTERNATIONAL INC | 6,357,133 | $50.92M | 1.3% | $6.41 | — | COM | 21887L107 |
| ISRG | INTUITIVE SURGICAL INC | 100,000 | $47.85M | 1.3% | $148.81 | +2.5% | COM NEW | 46120E602 |
| HUM | HUMANA INC | 148,218 | $44.11M | 1.2% | $247.58 | +10.8% | COM | 444859102 |
| CTMX | CYTOMX THERAPEUTICS INC | 1,921,715 | $43.93M | 1.2% | $16.15 | +58.1% | COM | 23284F105 |
| ARGX | ARGENX SE ADR | 529,560 | $43.88M | 1.2% | $28.03 | — | ADR | 04016X101 |
| — | DBV TECHNOLOGIES SA SHS SPONSORED AMERICAN DEPOSIT | 2,108,198 | $40.67M | 1.1% | $26.47 | — | ADR | 23306J101 |
| XNCR | XENCOR INC | 1,068,095 | $39.53M | 1.0% | $11.77 | +192.7% | COM | 98401F105 |
| — | CYMABAY THERAPEUTICS INC | 2,742,821 | $36.81M | 1.0% | $8.36 | — | COM | 23257D103 |
| — | ARENA PHARMACEUTICALS INC | 841,978 | $36.71M | 1.0% | $42.62 | — | COM NEW | 040047607 |
| — | MIRATI THERAPEUTICS INC | 713,191 | $35.16M | 0.9% | $48.03 | — | COM | 60468T105 |
| ADMA | ADMA BIOLOGICS INC | 6,521,102 | $29.41M | 0.8% | $4.10 | +21.7% | COM | 000899104 |
| — | ADAMAS PHARMACEUTICALS INC | 1,084,159 | $28M | 0.7% | $24.71 | — | COM | 00548A106 |
| PBYI | PUMA BIOTECHNOLOGY INC | 564,579 | $27.67M | 0.7% | $62.36 | -7.1% | COM | 74587V107 |
| — | VBI VACCINES INC | 9,665,843 | $26.58M | 0.7% | $3.58 | — | COM NEW | 91822J103 |
| — | ENDOCYTE INC | 1,921,700 | $26.52M | 0.7% | $5.92 | — | COM | 29269A102 |
| — | AUDENTES THERAPEUTICS INC | 660,406 | $25.23M | 0.7% | $19.96 | — | COM | 05070R104 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 800,686 | $25.03M | 0.7% | $26.65 | +2.6% | COM | 76243J105 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 308,006 | $24.99M | 0.7% | $34.30 | +103.9% | COM | 450056106 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $24.53M | 0.6% | $6.64 | +20.2% | COM | 01438T106 |
| — | ATHENAHEALTH INC | 150,000 | $23.87M | 0.6% | $159.14 | — | COM | 04685W103 |
| — | GTX INC DEL | 1,501,501 | $22.99M | 0.6% | $15.31 | — | COM NEW | 40052B207 |
| AKBA | AKEBIA THERAPEUTICS INC | 2,215,400 | $22.11M | 0.6% | $13.99 | -28.4% | COM | 00972D105 |
| — | NEPTUNE TECHNOLOGIES AND BIORESO | 8,574,015 | $20.38M | 0.5% | $2.95 | — | COM | 64077P108 |
| — | MOTUS GI HLDGS INC | 2,810,542 | $20.21M | 0.5% | $4.48 | — | COM | 62014P108 |
| — | ZYMEWORKS INC | 1,123,890 | $15.92M | 0.4% | $10.53 | — | COM | 98985W102 |
| — | ABIOMED INC | 36,646 | $14.99M | 0.4% | $221.08 | — | COM | 003654100 |
| — | INVITAE CORP | 2,021,100 | $14.86M | 0.4% | $8.88 | — | COM | 46185L103 |
| — | EIDOS THERAPEUTICS INC | 686,922 | $13.97M | 0.4% | $20.34 | — | COM | 28249H104 |
| GLPG | GALAPAGOS NV | 150,875 | $13.91M | 0.4% | $67.75 | — | SPON ADR | 36315X101 |
| — | SIERRA ONCOLOGY INC | 4,500,000 | $13.32M | 0.3% | $2.12 | — | COM | 82640U107 |
| VRTX | VERTEX PHARMACEUTICALS INC | 75,898 | $12.9M | 0.3% | $100.79 | +53.8% | COM | 92532F100 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $12.81M | 0.3% | $3.40 | — | W EXP 12/24/201 | 00289Y115 |
| TDOC | TELADOC INC | 195,000 | $11.32M | 0.3% | $37.75 | +29.4% | COM | 87918A105 |
| WVE | WAVE LIFE SCIENCES LTD | 282,798 | $10.82M | 0.3% | $17.43 | +147.0% | SHS | Y95308105 |
| — | MENLO THERAPEUTICS INC | 1,241,287 | $10.08M | 0.3% | $37.58 | — | COM | 586858102 |
| — | SYNLOGIC INC | 942,852 | $9.268M | 0.2% | $16.39 | — | COM | 87166L100 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 32,213 | $9.01M | 0.2% | $57.12 | +207.4% | COM | 558868105 |
| — | XERIS PHARMACEUTICALS INC | 450,000 | $8.541M | 0.2% | $18.98 | — | COM | 98422L107 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $8.458M | 0.2% | $1.05 | — | NOTE 3.005 12/0 | 00182CAA1 |
| AXGN | AXOGEN INC | 165,000 | $8.291M | 0.2% | $44.06 | 0.0% | COM | 05463X106 |
| — | FLEXION THERAPEUTICS INC | 307,989 | $7.962M | 0.2% | $25.04 | — | COM | 33938J106 |
| — | CLEARSIDE BIOMEDICAL INC | 707,581 | $7.599M | 0.2% | $7.69 | — | COM | 185063104 |
| — | MARINUS PHARMACEUTICALS INC | 907,732 | $6.417M | 0.2% | $5.87 | — | COM | 56854Q101 |
| — | TRANSLATE BIO INC | 500,000 | $6.325M | 0.2% | $12.65 | — | COM | 89374L104 |
| — | ONCOMED PHARMACEUTICALS | 2,620,897 | $6.054M | 0.2% | $4.27 | — | COM | 68234X102 |
| — | ASSEMBLY BIOSCIENCES INC | 150,695 | $5.909M | 0.2% | $13.93 | — | COM | 045396108 |
| CDNA | CAREDX INC | 467,676 | $5.724M | 0.2% | $6.23 | +83.9% | COM | 14167L103 |
| — | FOAMIX PHARMACEUTICALS LTD | 1,117,324 | $5.598M | 0.1% | $7.58 | — | SHS | M46135105 |
| — | HISTOGENICS CORP | 2,203,277 | $5.508M | 0.1% | $3.12 | — | COM | 43358V109 |
| ARWR | ARROWHEAD PHARMACEUTICALS INC | 365,445 | $4.97M | 0.1% | $6.16 | +51.8% | COM | 04280A100 |
| — | TESARO INC | 100,000 | $4.447M | 0.1% | $44.47 | — | COM | 881569107 |
| — | AVEO PHARMACEUTICALS INC | 1,891,192 | $4.274M | 0.1% | $1.03 | — | COM | 053588109 |
| — | MOLECULAR TEMPLATES INC | 724,133 | $3.787M | 0.1% | $5.84 | — | COM | 608550109 |
| — | INVACARE CORP | 200,000 | $3.72M | 0.1% | $19.75 | — | COM | 461203101 |
| — | ATHENEX INC | 190,000 | $3.545M | 0.1% | $17.01 | — | COM | 04685N103 |
| STIM | NEURONETICS INC | 125,500 | $3.34M | 0.1% | $27.20 | 0.0% | COM | 64131A105 |
| — | ODONATE THERAPEUTICS INC | 150,000 | $3.312M | 0.1% | $25.00 | — | COM | 676079106 |
| — | NUVECTRA CORP | 159,466 | $3.274M | 0.1% | $13.02 | — | COM | 67075N108 |
| — | ALLENA PHARMACEUTICALS INC | 250,000 | $3.258M | 0.1% | $10.06 | — | COM | 018119107 |
| GERN | GERON CORP | 2,550,000 | $2.922M | 0.1% | $3.82 | 0.0% | COM | 374163103 |
| — | ACHILLION PHARMACEUTICALS INC | 1,000,000 | $2.83M | 0.1% | $2.88 | — | COM | 00448Q201 |
| — | CHAMPIONS ONCOLOGY INC | 366,972 | $2.326M | 0.1% | $6.34 | — | COM NEW | 158990812 |
| — | KINIKSA PHARMACEUTICALS LTD | 111,111 | $1.928M | 0.1% | $17.35 | — | COM | G5269C101 |
| — | EIGER BIOPHARMACEUTICALS INC | 157,679 | $1.923M | 0.1% | $15.33 | — | COM | 28249U105 |
| — | AGILE THERAPEUTICS INC | 3,530,000 | $1.744M | 0.0% | $2.68 | — | COM | 00847L100 |
| — | STRONGBRIDGE BIOPHARMA PLC | 275,000 | $1.65M | 0.0% | $7.25 | — | COM | G85347105 |
| EVH | EVOLENT HEALTH INC | 70,000 | $1.474M | 0.0% | $18.93 | 0.0% | CL A | 30050B101 |
| — | VICAL INC | 1,142,858 | $1.314M | 0.0% | $1.83 | — | COM NEW | 925602203 |
| — | FIAT CHRYSLER AUTOMOBILES N. | 62,000 | $1.171M | 0.0% | $14.53 | — | SHS | N31738102 |
| — | CAPITAL SR LIVING CORP | 100,173 | $1.069M | 0.0% | $18.29 | — | COM | 140475104 |
| — | ABEONA THERAPEUTICS INC | 59,662 | $954K | 0.0% | $13.62 | — | COM | 00289Y107 |
| — | TABULA RASA HEALTHCARE INC | 14,663 | $936K | 0.0% | $38.81 | — | COM | 873379101 |
| ONC | BEIGENE LTD | 5,700 | $876K | 0.0% | $103.51 | — | SPONSORED ADR | 07725L102 |
| — | ALLIQUA BIOMEDICAL INC | 423,394 | $867K | 0.0% | $1.81 | — | COM PAR | 019621309 |
| RACE | FERRARI N.V. | 6,200 | $837K | 0.0% | $40.37 | +225.7% | COM | N3167Y103 |
| — | PROTEON THERAPEUTICS INC | 334,116 | $819K | 0.0% | $8.74 | — | COM | 74371L109 |
| — | AZURRX BIOPHARMA INC | 227,272 | $730K | 0.0% | $4.74 | — | COM | 05502L105 |
| — | ARRAY BIOPHARMA INC | 40,133 | $673K | 0.0% | $16.32 | — | COM | 04269X105 |
| — | LOXO ONCOLOGY INC | 3,765 | $653K | 0.0% | $173.44 | — | COM | 548862101 |
| PTCT | PTC THERAPEUTICS INC | 19,367 | $653K | 0.0% | $25.34 | +23.1% | COM | 69366J200 |
| — | G1 THERAPEUTICS INC | 14,055 | $611K | 0.0% | $43.47 | — | COM | 3621LQ109 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 49,302 | $585K | 0.0% | $11.87 | — | SPONDS ADR | 00653A107 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 24,213 | $577K | 0.0% | $24.59 | 0.0% | COM | 19459J104 |
| VRAYQ | VIEWRAY INC | 75,000 | $519K | 0.0% | $8.17 | -11.1% | COM | 92672L107 |
| — | MOMENTA PHARMACEUTICALS INC | 24,489 | $501K | 0.0% | $20.46 | — | COM | 60877T100 |
| — | SENSEONICS HLDGS INC | 115,000 | $473K | 0.0% | $2.90 | — | COM | 81727U105 |
| — | ADVERUM BIOTECHNOLOGIES INC | 80,845 | $428K | 0.0% | $5.80 | — | COM | 00773U108 |
| — | PERNIX THERAPEUTICS HLDGS IN | 1,000,000 | $426K | 0.0% | $0.20 | — | DBVC 4.250% 4/0 | 71426VAK4 |
| — | VITAL THERAPIES INC | 150,000 | $405K | 0.0% | $2.70 | — | COM | 92847R104 |
| — | CASI PHARMACEUTICALS INC | 43,682 | $360K | 0.0% | $3.25 | — | COM | 14757U109 |
| SGMO | SANGAMO THERAPEUTICS INC | 25,000 | $355K | 0.0% | $21.38 | -22.3% | COM | 800677106 |
| — | VERONA PHARMA PLC | 22,327 | $307K | 0.0% | $11.65 | — | SPONSORED ADR | 925050106 |
| HCM | HUTCHISON CHINA MEDITECH LTD | 10,000 | $301K | 0.0% | $27.30 | — | SPONSORED ADR | 44842L103 |
| — | NEKTAR THERAPEUTICS | 6,057 | $296K | 0.0% | $106.32 | — | COM | 640268108 |
| — | AEGLEA BIOTHERAPEUTICS INC | 25,694 | $272K | 0.0% | $10.59 | — | COM | 00773J103 |
| VCEL | VERICEL CORP | 27,211 | $264K | 0.0% | $8.27 | +50.6% | COM | 92346J108 |
| TGTX | TG THERAPEUTICS INC | 100,000 | $258K | 0.0% | $13.75 | 0.0% | COM | 88322Q108 |
| — | ACASTI PHARMA INC | 206,677 | $117K | 0.0% | $2.32 | — | CL A NEW | 00430K402 |
| — | ONCOSEC MED INC | 50,000 | $69,000 | 0.0% | $1.88 | — | COM | 68234L207 |
| — | ELLOX PHARMACEUTICALS INC | 2,961 | $50,000 | 0.0% | $16.89 | — | COM | 29014R103 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $5,000 | 0.0% | $1.50 | — | COM | 14070B101 |