Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2019 (← Previous) (Next →)
Filing Date: May 16, 2019
Total Value: $3.544B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| NBIX | NEUROCRINE BIOSCIENCES INC | 3,758,662 | $331M | 9.3% | $36.07 | +131.7% | COM | 64125C109 |
| FOLD | AMICUS THERAPEUTICS INC | 21,639,486 | $294M | 8.3% | $6.01 | +103.2% | COM | 03152W109 |
| — | GLOBAL BLOOD THERAPEUTICS INC | 5,525,726 | $292M | 8.3% | $31.02 | — | COM | 37890U108 |
| — | ZOGENIX INC | 3,869,491 | $213M | 6.0% | $16.63 | — | COM | 98978L204 |
| — | AMARIN CORPORATION PLC | 6,540,957 | $136M | 3.8% | $15.44 | — | SPONS ADR NEW | 023111206 |
| ASND | ASCENDIS PHARMA A S | 1,113,328 | $131M | 3.7% | $68.34 | — | SPONSORED ADR | 04351P101 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 12,235,811 | $116M | 3.3% | $9.56 | +1.6% | COM | 462260100 |
| MGTX | MEIRAGTX HOLDINGS PLC | 6,007,746 | $104M | 2.9% | $13.56 | +3.9% | COM | G59665102 |
| — | ARRAY BIOPHARMA INC | 4,228,900 | $103M | 2.9% | $24.38 | — | COM | 04269X105 |
| — | BLUEPRINT MEDICINES CORP | 1,271,054 | $102M | 2.9% | $65.89 | — | COM | 09627Y109 |
| — | QUOTIENT LTD | 10,789,054 | $97.21M | 2.7% | $7.33 | — | SHS | G73268107 |
| — | MIRATI THERAPEUTICS INC | 1,164,382 | $85.35M | 2.4% | $69.88 | — | COM | 60468T105 |
| — | RETROPHIN INC | 3,054,707 | $69.13M | 2.0% | $16.02 | — | COM | 761299106 |
| RGNX | REGENXBIO INC | 1,145,726 | $65.66M | 1.9% | $38.79 | +27.7% | COM | 75901B107 |
| MMSI | MERIT MEDICAL SYSTEMS INC | 1,053,098 | $65.11M | 1.8% | $43.97 | +29.0% | COM | 589889104 |
| — | ARENA PHARMACEUTICALS INC | 1,400,171 | $62.77M | 1.8% | $43.70 | — | COM | 040047607 |
| — | ATHENEX INC | 5,096,022 | $62.43M | 1.8% | $11.60 | — | COM | 04685N103 |
| CRNX | CRINETICS PHARMACEUTICALS INC | 2,587,953 | $58.9M | 1.7% | $29.69 | -17.2% | COM | 22663K107 |
| — | CYMABAY THERAPEUTICS INC | 4,212,821 | $55.95M | 1.6% | $10.41 | — | COM | 23257D103 |
| — | ALBIREO PHARMA INC | 1,704,330 | $54.9M | 1.5% | $24.69 | — | COM | 01345P106 |
| — | MYOKARDIA INC | 988,511 | $51.39M | 1.5% | $30.93 | — | COM | 62857M105 |
| — | INVITAE CORP | 2,171,918 | $50.87M | 1.4% | $10.95 | — | COM | 46185L103 |
| ALLO | ALLOGENE THERAPEUTICS INC | 1,543,790 | $44.63M | 1.3% | $26.57 | +9.2% | COM | 019770106 |
| — | VBI VACCINES INC | 23,951,556 | $42.63M | 1.2% | $2.40 | — | COM | 91822J103 |
| — | MOMENTA PHARMACEUTICALS INC | 2,875,000 | $41.77M | 1.2% | $11.16 | — | COM | 60877T100 |
| — | VERRICA PHARMACEUTICALS INC | 3,410,412 | $38.54M | 1.1% | $19.73 | — | COM | 92511W108 |
| — | SOLID BIOSCIENCES INC | 3,927,222 | $36.13M | 1.0% | $9.20 | — | COM | 3422E1055 |
| VRAYQ | VIEWRAY INC | 4,805,650 | $35.51M | 1.0% | $9.31 | -17.1% | COM | 92672L107 |
| — | KADMON HOLDINGS INC | 13,165,746 | $34.76M | 1.0% | $4.47 | — | COM | 48283N106 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,173,923 | $34.12M | 1.0% | $17.48 | -15.4% | COM | 23284F105 |
| — | NEPTUNE WELLNESS SOLUTIONS INC | 8,891,452 | $28.36M | 0.8% | $3.88 | — | COM | 64079L105 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $27.86M | 0.8% | $6.64 | +28.1% | COM | 01438T106 |
| — | DOVA PHARMACEUTICALS INC | 3,125,851 | $27.79M | 0.8% | $24.78 | — | COM | 25985T102 |
| TDOC | TELADOC HEALTH INC | 495,000 | $27.52M | 0.8% | $61.07 | -0.0% | COM | 87918A105 |
| — | CONCERT PHARMACEUTICALS INC | 2,204,641 | $26.61M | 0.8% | $12.16 | — | COM | 206022105 |
| — | NEVRO CORP | 416,949 | $26.06M | 0.7% | $62.51 | — | COM | 64157F103 |
| — | PROTAGONIST THERAPEUTICS INC | 2,071,297 | $26.04M | 0.7% | $10.55 | — | COM | 4366E1029 |
| ADMA | ADMA BIOLOGICS INC | 6,521,102 | $24.71M | 0.7% | $4.10 | -13.7% | COM | 000899104 |
| — | VAPOTHERM INC | 1,246,315 | $24.49M | 0.7% | $19.94 | — | COM | 922107107 |
| KOD | KODIAK SCIENCES INC | 3,135,199 | $20.47M | 0.6% | $8.85 | -16.5% | COM | 50015M109 |
| EHTH | EHEALTH INC | 289,857 | $18.07M | 0.5% | $49.69 | +10.9% | COM | 28238P109 |
| — | FOAMIX PHARMACEUTICALS LTD | 4,661,824 | $17.48M | 0.5% | $5.40 | — | SHS | M46135105 |
| — | AXONICS MODULATION TECHNOLOGIES INC | 685,756 | $16.42M | 0.5% | $14.56 | — | COM | 05465P101 |
| — | EIDOS THERAPEUTICS INC | 686,992 | $16.11M | 0.5% | $20.34 | — | COM | 28249H104 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 200,000 | $14.99M | 0.4% | $85.47 | 0.0% | COM | 450056106 |
| BHC | BAUSCH HEALTH COS INC | 600,000 | $14.82M | 0.4% | $23.88 | 0.0% | COM | 071734107 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 614,242 | $14.77M | 0.4% | $25.66 | +3.4% | COM | G31249108 |
| — | AQUESTIVE THERAPEUTICS INC | 2,113,400 | $14.6M | 0.4% | $6.30 | — | COM | 3843E1047 |
| AKBA | AKEBIA THERAPEUTICS INC | 1,703,440 | $13.95M | 0.4% | $13.51 | -49.2% | COM | 00972D105 |
| QURE | UNIQURE NV. | 231,820 | $13.83M | 0.4% | $20.73 | +115.5% | SHS | N90064101 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 502,970 | $13.79M | 0.4% | $26.65 | +7.8% | COM | 76243J105 |
| — | MEI PHARMA INC | 4,400,440 | $13.51M | 0.4% | $2.64 | — | COM NEW | 55279B202 |
| — | MARKER THERAPEUTICS INC | 2,000,000 | $13.2M | 0.4% | $5.55 | — | COM | 57055L107 |
| — | AGILE THERAPEUTICS INC | 8,426,750 | $12.72M | 0.4% | $1.51 | — | COM | 00847L100 |
| — | MOTUS GI HLDGS INC | 3,210,542 | $12.52M | 0.4% | $4.31 | — | COM | 62014P108 |
| — | MOLECULAR TEMPLATES INC | 1,974,133 | $11.47M | 0.3% | $5.56 | — | COM | 608550109 |
| PRQR | PROQR THERAPEUTICS N.V. | 722,523 | $10.02M | 0.3% | $10.63 | +40.5% | SHS EURO | N71542109 |
| ALEC | ALECTOR INC | 511,731 | $9.579M | 0.3% | $18.92 | 0.0% | COM | 014442107 |
| — | ORCHARD THERAPEUTICS PLC | 521,800 | $9.329M | 0.3% | $15.73 | — | ADS | 68570P101 |
| HUM | HUMANA INC | 35,000 | $9.31M | 0.3% | $271.28 | 0.0% | COM | 444859102 |
| — | DBV TECHNOLOGIES S A | 1,128,524 | $8.7M | 0.2% | $20.58 | — | SPONSORED ADR | 23306J101 |
| UROV | UROVANT SCIENCES LTD | 865,359 | $8.697M | 0.2% | $10.38 | — | COM | G9381B108 |
| — | ZYMEWORKS INC | 573,890 | $8.529M | 0.2% | $10.53 | — | COM | 98985W102 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $8.239M | 0.2% | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| RCKT | ROCKET PHARMACEUTICALS INC | 458,173 | $8.036M | 0.2% | $16.21 | -2.6% | COM | 77313F106 |
| — | SYNLOGIC INC | 867,852 | $6.587M | 0.2% | $16.39 | — | COM | 87166L100 |
| ARWR | ARROWHEAD PHARMACEUTICALS INC | 330,738 | $6.069M | 0.2% | $7.12 | +131.7% | COM | 04280A100 |
| — | SHOCKWAVE MEDICAL INC | 150,000 | $5.021M | 0.1% | $33.47 | — | COM | 82489T104 |
| — | SIERRA ONCOLOGY INC | 2,666,190 | $4.559M | 0.1% | $2.12 | — | COM | 82640U107 |
| — | TRANSLATE BIO INC | 435,000 | $4.433M | 0.1% | $12.65 | — | COM | 89374L104 |
| LIVN | LIVANOVA PLC | 40,000 | $3.89M | 0.1% | $93.36 | 0.0% | SHS | G5509L101 |
| RARE | ULTRAGENYX PHARMACEUTICAL INC | 50,000 | $3.468M | 0.1% | $57.14 | 0.0% | COM | 90400D108 |
| — | INTERSECT ENT INC | 70,000 | $2.251M | 0.1% | $32.16 | — | COM | 46071F103 |
| — | VERU INC | 1,425,000 | $2.081M | 0.1% | $1.42 | — | COM | 92536C103 |
| — | EIGER BIOPHARMACEUTICALS INC | 139,890 | $1.955M | 0.1% | $15.33 | — | COM | 28249U105 |
| — | ABEONA THERAPEUTICS INC | 659,636 | $1.906M | 0.1% | $3.40 | — | *W EXP 12/24/201 | 00289Y115 |
| — | ACASTI PHARMA INC | 1,779,882 | $1.815M | 0.1% | $0.83 | — | CL A NEW | 00430K402 |
| — | ONCOMED PHARMACEUTICALS INC | 1,719,111 | $1.787M | 0.1% | $4.27 | — | COM | 68234X102 |
| — | VOCERA COMMUNICATIONS INC | 50,000 | $1.582M | 0.0% | $31.64 | — | COM | 92857F107 |
| AORT | CRYOLIFE INC | 50,000 | $1.459M | 0.0% | $28.53 | 0.0% | COM | 228903100 |
| — | ABEONA THERAPEUTICS INC | 180,797 | $1.331M | 0.0% | $13.00 | — | COM | 00289Y107 |
| — | AVEDRO INC | 100,000 | $1.227M | 0.0% | $12.27 | — | COM | 05355N109 |
| — | ALLENA PHARMACEUTICALS INC | 132,300 | $929K | 0.0% | $10.06 | — | COM | 018119107 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $920K | 0.0% | $14.84 | — | SHS | N31739102 |
| RACE | FERRARI N.V. | 6,200 | $830K | 0.0% | $40.37 | +203.4% | COM | N3167Y103 |
| TNDM | TANDEM DIABETES CARE INC | 12,844 | $816K | 0.0% | $35.31 | +48.8% | COM | 875372203 |
| VCYT | VERACYTE INC | 31,521 | $789K | 0.0% | $19.10 | 0.0% | COM | 92337F107 |
| AXSM | AXSOME THERAPEUTICS INC | 53,879 | $767K | 0.0% | $9.29 | 0.0% | COM | 05464T104 |
| — | CLOVIS ONCOLOGY INC | 200,000 | $660K | 0.0% | — | — | Put | 189464100 |
| BIIB | BIOGEN INC | 400,000 | $620K | 0.0% | — | — | Call | 09062X103 |
| LAB | FLUIDIGM CORP | 46,030 | $612K | 0.0% | $10.54 | 0.0% | COM | 34385P108 |
| — | FIBROGEN INC | 9,306 | $506K | 0.0% | $54.37 | — | COM | 31572Q808 |
| VCEL | VERICEL CORP | 28,090 | $492K | 0.0% | $8.48 | +115.6% | COM | 92346J108 |
| SRPT | SAREPTA THERAPEUTICS INC | 100,000 | $421K | 0.0% | — | — | Call | 803607100 |
| ACAD | ACADIA PHARMACEUTICALS INC | 14,897 | $400K | 0.0% | $23.35 | 0.0% | COM | 004225108 |
| — | BIOTELEMETRY INC | 6,369 | $399K | 0.0% | $62.65 | — | COM | 090672106 |
| EOLS | EVOLUS INC | 15,232 | $344K | 0.0% | $21.62 | 0.0% | COM | 30052C107 |
| — | OUTLOOK THERAPEUTICS INC | 420,875 | $159K | 0.0% | $0.17 | — | *W EXP 02/18/202 | 69012T115 |
| AGIO | AGIOS PHARMACEUTICALS INC | 200,000 | $140K | 0.0% | — | — | Call | 00847X104 |
| — | CLOVIS ONCOLOGY INC | 200,000 | $125K | 0.0% | — | — | Call | 189464100 |
| — | IMMUNOMEDICS INC | 200,000 | $125K | 0.0% | $15.18 | — | Call | 452907108 |
| — | SOLID BIOSCIENCES INC | 10,000 | $29,000 | 0.0% | $9.20 | — | Call | 3422E1055 |
| ASND | ASCENDIS PHARMA A S | 200,000 | $25,000 | 0.0% | $68.34 | — | Put | 04351P101 |
| — | ONCOSEC MEDICAL INC | 30,000 | $17,000 | 0.0% | $1.88 | — | COM | 68234L207 |
| — | IMMUNOGEN INC | 600,000 | $15,000 | 0.0% | — | — | Call | 45253H101 |