Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2019 (← Previous) (Next →)
Filing Date: Feb 19, 2020
Total Value: $5.034B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | GLOBAL BLOOD THERAPEUTICS INC | 5,865,726 | $466M | 9.3% | $79.49 | $32.23 | — | COM | 37890U108 |
| — | MIRATI THERAPEUTICS INC | 3,203,406 | $413M | 8.2% | $128.86 | $88.23 | — | COM | 60468T105 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 3,612,554 | $388M | 7.7% | $107.49 * | $39.11 | +167.7% | COM | 64125C109 |
| KOD | KODIAK SCIENCES INC | 3,663,557 | $264M | 5.2% | $71.95 * | $12.82 | +183.7% | COM | 50015M109 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 9,416,202 | $261M | 5.2% | $27.68 * | $9.56 | +138.0% | COM | 462260100 |
| FOLD | AMICUS THERAPEUTICS INC | 25,132,364 | $245M | 4.9% | $9.74 * | $6.67 | +37.2% | COM | 03152W109 |
| — | ZOGENIX INC | 3,709,152 | $193M | 3.8% | $52.13 | $20.89 | — | COM | 98978L204 |
| — | ATHENEX INC | 11,532,467 | $176M | 3.5% | $15.27 | $14.97 | — | COM | 04685N103 |
| — | AMARIN CORPORATION PLC | 7,106,079 | $152M | 3.0% | $21.44 | $15.39 | — | SPONS ADR NEW | 023111206 |
| BBIO | BRIDGEBIO PHARMA INC | 6,706,268 | $142M | 2.8% | $21.21 * | $27.26 | +1.7% | COM | 10806X102 |
| MGTX | MEIRAGTX HOLDINGS PLC | 6,433,277 | $129M | 2.6% | $20.02 * | $14.20 | +20.5% | COM | G59665102 |
| — | SPRINGWORKS THERAPEUTICS INC | 3,337,522 | $128M | 2.6% | $38.49 | $22.28 | — | COM | 85205L107 |
| — | QUOTIENT LTD | 13,289,054 | $126M | 2.5% | $9.51 | $7.74 | — | COM | G73268107 |
| — | ZYMEWORKS INC | 2,403,026 | $109M | 2.2% | $45.46 | $19.22 | — | COM | 98985W102 |
| — | NEVRO CORP | 763,886 | $89.79M | 1.8% | $117.54 | $63.98 | — | COM | 64157F103 |
| — | MYOKARDIA INC | 1,206,411 | $87.93M | 1.7% | $72.88 | $35.88 | — | COM | 62857M105 |
| — | KADMON HOLDINGS INC | 14,636,334 | $66.3M | 1.3% | $4.53 | $4.47 | — | COM | 48283N106 |
| CRNX | CRINETICS PHARMACEUTICALS INC | 2,587,953 | $64.93M | 1.3% | $25.09 * | $29.69 | -35.9% | COM | 22663K107 |
| — | VBI VACCINES INC | 45,951,556 | $63.41M | 1.3% | $1.38 | $1.73 | — | COM | 91822J103 |
| — | MOMENTA PHARMACEUTICALS INC | 2,835,637 | $55.95M | 1.1% | $19.73 | $11.17 | — | COM | 60877T100 |
| — | VERRICA PHARMACEUTICALS INC | 3,410,412 | $52.02M | 1.0% | $15.25 | $19.73 | — | COM | 92511W108 |
| RCKT | ROCKET PHARMACUETICALS INC | 2,239,241 | $50.97M | 1.0% | $22.76 * | $17.11 | -2.4% | COM | 77313F106 |
| — | FREQUENCY THERAPEUTICS INC | 3,034,296 | $49.81M | 1.0% | $16.42 | $16.42 | — | COM | 35803L108 |
| — | BLUEPRINT MEDICINES CORP | 618,624 | $49.56M | 1.0% | $80.11 | $65.89 | — | COM | 09627Y109 |
| — | DBV TECHNOLOGIES SA | 4,367,809 | $46.73M | 0.9% | $10.70 | $11.84 | — | SPONSORED ADR | 23306J101 |
| ADMA | ADMA BIOLOGICS INC | 11,521,102 | $46.08M | 0.9% | $4.00 * | $4.23 | +3.0% | COM | 000899104 |
| — | PROVENTION BIO INC | 2,921,574 | $43.53M | 0.9% | $14.90 | $13.06 | — | COM | 74374N102 |
| — | ALBIREO PHARMA INC | 1,704,330 | $43.32M | 0.9% | $25.42 | $24.69 | — | COM | 01345P106 |
| — | ARENA PHARMACEUTICALS INC | 953,129 | $43.29M | 0.9% | $45.42 | $43.70 | — | COM | 040047607 |
| AGIO | AGIOS PHARMACEUTICALS INC | 900,000 | $42.98M | 0.9% | $47.75 * | $37.79 | 0.0% | COM | 00847X104 |
| — | RETROPHIN INC | 2,890,608 | $41.05M | 0.8% | $14.20 | $16.80 | — | COM | 761299106 |
| ALLO | ALLOGENE THERAPEUTICS INC | 1,543,790 | $40.11M | 0.8% | $25.98 * | $26.57 | +3.7% | COM | 019770106 |
| — | EIDOS THERAPEUTICS INC | 697,524 | $40.03M | 0.8% | $57.39 | $20.90 | — | COM | 28249H104 |
| UROV | UROVANT SCIENCES LTD | 2,406,931 | $37.33M | 0.7% | $15.51 | $9.55 | — | COM | G9381B108 |
| — | FOAMIX PHARMACEUTICALS LTD | 11,203,881 | $37.31M | 0.7% | $3.33 | $4.02 | — | COM | M46135105 |
| — | NEPTUNE WELLNESS SOLUTIONS INC | 13,436,906 | $36.75M | 0.7% | $2.74 | $3.77 | — | COM | 64079L105 |
| — | MOLECULAR TEMPLATES INC | 2,474,133 | $34.6M | 0.7% | $13.99 | $7.26 | — | COM | 608550109 |
| — | SOLID BIOSCIENCES INC | 6,749,803 | $30.04M | 0.6% | $4.45 | $4.45 | — | COM | 3422E1055 |
| — | AGILE THERAPEUTICS INC | 11,919,925 | $29.8M | 0.6% | $2.50 | $1.55 | — | COM | 00847L100 |
| ESTA | ESTABLISHMENT LABS HOLDINGS INC | 1,050,528 | $29.06M | 0.6% | $27.66 * | $24.75 | -10.5% | COM | G31249108 |
| — | INTRA-CELLULAR THERAPIES INC | 800,600 | $28.57M | 0.6% | $35.69 | — | — | Call | 46116X101 |
| — | TURNING POINT THERAPEUTICS I | 437,390 | $27.25M | 0.5% | $62.29 | $39.81 | — | COM | 90041T108 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,253,923 | $27.04M | 0.5% | $8.31 * | $17.25 | -60.9% | COM | 23284F105 |
| BIO | BIO-RAD LABORATORIES INC | 68,489 | $25.34M | 0.5% | $370.03 * | $327.56 | +7.6% | CL A | 090572207 |
| RGNX | REGENXBIO INC | 608,000 | $24.91M | 0.5% | $40.97 * | $38.79 | +1.8% | COM | 75901B107 |
| — | VAPOTHERM INC | 1,743,767 | $21.2M | 0.4% | $12.16 | $18.08 | — | COM | 922107107 |
| — | CONCERT PHARMACEUTICALS INC | 2,150,641 | $19.84M | 0.4% | $9.23 | $12.16 | — | COM | 206022105 |
| STOK | STOKE THERAPEUTICS INC | 671,978 | $19.03M | 0.4% | $28.32 * | $26.85 | -6.3% | COM | 86150R107 |
| EHTH | EHEALTH INC | 197,720 | $19M | 0.4% | $96.08 * | $54.08 | +43.5% | COM | 28238P109 |
| TNDM | TANDEM DIABETES CARE INC | 310,000 | $18.48M | 0.4% | $59.61 * | $61.12 | +0.9% | COM | 875372203 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $17.93M | 0.4% | $5.81 | $6.64 | -13.0% | COM | 01438T106 |
| — | Y-MABS THERAPEUTICS INC | 562,237 | $17.57M | 0.3% | $31.25 | $26.06 | — | COM | 984241109 |
| TXG | 10X GENOMICS INC | 220,000 | $16.77M | 0.3% | $76.25 * | $55.34 | +8.6% | CLASS A COM | 88025U109 |
| ARVN | ARVINAS INC | 400,000 | $16.44M | 0.3% | $41.09 * | $29.28 | 0.0% | COM | 04335A105 |
| ANAB | ANAPTYSBIO INC | 1,000,000 | $16.25M | 0.3% | $16.25 * | $23.65 | 0.0% | COM | 032724106 |
| AUPH | AURINIA PHARMACEUTICALS INC | 716,666 | $14.52M | 0.3% | $20.26 * | $9.21 | 0.0% | COM | 05156V102 |
| — | REVANCE THERAPEUTICS INC | 820,377 | $13.31M | 0.3% | $16.23 | $16.23 | — | COM | 761330109 |
| — | AQUESTIVE THERAPEUTICS INC | 2,250,000 | $13.1M | 0.3% | $5.82 | $6.27 | — | COM | 3843E1047 |
| — | INTERCEPT PHARMACEUTICALS INC | 97,600 | $12.1M | 0.2% | $123.92 | $79.57 | — | COM | 45845P108 |
| — | MORPHIC HOLDING INC | 650,000 | $11.15M | 0.2% | $17.16 | $19.82 | — | COM | 61775R105 |
| — | MEI PHARMA INC | 4,400,440 | $10.91M | 0.2% | $2.48 | $2.48 | — | COM NEW | 552996456 |
| SCPE/U | SC HEALTH CORP | 1,000,000 | $10.36M | 0.2% | $10.36 | $10.35 | — | UNIT 99/99/9999 | G78516302 |
| VRAYQ | VIEWRAY INC | 2,451,748 | $10.35M | 0.2% | $4.22 * | $9.17 | -64.7% | COM | 92672L107 |
| FULC | FULCRUM THERAPEUTICS INC | 600,000 | $9.984M | 0.2% | $16.64 * | $11.06 | -13.6% | COM | 359616109 |
| — | IMMUNOVANT INC | 400,000 | $9.948M | 0.2% | $24.87 | $24.87 | — | UNIT 12/18/2024 | 45258J201 |
| HCAT | HEALTH CATALYST INC | 283,698 | $9.844M | 0.2% | $34.70 * | $37.76 | -12.3% | COM | 42225T107 |
| — | MOTUS GI HLDGS INC | 4,210,542 | $9.642M | 0.2% | $2.29 | $4.01 | — | COM | 62014P108 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 305,000 | $9.126M | 0.2% | $29.92 * | $43.67 | -34.3% | COM | 00650F109 |
| ALEC | ALECTOR INC | 511,731 | $8.817M | 0.2% | $17.23 | $18.92 | -10.1% | COM | 014442107 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 421,272 | $8.67M | 0.2% | $20.58 * | $16.67 | 0.0% | COM | 19459J104 |
| IDYA | IDEAYA BIOSCIENCES INC | 1,141,484 | $8.561M | 0.2% | $7.50 * | $10.88 | -34.4% | COM | 45166A102 |
| — | IVERIC BIO INC | 990,289 | $8.497M | 0.2% | $8.58 | $8.58 | — | COM | 46583P102 |
| — | CERNER CORP | 105,000 | $7.706M | 0.2% | $73.39 | $70.16 | — | COM | 156782104 |
| ZBH | ZIMMER BIOMET HLDGS INC | 50,000 | $7.484M | 0.1% | $149.68 * | $122.61 | +7.1% | COM | 98956P102 |
| — | NEOLEUKIN THERAPEUTICS INC | 500,000 | $6.16M | 0.1% | $12.32 | $12.32 | — | COM | 64049K104 |
| — | VOCERA COMMUNICATIONS INC | 296,420 | $6.154M | 0.1% | $20.76 | $24.49 | — | COM | 92857F107 |
| — | VERU INC | 1,650,000 | $5.528M | 0.1% | $3.35 | $1.52 | — | COM | 92536C103 |
| — | INVITAE CORP | 336,308 | $5.425M | 0.1% | $16.13 | $10.95 | — | COM | 46185L103 |
| — | ABEONA THERAPEUTICS INC | 1,500,000 | $4.905M | 0.1% | $3.27 | $3.27 | — | COM | 00289Y107 |
| TWST | TWIST BIOSCIENCE CORP | 215,856 | $4.533M | 0.1% | $21.00 * | $25.89 | -9.6% | COM | 90184D100 |
| — | ACASTI PHARMA INC | 1,779,882 | $4.361M | 0.1% | $2.45 | $0.83 | — | COM | 00430K402 |
| GRTX | GALERA THERAPEUTICS INC | 325,000 | $4.277M | 0.1% | $13.16 * | $12.19 | 0.0% | COM | 36338D108 |
| ATEC | ALPHATEC HOLDINGS INC | 561,574 | $3.984M | 0.1% | $7.09 * | $5.20 | +23.5% | COM | 02081G201 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 170,859 | $3.922M | 0.1% | $22.95 * | $22.21 | 0.0% | COM | 76243J105 |
| — | TRANSLATE BIO INC | 435,000 | $3.541M | 0.1% | $8.14 | $12.65 | — | COM | 89374L104 |
| — | THERAPEUTICSMD INC | 1,096,101 | $2.653M | 0.1% | $2.42 | $2.42 | — | COM | 88338N107 |
| — | EIGER BIOPHARMACEUTICALS INC | 139,890 | $2.084M | 0.0% | $14.90 | $15.33 | — | COM | 28249U105 |
| ARWR | ARROWHEAD PHARMACEUTICALS INC | 30,738 | $1.95M | 0.0% | $63.44 * | $7.12 | +597.0% | COM | 04280A100 |
| PHR | PHREESIA INC | 70,000 | $1.865M | 0.0% | $26.64 * | $27.64 | 0.0% | COM | 71944F106 |
| XBI | SPDR SERIES TRUST | 1,000,000 | $1.558M | 0.0% | $1.56 | — | — | Put | 78464A870 |
| — | AXONICS MODULATION TECH INC | 55,000 | $1.524M | 0.0% | $27.71 | $27.71 | — | COM | 05465P101 |
| AORT | CRYOLIFE INC | 50,000 | $1.355M | 0.0% | $27.10 * | $28.53 | -13.9% | COM | 228903100 |
| — | SHOCKWAVE MED INC | 30,000 | $1.318M | 0.0% | $43.93 | $43.93 | — | COM | 82489T104 |
| — | KARYOPHARM THERAPEUTICS INC | 54,645 | $1.048M | 0.0% | $19.18 | $9.63 | — | COM | 48576U106 |
| RACE | FERRARI N.V. | 6,200 | $1.026M | 0.0% | $165.48 * | $40.37 | +300.8% | COM | N3167Y103 |
| — | SELECT INTERIOR CONCEPTS INC | 105,105 | $945K | 0.0% | $8.99 | $12.97 | — | COM | 816120307 |
| — | SIERRA ONCOLOGY INC | 2,666,190 | $910K | 0.0% | $0.34 | $2.12 | — | COM | 82640U107 |
| — | DECIPHERA PHARMACEUTICALS INC | 14,326 | $892K | 0.0% | $62.26 | $62.26 | — | COM | 24344T101 |
| — | DICERNA PHARMACEUTICALS INC | 36,496 | $804K | 0.0% | $22.03 | $22.03 | — | COM | 253031108 |
| NVCR | NOVOCURE LTD | 9,489 | $800K | 0.0% | $84.31 * | $79.97 | +0.9% | COM | G6674U108 |
| — | ZYNERBA PHARMACEUTICALS INC | 200,000 | $790K | 0.0% | $3.95 | — | — | Put | 98986X109 |
| MREO | MEREO BIOPHARMA GROUP PLC | 179,419 | $588K | 0.0% | $3.28 | $2.52 | — | ADS | 589492107 |
| — | OPTINOSE INC | 58,005 | $535K | 0.0% | $9.22 | $9.22 | — | COM | 68404V100 |
| — | KARUNA THERAPEUTICS INC | 6,944 | $523K | 0.0% | $75.32 | $75.32 | — | COM | 48576A100 |
| NTRA | NATERA INC | 14,549 | $490K | 0.0% | $33.68 * | $22.06 | +67.0% | COM | 632307104 |
| KRMD | REPRO MED SYS INC | 74,813 | $489K | 0.0% | $6.54 * | $4.66 | 0.0% | COM | 759910102 |
| ACAD | ACADIA PHARMACEUTICALS INC | 11,256 | $482K | 0.0% | $42.82 | $43.50 | 0.0% | COM | 004225108 |
| — | ARAVIVE INC | 32,895 | $450K | 0.0% | $13.68 | $13.68 | — | COM | 03890D108 |
| — | CONSTELLATION PHARMCETICLS INC | 6,000 | $283K | 0.0% | $47.17 | $47.17 | — | COM | 210373106 |
| — | PROTEON THERAPEUTICS INC | 341,743 | $140K | 0.0% | $0.41 | $0.41 | — | COM | 74371L109 |
| — | AVADEL PHARMACEUTICALS PLC | 8,681 | $66,000 | 0.0% | $7.60 | $7.60 | — | SPONSORED ADR | 05337M104 |
| — | OUTLOOK THERAPEUTICS INC | 420,875 | $33,000 | 0.0% | $0.08 | $0.17 | — | *W EXP 02/18/202 | 69012T115 |
| — | RESTORBIO INC | 9,306 | $14,000 | 0.0% | $1.50 | $1.50 | — | COM | 76133L103 |
| ONC | BEIGENE LTD | 200,000 | $4,000 | 0.0% | $0.02 | — | — | Put | 07725L102 |