Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2023 (← Previous) (Next →)
Filing Date: Nov 14, 2023
Total Value: $2.998B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 27,692,917 | $337M | 11.2% | $12.16 * | $7.31 | +76.4% | COM | 03152W109 |
| — | CEREVEL THERAPEUTICS HLDNG I | 10,088,385 | $220M | 7.3% | $21.83 | $24.16 | — | COM | 15678U128 |
| IMVT | IMMUNOVANT INC | 3,814,691 | $146M | 4.9% | $38.39 * | $19.36 | +16.7% | COM | 45258J102 |
| ACLX | ARCELLX INC | 3,965,978 | $142M | 4.7% | $35.88 * | $21.79 | +58.2% | COMMON STOCK | 03940C100 |
| NUVL | NUVALENT INC | 2,463,451 | $113M | 3.8% | $45.97 * | $25.13 | +76.6% | COM | 670703107 |
| SLNO | SOLENO THERAPEUTICS INC | 3,074,542 | $90.73M | 3.0% | $29.51 * | $4.79 | +26.3% | COM | 834203309 |
| LIANY | LIANBIO | 57,558,451 | $85.76M | 2.9% | $1.49 | $6.09 | — | SPONSORED ADS | 53000N108 |
| — | AKERO THERAPEUTICS INC | 1,619,425 | $81.91M | 2.7% | $50.58 | $43.66 | — | COM | 00973Y108 |
| — | INHIBRX INC | 4,256,104 | $78.1M | 2.6% | $18.35 | $23.15 | — | COM | 45720L107 |
| ALDX | ALDEYRA THERAPEUTICS INC | 11,350,085 | $75.82M | 2.5% | $6.68 * | $8.11 | -8.6% | COM | 01438T106 |
| ARGX | ARGENX SE | 150,600 | $74.04M | 2.5% | $491.63 | $444.94 | — | SPONSORED ADR | 04016X101 |
| PCVX | VAXCYTE INC | 1,342,751 | $68.45M | 2.3% | $50.98 * | $41.49 | +18.9% | COM | 92243G108 |
| — | VERONA PHARMA PLC | 4,007,197 | $65.32M | 2.2% | $16.30 | $12.90 | — | SPONSORED ADS | 925050106 |
| — | CYMABAY THERAPEUTICS INC | 4,043,191 | $60.28M | 2.0% | $14.91 | $8.78 | — | COM | 23257D103 |
| MGTX | MEIRAGTX HLDGS PLC | 11,331,103 | $55.64M | 1.9% | $4.91 * | $11.20 | -45.8% | COM | G59665102 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 11,962,938 | $54.43M | 1.8% | $4.55 * | $12.84 | -49.1% | COM | 462260100 |
| — | LYRA THERAPEUTICS INC | 12,757,562 | $49.88M | 1.7% | $3.91 | $6.65 | — | COM | 55234L105 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 2,688,873 | $49.23M | 1.6% | $18.31 * | $20.97 | +0.8% | COM | 03237H101 |
| BBIO | BRIDGEBIO PHARMA | 1,748,933 | $46.12M | 1.5% | $26.37 * | $30.14 | -5.9% | COM | 10806X102 |
| MDT | MEDTRONIC PLC | 587,000 | $46M | 1.5% | $78.36 | $79.06 | -1.6% | SHS | G5960L103 |
| ROIV | ROIVANT SCIENCES LTD | 3,819,456 | $44.61M | 1.5% | $11.68 * | $7.48 | +51.1% | SHS | G76279101 |
| IRON | DISC MEDICINE INC | 895,641 | $42.08M | 1.4% | $46.98 * | $37.96 | +31.8% | COM | 254604101 |
| IMTX | IMMATICS N.V | 3,491,500 | $40.43M | 1.3% | $11.58 * | $10.48 | +13.9% | SHS | N44445109 |
| APGE | APOGEE THERAPEUTICS INC | 1,827,901 | $38.93M | 1.3% | $21.30 * | $22.03 | 0.0% | COM | 03770N101 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1,263,732 | $37.58M | 1.3% | $29.74 * | $25.03 | -17.7% | COM | 22663K107 |
| RVMD | REVOLUTION MEDICINES INC | 1,321,795 | $36.59M | 1.2% | $27.68 * | $29.66 | 0.0% | COM | 76155X100 |
| — | SPRINGWORKS THERAPEUTICS INC | 1,520,416 | $35.15M | 1.2% | $23.12 | $36.75 | — | COM | 85205L107 |
| AXSM | AXSOME THERAPEUTICS INC | 481,649 | $33.66M | 1.1% | $69.89 * | $74.20 | +0.7% | COM | 05464T104 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 996,306 | $32.65M | 1.1% | $32.77 * | $35.60 | -2.5% | COM | 413197104 |
| — | RAPT THERAPEUTICS INC | 1,920,658 | $31.92M | 1.1% | $16.62 | $21.27 | — | COM | 75382E109 |
| RCKT | ROCKET PHARMACEUTICALS INC | 1,517,467 | $31.09M | 1.0% | $20.49 * | $20.19 | -10.0% | COM | 77313F106 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 9,111,151 | $28.79M | 1.0% | $3.16 * | $10.71 | -69.6% | COM | 63909J108 |
| ACRV | ACRIVON THERAPEUTICS INC | 3,007,858 | $28.76M | 1.0% | $9.56 * | $12.69 | -9.0% | COMMON STOCK | 004890109 |
| TNGX | TANGO THERAPEUTICS INC | 2,418,968 | $27.24M | 0.9% | $11.26 * | $6.10 | 0.0% | COM | 87583X109 |
| ADMA | ADMA BIOLOGICS INC | 6,984,319 | $25M | 0.8% | $3.58 * | $3.92 | -1.9% | COM | 000899104 |
| TMCI | TREACE MED CONCEPTS INC | 1,834,060 | $24.04M | 0.8% | $13.11 * | $25.52 | -28.3% | COM | 89455T109 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $23.04M | 0.8% | $17.77 | $28.48 | -37.9% | COM | 87650L103 |
| COGT | COGENT BIOSCIENCES INC | 2,309,470 | $22.52M | 0.8% | $9.75 * | $11.14 | +6.4% | COM | 19240Q201 |
| SRPT | SAREPTA THERAPEUTICS INC | 182,720 | $22.15M | 0.7% | $121.22 * | $111.68 | +1.2% | COM | 803607100 |
| MIRM | MIRUM PHARMACEUTICALS INC | 672,042 | $21.24M | 0.7% | $31.60 * | $23.27 | +17.7% | COM | 604749101 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 2,432,089 | $21.21M | 0.7% | $8.72 * | $10.82 | -37.9% | COM | 68572M106 |
| XENE | XENON PHARMACEUTICALS INC | 617,500 | $21.09M | 0.7% | $34.16 * | $19.81 | +88.8% | COM | 98420N105 |
| — | VERRICA PHARMACEUTICALS INC | 5,038,983 | $19.58M | 0.7% | $3.88 | $14.50 | — | COM | 92511W108 |
| BHVN | BIOHAVEN LTD | 751,820 | $19.55M | 0.7% | $26.01 * | $19.26 | +7.9% | COM | G1110E107 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 124,637 | $18.2M | 0.6% | $146.04 * | $90.28 | +108.5% | COM | 558868105 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 159,242 | $17.91M | 0.6% | $112.50 * | $70.38 | +49.6% | COM | 64125C109 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,054,273 | $17.59M | 0.6% | $16.68 * | $19.62 | -1.1% | COM | 74366E102 |
| — | RAYZEBIO INC | 776,805 | $17.25M | 0.6% | $22.20 | $22.20 | — | COM | 75525N107 |
| CABA | CABALETTA BIO INC | 1,132,491 | $17.24M | 0.6% | $15.22 * | $8.98 | +52.2% | COM | 12674W109 |
| RLAY | RELAY THERAPEUTICS INC | 1,943,097 | $16.34M | 0.5% | $8.41 * | $38.13 | -71.8% | COM | 75943R102 |
| — | ASTRIA THERAPEUTICS INC | 2,189,462 | $16.33M | 0.5% | $7.46 | $11.35 | — | COM | 04635X102 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,011,205 | $15.51M | 0.5% | $15.34 * | $21.18 | -9.9% | COM | 92790C104 |
| AORT | ARTIVION INC | 931,352 | $14.12M | 0.5% | $15.16 * | $19.72 | -17.9% | COM | 228903100 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 277,683 | $13.63M | 0.5% | $49.07 * | $43.69 | +36.8% | COM | G31249108 |
| EOLS | EVOLUS INC | 1,485,801 | $13.58M | 0.5% | $9.14 | $8.97 | 0.0% | COM | 30052C107 |
| TCMD | TACTILE SYS TECHNOLOGY INC | 707,159 | $9.936M | 0.3% | $14.05 * | $14.76 | +32.6% | COM | 87357P100 |
| BMEA | BIOMEA FUSION | 716,441 | $9.858M | 0.3% | $13.76 * | $22.74 | -20.7% | COM | 09077A106 |
| — | ATHIRA PHARMA INC | 4,797,278 | $9.691M | 0.3% | $2.02 | $14.05 | — | COM | 04746L104 |
| NTRA | NATERA INC | 218,178 | $9.654M | 0.3% | $44.25 * | $47.83 | +6.6% | COM | 632307104 |
| ZYME | ZYMEWORKS INC | 1,446,123 | $9.168M | 0.3% | $6.34 * | $7.03 | +5.1% | COM | 98985Y108 |
| SLDB | SOLID BIOSCIENCES INC | 3,495,933 | $8.81M | 0.3% | $2.52 * | $6.55 | -40.8% | COM NEW | 83422E204 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 380,828 | $8.73M | 0.3% | $22.93 * | $22.39 | 0.0% | COM | 76243J105 |
| — | CAREMAX INC | 3,823,557 | $8.106M | 0.3% | $2.12 | $10.31 | — | COM CL A | 14171W103 |
| PRTA | PROTHENA CORP PLC | 165,615 | $7.991M | 0.3% | $48.25 * | $32.48 | +82.9% | SHS | G72800108 |
| — | OUTSET MED INC | 661,977 | $7.202M | 0.2% | $10.88 | $45.00 | — | COM | 690145107 |
| — | FUSION PHARMACEUTICALS INC | 2,751,395 | $7.154M | 0.2% | $2.60 | $3.77 | — | COM | 36118A100 |
| — | LANDOS BIOPHARMA INC | 1,486,991 | $5.77M | 0.2% | $3.88 | $4.21 | — | COM NEW | 515069201 |
| — | AKERO THERAPEUTICS INC | 800,000 | $5.46M | 0.2% | $6.83 | $43.66 | — | Call | 00973Y108 |
| TERN | TERNS PHARMACEUTICALS INC | 1,075,000 | $5.407M | 0.2% | $5.03 * | $6.35 | 0.0% | COM | 880881107 |
| TYRA | TYRA BIOSCIENCES INC | 360,000 | $4.957M | 0.2% | $13.77 * | $19.11 | -22.4% | COM | 90240B106 |
| NBTX | NANOBIOTIX | 555,066 | $4.857M | 0.2% | $8.75 | $16.50 | — | SPONSORED ADS | 63009J107 |
| AXGN | AXOGEN INC | 875,898 | $4.379M | 0.1% | $5.00 * | $10.29 | -32.7% | COM | 05463X106 |
| — | ENVVENO MEDICAL CORPORATION | 781,615 | $4.213M | 0.1% | $5.39 | $6.59 | — | COM | 29415J106 |
| — | X4 PHARMACEUTICALS INC | 3,545,454 | $3.865M | 0.1% | $1.09 | $0.87 | — | COM | 98420X103 |
| NVAX | NOVAVAX INC | 1,300,000 | $3.773M | 0.1% | $2.90 | — | — | Put | 670002401 |
| — | SOMALOGIC INC | 1,500,000 | $3.585M | 0.1% | $2.39 | $12.39 | — | CLASS A COM | 83444K105 |
| TVTX | TRAVERE THERAPEUTICS INC | 400,000 | $3.576M | 0.1% | $8.94 * | $16.14 | -12.6% | COM | 89422G107 |
| SRPT | SAREPTA THERAPEUTICS INC | 100,000 | $3.13M | 0.1% | $31.30 * | $111.68 | +1.2% | Call | 803607100 |
| — | POINT BIOPHARMA GLOBAL INC | 800,000 | $2.63M | 0.1% | $3.29 | — | — | Put | 730541109 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 300,000 | $2.623M | 0.1% | $8.74 | — | — | Put | 03969K108 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 750,000 | $2.513M | 0.1% | $3.35 | — | — | Put | 30233G209 |
| — | KRONOS BIO INC | 1,752,745 | $2.279M | 0.1% | $1.30 | $29.87 | — | COM | 50107A104 |
| — | FORTE BIOSCIENCES INC | 3,265,359 | $2.162M | 0.1% | $0.66 | $0.66 | — | COM | 34962G109 |
| — | ACELYRIN INC | 200,000 | $2.034M | 0.1% | $10.17 | $20.90 | — | COM | 00445A100 |
| — | 89BIO INC | 400,000 | $1.62M | 0.1% | $4.05 | — | — | Call | 282559103 |
| ACRS | ACLARIS THERAPEUTICS INC | 500,000 | $1.45M | 0.0% | $2.90 | — | — | Put | 00461U105 |
| SYRE | AEGLEA BIOTHERAPEUTICS INC | 81,116 | $994K | 0.0% | $12.25 * | $13.22 | 0.0% | COM NEW | 00773J202 |
| — | VBI VACCINES INC CDA | 1,381,355 | $926K | 0.0% | $0.67 | $3.29 | — | COM NEW | 91822J202 |
| — | SINGULAR GENOMICS SYSTEMS IN | 2,363,214 | $900K | 0.0% | $0.38 | $24.49 | — | COM | 82933R100 |
| — | VERU INC | 1,089,878 | $784K | 0.0% | $0.72 | $1.17 | — | COM | 92536C103 |
| VKTX | VIKING THERAPEUTICS INC | 300,000 | $240K | 0.0% | $0.80 * | $10.33 | +38.5% | Call | 92686J106 |
| APLS | APELLIS PHARMACEUTICALS INC | 100,000 | $72,500 | 0.0% | $0.72 * | $66.74 | -34.2% | Put | 03753U106 |
| CYPH | LEAP THERAPEUTICS INC | 44,971 | $62,059 | 0.0% | $1.38 * | $5.02 | -53.7% | COM NEW | 52187K200 |
| — | MOTUS GI HLDGS INC | 90,027 | $40,512 | 0.0% | $0.45 | $2.45 | — | COM NEW | 62014P405 |
| — | CAREMAX INC | 60,000 | $11,250 | 0.0% | $0.19 | $4.72 | — | *W EXP 06/08/202 | 14171W111 |
| — | EQRX INC | 250,000 | $10,000 | 0.0% | $0.04 | $1.06 | — | *W EXP 12/17/202 | 26886C115 |
| SRZNW | SURROZEN INC | 166,666 | $6,667 | 0.0% | $0.04 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |