Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2025 (← Previous) (Next →)
Filing Date: Nov 14, 2025
Total Value: $3.463B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| RYTM | RHYTHM PHARMACEUTICALS INC | 419,104,969 | $288M | 8.3% | $0.69 * | $92.51 | +0.4% | COM | 76243J105 |
| ASND | ASCENDIS PHARMA A/S | 1,088,501 | $216M | 6.2% | $198.81 | $175.60 | — | SPONSORED ADR | 04351P101 |
| ACLX | ARCELLX INC | 2,468,353 | $203M | 5.9% | $82.10 * | $24.76 | +190.8% | COMMON STOCK | 03940C100 |
| CELC | CELCUITY INC | 2,956,319 | $146M | 4.2% | $49.40 * | $25.39 | +57.7% | COM | 15102K100 |
| NUVL | NUVALENT INC | 1,562,336 | $135M | 3.9% | $86.48 * | $43.25 | +82.8% | COM | 670703107 |
| — | MERUS N V | 1,353,093 | $127M | 3.7% | $94.15 | $70.83 | — | COM | N5749R100 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 8,952,365 | $122M | 3.5% | $13.59 * | $4.53 | +107.8% | COM | 03237H101 |
| ROIV | ROIVANT SCIENCES LTD | 7,368,461 | $111M | 3.2% | $15.13 * | $11.68 | +6.0% | SHS | G76279101 |
| MGTX | MEIRAGTX HLDGS PLC | 12,626,103 | $104M | 3.0% | $8.22 * | $10.52 | -24.8% | COM | G59665102 |
| INSM | INSMED INC | 702,130 | $101M | 2.9% | $144.01 * | $72.15 | +69.8% | COM PAR $.01 | 457669307 |
| TVTX | TRAVERE THERAPEUTICS INC | 3,794,615 | $90.69M | 2.6% | $23.90 * | $18.31 | +2.7% | COM | 89422G107 |
| AORT | ARTIVION INC | 2,020,000 | $85.53M | 2.5% | $42.34 * | $19.16 | +96.7% | COM | 228903100 |
| PRAX | PRAXIS PRECISION MEDICINES I | 1,564,554 | $82.92M | 2.4% | $53.00 * | $49.76 | -2.6% | COM NEW | 74006W207 |
| IMTX | IMMATICS N.V | 9,383,456 | $79.95M | 2.3% | $8.52 * | $10.65 | -42.2% | SHS | N44445109 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 3,100,902 | $75.2M | 2.2% | $24.25 | $20.01 | — | SPONSORED ADS | 152309100 |
| SLDB | SOLID BIOSCIENCES INC | 11,833,539 | $73.01M | 2.1% | $6.17 * | $6.40 | -8.7% | COM NEW | 83422E204 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,030,134 | $68.43M | 2.0% | $66.43 * | $26.52 | +114.3% | COM | 74366E102 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 450,050 | $63.18M | 1.8% | $140.38 * | $124.99 | +8.4% | COM | 64125C109 |
| EWTX | EDGEWISE THERAPEUTICS INC | 3,795,894 | $61.57M | 1.8% | $16.22 * | $22.55 | -37.1% | COM | 28036F105 |
| — | VERONA PHARMA PLC | 524,088 | $55.93M | 1.6% | $106.71 | $23.99 | — | SPONSORED ADS | 925050106 |
| PEN | PENUMBRA INC | 220,547 | $55.87M | 1.6% | $253.32 | $255.20 | -1.2% | COM | 70975L107 |
| — | AKERO THERAPEUTICS INC | 1,135,766 | $53.93M | 1.6% | $47.48 | $40.07 | — | COM | 00973Y108 |
| APGE | APOGEE THERAPEUTICS INC | 1,351,989 | $53.71M | 1.6% | $39.73 * | $27.98 | +36.4% | COM | 03770N101 |
| OMDA | OMADA HEALTH INC | 2,396,330 | $52.98M | 1.5% | $22.11 * | $17.31 | +18.3% | COM | 68170A108 |
| FOLD | AMICUS THERAPEUTICS INC | 6,370,851 | $50.2M | 1.4% | $7.88 * | $7.36 | -3.4% | COM | 03152W109 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $47.21M | 1.4% | $7.28 | $11.36 | — | COM | 04635X102 |
| INBX | INHIBRX BIOSCIENCES INC | 1,327,707 | $44.72M | 1.3% | $33.68 * | $17.99 | +36.8% | COM | 45720N103 |
| RGEN | REPLIGEN CORP | 270,428 | $36.15M | 1.0% | $133.67 * | $137.82 | -11.9% | COM | 759916109 |
| ZYME | ZYMEWORKS INC | 2,090,663 | $35.71M | 1.0% | $17.08 * | $10.73 | +33.4% | COM | 98985Y108 |
| SION | SIONNA THERAPEUTICS INC | 1,179,098 | $34.68M | 1.0% | $29.41 * | $16.34 | +33.1% | COM | 829401108 |
| CAI | CARIS LIFE SCIENCES INC | 1,098,163 | $33.22M | 1.0% | $30.25 * | $26.95 | +18.3% | COM | 142152107 |
| ABVX | ABIVAX SA | 388,608 | $32.99M | 1.0% | $84.90 | $84.90 | — | SPONSORED ADS | 00370M103 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,462,400 | $31.56M | 0.9% | $21.58 * | $18.02 | +0.1% | COM | 92790C104 |
| CTMX | CYTOMX THERAPEUTICS INC | 9,680,185 | $30.88M | 0.9% | $3.19 * | $1.79 | +25.9% | COM | 23284F105 |
| BSX | BOSTON SCIENTIFIC CORP | 310,000 | $30.27M | 0.9% | $97.63 * | $101.21 | +2.3% | COM | 101137107 |
| ALDX | ALDEYRA THERAPEUTICS INC | 5,222,311 | $27.26M | 0.8% | $5.22 | $7.22 | -27.8% | COM | 01438T106 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 449,290 | $27.25M | 0.8% | $60.66 * | $35.55 | +9.2% | COM NEW | 10919W405 |
| IMVT | IMMUNOVANT INC | 1,587,890 | $25.6M | 0.7% | $16.12 | $23.44 | -30.9% | COM | 45258J102 |
| EXAS | EXACT SCIENCES CORP | 465,487 | $25.47M | 0.7% | $54.71 * | $49.96 | 0.0% | COM | 30063P105 |
| PVLA | PALVELLA THERAPEUTICS INC NE | 395,093 | $24.77M | 0.7% | $62.69 * | $44.59 | 0.0% | COM | 697947109 |
| ORKA | ORUKA THERAPEUTICS INC | 1,268,021 | $24.38M | 0.7% | $19.23 * | $14.82 | 0.0% | COM | 687604108 |
| ISRG | INTUITIVE SURGICAL INC | 52,119 | $23.31M | 0.7% | $447.23 * | $381.98 | +25.6% | COM NEW | 46120E602 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 123,000 | $21.15M | 0.6% | $171.99 * | $158.94 | 0.0% | COM | 450056106 |
| AQST | AQUESTIVE THERAPEUTICS INC | 3,760,099 | $21.02M | 0.6% | $5.59 * | $3.57 | +21.2% | COM | 03843E104 |
| SYRE | SPYRE THERAPEUTICS INC | 1,229,445 | $20.61M | 0.6% | $16.76 * | $16.88 | -3.4% | COM NEW | 00773J202 |
| ADGM | ADAGIO MED HLDGS INC | 9,876,576 | $19.16M | 0.6% | $1.94 * | $4.76 | -67.4% | COM | 00534B100 |
| AXSM | AXSOME THERAPEUTICS INC | 148,900 | $18.08M | 0.5% | $121.45 * | $77.79 | +44.8% | COM | 05464T104 |
| ADMA | ADMA BIOLOGICS INC | 1,153,468 | $16.91M | 0.5% | $14.66 * | $8.62 | +98.7% | COM | 000899104 |
| ENGN | ENGENE HOLDINGS INC | 2,097,236 | $14.32M | 0.4% | $6.83 * | $4.56 | 0.0% | COM | 29286M105 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 5,292,556 | $13.13M | 0.4% | $2.48 * | $8.01 | -65.6% | COM | 68572M106 |
| NRIX | NURIX THERAPEUTICS INC | 1,416,149 | $13.09M | 0.4% | $9.24 * | $13.26 | -21.7% | COM | 67080M103 |
| RAPP | RAPPORT THERAPEUTICS INC | 403,923 | $12M | 0.3% | $29.70 * | $17.84 | 0.0% | COM | 75383L102 |
| OM | OUTSET MED INC | 833,333 | $11.77M | 0.3% | $14.12 * | $11.92 | +30.8% | COM NEW | 690145206 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $10.64M | 0.3% | $0.84 * | $8.54 | -91.4% | COM | 63909J108 |
| CRVS | CORVUS PHARMACEUTICALS INC | 1,438,595 | $10.6M | 0.3% | $7.37 * | $3.64 | +40.7% | COM | 221015100 |
| KOD | KODIAK SCIENCES INC | 634,577 | $10.39M | 0.3% | $16.37 * | $8.62 | 0.0% | COM | 50015M109 |
| SEPN | SEPTERNA INC | 541,450 | $10.18M | 0.3% | $18.81 * | $8.24 | +59.3% | COM | 81734D104 |
| GOSS | GOSSAMER BIO INC | 3,812,797 | $10.03M | 0.3% | $2.63 * | $2.20 | 0.0% | COM | 38341P102 |
| KYMR | KYMERA THERAPEUTICS INC | 169,796 | $9.61M | 0.3% | $56.60 * | $34.43 | +31.0% | COM | 501575104 |
| IKT | INHIBIKASE THERAPEUTICS INC | 5,421,568 | $8.783M | 0.3% | $1.62 * | $2.49 | -30.6% | COM NEW | 45719W205 |
| — | CELCUITY INC | 6,500,000 | $8.724M | 0.3% | $1.34 | $1.34 | — | NOTE 2.750% 8/0 | 15102KAA8 |
| CTNM | CONTINEUM THERAPEUTICS INC | 714,592 | $8.396M | 0.2% | $11.75 * | $15.93 | -49.4% | CL A | 21217B100 |
| XENE | XENON PHARMACEUTICALS INC | 200,791 | $8.062M | 0.2% | $40.15 * | $26.63 | +32.3% | COM | 98420N105 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 1,705,130 | $7.673M | 0.2% | $4.50 * | $5.59 | -29.9% | COM | 03675P102 |
| JANX | JANUX THERAPEUTICS INC | 292,686 | $7.153M | 0.2% | $24.44 | $50.50 | -51.8% | COM | 47103J105 |
| IRD | OPUS GENETICS INC | 4,325,000 | $7.136M | 0.2% | $1.65 * | $1.12 | +11.2% | COM | 67577R102 |
| TEM | TEMPUS AI INC | 85,000 | $6.86M | 0.2% | $80.71 * | $70.04 | 0.0% | CL A | 88023B103 |
| DYN | DYNE THERAPEUTICS INC | 540,444 | $6.837M | 0.2% | $12.65 * | $20.29 | -43.8% | COM | 26818M108 |
| KRYS | KRYSTAL BIOTECH INC | 35,000 | $6.179M | 0.2% | $176.53 * | $149.68 | 0.0% | COM | 501147102 |
| BBNX | BETA BIONICS INC | 277,944 | $5.523M | 0.2% | $19.87 * | $18.64 | -5.7% | COM | 08659B102 |
| CBIO | CRESCENT BIOPHARMA INC. | 453,686 | $5.394M | 0.2% | $11.89 * | $21.15 | -37.3% | COM | G2545C104 |
| HTFL | HEARTFLOW INC | 150,000 | $5.049M | 0.1% | $33.66 * | $32.24 | 0.0% | COM | 42238D107 |
| RAPT | RAPT THERAPEUTICS INC | 183,890 | $4.743M | 0.1% | $25.79 * | $7.63 | +71.5% | COM NEW | 75382E208 |
| PEPG | PEPGEN INC | 829,870 | $3.834M | 0.1% | $4.62 * | $1.61 | 0.0% | COM | 713317105 |
| BLTE | BELITE BIO INC | 49,788 | $3.684M | 0.1% | $74.00 | $74.00 | — | SPONSORED ADS | 07782B104 |
| — | SCPHARMACEUTICALS INC | 583,142 | $3.306M | 0.1% | $5.67 | $3.84 | — | COM | 810648105 |
| VKTX | VIKING THERAPEUTICS INC | 105,597 | $2.775M | 0.1% | $26.28 * | $52.65 | -43.3% | COM | 92686J106 |
| PYXS | PYXIS ONCOLOGY INC | 1,178,307 | $2.616M | 0.1% | $2.22 * | $1.44 | 0.0% | COMMON STOCK | 747324101 |
| LONA | ATHIRA PHARMA INC | 540,296 | $2.237M | 0.1% | $4.14 * | $3.92 | 0.0% | COM | 04746L203 |
| SPRY | ARS PHARMACEUTICALS INC | 200,000 | $2.01M | 0.1% | $10.05 | — | — | Put | 82835W108 |
| TRIB | TRINITY BIOTECH PLC | 1,790,000 | $1.862M | 0.1% | $1.04 | $0.65 | — | SPONS ADR NEW | 896438504 |
| AVTX | AVALO THERAPEUTICS INC | 139,667 | $1.775M | 0.1% | $12.71 * | $7.58 | +13.5% | COM NEW | 05338F306 |
| — | ENVVENO MEDICAL CORPORATION | 1,759,035 | $1.594M | 0.0% | $0.91 | $3.16 | — | COM | 29415J106 |
| LYRA | LYRA THERAPEUTICS INC | 229,382 | $1.498M | 0.0% | $6.53 * | $8.30 | -11.6% | COM NEW | 55234L204 |
| QURE | UNIQURE NV | 20,000 | $1.167M | 0.0% | $58.37 * | $18.16 | 0.0% | SHS | N90064101 |
| LXEO | LEXEO THERAPEUTICS INC | 139,835 | $929K | 0.0% | $6.64 * | $11.93 | -59.4% | COM | 52886X107 |
| BDSX | BIODESIX | 108,694 | $821K | 0.0% | $7.55 | $7.69 | 0.0% | COM | 09075X207 |
| ANRO | ALTO NEUROSCIENCE INC | 155,366 | $625K | 0.0% | $4.02 * | $3.32 | 0.0% | COM SHS | 02157Q109 |
| APYX | APYX MEDICAL CORPORATION | 150,000 | $321K | 0.0% | $2.14 | $1.40 | +51.3% | COM | 03837C106 |
| ENSC | ENSYSCE BIOSCIENCES INC | 86,666 | $205K | 0.0% | $2.37 * | $6.89 | -68.8% | COM NEW | 293602504 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $74,975 | 0.0% | $0.30 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| SRZNW | SURROZEN INC | 166,666 | $2,967 | 0.0% | $0.02 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |