CIK: 0001224962 · Show all filings
Period: Q3 2025 (← Previous) (Next →)
Filing Date: Nov 14, 2025
Total Value ($000): $3,463,099 (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value ($000) | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| RYTM | RHYTHM PHARMACEUTICALS INC | 419,104,969 | $288,391 | 8.3% | $92.51 | +0.4% | COM | 76243J105 |
| ASND | ASCENDIS PHARMA A/S | 1,088,501 | $216,405 | 6.2% | $175.60 | — | SPONSORED ADR | 04351P101 |
| ACLX | ARCELLX INC | 2,468,353 | $202,652 | 5.9% | $24.76 | +190.8% | COMMON STOCK | 03940C100 |
| CELC | CELCUITY INC | 2,956,319 | $146,042 | 4.2% | $25.39 | +57.7% | COM | 15102K100 |
| NUVL | NUVALENT INC | 1,562,336 | $135,111 | 3.9% | $43.25 | +82.8% | COM | 670703107 |
| — | MERUS N V | 1,353,093 | $127,394 | 3.7% | $70.83 | — | COM | N5749R100 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 8,952,365 | $121,663 | 3.5% | $4.53 | +107.8% | COM | 03237H101 |
| ROIV | ROIVANT SCIENCES LTD | 7,368,461 | $111,485 | 3.2% | $11.68 | +6.0% | SHS | G76279101 |
| MGTX | MEIRAGTX HLDGS PLC | 12,626,103 | $103,793 | 3.0% | $10.52 | -24.8% | COM | G59665102 |
| INSM | INSMED INC | 702,130 | $101,114 | 2.9% | $72.15 | +69.8% | COM PAR $.01 | 457669307 |
| TVTX | TRAVERE THERAPEUTICS INC | 3,794,615 | $90,691 | 2.6% | $18.31 | +2.7% | COM | 89422G107 |
| AORT | ARTIVION INC | 2,020,000 | $85,527 | 2.5% | $19.16 | +96.7% | COM | 228903100 |
| PRAX | PRAXIS PRECISION MEDICINES I | 1,564,554 | $82,921 | 2.4% | $49.76 | -2.6% | COM NEW | 74006W207 |
| IMTX | IMMATICS N.V | 9,383,456 | $79,947 | 2.3% | $10.65 | -42.2% | SHS | N44445109 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 3,100,902 | $75,197 | 2.2% | $20.01 | — | SPONSORED ADS | 152309100 |
| SLDB | SOLID BIOSCIENCES INC | 11,833,539 | $73,013 | 2.1% | $6.40 | -8.7% | COM NEW | 83422E204 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,030,134 | $68,432 | 2.0% | $26.52 | +114.3% | COM | 74366E102 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 450,050 | $63,178 | 1.8% | $124.99 | +8.4% | COM | 64125C109 |
| EWTX | EDGEWISE THERAPEUTICS INC | 3,795,894 | $61,569 | 1.8% | $22.55 | -37.1% | COM | 28036F105 |
| — | VERONA PHARMA PLC | 524,088 | $55,925 | 1.6% | $23.99 | — | SPONSORED ADS | 925050106 |
| PEN | PENUMBRA INC | 220,547 | $55,869 | 1.6% | $255.20 | -1.2% | COM | 70975L107 |
| — | AKERO THERAPEUTICS INC | 1,135,766 | $53,926 | 1.6% | $40.07 | — | COM | 00973Y108 |
| APGE | APOGEE THERAPEUTICS INC | 1,351,989 | $53,715 | 1.6% | $27.98 | +36.4% | COM | 03770N101 |
| OMDA | OMADA HEALTH INC | 2,396,330 | $52,983 | 1.5% | $17.31 | +18.3% | COM | 68170A108 |
| FOLD | AMICUS THERAPEUTICS INC | 6,370,851 | $50,202 | 1.4% | $7.36 | -3.4% | COM | 03152W109 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $47,214 | 1.4% | $11.36 | — | COM | 04635X102 |
| INBX | INHIBRX BIOSCIENCES INC | 1,327,707 | $44,717 | 1.3% | $17.99 | +36.8% | COM | 45720N103 |
| RGEN | REPLIGEN CORP | 270,428 | $36,148 | 1.0% | $137.82 | -11.9% | COM | 759916109 |
| ZYME | ZYMEWORKS INC | 2,090,663 | $35,709 | 1.0% | $10.73 | +33.4% | COM | 98985Y108 |
| SION | SIONNA THERAPEUTICS INC | 1,179,098 | $34,677 | 1.0% | $16.34 | +33.1% | COM | 829401108 |
| CAI | CARIS LIFE SCIENCES INC | 1,098,163 | $33,219 | 1.0% | $26.95 | +18.3% | COM | 142152107 |
| ABVX | ABIVAX SA | 388,608 | $32,993 | 1.0% | $84.90 | — | SPONSORED ADS | 00370M103 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,462,400 | $31,559 | 0.9% | $18.02 | +0.1% | COM | 92790C104 |
| CTMX | CYTOMX THERAPEUTICS INC | 9,680,185 | $30,880 | 0.9% | $1.79 | +25.9% | COM | 23284F105 |
| BSX | BOSTON SCIENTIFIC CORP | 310,000 | $30,265 | 0.9% | $101.21 | +2.3% | COM | 101137107 |
| ALDX | ALDEYRA THERAPEUTICS INC | 5,222,311 | $27,260 | 0.8% | $7.22 | -27.8% | COM | 01438T106 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 449,290 | $27,254 | 0.8% | $35.55 | +9.2% | COM NEW | 10919W405 |
| IMVT | IMMUNOVANT INC | 1,587,890 | $25,597 | 0.7% | $23.44 | -30.9% | COM | 45258J102 |
| EXAS | EXACT SCIENCES CORP | 465,487 | $25,467 | 0.7% | $49.96 | 0.0% | COM | 30063P105 |
| PVLA | PALVELLA THERAPEUTICS INC NE | 395,093 | $24,768 | 0.7% | $44.59 | 0.0% | COM | 697947109 |
| ORKA | ORUKA THERAPEUTICS INC | 1,268,021 | $24,384 | 0.7% | $14.82 | 0.0% | COM | 687604108 |
| ISRG | INTUITIVE SURGICAL INC | 52,119 | $23,309 | 0.7% | $381.98 | +25.6% | COM NEW | 46120E602 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 123,000 | $21,155 | 0.6% | $158.94 | 0.0% | COM | 450056106 |
| AQST | AQUESTIVE THERAPEUTICS INC | 3,760,099 | $21,019 | 0.6% | $3.57 | +21.2% | COM | 03843E104 |
| SYRE | SPYRE THERAPEUTICS INC | 1,229,445 | $20,605 | 0.6% | $16.88 | -3.4% | COM NEW | 00773J202 |
| ADGM | ADAGIO MED HLDGS INC | 9,876,576 | $19,161 | 0.6% | $4.76 | -67.4% | COM | 00534B100 |
| AXSM | AXSOME THERAPEUTICS INC | 148,900 | $18,084 | 0.5% | $77.79 | +44.8% | COM | 05464T104 |
| ADMA | ADMA BIOLOGICS INC | 1,153,468 | $16,910 | 0.5% | $8.62 | +98.7% | COM | 000899104 |
| ENGN | ENGENE HOLDINGS INC | 2,097,236 | $14,324 | 0.4% | $4.56 | 0.0% | COM | 29286M105 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 5,292,556 | $13,126 | 0.4% | $8.01 | -65.6% | COM | 68572M106 |
| NRIX | NURIX THERAPEUTICS INC | 1,416,149 | $13,085 | 0.4% | $13.26 | -21.7% | COM | 67080M103 |
| RAPP | RAPPORT THERAPEUTICS INC | 403,923 | $11,997 | 0.3% | $17.84 | 0.0% | COM | 75383L102 |
| OM | OUTSET MED INC | 833,333 | $11,767 | 0.3% | $11.92 | +30.8% | COM NEW | 690145206 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $10,642 | 0.3% | $8.54 | -91.4% | COM | 63909J108 |
| CRVS | CORVUS PHARMACEUTICALS INC | 1,438,595 | $10,602 | 0.3% | $3.64 | +40.7% | COM | 221015100 |
| KOD | KODIAK SCIENCES INC | 634,577 | $10,388 | 0.3% | $8.62 | 0.0% | COM | 50015M109 |
| SEPN | SEPTERNA INC | 541,450 | $10,185 | 0.3% | $8.24 | +59.3% | COM | 81734D104 |
| GOSS | GOSSAMER BIO INC | 3,812,797 | $10,028 | 0.3% | $2.20 | 0.0% | COM | 38341P102 |
| KYMR | KYMERA THERAPEUTICS INC | 169,796 | $9,610 | 0.3% | $34.43 | +31.0% | COM | 501575104 |
| IKT | INHIBIKASE THERAPEUTICS INC | 5,421,568 | $8,783 | 0.3% | $2.49 | -30.6% | COM NEW | 45719W205 |
| — | CELCUITY INC | 6,500,000 | $8,724 | 0.3% | $1.34 | — | NOTE 2.750% 8/0 | 15102KAA8 |
| CTNM | CONTINEUM THERAPEUTICS INC | 714,592 | $8,396 | 0.2% | $15.93 | -49.4% | CL A | 21217B100 |
| XENE | XENON PHARMACEUTICALS INC | 200,791 | $8,062 | 0.2% | $26.63 | +32.3% | COM | 98420N105 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 1,705,130 | $7,673 | 0.2% | $5.59 | -29.9% | COM | 03675P102 |
| JANX | JANUX THERAPEUTICS INC | 292,686 | $7,153 | 0.2% | $50.50 | -51.8% | COM | 47103J105 |
| IRD | OPUS GENETICS INC | 4,325,000 | $7,136 | 0.2% | $1.12 | +11.2% | COM | 67577R102 |
| TEM | TEMPUS AI INC | 85,000 | $6,860 | 0.2% | $70.04 | 0.0% | CL A | 88023B103 |
| DYN | DYNE THERAPEUTICS INC | 540,444 | $6,837 | 0.2% | $20.29 | -43.8% | COM | 26818M108 |
| KRYS | KRYSTAL BIOTECH INC | 35,000 | $6,179 | 0.2% | $149.68 | 0.0% | COM | 501147102 |
| BBNX | BETA BIONICS INC | 277,944 | $5,523 | 0.2% | $18.64 | -5.7% | COM | 08659B102 |
| CBIO | CRESCENT BIOPHARMA INC. | 453,686 | $5,394 | 0.2% | $21.15 | -37.3% | COM | G2545C104 |
| HTFL | HEARTFLOW INC | 150,000 | $5,049 | 0.1% | $32.24 | 0.0% | COM | 42238D107 |
| RAPT | RAPT THERAPEUTICS INC | 183,890 | $4,743 | 0.1% | $7.63 | +71.5% | COM NEW | 75382E208 |
| PEPG | PEPGEN INC | 829,870 | $3,834 | 0.1% | $1.61 | 0.0% | COM | 713317105 |
| BLTE | BELITE BIO INC | 49,788 | $3,684 | 0.1% | $74.00 | — | SPONSORED ADS | 07782B104 |
| — | SCPHARMACEUTICALS INC | 583,142 | $3,306 | 0.1% | $3.84 | — | COM | 810648105 |
| VKTX | VIKING THERAPEUTICS INC | 105,597 | $2,775 | 0.1% | $52.65 | -43.3% | COM | 92686J106 |
| PYXS | PYXIS ONCOLOGY INC | 1,178,307 | $2,616 | 0.1% | $1.44 | 0.0% | COMMON STOCK | 747324101 |
| LONA | ATHIRA PHARMA INC | 540,296 | $2,237 | 0.1% | $3.92 | 0.0% | COM | 04746L203 |
| SPRY | ARS PHARMACEUTICALS INC | 200,000 | $2,010 | 0.1% | — | — | Put | 82835W108 |
| TRIB | TRINITY BIOTECH PLC | 1,790,000 | $1,862 | 0.1% | $0.65 | — | SPONS ADR NEW | 896438504 |
| AVTX | AVALO THERAPEUTICS INC | 139,667 | $1,775 | 0.1% | $7.58 | +13.5% | COM NEW | 05338F306 |
| — | ENVVENO MEDICAL CORPORATION | 1,759,035 | $1,594 | 0.0% | $3.16 | — | COM | 29415J106 |
| LYRA | LYRA THERAPEUTICS INC | 229,382 | $1,498 | 0.0% | $8.30 | -11.6% | COM NEW | 55234L204 |
| QURE | UNIQURE NV | 20,000 | $1,167 | 0.0% | $18.16 | 0.0% | SHS | N90064101 |
| LXEO | LEXEO THERAPEUTICS INC | 139,835 | $929 | 0.0% | $11.93 | -59.4% | COM | 52886X107 |
| BDSX | BIODESIX | 108,694 | $821 | 0.0% | $7.69 | 0.0% | COM | 09075X207 |
| ANRO | ALTO NEUROSCIENCE INC | 155,366 | $625 | 0.0% | $3.32 | 0.0% | COM SHS | 02157Q109 |
| APYX | APYX MEDICAL CORPORATION | 150,000 | $321 | 0.0% | $1.40 | +51.3% | COM | 03837C106 |
| ENSC | ENSYSCE BIOSCIENCES INC | 86,666 | $205 | 0.0% | $6.89 | -68.8% | COM NEW | 293602504 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $75 | 0.0% | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| SRZNW | SURROZEN INC | 166,666 | $3 | 0.0% | $1.14 | — | *W EXP 08/01/203 | 86889P117 |