Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NBIX	NEUROCRINE BIOSCIENCES SHARES	3,366,530	$146M	8.3%	$24.28	+76.4%	COM	64125C109
—	GLOBAL BLOOD THERAPEUTICS SHARES	3,858,978	$142M	8.1%	$27.36	—	COM	37890U108
FOLD	AMICUS THERAPEUTICS SHARES	17,296,672	$123M	7.0%	$3.99	+58.5%	COM	03152W109
—	VERSARTIS SHARES	4,407,317	$94.1M	5.4%	$14.64	—	COM	92529L102
—	LA JOLLA PHARMACEUTICAL SHARES	2,139,274	$63.86M	3.6%	$22.99	—	COM	503459604
ALNY	ALNYLAM PHARMACEUTICALS SHARES	1,103,475	$56.55M	3.2%	$45.75	+1.0%	COM	02043Q107
SRPT	SAREPTA THERAPEUTICS SHARES	1,771,029	$52.42M	3.0%	$24.99	+23.8%	COM	803607100
—	RETROPHIN SHARES	2,807,525	$51.83M	3.0%	$14.79	—	COM	761299106
—	NXSTAGE MEDICAL SHARES	1,818,189	$48.78M	2.8%	$22.78	—	COM	67072V103
XNCR	XENCOR SHARES	1,607,018	$38.44M	2.2%	$11.62	+107.4%	COM	98401F105
ACRS	ACLARIS THERAPEUTICS SHARES	1,260,847	$37.6M	2.1%	$24.04	+20.0%	COM	00461U105
—	TESARO SHARES	241,028	$37.09M	2.1%	$40.07	—	COM	881569107
—	VBI VACCINES SHARES	6,565,843	$36.05M	2.1%	$3.25	—	COM	91822J103
—	RADIUS HEALTH SHARES	910,872	$35.2M	2.0%	$43.12	—	COM	750469207
—	AVEXIS SHARES	448,501	$34.1M	1.9%	$45.07	—	COM	05366U100
EVH	EVOLENT HEALTH SHARES CLASS A	1,444,500	$32.21M	1.8%	$17.81	+7.8%	COM	30050B101
VRTX	VERTEX PHARMACEUTICALS SHARES	293,509	$32.09M	1.8%	$94.81	-7.1%	COM	92532F100
RGNX	REGENXBIO SHARES	1,396,244	$26.95M	1.5%	$19.87	-2.9%	COM	75901B107
—	LION BIOTECHNOLOGIES SHARES	3,567,553	$26.58M	1.5%	$8.82	—	COM	53619R102
CTMX	CYTOMX THERAPEUTICS SHARES	1,530,659	$26.43M	1.5%	$12.53	+5.0%	COM	23284F105
ANAB	ANAPTYSBIO SHARES	881,957	$24.47M	1.4%	$23.32	0.0%	COM	032724106
—	ZOGENIX SHARES	2,203,302	$23.91M	1.4%	$11.29	—	COM	98978L204
ARDX	ARDELYX SHARES	1,886,196	$23.86M	1.4%	$12.08	+8.9%	COM	039697107
GLPG	GALAPAGOS ADR REPRESENTING SHARES	271,405	$23.39M	1.3%	$67.75	—	COM	36315X101
—	DBV TECHNOLOGIES ADR REPRESENTING 0.5 SHARES	591,765	$20.84M	1.2%	$34.37	—	COM	23306J101
—	QUOTIENT SHARES	2,917,785	$20.37M	1.2%	$9.88	—	COM	G73268107
—	NEVRO SHARES	217,292	$20.36M	1.2%	$93.70	—	COM	64157F103
—	KADMON SHARES	5,185,847	$18.77M	1.1%	$5.20	—	COM	48283N106
—	BLUEPRINT MEDICINES SHARES	461,642	$18.46M	1.1%	$31.50	—	COM	09627Y109
WVE	WAVE LIFE SCIENCES SHARES	665,198	$18.29M	1.0%	$17.06	+63.7%	COM	Y95308105
—	ACCELERON PHARMA SHARES	663,857	$17.57M	1.0%	$28.39	—	COM	00434H108
—	ACELRX PHARMACEUTICALS SHARES	5,408,728	$17.04M	1.0%	$9.69	—	COM	00444T100
—	ASSEMBLY BIOSCIENCES SHARES	664,354	$16.93M	1.0%	$7.21	—	COM	045396108
—	AVADEL PHARMACEUTICALS ADR	1,408,240	$13.63M	0.8%	$10.38	—	COM	05337M104
ALDX	ALDEYRA THERAPEUTICS SHARES	2,885,458	$12.9M	0.7%	$6.73	-23.5%	COM	01438T106
—	AMAG PHARMACEUTICALS SHARES	560,000	$12.63M	0.7%	$22.62	—	COM	00163U106
ANIP	ANI PHARMACEUTICALS SHARES	254,889	$12.62M	0.7%	$60.02	-6.5%	COM	00182C103
—	CORIUM INTERNATIONAL SHARES	2,654,485	$11.1M	0.6%	$4.18	—	COM	21887L107
—	ABIOMED SHARES	85,000	$10.64M	0.6%	$125.20	—	COM	003654100
—	CORBUS PHARMACEUTICALS HOLDINGS SHARES	1,250,000	$10.31M	0.6%	$2.85	—	COM	21833P103
IRTC	IRHYTHM TECHNOLOGIES SHARES	271,057	$10.19M	0.6%	$26.94	+27.7%	COM	450056106
—	CLOVIS ONCOLOGY SHARES	157,754	$10.04M	0.6%	$36.05	—	COM	189464100
BIO	BIO RAD LABORATORIES SHARES CLASS A	49,416	$9.851M	0.6%	$177.89	+8.3%	COM	090572207
EXAS	EXACT SCIENCES SHARES	410,000	$9.684M	0.6%	$19.82	0.0%	COM	30063P105
—	ANTARES PHARMA SHARES	2,917,253	$8.285M	0.5%	$2.33	—	COM	036642106
—	MYOKARDIA SHARES	624,694	$8.214M	0.5%	$15.01	—	COM	62857M105
—	CAPITAL SENIOR LIVING SHARES	575,173	$8.087M	0.5%	$19.70	—	COM	140475104
—	ALDER BIOPHARMACEUTICALS SHARES	384,169	$7.991M	0.5%	$32.77	—	COM	014339105
—	ANI PHARMACEUTICALS INC 01DEC19 3.0PCT	7,500,000	$7.958M	0.5%	$1.05	—	NOTE	00182CAA1
—	FORWARD PHARMA ADR REPRESENTING 1 SHARES	354,241	$7.634M	0.4%	$18.28	—	COM	34986J105
QURE	UNIQURE SHARES	1,265,963	$7.317M	0.4%	$18.17	-66.9%	COM	N90064101
—	MINERVA NEUROSCIENCES INC	810,537	$6.565M	0.4%	$5.00	—	COM	603380106
—	FOAMIX PHARMACEUTICALS SHARES	1,322,994	$6.549M	0.4%	$7.58	—	COM	M46135105
—	CIDARA THERAPEUTICS SHARES	826,369	$6.445M	0.4%	$12.72	—	COM	171757107
—	VIVEVE MEDICAL SHARES	938,742	$5.942M	0.3%	$6.33	—	COM	92852W204
HUM	HUMANA SHARES	27,500	$5.669M	0.3%	$190.74	+0.6%	COM	444859102
—	SIERRA ONCOLOGY SHARES	3,703,704	$5.667M	0.3%	$1.53	—	COM	82640U107
—	CLEARSIDE BIOMEDICAL SHARES	712,062	$5.653M	0.3%	$7.22	—	COM	185063104
—	INVITAE SHARES	480,000	$5.309M	0.3%	$7.94	—	COM	46185L103
—	PFENEX SHARES	892,847	$5.187M	0.3%	$13.00	—	COM	717071104
—	ZYNERBA PHARMACEUTICALS INC	251,328	$5.051M	0.3%	$12.65	—	COM	98986X109
—	AXOVANT SCIENCES SHARES	310,000	$4.631M	0.3%	$14.94	—	COM	G0750W104
—	NEPTUNE TECHNOLOGIES AND BIORESOURCES SHARES	6,519,634	$4.61M	0.3%	$3.13	—	COM	64077P108
—	SYNERGY PHARMACEUTICALS SHARES	978,100	$4.558M	0.3%	$5.32	—	COM	871639308
JAZZ	JAZZ PHARMACEUTICALS SHARES	30,000	$4.354M	0.2%	$111.38	+16.9%	COM	G50871105
—	PEREGRINE PHARMACEUTICALS INC 10.5	200,000	$4.342M	0.2%	$19.91	—	COM	713661403
—	DERMIRA SHARES	115,583	$3.943M	0.2%	$22.40	—	COM	24983L104
—	PSIVIDA SHARES	2,279,706	$3.921M	0.2%	$2.93	—	COM	74440J101
—	ABEONA THERAPEUTICS SHARES CW-19	1,259,636	$3.69M	0.2%	$3.25	—	COM	00289y115
ADMA	ADMA BIOLOGICS SHARES	721,102	$3.519M	0.2%	$6.35	-22.3%	COM	000899104
AMGN	AMGEN SHARES	20,000	$3.281M	0.2%	$127.19	0.0%	COM	031162100
—	ONCOBIOLOGICS SHARES	1,181,874	$3.167M	0.2%	$3.40	—	COM	68235M105
—	ABEONA THERAPEUTICS SHARES	622,873	$3.114M	0.2%	$4.32	—	COM	00289Y107
—	HISTOGENCIS CORP	1,777,777	$3.075M	0.2%	$3.21	—	COM	43358V109
—	AVEO PHARMACEUTICALS SHARES	5,108,808	$3.014M	0.2%	$0.82	—	COM	053588109
XENE	XENON PHARMACEUTICALS SHARES	723,853	$2.895M	0.2%	$9.34	-15.9%	COM	98420N105
—	OCERA THERAPEUTICS SHARES	2,150,000	$2.817M	0.2%	$1.31	—	COM	67552A108
—	MGC DIAGNOSTICS SHARES	302,327	$2.524M	0.1%	$8.55	—	COM	552768103
—	PORTOLA PHARMACEUTICALS SHARES	57,870	$2.268M	0.1%	$39.19	—	COM	737010108
—	AERIE PHARMACEUTICALS SHARES	50,000	$2.268M	0.1%	$37.74	—	COM	00771V108
—	ALLIQUA BIOMEDICAL SHARES	4,233,951	$2.136M	0.1%	$0.64	—	COM	019621200
UNH	UNITEDHEALTH GROUP SHARES	13,000	$2.132M	0.1%	$131.74	+7.9%	COM	91324P102
—	RA PHARMACEUTICALS SHARES	100,000	$2.129M	0.1%	$15.19	—	COM	74933V108
—	SELECTA BIOSCIENCES SHARES	141,875	$2.032M	0.1%	$13.99	—	COM	816212104
—	SAGE THERAPEUTICS INC REGISTERED SHARES CALL 80 05/19/2017	200,000	$1.966M	0.1%	—	—	Call	78667J108
—	IMMUNOMEDICS SHARES	300,060	$1.941M	0.1%	$6.47	—	COM	452907108
—	EIGER BIOPHARMACEUTICALS SHARES	157,679	$1.805M	0.1%	$15.33	—	COM	28249U105
—	BRAINSTORM CELL THERAPEUTICS INC SHARES (OLD)	400,000	$1.7M	0.1%	$4.25	—	COM	10501E102
—	AFFIMED SHARES	734,301	$1.689M	0.1%	$2.48	—	COM	N01045108
ARWR	ARROWHEAD PHARMACEUTICALS SHARES	847,458	$1.567M	0.1%	$1.98	0.0%	COM	04280A100
—	AXOVANT SCIENCES LTD REGISTERED SHARES CALL 25 10/20/2017	200,000	$1.42M	0.1%	$14.94	—	Call	G0750W104
—	CURIS SHARES	500,000	$1.39M	0.1%	$2.78	—	COM	231269101
CSBR	CHAMPIONS ONCOLOGY SHARES	366,972	$1.163M	0.1%	$6.08	-42.5%	COM	15870P307
—	BELLICUM PHARMACEUTICALS SHARES	86,200	$1.064M	0.1%	$12.34	—	COM	079481107
EXEL	EXELIXIS SHARES	46,361	$1.005M	0.1%	$14.43	+41.0%	COM	30161Q104
—	AKORN SHARES	40,000	$963K	0.1%	$24.07	—	COM	009728106
—	ZOSANO PHARMA SHARES	500,000	$950K	0.1%	$1.90	—	COM	98979H103
—	AZURRX BIOPHARMA SHARES	227,272	$877K	0.0%	$4.74	—	COM	05502L105
INCY	INCYTE SHARES	5,619	$751K	0.0%	$84.26	+51.1%	COM	45337C102
—	WELLCARE HEALTHCARE PLANS SHARES	5,283	$741K	0.0%	$94.74	—	COM	94946T106
—	FIAT CHRYSLER AUTOMOBILES SHARES	62,000	$678K	0.0%	$14.53	—	COM	N31738102
LNTH	LANTHEUS HOLDINGS SHARES	53,763	$672K	0.0%	$6.62	+59.8%	COM	516544103
MTST	METASTAT SHARES	500,000	$662K	0.0%	$2.15	-30.5%	COM	59140A203
—	HESKA SHARES	6,300	$661K	0.0%	$104.92	—	COM	42805E306
OSUR	ORASURE TECHNOLOGIES SHARES	47,125	$609K	0.0%	$10.34	0.0%	COM	68554V108
ILMN	ILLUMINA SHARES	3,500	$597K	0.0%	$157.56	0.0%	COM	452327109
—	ACHAOGEN SHARES	23,496	$593K	0.0%	$25.24	—	COM	004449104
—	PROTEON THERAPEUTICS SHARES	334,116	$585K	0.0%	$8.74	—	COM	74371L109
—	RADIUS HEALTH INC REGISTERED SHARES PUT 30 07/21/2017	9,800	$570K	0.0%	$43.12	—	Put	750469207
—	HILL ROM HOLDINGS SHARES	7,930	$560K	0.0%	$62.01	—	COM	431475102
MASI	MASIMO SHARES	5,945	$554K	0.0%	$82.32	0.0%	COM	574795100
CNC	CENTENE SHARES	7,726	$551K	0.0%	$33.47	0.0%	COM	15135B101
MDRX	ALLSCRIPTS HEALTHCARE SOLUTIONS SHARES	42,955	$545K	0.0%	$11.86	0.0%	COM	01988P108
—	PRA HEALTH SCIENCES SHARES	8,308	$542K	0.0%	$65.24	—	COM	69354M108
—	HMS HOLDINGS SHARES	26,553	$540K	0.0%	$20.34	—	COM	40425J101
MCK	MCKESSON SHARES	3,601	$534K	0.0%	$154.96	-11.9%	COM	58155Q103
—	CAMBREX SHARES	9,515	$524K	0.0%	$55.07	—	COM	132011107
PAHC	PHIBRO ANIMAL HEALTH SHARES CLASS A	18,382	$517K	0.0%	$28.21	0.0%	COM	71742Q106
—	QUALITY SYSTEMS SHARES	33,875	$516K	0.0%	$15.23	—	COM	747582104
ELV	ANTHEM SHARES	3,081	$510K	0.0%	$141.45	0.0%	COM	036752103
VNDA	VANDA PHARMACEUTICALS SHARES	36,232	$507K	0.0%	$14.25	0.0%	COM	921659108
—	CUTERA SHARES	23,981	$496K	0.0%	$20.68	—	COM	232109108
RACE	FERRARI SHARES	6,200	$461K	0.0%	$40.37	+60.9%	COM	N3167Y103
AKBA	AKEBIA THERAPEUTICS SHARES	49,624	$457K	0.0%	$8.44	+15.7%	COM	00972D105
—	BLUEBIRD BIO SHARES	4,644	$422K	0.0%	$90.87	—	COM	09609G100
—	ONCOBIOLOGICS EQUITY WARRANTS SERIES A EXP 18TH FEB 2018	462,500	$370K	0.0%	$0.46	—	COM	68235M113
—	AURIS MEDICAL HOLDING SHARES	400,000	$368K	0.0%	$0.92	—	COM	H03579101
—	PERNIX THERAPEUTICS HOLD 01APR21 4.25PCT	1,000,000	$275K	0.0%	$0.20	—	COM	71426VAK4
—	QUORUM HEALTH SHARES	50,604	$275K	0.0%	$5.43	—	COM	74909E106
—	LHC GROUP SHARES	4,745	$256K	0.0%	$36.88	—	COM	50187A107
ARNI	ARNO THERAPEUTICS SHARES	4,177,577	$254K	0.0%	$0.59	-82.6%	COM	042564203
—	ACASTI PHARMA SHARES CLASS A	186,559	$254K	0.0%	$2.51	—	COM	00430K402
—	ONCOBIOLOGICS EQUITY WARRANTS SERIES B EXP 18TH MAY 2018	462,500	$231K	0.0%	$0.66	—	COM	68235M121
—	ARRAY BIOPHARMA SHARES	25,510	$228K	0.0%	$8.94	—	COM	04269X105
EVH	EVOLENT HEALTH INC SHARES -A- CALL 20 06/16/2017	50,000	$190K	0.0%	$17.81	+7.8%	Call	30050B101
—	AUDENTES THERAPEUTICS SHARES	7,500	$128K	0.0%	$17.87	—	COM	05070R104
—	IGNYTA SHARES	6,584	$57,000	0.0%	$15.09	—	COM	451731103
—	R1 RCM SHARES	17,976	$56,000	0.0%	$3.12	—	COM	749397105
—	AEGLEA BIOTHERAPEUTICS SHARES	5,833	$43,000	0.0%	$4.86	—	COM	00773J103
ABBV	ABBVIE SHARES	380	$25,000	0.0%	$43.48	0.0%	COM	00287Y109
—	CELLDEX THERAPEUTICS SHARES	6,970	$25,000	0.0%	$3.59	—	COM	15117B103
—	CHINA BIOLOGIC PRODUCTS SHARES	236	$24,000	0.0%	$114.50	—	COM	16938C106
BMRN	BIOMARIN PHARMACEUTICAL SHARES	250	$22,000	0.0%	$94.17	-5.5%	COM	09061G101
—	EPIZYME SHARES	1,165	$20,000	0.0%	$17.17	—	COM	29428V104
ABT	ABBOTT LABORATORIES SHARES	415	$18,000	0.0%	$35.93	+2.8%	COM	002824100
—	PEREGRINE PHARMACEUTICALS SHARES	24,332	$16,000	0.0%	$0.37	—	COM	713661304
—	AGENUS SHARES	3,600	$14,000	0.0%	$7.18	—	COM	00847G705
—	CAPRICOR THERAPEUTICS SHARES	4,000	$13,000	0.0%	$8.75	—	COM	14070B101
WST	WEST PHARMACEUTICAL SERVICES SHARES	138	$11,000	0.0%	$76.11	+6.5%	COM	955306105
—	ALCOBRA SHARES	9,109	$10,000	0.0%	$1.10	—	COM	M2239P109
—	SEVION THERAPEUTICS INC	59,220	$9,000	0.0%	$0.20	—	COM	81834Q104
—	THERAPEUTICSMD SHARES	1,081	$8,000	0.0%	$5.77	—	COM	88338N107
—	CASCADIAN THERAPEUTICS SHARES	1,966	$8,000	0.0%	$4.31	—	COM	14740B606
—	FIVE PRIME THERAPEUTICS SHARES	127	$5,000	0.0%	$26.96	—	COM	33830X104
—	OPHTHOTECH SHARES	1,600	$5,000	0.0%	$3.13	—	COM	683745103
TNGNQ	TENGION INC	1,826,399	$3,000	0.0%	$0.00	+108.7%	COM	88034G208
CERS	CERUS SHARES	740	$3,000	0.0%	$4.24	0.0%	COM	157085101
AORT	CRYOLIFE SHARES	123	$2,000	0.0%	$15.12	+16.8%	COM	228903100
—	AEVI GENOMIC MEDICINE SHARES	940	$2,000	0.0%	$5.18	—	COM	00835P105
—	APTEVO THERAPEUTICS SHARES	450	$1,000	0.0%	$2.56	—	COM	03835L108
—	CREDIT SUISSE VELOCITYSHARES DAILY INVERSE VIX SHORT TERM ET	16	$1,000	0.0%	$62.50	—	COM	22542D795
ATRC	ATRICURE SHARES	55	$1,000	0.0%	$17.89	-2.1%	COM	04963C209
BSX	BOSTON SCIENTIFIC SHARES	3	$0	0.0%	$21.82	+11.4%	COM	101137107
IWS	ISHARES RUSSELL MID-CAP VALUE ETF	2	$0	0.0%	—	—	COM	464287473
IVV	ISHARES CORE SandP 500 ETF	1	$0	0.0%	—	—	COM	464287200
TLT	ISHARES 20 PLUS YEAR TREASURY BOND ETF	2	$0	0.0%	—	—	NOTE	464287432
DHR	DANAHER SHARES	3	$0	0.0%	$66.37	+7.4%	COM	235851102
NPCUF	ALLON THERAPEUTICS SHARES	751,124	$0	0.0%	$0.00	-83.5%	COM	019774108
—	OBALON THERAPEUTICS SHARES	4	$0	0.0%	—	—	COM	67424L100
—	AGILE THERAPEUTICS SHARES	42	$0	0.0%	$7.06	—	COM	00847L100
ACHC	ACADIA HEALTHCARE COMPANY SHARES	1	$0	0.0%	$40.58	0.0%	COM	00404A109
—	TRACON PHARMACEUTICALS SHARES	50	$0	0.0%	$4.90	—	COM	89237H100