5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value: $419M (100.0% shares, 0.0% debt)

Holdings (31)

TRDA ENTRADA THERAPEUTICS INC 18.2%

Value $76.22M Shares 4,408,379 Est. Cost $17.12 Unrealized —

ELVN ENLIVEN THERAPEUTICS INC 8.8%

Value $36.67M Shares 1,629,765 Est. Cost $20.34 Unrealized +27.5%

SKYE SKYE BIOSCIENCE INC 6.7%

Value $28.05M Shares 9,913,168 Est. Cost $11.84 Unrealized -64.7%

TECX TECTONIC THERAPEUTIC INC 6.6%

Value $27.55M Shares 596,660 Est. Cost $15.77 Unrealized +168.1%

ARTV ARTIVA BIOTHERAPEUTICS INC 5.7%

Value $23.72M Shares 2,353,304 Est. Cost $11.59 Unrealized +3.6%

DNTH DIANTHUS THERAPEUTICS INC 5.3%

Value $22.4M Shares 1,027,711 Est. Cost $12.62 Unrealized +103.8%

BHVN BIOHAVEN LTD 4.3%

Value $17.89M Shares 478,972 Est. Cost $33.89 Unrealized +37.7%

PHVS PHARVARIS N V 3.6%

Value $15.29M Shares 797,600 Est. Cost $19.05 Unrealized +8.1%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 3.6%

Value $15.29M Shares 282,313 Est. Cost $25.81 Unrealized +97.8%

CAMP CAMP4 THERAPEUTICS CORP 3.6%

Value $15.28M Shares 2,927,915 Est. Cost $8.22 Unrealized 0.0%

VRDN VIRIDIAN THERAPEUTICS INC 3.4%

Value $14.12M Shares 736,595 Est. Cost $17.93 Unrealized +21.2%

CNTA CENTESSA PHARMACEUTICALS PLC 3.3%

Value $13.92M Shares 830,945 Est. Cost $11.45 Unrealized —

ERAS ERASCA INC 3.2%

Value $13.57M Shares 5,405,404 Est. Cost $2.16 Unrealized +27.1%

PRAX PRAXIS PRECISION MEDICINES I 3.1%

Value $13.08M Shares 170,000 Est. Cost $44.86 Unrealized +61.3%

TYRA TYRA BIOSCIENCES INC 3.1%

Value $13.06M Shares 939,298 Est. Cost $15.18 Unrealized +19.5%

CLDX CELLDEX THERAPEUTICS INC NEW 3.0%

Value $12.57M Shares 497,270 Est. Cost $32.09 Unrealized -15.3%

EYPT EYEPOINT PHARMACEUTICALS INC 1.9%

Value $7.822M Shares 1,050,000 Est. Cost $9.03 Unrealized +3.1%

VKTX VIKING THERAPEUTICS INC 1.8%

Value $7.629M Shares 189,593 Est. Cost $14.60 Unrealized +290.7%

— VOR BIOPHARMA INC 1.7%

Value $7.062M Shares 6,361,723 Est. Cost $43.10 Unrealized —

ANAB ANAPTYSBIO INC 1.1%

Value $4.736M Shares 357,733 Est. Cost $28.24 Unrealized -14.2%

— AKERO THERAPEUTICS INC 1.1%

Value $4.59M Shares 165,000 Est. Cost $27.82 Unrealized —

— SCPHARMACEUTICALS INC 1.0%

Value $4.25M Shares 1,200,647 Est. Cost $5.92 Unrealized —

TARA PROTARA THERAPEUTICS INC 1.0%

Value $4.224M Shares 800,000 Est. Cost $3.23 Unrealized 0.0%

GHRS GH RESEARCH PLC 1.0%

Value $4.009M Shares 572,665 Est. Cost $10.15 Unrealized -20.8%

— RALLYBIO CORP 0.8%

Value $3.485M Shares 3,630,724 Est. Cost $17.58 Unrealized —

SLN SILENCE THERAPEUTICS PLC 0.8%

Value $3.276M Shares 476,200 Est. Cost $21.60 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.6%

Value $2.53M Shares 541,666 Est. Cost $14.14 Unrealized —

ALEC ALECTOR INC 0.4%

Value $1.882M Shares 995,841 Est. Cost $3.76 Unrealized 0.0%

— MERSANA THERAPEUTICS INC 0.4%

Value $1.866M Shares 1,305,000 Est. Cost $4.03 Unrealized —

— CIDARA THERAPEUTICS INC 0.4%

Value $1.525M Shares 56,725 Est. Cost $11.94 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.4%

Value $1.485M Shares 490,000 Est. Cost $23.99 Unrealized -86.3%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
TRDA	ENTRADA THERAPEUTICS INC	4,408,379	$76.22M	18.2%	$17.12	—	COM	29384C108
ELVN	ENLIVEN THERAPEUTICS INC	1,629,765	$36.67M	8.8%	$20.34	+27.5%	COM	29337E102
SKYE	SKYE BIOSCIENCE INC	9,913,168	$28.05M	6.7%	$11.84	-64.7%	COM NEW	83086J200
TECX	TECTONIC THERAPEUTIC INC	596,660	$27.55M	6.6%	$15.77	+168.1%	COM	878972108
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$23.72M	5.7%	$11.59	+3.6%	COM	04317A107
DNTH	DIANTHUS THERAPEUTICS INC	1,027,711	$22.4M	5.3%	$12.62	+103.8%	COM	252828108
BHVN	BIOHAVEN LTD	478,972	$17.89M	4.3%	$33.89	+37.7%	COM	G1110E107
PHVS	PHARVARIS N V	797,600	$15.29M	3.6%	$19.05	+8.1%	COM	N69605108
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	282,313	$15.29M	3.6%	$25.81	+97.8%	CLASS A ORD	61559X104
CAMP	CAMP4 THERAPEUTICS CORP	2,927,915	$15.28M	3.6%	$8.22	0.0%	COM	13463J101
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$14.12M	3.4%	$17.93	+21.2%	COM	92790C104
CNTA	CENTESSA PHARMACEUTICALS PLC	830,945	$13.92M	3.3%	$11.45	—	SPONSORED ADS	152309100
ERAS	ERASCA INC	5,405,404	$13.57M	3.2%	$2.16	+27.1%	COM	29479A108
PRAX	PRAXIS PRECISION MEDICINES I	170,000	$13.08M	3.1%	$44.86	+61.3%	COM NEW	74006W207
TYRA	TYRA BIOSCIENCES INC	939,298	$13.06M	3.1%	$15.18	+19.5%	COM	90240B106
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$12.57M	3.0%	$32.09	-15.3%	COM NEW	15117B202
EYPT	EYEPOINT PHARMACEUTICALS INC	1,050,000	$7.822M	1.9%	$9.03	+3.1%	COM NEW	30233G209
VKTX	VIKING THERAPEUTICS INC	189,593	$7.629M	1.8%	$14.60	+290.7%	COM	92686J106
—	VOR BIOPHARMA INC	6,361,723	$7.062M	1.7%	$43.10	—	COM	929033108
ANAB	ANAPTYSBIO INC	357,733	$4.736M	1.1%	$28.24	-14.2%	COM	032724106
—	AKERO THERAPEUTICS INC	165,000	$4.59M	1.1%	$27.82	—	COM	00973Y108
—	SCPHARMACEUTICALS INC	1,200,647	$4.25M	1.0%	$5.92	—	COM	810648105
TARA	PROTARA THERAPEUTICS INC	800,000	$4.224M	1.0%	$3.23	0.0%	COM STK	74365U107
GHRS	GH RESEARCH PLC	572,665	$4.009M	1.0%	$10.15	-20.8%	ORDINARY SHARES	G3855L106
—	RALLYBIO CORP	3,630,724	$3.485M	0.8%	$17.58	—	COM	75120L100
SLN	SILENCE THERAPEUTICS PLC	476,200	$3.276M	0.8%	$21.60	—	ADS	82686Q101
—	ADVERUM BIOTECHNOLOGIES INC	541,666	$2.53M	0.6%	$14.14	—	COM NEW	00773U207
ALEC	ALECTOR INC	995,841	$1.882M	0.4%	$3.76	0.0%	COM	014442107
—	MERSANA THERAPEUTICS INC	1,305,000	$1.866M	0.4%	$4.03	—	COM	59045L106
—	CIDARA THERAPEUTICS INC	56,725	$1.525M	0.4%	$11.94	—	COM NEW	171757206
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$1.485M	0.4%	$23.99	-86.3%	COM	98943L107