5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q3 2024 (← Previous) (Next →)

Filing Date: Nov 14, 2024

Total Value: $484M (100.0% shares, 0.0% debt)

Holdings (28)

TRDA ENTRADA THERAPEUTICS INC 14.6%

Value $70.45M Shares 4,408,379 Est. Cost $17.12 Unrealized —

ELVN ENLIVEN THERAPEUTICS INC 9.2%

Value $44.75M Shares 1,752,174 Est. Cost $20.34 Unrealized +13.9%

SKYE SKYE BIOSCIENCE INC 8.0%

Value $38.76M Shares 9,913,168 Est. Cost $11.84 Unrealized -52.6%

ARTV ARTIVA BIOTHERAPEUTICS INC 7.5%

Value $36.36M Shares 2,353,304 Est. Cost $11.59 Unrealized 0.0%

DNTH DIANTHUS THERAPEUTICS INC 7.0%

Value $33.72M Shares 1,231,619 Est. Cost $12.62 Unrealized +120.8%

BHVN BIOHAVEN LTD 4.9%

Value $23.93M Shares 478,972 Est. Cost $33.89 Unrealized +14.8%

TYRA TYRA BIOSCIENCES INC 4.6%

Value $22.08M Shares 939,298 Est. Cost $15.18 Unrealized +38.3%

CNTA CENTESSA PHARMACEUTICALS PLC 4.2%

Value $20.55M Shares 1,285,000 Est. Cost $11.45 Unrealized —

TECX TECTONIC THERAPEUTIC INC 4.0%

Value $19.59M Shares 646,524 Est. Cost $15.77 Unrealized +15.9%

PRAX PRAXIS PRECISION MEDICINES I 4.0%

Value $19.56M Shares 340,000 Est. Cost $44.86 Unrealized +20.4%

CLDX CELLDEX THERAPEUTICS INC NEW 3.5%

Value $16.9M Shares 497,270 Est. Cost $32.09 Unrealized +18.7%

VRDN VIRIDIAN THERAPEUTICS INC 3.5%

Value $16.76M Shares 736,595 Est. Cost $17.93 Unrealized -8.8%

VKTX VIKING THERAPEUTICS INC 3.1%

Value $15.04M Shares 237,560 Est. Cost $14.60 Unrealized +302.0%

PHVS PHARVARIS N V 3.1%

Value $14.77M Shares 797,600 Est. Cost $19.05 Unrealized -4.1%

ERAS ERASCA INC 3.0%

Value $14.76M Shares 5,405,404 Est. Cost $2.16 Unrealized +30.5%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 2.9%

Value $14.23M Shares 282,313 Est. Cost $25.81 Unrealized +81.6%

ANAB ANAPTYSBIO INC 2.5%

Value $11.98M Shares 357,733 Est. Cost $28.24 Unrealized +21.0%

SLN SILENCE THERAPEUTICS PLC 1.8%

Value $8.657M Shares 476,200 Est. Cost $21.60 Unrealized —

EYPT EYEPOINT PHARMACEUTICALS INC 1.7%

Value $8.389M Shares 1,050,000 Est. Cost $9.03 Unrealized -2.7%

COGT COGENT BIOSCIENCES INC 1.3%

Value $6.068M Shares 561,854 Est. Cost $6.91 Unrealized +40.8%

— SCPHARMACEUTICALS INC 1.1%

Value $5.475M Shares 1,200,647 Est. Cost $5.92 Unrealized —

— VOR BIOPHARMA INC 0.9%

Value $4.453M Shares 6,361,723 Est. Cost $43.10 Unrealized —

— RALLYBIO CORP 0.9%

Value $4.248M Shares 3,630,724 Est. Cost $17.58 Unrealized —

GHRS GH RESEARCH PLC 0.8%

Value $3.831M Shares 572,665 Est. Cost $10.15 Unrealized +1.0%

— ADVERUM BIOTECHNOLOGIES INC 0.8%

Value $3.802M Shares 541,666 Est. Cost $14.14 Unrealized —

— MERSANA THERAPEUTICS INC 0.5%

Value $2.466M Shares 1,305,000 Est. Cost $4.03 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.4%

Value $1.803M Shares 490,000 Est. Cost $23.99 Unrealized -84.9%

— CIDARA THERAPEUTICS INC 0.1%

Value $610K Shares 56,725 Est. Cost $11.94 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
TRDA	ENTRADA THERAPEUTICS INC	4,408,379	$70.45M	14.6%	$17.12	—	COM	29384C108
ELVN	ENLIVEN THERAPEUTICS INC	1,752,174	$44.75M	9.2%	$20.34	+13.9%	COM	29337E102
SKYE	SKYE BIOSCIENCE INC	9,913,168	$38.76M	8.0%	$11.84	-52.6%	COM NEW	83086J200
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$36.36M	7.5%	$11.59	0.0%	COM	04317A107
DNTH	DIANTHUS THERAPEUTICS INC	1,231,619	$33.72M	7.0%	$12.62	+120.8%	COM	252828108
BHVN	BIOHAVEN LTD	478,972	$23.93M	4.9%	$33.89	+14.8%	COM	G1110E107
TYRA	TYRA BIOSCIENCES INC	939,298	$22.08M	4.6%	$15.18	+38.3%	COM	90240B106
CNTA	CENTESSA PHARMACEUTICALS PLC	1,285,000	$20.55M	4.2%	$11.45	—	SPONSORED ADS	152309100
TECX	TECTONIC THERAPEUTIC INC	646,524	$19.59M	4.0%	$15.77	+15.9%	COM	878972108
PRAX	PRAXIS PRECISION MEDICINES I	340,000	$19.56M	4.0%	$44.86	+20.4%	COM NEW	74006W207
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$16.9M	3.5%	$32.09	+18.7%	COM NEW	15117B202
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$16.76M	3.5%	$17.93	-8.8%	COM	92790C104
VKTX	VIKING THERAPEUTICS INC	237,560	$15.04M	3.1%	$14.60	+302.0%	COM	92686J106
PHVS	PHARVARIS N V	797,600	$14.77M	3.1%	$19.05	-4.1%	COM	N69605108
ERAS	ERASCA INC	5,405,404	$14.76M	3.0%	$2.16	+30.5%	COM	29479A108
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	282,313	$14.23M	2.9%	$25.81	+81.6%	CLASS A ORD	61559X104
ANAB	ANAPTYSBIO INC	357,733	$11.98M	2.5%	$28.24	+21.0%	COM	032724106
SLN	SILENCE THERAPEUTICS PLC	476,200	$8.657M	1.8%	$21.60	—	ADS	82686Q101
EYPT	EYEPOINT PHARMACEUTICALS INC	1,050,000	$8.389M	1.7%	$9.03	-2.7%	COM NEW	30233G209
COGT	COGENT BIOSCIENCES INC	561,854	$6.068M	1.3%	$6.91	+40.8%	COM	19240Q201
—	SCPHARMACEUTICALS INC	1,200,647	$5.475M	1.1%	$5.92	—	COM	810648105
—	VOR BIOPHARMA INC	6,361,723	$4.453M	0.9%	$43.10	—	COM	929033108
—	RALLYBIO CORP	3,630,724	$4.248M	0.9%	$17.58	—	COM	75120L100
GHRS	GH RESEARCH PLC	572,665	$3.831M	0.8%	$10.15	+1.0%	ORDINARY SHARES	G3855L106
—	ADVERUM BIOTECHNOLOGIES INC	541,666	$3.802M	0.8%	$14.14	—	COM NEW	00773U207
—	MERSANA THERAPEUTICS INC	1,305,000	$2.466M	0.5%	$4.03	—	COM	59045L106
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$1.803M	0.4%	$23.99	-84.9%	COM	98943L107
—	CIDARA THERAPEUTICS INC	56,725	$610K	0.1%	$11.94	—	COM NEW	171757206