BAKER BROS. ADVISORS LP Diversified Active

Location: New York, NY

CIK: 0001263508 · Show all filings

Period: Q4 2023 (← Previous) (Next →)

Filing Date: Feb 14, 2024

Total Value: $8.789B (98.4% shares, 1.6% debt)

Holdings (84)

INCY Incyte Corporation 25.8%
Value $2.272B Shares 36,179,122 Est. Cost $72.80 Unrealized -22.3%
ONC BeiGene, Ltd. 21.7%
Value $1.906B Shares 10,568,897 Est. Cost $136.93 Unrealized
ACAD ACADIA Pharmaceuticals Inc. 15.3%
Value $1.342B Shares 42,864,612 Est. Cost $18.93 Unrealized +26.2%
MDGL Madrigal Pharmaceuticals, Inc. 5.2%
Value $456M Shares 1,969,798 Est. Cost $119.77 Unrealized +46.1%
RYTM Rhythm Pharmaceuticals, Inc. 3.3%
Value $294M Shares 6,398,365 Est. Cost $23.49 Unrealized +34.3%
Mirati Therapeutics, Inc. 2.8%
Value $242M Shares 4,121,440 Est. Cost $46.47 Unrealized
IMCR Immunocore Holdings plc 2.0%
Value $172M Shares 2,520,731 Est. Cost $42.57 Unrealized
KYMR Kymera Therapeutics, Inc. 1.7%
Value $153M Shares 5,995,928 Est. Cost $28.14 Unrealized -36.4%
RVMD Revolution Medicines, Inc. 1.7%
Value $148M Shares 5,148,657 Est. Cost $25.21 Unrealized -4.7%
Invitae Corporation 1.5%
Value $131M Shares 300,000,000 Est. Cost $0.45 Unrealized
ABCL AbCellera Biologics Inc. 1.5%
Value $131M Shares 22,909,753 Est. Cost $24.23 Unrealized -80.9%
ROIV Roivant Sciences Ltd. 1.0%
Value $85.27M Shares 7,593,024 Est. Cost $8.98 Unrealized +8.5%
REPL Replimune Group, Inc. 0.9%
Value $80.47M Shares 9,545,336 Est. Cost $15.29 Unrealized -24.2%
TRDA Entrada Therapeutics, Inc. 0.8%
Value $73.43M Shares 4,865,819 Est. Cost $16.96 Unrealized
RARE Ultragenyx Pharmaceutical Inc. 0.8%
Value $70.13M Shares 1,466,547 Est. Cost $65.34 Unrealized -40.7%
Cerevel Therapeutics Holdings, Inc. 0.8%
Value $67.84M Shares 1,600,000 Est. Cost $42.40 Unrealized
IMTX Immatics N.V. 0.7%
Value $61.48M Shares 5,838,853 Est. Cost $10.79 Unrealized -14.7%
BCRX BioCryst Pharmaceuticals, Inc. 0.7%
Value $60.66M Shares 10,126,176 Est. Cost $6.35 Unrealized -8.8%
ARGX argenx SE 0.7%
Value $57.53M Shares 151,215 Est. Cost $79.01 Unrealized
DNLI Denali Therapeutics Inc. 0.6%
Value $55.95M Shares 2,607,196 Est. Cost $25.93 Unrealized -23.6%
Akero Therapeutics, Inc. 0.6%
Value $55.3M Shares 2,368,378 Est. Cost $33.89 Unrealized
KOD Kodiak Sciences Inc. 0.6%
Value $52.62M Shares 17,310,490 Est. Cost $30.30 Unrealized -92.7%
Kiniksa Pharmaceuticals, Ltd. 0.6%
Value $49.28M Shares 2,809,577 Est. Cost $17.35 Unrealized
XENE Xenon Pharmaceuticals Inc. 0.5%
Value $45.77M Shares 993,679 Est. Cost $18.51 Unrealized +90.9%
PRLD Prelude Therapeutics Inc. 0.5%
Value $43.23M Shares 10,123,824 Est. Cost $28.24 Unrealized -89.2%
CERS Cerus Corporation 0.5%
Value $42.07M Shares 19,477,339 Est. Cost $4.19 Unrealized -60.6%
NRIX Nurix Therapeutics, Inc. 0.5%
Value $40.06M Shares 3,882,125 Est. Cost $22.27 Unrealized -69.2%
Aerovate Therapeutics, Inc. 0.4%
Value $38.03M Shares 1,680,517 Est. Cost $21.15 Unrealized
IDYA IDEAYA Biosciences, Inc. 0.4%
Value $37.79M Shares 1,062,123 Est. Cost $14.62 Unrealized +104.1%
EWTX Edgewise Therapeutics, Inc. 0.4%
Value $34.05M Shares 3,112,786 Est. Cost $11.06 Unrealized -36.5%
SERA Sera Prognostics, Inc. 0.4%
Value $32.5M Shares 5,434,399 Est. Cost $3.07 Unrealized -5.4%
BCYC Bicycle Therapeutics plc 0.4%
Value $32.37M Shares 1,790,390 Est. Cost $20.52 Unrealized
IGM Biosciences, Inc. 0.3%
Value $30.67M Shares 3,691,011 Est. Cost $16.39 Unrealized
BMEA Biomea Fusion, Inc. 0.3%
Value $30.62M Shares 2,108,949 Est. Cost $8.56 Unrealized +41.9%
GLUE Monte Rosa Therapeutics, Inc. 0.3%
Value $27.78M Shares 4,916,095 Est. Cost $6.49 Unrealized -39.6%
Verve Therapeutics, Inc. 0.3%
Value $23.58M Shares 1,691,530 Est. Cost $52.72 Unrealized
KRYS Krystal Biotech, Inc. 0.2%
Value $21.08M Shares 169,934 Est. Cost $34.45 Unrealized +221.9%
Gracell Biotechnologies Inc. 0.2%
Value $20.88M Shares 2,080,000 Est. Cost $7.04 Unrealized
IMVT Immunovant, Inc. 0.2%
Value $17.91M Shares 425,009 Est. Cost $22.60 Unrealized +62.8%
TCRX TScan Therapeutics, Inc. 0.2%
Value $16.24M Shares 2,784,792 Est. Cost $6.08 Unrealized -24.7%
DAWN Day One Biopharmaceuticals, Inc. 0.2%
Value $14.6M Shares 1,000,000 Est. Cost $13.06 Unrealized -7.2%
DBV Technologies S.A. 0.2%
Value $13.92M Shares 14,614,264 Est. Cost $19.06 Unrealized
RLAY Relay Therapeutics, Inc. 0.1%
Value $12.77M Shares 1,160,117 Est. Cost $13.78 Unrealized -38.8%
SPRY ARS Pharmaceuticals, Inc. 0.1%
Value $11M Shares 2,006,451 Est. Cost $6.49 Unrealized -32.5%
STOK Stoke Therapeutics, Inc. 0.1%
Value $10.68M Shares 2,030,134 Est. Cost $8.98 Unrealized -52.4%
2seventy bio, Inc. 0.1%
Value $10.66M Shares 2,497,526 Est. Cost $18.72 Unrealized
INSM Insmed Incorporated 0.1%
Value $10.63M Shares 343,000 Est. Cost $19.59 Unrealized +32.4%
CLDX Celldex Therapeutics, Inc. 0.1%
Value $9.822M Shares 247,644 Est. Cost $29.41 Unrealized 0.0%
PRME Prime Medicine, Inc. 0.1%
Value $9.112M Shares 1,028,466 Est. Cost $18.06 Unrealized -57.4%
NGNE Neurogene Inc. 0.1%
Value $8.789M Shares 453,516 Est. Cost $14.32 Unrealized 0.0%
ADAPY Adaptimmune Therapeutics plc 0.1%
Value $8.699M Shares 10,969,282 Est. Cost $5.27 Unrealized
SANA Sana Biotechnology, Inc. 0.1%
Value $8.16M Shares 2,000,000 Est. Cost $4.00 Unrealized -7.8%
SGMT Sagimet Biosciences Inc. 0.1%
Value $7.894M Shares 1,456,518 Est. Cost $9.53 Unrealized -50.5%
CELC Celcuity Inc. 0.1%
Value $7.802M Shares 535,478 Est. Cost $9.83 Unrealized +22.8%
Athira Pharma, Inc. 0.1%
Value $7.664M Shares 3,153,807 Est. Cost $6.91 Unrealized
OPTEY Opthea Limited 0.1%
Value $7.637M Shares 2,588,645 Est. Cost $11.12 Unrealized
TNGX Tango Therapeutics, Inc. 0.1%
Value $7.425M Shares 750,000 Est. Cost $11.99 Unrealized -27.6%
TSHA Taysha Gene Therapies, Inc. 0.1%
Value $7.088M Shares 4,004,756 Est. Cost $1.91 Unrealized +4.1%
HOOKIPA Pharma Inc. 0.1%
Value $6.584M Shares 8,128,151 Est. Cost $1.55 Unrealized
Invitae Corporation 0.1%
Value $6.273M Shares 9,274,000 Est. Cost $0.67 Unrealized
MIRM Mirum Pharmaceuticals, Inc. 0.1%
Value $5.623M Shares 190,476 Est. Cost $27.38 Unrealized +10.5%
XNCR Xencor, Inc. 0.1%
Value $5.21M Shares 245,431 Est. Cost $23.51 Unrealized -19.1%
CYPH Leap Therapeutics, Inc. 0.1%
Value $4.859M Shares 1,172,175 Est. Cost $5.02 Unrealized -56.9%
DSGN Design Therapeutics, Inc. 0.0%
Value $3.975M Shares 1,500,000 Est. Cost $13.49 Unrealized -83.0%
TLIS Talis Biomedical Corporation 0.0%
Value $3.787M Shares 508,323 Est. Cost $7.25 Unrealized -10.2%
Perspective Therapeutics, Inc. 0.0%
Value $3.071M Shares 7,639,703 Est. Cost $0.39 Unrealized
PCVX Vaxcyte, Inc. 0.0%
Value $3.07M Shares 48,885 Est. Cost $39.24 Unrealized +32.3%
Praxis Precision Medicines, Inc. 0.0%
Value $2.931M Shares 131,533 Est. Cost $2.34 Unrealized
IPSC Century Therapeutics, Inc. 0.0%
Value $2.648M Shares 797,460 Est. Cost $9.79 Unrealized -81.4%
Mersana Therapeutics, Inc. 0.0%
Value $2.52M Shares 1,086,115 Est. Cost $4.11 Unrealized
CMPX Compass Therapeutics, Inc. 0.0%
Value $2.43M Shares 1,557,630 Est. Cost $3.99 Unrealized -56.6%
Achilles Therapeutics plc 0.0%
Value $1.869M Shares 2,102,792 Est. Cost $16.55 Unrealized
KALA KALA BIO, Inc. 0.0%
Value $1.866M Shares 266,613 Est. Cost $11.98 Unrealized -40.9%
Aligos Therapeutics, Inc. 0.0%
Value $1.379M Shares 2,076,400 Est. Cost $24.92 Unrealized
Invitae Corporation 0.0%
Value $1.106M Shares 1,764,546 Est. Cost $24.10 Unrealized
PFE Pfizer Inc. 0.0%
Value $1.008M Shares 35,000 Est. Cost $26.40 Unrealized 0.0%
PMVP PMV Pharmaceuticals, Inc. 0.0%
Value $998K Shares 322,024 Est. Cost $14.45 Unrealized -81.7%
WHWK Aadi Bioscience, Inc. 0.0%
Value $508K Shares 251,727 Est. Cost $13.14 Unrealized -68.1%
TARA Protara Therapeutics, Inc. 0.0%
Value $374K Shares 199,671 Est. Cost $30.96 Unrealized -95.2%
CABA Cabaletta Bio, Inc. 0.0%
Value $303K Shares 13,331 Est. Cost $8.14 Unrealized +106.6%
FHTX Foghorn Therapeutics Inc. 0.0%
Value $290K Shares 45,027 Est. Cost $14.37 Unrealized -70.0%
Atreca, Inc. 0.0%
Value $287K Shares 2,177,499 Est. Cost $18.84 Unrealized
TYRA Tyra Biosciences, Inc. 0.0%
Value $147K Shares 10,607 Est. Cost $12.95 Unrealized 0.0%
SRZNW Surrozen, Inc. 0.0%
Value $16,167 Shares 833,333 Est. Cost $1.14 Unrealized