Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q3 2023 (← Previous) (Next →)
Filing Date: Nov 14, 2023
Total Value: $17.35B (99.2% shares, 0.8% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seagen Inc. | 44,554,162 | $9.452B | 54.5% | $195.69 | — | COM | 81181C104 |
| ONC | BeiGene, Ltd. | 11,668,897 | $2.099B | 12.1% | $136.93 | — | SPONSORED ADR | 07725L102 |
| INCY | Incyte Corporation | 36,178,566 | $2.09B | 12.0% | $72.80 | -13.4% | COM | 45337C102 |
| ACAD | ACADIA Pharmaceuticals Inc. | 42,864,612 | $893M | 5.1% | $18.93 | +43.5% | COM | 004225108 |
| BMRN | BioMarin Pharmaceutical Inc. | 3,810,248 | $337M | 1.9% | $81.02 | +9.8% | COM | 09061G101 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,545,113 | $226M | 1.3% | $104.60 | +79.9% | COM | 558868105 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 6,702,349 | $154M | 0.9% | $23.49 | -4.6% | COM | 76243J105 |
| ROIV | Roivant Sciences Ltd. | 11,877,171 | $139M | 0.8% | $8.98 | +25.8% | SHS | G76279101 |
| IMCR | Immunocore Holdings plc | 2,520,731 | $131M | 0.8% | $42.57 | — | ADS | 45258D105 |
| — | Invitae Corporation | 300,000,000 | $130M | 0.8% | $0.45 | — | Note 1.5% 4/1/2028 | 46185LAD5 |
| — | Akero Therapeutics, Inc. | 2,368,378 | $120M | 0.7% | $33.89 | — | COM | 00973Y108 |
| ABCL | AbCellera Biologics Inc. | 20,763,323 | $95.51M | 0.6% | $26.25 | -76.8% | COM | 00288U106 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,710,818 | $89.99M | 0.5% | $6.35 | +13.1% | COM | 09058V103 |
| REPL | Replimune Group, Inc. | 4,578,280 | $78.33M | 0.5% | $19.30 | +1.8% | COM | 76029N106 |
| TRDA | Entrada Therapeutics, Inc. | 4,865,819 | $76.88M | 0.4% | $16.96 | — | COM | 29384C108 |
| RVMD | Revolution Medicines, Inc. | 2,691,493 | $74.5M | 0.4% | $26.29 | +12.8% | COM | 76155X100 |
| ARGX | argenx SE | 151,215 | $74.34M | 0.4% | $79.01 | — | SPONSORED ADR | 04016X101 |
| — | SpringWorks Therapeutics, Inc. | 2,999,846 | $69.36M | 0.4% | $25.92 | — | COM | 85205L107 |
| KYMR | Kymera Therapeutics, Inc. | 4,750,400 | $66.03M | 0.4% | $30.83 | -34.8% | COM | 501575104 |
| IMTX | Immatics N.V. | 5,640,816 | $65.32M | 0.4% | $10.84 | +10.1% | SHS | N44445109 |
| — | Mirati Therapeutics, Inc. | 1,409,784 | $61.41M | 0.4% | $22.85 | — | COM | 60468T105 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,809,577 | $48.8M | 0.3% | $17.35 | — | COM CL A | G5269C101 |
| RARE | Ultragenyx Pharmaceutical Inc. | 1,366,547 | $48.72M | 0.3% | $67.29 | -41.1% | COM | 90400D108 |
| DNLI | Denali Therapeutics Inc. | 2,292,003 | $47.28M | 0.3% | $26.77 | -5.2% | COM | 24823R105 |
| PRLD | Prelude Therapeutics Inc. | 10,123,824 | $31.28M | 0.2% | $28.24 | -86.7% | COM | 74065P101 |
| KOD | Kodiak Sciences Inc. | 17,310,490 | $31.16M | 0.2% | $30.30 | -88.4% | COM | 50015M109 |
| NRIX | Nurix Therapeutics, Inc. | 3,882,125 | $30.51M | 0.2% | $22.27 | -59.0% | COM | 67080M103 |
| BMEA | Biomea Fusion, Inc. | 2,108,949 | $29.02M | 0.2% | $8.56 | +110.5% | COM | 09077A106 |
| IDYA | IDEAYA Biosciences, Inc. | 1,062,123 | $28.66M | 0.2% | $14.62 | +73.4% | COM | 45166A102 |
| CERS | Cerus Corporation | 17,239,501 | $27.93M | 0.2% | $4.51 | -54.0% | COM | 157085101 |
| — | Aerovate Therapeutics, Inc. | 1,963,479 | $26.64M | 0.2% | $21.15 | — | COM | 008064107 |
| — | IGM Biosciences, Inc. | 3,157,764 | $26.37M | 0.2% | $17.75 | — | COM | 449585108 |
| XENE | Xenon Pharmaceuticals Inc. | 751,639 | $25.68M | 0.1% | $13.09 | +185.8% | COM | 98420N105 |
| CABA | Cabaletta Bio, Inc. | 1,594,000 | $24.26M | 0.1% | $8.14 | +67.9% | COM | 12674W109 |
| GLUE | Monte Rosa Therapeutics, Inc. | 4,916,095 | $23.55M | 0.1% | $6.49 | -0.8% | COM | 61225M102 |
| — | DBV Technologies S.A. | 14,614,264 | $19.88M | 0.1% | $19.06 | — | SPONSORED ADR | 23306J101 |
| KRYS | Krystal Biotech, Inc. | 169,934 | $19.71M | 0.1% | $34.45 | +254.2% | COM | 501147102 |
| — | Verve Therapeutics, Inc. | 1,416,530 | $18.78M | 0.1% | $60.25 | — | COM | 92539P101 |
| BCYC | Bicycle Therapeutics plc | 843,814 | $16.95M | 0.1% | $23.26 | — | SPONSORED ADS | 088786108 |
| IMVT | Immunovant, Inc. | 425,009 | $16.32M | 0.1% | $22.60 | 0.0% | COM | 45258J102 |
| COGT | Cogent Biosciences, Inc. | 1,292,966 | $12.61M | 0.1% | $11.57 | +2.5% | COM | 19240Q201 |
| DAWN | Day One Biopharmaceuticals, Inc. | 1,000,000 | $12.27M | 0.1% | $13.06 | -0.1% | COM | 23954D109 |
| PRME | Prime Medicine, Inc. | 1,028,466 | $9.812M | 0.1% | $18.06 | -28.1% | COM | 74168J101 |
| — | 2seventy bio, Inc. | 2,497,526 | $9.79M | 0.1% | $18.72 | — | COM | 901384107 |
| RLAY | Relay Therapeutics, Inc. | 1,160,117 | $9.757M | 0.1% | $13.78 | -22.0% | COM | 75943R102 |
| PACB | Pacific Biosciences of California, Inc. | 1,127,782 | $9.417M | 0.1% | $15.59 | -26.7% | COM | 69404D108 |
| INSM | Insmed Incorporated | 343,000 | $8.661M | 0.0% | $19.59 | +16.7% | COM PAR $.01 | 457669307 |
| ADAPY | Adaptimmune Therapeutics plc | 10,969,282 | $8.556M | 0.0% | $5.27 | — | SPONSORED ADR | 00653A107 |
| TNGX | Tango Therapeutics, Inc. | 750,000 | $8.445M | 0.0% | $11.99 | -49.1% | COM | 87583X109 |
| HRTX | Heron Therapeutics, Inc. | 8,131,678 | $8.376M | 0.0% | $17.29 | -91.8% | COM | 427746102 |
| ARVN | Arvinas, Inc. | 413,481 | $8.121M | 0.0% | $24.53 | 0.0% | COM | 04335A105 |
| TSHA | Taysha Gene Therapies, Inc. | 2,504,756 | $7.915M | 0.0% | $1.87 | 0.0% | COM SHS | 877619106 |
| SANA | Sana Biotechnology, Inc. | 2,000,000 | $7.74M | 0.0% | $4.00 | +34.5% | COM | 799566104 |
| — | bluebird bio, Inc. | 2,499,715 | $7.599M | 0.0% | $22.65 | — | COM | 09609G100 |
| SPRY | ARS Pharmaceuticals, Inc. | 2,006,451 | $7.584M | 0.0% | $6.49 | +1.2% | COM | 82835W108 |
| SGMT | Sagimet Biosciences Inc. | 815,359 | $7.175M | 0.0% | $13.31 | 0.0% | COM | 786700104 |
| TCRX | TScan Therapeutics, Inc. | 2,784,792 | $7.129M | 0.0% | $6.08 | -61.6% | COM | 89854M101 |
| GERN | Geron Corporation | 3,061,224 | $6.49M | 0.0% | $2.84 | -4.4% | COM | 374163103 |
| — | Athira Pharma, Inc. | 3,153,807 | $6.371M | 0.0% | $6.91 | — | COM | 04746L104 |
| ALEC | Alector, Inc. | 964,851 | $6.252M | 0.0% | $12.71 | -49.1% | COM | 014442107 |
| — | Invitae Corporation | 9,274,000 | $6.208M | 0.0% | $0.67 | — | Series A 4.5% 3/15/2028 | 46185LAH6 |
| MIRM | Mirum Pharmaceuticals, Inc. | 190,476 | $6.019M | 0.0% | $27.38 | 0.0% | COM | 604749101 |
| EWTX | Edgewise Therapeutics, Inc. | 1,049,699 | $6.015M | 0.0% | $19.01 | -64.2% | COM | 28036F105 |
| SMMT | Summit Therapeutics Inc. | 3,140,473 | $5.873M | 0.0% | $2.44 | -21.8% | COM | 86627T108 |
| STOK | Stoke Therapeutics, Inc. | 1,485,915 | $5.855M | 0.0% | $10.71 | -38.6% | COM | 86150R107 |
| — | HOOKIPA Pharma Inc. | 8,065,398 | $4.968M | 0.0% | $1.55 | — | COM | 43906K100 |
| — | Morphic Holding, Inc. | 215,800 | $4.944M | 0.0% | $22.91 | — | COM | 61775R105 |
| CELC | Celcuity Inc. | 535,478 | $4.894M | 0.0% | $9.83 | 0.0% | COM | 15102K100 |
| — | Neoleukin Therapeutics, Inc. | 1,221,414 | $4.825M | 0.0% | $3.95 | — | COM | 64049K203 |
| WHWK | Aadi Bioscience, Inc. | 989,928 | $4.791M | 0.0% | $13.14 | -55.8% | COM | 00032Q104 |
| OPTEY | Opthea Limited | 2,690,891 | $4.688M | 0.0% | $11.12 | — | SPONSORED ADS | 68386J208 |
| NTRA | Natera, Inc. | 100,000 | $4.425M | 0.0% | $37.02 | +37.7% | COM | 632307104 |
| DSGN | Design Therapeutics, Inc. | 1,500,000 | $3.54M | 0.0% | $13.49 | -65.4% | COM | 25056L103 |
| — | Praxis Precision Medicines, Inc. | 1,879,915 | $3.215M | 0.0% | $2.34 | — | COM | 74006W108 |
| CMPX | Compass Therapeutics, Inc. | 1,557,630 | $3.069M | 0.0% | $3.99 | -38.0% | COM | 20454B104 |
| TLIS | Talis Biomedical Corporation | 508,323 | $2.933M | 0.0% | $7.25 | -6.0% | COM | 87424L207 |
| — | Gracell Biotechnologies Inc. | 1,000,000 | $2.88M | 0.0% | $3.81 | — | SPONSORED ADS | 38406L103 |
| SERA | Sera Prognostics, Inc. | 1,515,342 | $2.819M | 0.0% | $3.50 | -31.7% | CLASS A COM | 81749D107 |
| PCVX | Vaxcyte, Inc. | 48,885 | $2.492M | 0.0% | $39.24 | +25.7% | COM | 92243G108 |
| XNCR | Xencor, Inc. | 123,127 | $2.481M | 0.0% | $27.96 | -18.7% | COM | 98401F105 |
| KALA | KALA BIO, Inc. | 266,613 | $2.373M | 0.0% | $11.98 | +9.6% | COM | 483119202 |
| — | Achilles Therapeutics plc | 2,557,149 | $2.327M | 0.0% | $16.55 | — | SPONSORED ADS | 00449L102 |
| IPSC | Century Therapeutics, Inc. | 1,149,340 | $2.299M | 0.0% | $9.79 | -72.8% | COM | 15673T100 |
| — | Affimed N.V. | 4,448,644 | $2.126M | 0.0% | $4.50 | — | COM | N01045108 |
| — | Perspective Therapeutics, Inc. | 7,639,703 | $2.091M | 0.0% | $0.39 | — | COM | 46489V104 |
| — | Instil Bio, Inc. | 4,704,395 | $2.013M | 0.0% | $18.68 | — | COM | 45783C101 |
| PMVP | PMV Pharmaceuticals, Inc. | 322,024 | $1.977M | 0.0% | $14.45 | -52.4% | COM | 69353Y103 |
| ANAB | AnaptysBio, Inc. | 106,197 | $1.907M | 0.0% | $27.04 | -29.4% | COM | 032724106 |
| — | POINT Biopharma Global Inc. | 249,968 | $1.667M | 0.0% | $7.73 | — | COM | 730541109 |
| — | iTeos Therapeutics, Inc. | 150,346 | $1.646M | 0.0% | $24.67 | — | COM | 46565G104 |
| CYPH | Leap Therapeutics, Inc. | 1,172,175 | $1.618M | 0.0% | $5.02 | -53.7% | COM | 52187K200 |
| — | Aligos Therapeutics, Inc. | 2,076,400 | $1.551M | 0.0% | $24.92 | — | COM | 01626L105 |
| — | Mersana Therapeutics, Inc. | 1,086,115 | $1.379M | 0.0% | $4.11 | — | COM | 59045L106 |
| — | Vor Biopharma Inc. | 633,848 | $1.344M | 0.0% | $4.75 | — | COM | 929033108 |
| — | Invitae Corporation | 1,764,546 | $1.068M | 0.0% | $24.10 | — | COM | 46185L103 |
| RNAM | Avidity Biosciences, Inc. | 166,347 | $1.061M | 0.0% | $18.93 | -54.5% | COM | 05370A108 |
| — | Atreca, Inc. | 3,532,760 | $922K | 0.0% | $18.84 | — | CL A COM | 04965G109 |
| — | Genetron Holdings Limited | 455,306 | $370K | 0.0% | $13.55 | — | ADS | 37186H100 |
| TARA | Protara Therapeutics, Inc. | 199,671 | $333K | 0.0% | $30.96 | -92.6% | COM STK | 74365U107 |
| FHTX | Foghorn Therapeutics Inc. | 45,027 | $225K | 0.0% | $14.37 | -46.4% | COM | 344174107 |
| SRZNW | Surrozen, Inc. | 833,333 | $34,250 | 0.0% | $1.14 | — | W EXP 8/11/2026 | 86889P117 |