Location: San Diego, CA
CIK: 0001232621 · Show all filings
Period: Q1 2023 (← Previous) (Next →)
Filing Date: May 15, 2023
Total Value: $671M (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ANAB | ANAPTYSBIO INC | 2,032,561 | $44.23M | 6.6% | $21.76 * | $21.51 | +13.0% | COM | 032724106 |
| — | BLUEBIRD BIO INC | 9,882,827 | $31.43M | 4.7% | $3.18 | $3.78 | — | COM | 09609G100 |
| MIRM | MIRUM PHARMACEUTICALS INC | 1,170,000 | $28.1M | 4.2% | $24.02 * | $21.51 | +6.0% | COM | 604749101 |
| EOLS | EVOLUS INC | 3,197,399 | $27.05M | 4.0% | $8.46 * | $8.75 | +3.4% | COM | 30052C107 |
| TARS | TARSUS PHARMACEUTICALS INC | 2,034,158 | $25.57M | 3.8% | $12.57 * | $15.51 | -5.7% | COM | 87650L103 |
| NVO | NOVO-NORDISK A S | 135,000 | $21.48M | 3.2% | $159.14 | $159.14 | — | ADR | 670100205 |
| MRNA | MODERNA INC | 136,700 | $20.99M | 3.1% | $153.58 * | $164.11 | +0.5% | COM | 60770K107 |
| KALV | KALVISTA PHARMACEUTICALS INC | 2,651,393 | $20.84M | 3.1% | $7.86 * | $9.23 | -19.1% | COM | 483497103 |
| IMCR | IMMUNOCORE HLDGS PLC | 405,600 | $20.05M | 3.0% | $49.44 | $30.74 | — | ADS | 45258D105 |
| AXSM | AXSOME THERAPEUTICS INC | 320,000 | $19.74M | 2.9% | $61.68 * | $57.63 | +14.0% | COM | 05464T104 |
| ONC | BEIGENE LTD | 85,000 | $18.32M | 2.7% | $215.53 | $134.82 | — | SPONSORED ADR | 07725L102 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 692,925 | $17.63M | 2.6% | $25.44 * | $15.92 | +101.4% | COM | 92790C104 |
| — | INTRA-CELLULAR THERAPIES INC | 300,000 | $16.25M | 2.4% | $54.15 | $59.78 | — | COM | 46116X101 |
| — | NEW YORK CMNTY BANCORP INC | 1,606,600 | $14.52M | 2.2% | $9.04 | $9.04 | — | COM | 649445103 |
| — | ADICET BIO INC | 2,520,000 | $14.52M | 2.2% | $5.76 | $6.52 | — | COM | 007002108 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 1,600,000 | $13.34M | 2.0% | $8.34 * | $10.59 | -9.1% | COM | 09058V103 |
| AZN | ASTRAZENECA PLC | 170,000 | $11.8M | 1.8% | $69.41 | $56.36 | — | SPONSORED ADR | 046353108 |
| ALT | ALTIMMUNE INC | 2,750,000 | $11.61M | 1.7% | $4.22 * | $9.59 | +23.9% | COM NEW | 02155H200 |
| PCVX | VAXCYTE INC | 300,000 | $11.24M | 1.7% | $37.48 * | $39.24 | +8.1% | COM | 92243G108 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 321,200 | $10.49M | 1.6% | $32.65 * | $41.60 | +9.5% | COM | 413197104 |
| LLY | LILLY ELI & CO | 30,000 | $10.3M | 1.5% | $343.42 * | $340.49 | -3.1% | COM | 532457108 |
| PYXS | PYXIS ONCOLOGY INC | 2,481,662 | $9.951M | 1.5% | $4.01 * | $1.97 | +1.3% | COMMON STOCK | 747324101 |
| ZYME | ZYMEWORKS DEL INC | 1,100,000 | $9.944M | 1.5% | $9.04 * | $8.10 | +7.6% | COM | 98985Y108 |
| — | JOUNCE THERAPEUTICS INC | 5,300,087 | $9.805M | 1.5% | $1.85 | $1.85 | — | COM | 481116101 |
| BCAB | BIOATLA INC | 3,624,076 | $9.713M | 1.4% | $2.68 * | $6.62 | -45.6% | COM | 09077B104 |
| COF | CAPITAL ONE FINL CORP | 100,000 | $9.616M | 1.4% | $96.16 * | $99.69 | 0.0% | COM | 14040H105 |
| CTMX | CYTOMX THERAPEUTICS INC | 6,093,032 | $9.2M | 1.4% | $1.51 * | $1.91 | +18.3% | COM | 23284F105 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 45,000 | $9.014M | 1.3% | $200.32 * | $191.81 | +9.6% | COM | 02043Q107 |
| — | AMARIN CORP PLC | 5,400,000 | $8.1M | 1.2% | $1.50 | $1.50 | — | SPONS ADR NEW | 023111206 |
| BIO | BIO RAD LABS INC | 16,000 | $7.664M | 1.1% | $479.02 * | $570.32 | -17.9% | CL A | 090572207 |
| — | THIRD HARMONIC BIO INC | 1,800,000 | $7.416M | 1.1% | $4.12 | $4.29 | — | COM | 88427A107 |
| IONS | IONIS PHARMACEUTICALS INC | 200,000 | $7.148M | 1.1% | $35.74 * | $32.73 | +14.7% | COM | 462222100 |
| — | BELLEROPHON THERAPEUTICS INC | 893,974 | $7.053M | 1.1% | $7.89 | $7.89 | — | COM NEW | 078771300 |
| — | KINIKSA PHARMACEUTICALS LTD | 600,000 | $6.456M | 1.0% | $10.76 | $9.90 | — | COM CL A | G5269C101 |
| NKTX | NKARTA INC | 1,785,829 | $6.34M | 0.9% | $3.55 * | $11.10 | -57.3% | COM | 65487U108 |
| CMA | COMERICA INC | 133,525 | $5.798M | 0.9% | $43.42 * | $54.87 | 0.0% | COM | 200340107 |
| QNCX | QUINCE THERAPEUTICS INC | 3,620,000 | $5.647M | 0.8% | $1.56 * | $0.98 | 0.0% | COM | 22053A107 |
| — | ENZO BIOCHEM INC | 2,300,000 | $5.589M | 0.8% | $2.43 | $2.43 | — | COM | 294100102 |
| CGEM | CULLINAN ONCOLOGY INC | 500,000 | $5.115M | 0.8% | $10.23 * | $11.56 | -4.7% | COM | 230031106 |
| — | TCR2 THERAPEUTICS INC | 3,399,745 | $5.1M | 0.8% | $1.50 | $2.51 | — | COM | 87808K106 |
| GNFTY | GENFIT S A | 1,212,515 | $4.971M | 0.7% | $4.10 | $4.77 | — | ADS | 372279109 |
| — | GRAPHITE BIO INC | 2,028,466 | $4.97M | 0.7% | $2.45 | $2.61 | — | COM | 38870X104 |
| — | IMMUNOGEN INC | 1,274,853 | $4.895M | 0.7% | $3.84 | $7.42 | — | COM | 45253H101 |
| — | MAGENTA THERAPEUTICS INC | 6,050,000 | $4.808M | 0.7% | $0.79 | $0.79 | — | COM | 55910K108 |
| C | CITIGROUP INC | 100,000 | $4.689M | 0.7% | $46.89 * | $44.28 | 0.0% | COM NEW | 172967424 |
| FATE | FATE THERAPEUTICS INC | 700,000 | $3.99M | 0.6% | $5.70 * | $6.03 | 0.0% | COM | 31189P102 |
| FRCB | FIRST REP BK SAN FRANCISCO C | 278,759 | $3.9M | 0.6% | $13.99 * | $102.43 | 0.0% | COM | 33616C100 |
| ENTA | ENANTA PHARMACEUTICALS INC | 90,000 | $3.64M | 0.5% | $40.44 * | $56.97 | -16.2% | COM | 29251M106 |
| GLPG | GALAPAGOS NV | 89,650 | $3.464M | 0.5% | $38.64 | $62.02 | — | SPON ADR | 36315X101 |
| AVIR | ATEA PHARMACEUTICALS INC | 1,002,582 | $3.359M | 0.5% | $3.35 * | $4.06 | 0.0% | COM | 04683R106 |
| — | ASLAN PHARMACEUTICALS LTD | 1,165,301 | $3.356M | 0.5% | $2.88 | $2.88 | — | SPON ADS NEW | 04522R200 |
| CVBF | CVB FINL CORP | 200,000 | $3.336M | 0.5% | $16.68 * | $19.92 | 0.0% | COM | 126600105 |
| — | ALIGOS THERAPEUTICS INC | 3,424,800 | $2.993M | 0.4% | $0.87 | $1.06 | — | COM | 01626L105 |
| — | ITEOS THERAPEUTICS INC | 216,700 | $2.949M | 0.4% | $13.61 | $27.47 | — | COM | 46565G104 |
| — | DYNAVAX TECHNOLOGIES CORP | 300,000 | $2.943M | 0.4% | $9.81 | $10.57 | — | COM NEW | 268158201 |
| ESPR | ESPERION THERAPEUTICS INC NE | 1,850,000 | $2.942M | 0.4% | $1.59 * | $5.16 | 0.0% | COM | 29664W105 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 100,000 | $2.934M | 0.4% | $29.34 * | $35.49 | -2.1% | COM | 03237H101 |
| INSM | INSMED INC | 166,203 | $2.834M | 0.4% | $17.05 * | $23.98 | -19.0% | COM PAR $.01 | 457669307 |
| RCUS | ARCUS BIOSCIENCES INC | 147,920 | $2.698M | 0.4% | $18.24 * | $33.51 | -43.0% | COM | 03969F109 |
| SPRY | ARS PHARMACEUTICALS INC | 409,463 | $2.666M | 0.4% | $6.51 * | $4.93 | +55.9% | COM | 82835W108 |
| — | ELEVATION ONCOLOGY INC | 1,400,000 | $2.66M | 0.4% | $1.90 | $1.57 | — | COM | 28623U101 |
| — | 2SEVENTY BIO INC | 250,000 | $2.55M | 0.4% | $10.20 | $17.06 | — | COMMON STOCK | 901384107 |
| EGRX | EAGLE PHARMACEUTICALS INC | 80,000 | $2.27M | 0.3% | $28.37 * | $36.69 | -19.1% | COM | 269796108 |
| — | BOLT BIOTHERAPEUTICS INC | 1,627,553 | $2.262M | 0.3% | $1.39 | $1.46 | — | COM | 097702104 |
| BKU | BANKUNITED INC | 100,000 | $2.258M | 0.3% | $22.58 * | $29.03 | 0.0% | COM | 06652K103 |
| — | PROMETHEUS BIOSCIENCES INC | 21,000 | $2.254M | 0.3% | $107.32 | $107.32 | — | COM | 74349U108 |
| ARVN | ARVINAS INC | 80,000 | $2.186M | 0.3% | $27.32 * | $37.14 | -14.9% | COM | 04335A105 |
| — | BELLUS HEALTH INC NEW | 300,000 | $2.16M | 0.3% | $7.20 | $7.20 | — | COM NEW | 07987C204 |
| — | EQUITY COMWLTH | 100,000 | $2.071M | 0.3% | $20.71 | $20.71 | — | COM SH BEN INT | 294628102 |
| — | VERITEX HLDGS INC | 110,000 | $2.009M | 0.3% | $18.26 | $18.26 | — | COM | 923451108 |
| IBRX | IMMUNITYBIO INC | 1,095,795 | $1.994M | 0.3% | $1.82 * | $3.11 | 0.0% | COM | 45256X103 |
| — | ALLAKOS INC | 447,967 | $1.993M | 0.3% | $4.45 | $9.79 | — | COM | 01671P100 |
| BHVN | BIOHAVEN LTD | 140,000 | $1.912M | 0.3% | $13.66 * | $14.12 | +12.7% | COM | G1110E107 |
| SFBS | SERVISFIRST BANCSHARES INC | 30,000 | $1.639M | 0.2% | $54.63 * | $63.35 | 0.0% | COM | 81768T108 |
| CHRS | COHERUS BIOSCIENCES INC | 200,000 | $1.368M | 0.2% | $6.84 * | $13.23 | -41.4% | COM | 19249H103 |
| — | MEI PHARMA INC | 5,163,456 | $1.182M | 0.2% | $0.23 | $0.23 | — | COM NEW | 55279B202 |
| UMBF | UMB FINL CORP | 20,000 | $1.154M | 0.2% | $57.72 * | $81.27 | 0.0% | COM | 902788108 |
| SCYX | SCYNEXIS INC | 383,179 | $1.15M | 0.2% | $3.00 * | $1.66 | 0.0% | COM NEW | 811292200 |
| — | SURFACE ONCOLOGY INC | 1,300,000 | $908K | 0.1% | $0.70 | $0.74 | — | COM | 86877M209 |
| — | ATHIRA PHARMA INC | 352,715 | $882K | 0.1% | $2.50 | $3.17 | — | COM | 04746L104 |
| HRTX | HERON THERAPEUTICS INC | 550,000 | $831K | 0.1% | $1.51 * | $10.44 | -76.0% | COM | 427746102 |
| TNGX | TANGO THERAPEUTICS INC | 200,000 | $790K | 0.1% | $3.95 * | $5.80 | 0.0% | COM | 87583X109 |
| VNDA | VANDA PHARMACEUTICALS INC | 100,000 | $679K | 0.1% | $6.79 * | $7.03 | 0.0% | COM | 921659108 |
| — | TONIX PHARMACEUTICALS HLDG C | 1,100,419 | $650K | 0.1% | $0.59 | $0.39 | — | COM NEW | 890260862 |
| — | NEXTCURE INC | 400,000 | $592K | 0.1% | $1.48 | $1.48 | — | COM | 65343E108 |
| IVVD | INVIVYD INC | 400,000 | $480K | 0.1% | $1.20 * | $1.82 | 0.0% | COM | 00534A102 |
| LIANY | LIANBIO | 209,600 | $411K | 0.1% | $1.96 | $1.87 | — | SPONSORED ADS | 53000N108 |
| — | PARDES BIOSCIENCES INC | 300,000 | $396K | 0.1% | $1.32 | $1.42 | — | COM | 69945Q105 |
| — | INSPIRATO INCORPORATED | 380,000 | $364K | 0.1% | $0.96 | $0.96 | — | COM CL A | 45791E107 |
| — | KRONOS BIO INC | 200,000 | $292K | 0.0% | $1.46 | $1.46 | — | COM | 50107A104 |
| — | PASSAGE BIO INC | 300,000 | $287K | 0.0% | $0.96 | $0.96 | — | COM | 702712100 |
| — | ORCHARD THERAPEUTICS PLC | 50,000 | $269K | 0.0% | $5.37 | $5.37 | — | SPON ADS NEW | 68570P200 |
| ATYR | ATYR PHARMA INC | 123,430 | $259K | 0.0% | $2.10 * | $5.98 | -63.4% | COM NEW | 002120202 |
| STEL | STELLAR BANCORP INC | 10,000 | $246K | 0.0% | $24.61 * | $28.13 | 0.0% | COM | 858927106 |
| MOLN | MOLECULAR PARTNERS AG | 38,253 | $231K | 0.0% | $6.04 | $6.39 | — | ADS | 60853G106 |
| RVPH | REVIVA PHARMACEUTCLS HLDGS I | 53,200 | $223K | 0.0% | $4.19 * | $4.11 | +6.1% | COM | 76152G100 |
| — | CYTEIR THERAPEUTICS INC | 100,000 | $182K | 0.0% | $1.82 | $1.82 | — | COM | 23284P103 |
| — | INSTIL BIO INC | 200,000 | $132K | 0.0% | $0.66 | $0.66 | — | COM | 45783C101 |
| TLPH | ACELRX PHARMACEUTICALS INC | 195,000 | $128K | 0.0% | $0.66 * | $2.81 | -43.8% | COM NEW | 00444T209 |
| — | VINCERX PHARMA INC | 101,762 | $106K | 0.0% | $1.04 | $16.05 | — | COM NEW | 92731L106 |
| — | NEKTAR THERAPEUTICS | 139,600 | $98,125 | 0.0% | $0.70 | $5.39 | — | COM | 640268108 |
| EQ | EQUILLIUM INC | 88,568 | $64,655 | 0.0% | $0.73 * | $0.96 | 0.0% | COM | 29446K106 |
| — | AVROBIO INC | 37,613 | $37,613 | 0.0% | $1.00 | $1.00 | — | COM | 05455M100 |