Location: San Diego, CA
CIK: 0001232621 · Show all filings
Period: Q4 2023 (← Previous) (Next →)
Filing Date: Feb 14, 2024
Total Value: $1.082B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | MIRATI THERAPEUTICS INC | 1,558,059 | $91.54M | 8.5% | $58.75 | $56.61 | — | COM | 60468T105 |
| — | IMMUNOGEN INC | 2,199,137 | $65.2M | 6.0% | $29.65 | $15.39 | — | COM | 45253H101 |
| TARS | TARSUS PHARMACEUTICALS INC | 2,204,797 | $44.65M | 4.1% | $20.25 * | $15.90 | +5.0% | COM | 87650L103 |
| KALV | KALVISTA PHARMACEUTICALS INC | 3,440,345 | $42.14M | 3.9% | $12.25 * | $9.46 | -3.8% | COM | 483497103 |
| LIANY | LIANBIO | 9,366,783 | $41.87M | 3.9% | $4.47 | $3.97 | — | SPONSORED ADS | 53000N108 |
| ANAB | ANAPTYSBIO INC | 1,950,609 | $41.78M | 3.9% | $21.42 * | $21.51 | -19.8% | COM | 032724106 |
| MIRM | MIRUM PHARMACEUTICALS INC | 1,137,107 | $33.57M | 3.1% | $29.52 * | $21.51 | +40.7% | COM | 604749101 |
| EOLS | EVOLUS INC | 3,097,399 | $32.62M | 3.0% | $10.53 * | $8.75 | +2.2% | COM | 30052C107 |
| ALT | ALTIMMUNE INC | 2,750,000 | $30.94M | 2.9% | $11.25 * | $9.59 | -56.5% | COM NEW | 02155H200 |
| IMCR | IMMUNOCORE HLDGS PLC | 405,600 | $27.71M | 2.6% | $68.32 | $30.74 | — | ADS | 45258D105 |
| AXSM | AXSOME THERAPEUTICS INC | 320,000 | $25.47M | 2.4% | $79.59 * | $57.63 | +16.0% | COM | 05464T104 |
| PTCT | PTC THERAPEUTICS INC | 900,000 | $24.8M | 2.3% | $27.56 * | $22.87 | 0.0% | COM | 69366J200 |
| — | GRACELL BIOTECHNOLOGIES INC | 2,191,417 | $22M | 2.0% | $10.04 | $9.52 | — | SPONSORED ADS | 38406L103 |
| RVMD | REVOLUTION MEDICINES INC | 679,630 | $19.49M | 1.8% | $28.68 * | $24.03 | 0.0% | COM | 76155X100 |
| PCVX | VAXCYTE INC | 300,000 | $18.84M | 1.7% | $62.80 * | $39.24 | +32.3% | COM | 92243G108 |
| LLY | ELI LILLY & CO | 30,000 | $17.49M | 1.6% | $582.92 | $340.49 | +68.9% | COM | 532457108 |
| — | NEW YORK CMNTY BANCORP INC | 1,606,600 | $16.44M | 1.5% | $10.23 | $9.04 | — | COM | 649445103 |
| — | INTRA-CELLULAR THERAPIES INC | 220,000 | $15.76M | 1.5% | $71.62 | $59.78 | — | COM | 46116X101 |
| ONC | BEIGENE LTD | 85,000 | $15.33M | 1.4% | $180.36 | $134.82 | — | SPONSORED ADR | 07725L102 |
| — | AVADEL PHARMACEUTICALS PLC | 1,079,528 | $15.24M | 1.4% | $14.12 | $10.58 | — | SPONSORED ADR | 05337M104 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 692,925 | $15.09M | 1.4% | $21.78 * | $15.92 | -0.8% | COM | 92790C104 |
| CRSP | CRISPR THERAPEUTICS AG | 215,000 | $13.46M | 1.2% | $62.60 * | $55.02 | 0.0% | NAMEN AKT | H17182108 |
| — | THESEUS PHARMACEUTICALS INC | 3,255,026 | $13.18M | 1.2% | $4.05 | $4.05 | — | COM | 88369M101 |
| AVIR | ATEA PHARMACEUTICALS INC | 4,076,741 | $12.43M | 1.1% | $3.05 | $3.69 | -17.9% | COM | 04683R106 |
| AZN | ASTRAZENECA PLC | 170,000 | $11.45M | 1.1% | $67.35 | $56.36 | — | SPONSORED ADR | 046353108 |
| ZYME | ZYMEWORKS INC | 1,100,000 | $11.43M | 1.1% | $10.39 * | $8.10 | -1.7% | COM | 98985Y108 |
| GSK | GSK PLC | 300,000 | $11.12M | 1.0% | $37.06 | $37.06 | — | SPONSORED ADR | 37733W204 |
| — | KINIKSA PHARMACEUTICALS LTD | 600,000 | $10.52M | 1.0% | $17.54 | $9.90 | — | COM CL A | G5269C101 |
| CTMX | CYTOMX THERAPEUTICS INC | 6,550,000 | $10.15M | 0.9% | $1.55 * | $1.88 | -30.1% | COM | 23284F105 |
| IONS | IONIS PHARMACEUTICALS INC | 200,000 | $10.12M | 0.9% | $50.59 * | $32.73 | +46.3% | COM | 462222100 |
| BEAM | BEAM THERAPEUTICS INC | 350,000 | $9.527M | 0.9% | $27.22 * | $24.84 | 0.0% | COM | 07373V105 |
| CYTK | CYTOKINETICS INC | 110,000 | $9.184M | 0.8% | $83.49 * | $36.21 | 0.0% | COM NEW | 23282W605 |
| ASND | ASCENDIS PHARMA A/S | 70,000 | $8.816M | 0.8% | $125.95 | $120.71 | — | SPONSORED ADR | 04351P101 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 271,200 | $8.76M | 0.8% | $32.30 * | $41.60 | -32.9% | COM | 413197104 |
| — | CYMABAY THERAPEUTICS INC | 350,000 | $8.267M | 0.8% | $23.62 | $18.64 | — | COM | 23257D103 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 1,000,000 | $8.13M | 0.8% | $8.13 * | $5.23 | 0.0% | COM | 462260100 |
| CGEM | CULLINAN ONCOLOGY INC | 771,138 | $7.858M | 0.7% | $10.19 * | $10.78 | -17.8% | COM | 230031106 |
| MRNA | MODERNA INC | 76,700 | $7.628M | 0.7% | $99.45 * | $164.11 | -48.8% | COM | 60770K107 |
| RCKT | ROCKET PHARMACEUTICALS INC | 250,000 | $7.492M | 0.7% | $29.97 * | $19.73 | +11.8% | COM | 77313F106 |
| — | GRAPHITE BIO INC | 2,491,780 | $6.528M | 0.6% | $2.62 | $2.61 | — | COM | 38870X104 |
| BCAB | BIOATLA INC | 2,524,076 | $6.209M | 0.6% | $2.46 * | $6.46 | -73.2% | COM | 09077B104 |
| — | KINNATE BIOPHARMA INC | 2,601,647 | $6.166M | 0.6% | $2.37 | $2.37 | — | COM | 49705R105 |
| ADMA | ADMA BIOLOGICS INC | 1,360,000 | $6.147M | 0.6% | $4.52 * | $3.72 | -0.5% | COM | 000899104 |
| NTLA | INTELLIA THERAPEUTICS INC | 200,000 | $6.098M | 0.6% | $30.49 * | $38.80 | -25.9% | COM | 45826J105 |
| CVBF | CVB FINL CORP | 300,000 | $6.057M | 0.6% | $20.19 * | $18.65 | -13.6% | COM | 126600105 |
| VSTM | VERASTEM INC | 741,514 | $6.036M | 0.6% | $8.14 * | $6.94 | +3.5% | COM NEW | 92337C203 |
| BHVN | BIOHAVEN LTD | 140,000 | $5.992M | 0.6% | $42.80 * | $14.12 | +120.2% | COM | G1110E107 |
| — | EQUITY COMWLTH | 300,000 | $5.76M | 0.5% | $19.20 | $19.15 | — | COM SH BEN INT | 294628102 |
| ESPR | ESPERION THERAPEUTICS INC NE | 1,850,000 | $5.532M | 0.5% | $2.99 * | $5.16 | -74.9% | COM | 29664W105 |
| — | RENEO PHARMACEUTICALS INC | 3,330,000 | $5.328M | 0.5% | $1.60 | $1.60 | — | COM | 75974E103 |
| NUVB | NUVATION BIO INC | 3,500,000 | $5.285M | 0.5% | $1.51 * | $1.29 | 0.0% | COM CL A | 67080N101 |
| DNTH | DIANTHUS THERAPEUTICS INC | 504,242 | $5.244M | 0.5% | $10.40 * | $12.62 | -12.4% | COM | 252828108 |
| BIO | BIO RAD LABS INC | 16,000 | $5.166M | 0.5% | $322.89 * | $508.83 | -38.4% | CL A | 090572207 |
| INSM | INSMED INC | 166,203 | $5.151M | 0.5% | $30.99 * | $23.98 | +8.2% | COM PAR $.01 | 457669307 |
| BDTX | BLACK DIAMOND THERAPEUTICS I | 1,803,200 | $5.067M | 0.5% | $2.81 * | $2.64 | -11.2% | COM | 09203E105 |
| AUPH | AURINIA PHARMACEUTICALS INC | 550,000 | $4.944M | 0.5% | $8.99 * | $9.90 | -16.8% | COM | 05156V102 |
| VTYX | VENTYX BIOSCIENCES INC | 2,000,000 | $4.94M | 0.5% | $2.47 * | $9.50 | 0.0% | COM | 92332V107 |
| — | VERITEX HLDGS INC | 210,000 | $4.887M | 0.5% | $23.27 | $18.10 | — | COM | 923451108 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 800,000 | $4.792M | 0.4% | $5.99 * | $9.70 | -40.3% | COM | 09058V103 |
| — | RAIN ONCOLOGY INC | 3,850,513 | $4.621M | 0.4% | $1.20 | $1.20 | — | COM | 75082Q105 |
| — | BLUEPRINT MEDICINES CORP | 50,000 | $4.612M | 0.4% | $92.24 | $92.24 | — | COM | 09627Y109 |
| USB | US BANCORP DEL | 100,000 | $4.328M | 0.4% | $43.28 * | $28.41 | +16.5% | COM NEW | 902973304 |
| — | DYNAVAX TECHNOLOGIES CORP | 300,000 | $4.194M | 0.4% | $13.98 | $10.57 | — | COM NEW | 268158201 |
| — | BOLT BIOTHERAPEUTICS INC | 3,652,244 | $4.091M | 0.4% | $1.12 | $1.34 | — | COM | 097702104 |
| QURE | UNIQURE NV | 600,000 | $4.062M | 0.4% | $6.77 * | $9.00 | -26.6% | SHS | N90064101 |
| DSGN | DESIGN THERAPEUTICS INC | 1,480,675 | $3.924M | 0.4% | $2.65 * | $4.45 | -48.6% | COM | 25056L103 |
| — | CARGO THERAPEUTICS INC | 160,544 | $3.717M | 0.3% | $23.15 | $23.15 | — | COM | 14179K101 |
| — | SPRINGWORKS THERAPEUTICS INC | 100,000 | $3.65M | 0.3% | $36.50 | $36.50 | — | COM | 85205L107 |
| NKTX | NKARTA INC | 550,000 | $3.63M | 0.3% | $6.60 * | $11.10 | -76.7% | COM | 65487U108 |
| BOH | BANK HAWAII CORP | 50,000 | $3.623M | 0.3% | $72.46 * | $44.03 | +17.8% | COM | 062540109 |
| ACAD | ACADIA PHARMACEUTICALS INC | 114,400 | $3.582M | 0.3% | $31.31 * | $26.75 | -10.7% | COM | 004225108 |
| IPSC | CENTURY THERAPEUTICS INC | 1,066,440 | $3.541M | 0.3% | $3.32 * | $1.82 | 0.0% | COM | 15673T100 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 4,387,238 | $3.479M | 0.3% | $0.79 | $0.92 | — | SPONDS ADR | 00653A107 |
| QNCX | QUINCE THERAPEUTICS INC | 3,220,000 | $3.381M | 0.3% | $1.05 | $0.98 | +2.3% | COM | 22053A107 |
| ARVN | ARVINAS INC | 80,000 | $3.293M | 0.3% | $41.16 * | $37.14 | -37.1% | COM | 04335A105 |
| — | KARUNA THERAPEUTICS INC | 10,000 | $3.165M | 0.3% | $316.51 | $169.09 | — | COM | 48576A100 |
| HRTX | HERON THERAPEUTICS INC | 1,850,000 | $3.145M | 0.3% | $1.70 * | $4.36 | -74.7% | COM | 427746102 |
| IFRX | INFLARX NV | 1,873,753 | $3.054M | 0.3% | $1.63 * | $4.48 | -61.7% | COM | N44821101 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 200,000 | $2.944M | 0.3% | $14.72 * | $15.33 | 0.0% | COM | 03237H101 |
| ENTA | ENANTA PHARMACEUTICALS INC | 300,000 | $2.823M | 0.3% | $9.41 | $9.32 | 0.0% | COM | 29251M106 |
| — | ATHIRA PHARMA INC | 1,152,715 | $2.801M | 0.3% | $2.43 | $2.66 | — | COM | 04746L104 |
| — | AMARIN CORP PLC | 3,086,544 | $2.685M | 0.2% | $0.87 | $1.43 | — | SPONS ADR NEW | 023111206 |
| FATE | FATE THERAPEUTICS INC | 700,000 | $2.618M | 0.2% | $3.74 * | $6.03 | -60.9% | COM | 31189P102 |
| — | SERES THERAPEUTICS INC | 1,792,888 | $2.51M | 0.2% | $1.40 | $1.40 | — | COM | 81750R102 |
| — | PASSAGE BIO INC | 2,400,000 | $2.424M | 0.2% | $1.01 | $0.99 | — | COM | 702712100 |
| — | ENZO BIOCHEM INC | 1,700,000 | $2.363M | 0.2% | $1.39 | $2.43 | — | COM | 294100102 |
| — | BLUEBIRD BIO INC | 1,700,000 | $2.346M | 0.2% | $1.38 | $3.78 | — | COM | 09609G100 |
| SPRY | ARS PHARMACEUTICALS INC | 409,463 | $2.244M | 0.2% | $5.48 * | $4.93 | -11.1% | COM | 82835W108 |
| EDIT | EDITAS MEDICINE INC | 200,000 | $2.026M | 0.2% | $10.13 * | $8.71 | +0.8% | COM | 28106W103 |
| SFBS | SERVISFIRST BANCSHARES INC | 30,000 | $1.999M | 0.2% | $66.63 * | $63.35 | -18.0% | COM | 81768T108 |
| PDSB | PDS BIOTECHNOLOGY CORP | 400,000 | $1.988M | 0.2% | $4.97 | $5.75 | -13.5% | COM | 70465T107 |
| TNGX | TANGO THERAPEUTICS INC | 200,000 | $1.98M | 0.2% | $9.90 * | $5.80 | +49.6% | COM | 87583X109 |
| — | ELEVATION ONCOLOGY INC | 3,667,600 | $1.97M | 0.2% | $0.54 | $1.54 | — | COM | 28623U101 |
| LITS | MEI PHARMA INC | 326,084 | $1.891M | 0.2% | $5.80 | $4.94 | +18.0% | COM | 55279B301 |
| GNFTY | GENFIT S A | 479,441 | $1.846M | 0.2% | $3.85 | $4.75 | — | ADS | 372279109 |
| ACRS | ACLARIS THERAPEUTICS INC | 1,753,335 | $1.841M | 0.2% | $1.05 * | $3.05 | 0.0% | COM | 00461U105 |
| TGTX | TG THERAPEUTICS INC | 100,000 | $1.708M | 0.2% | $17.08 * | $13.94 | -16.6% | COM | 88322Q108 |
| — | ADICET BIO INC | 876,352 | $1.656M | 0.2% | $1.89 | $6.52 | — | COM | 007002108 |
| — | ALIGOS THERAPEUTICS INC | 2,189,847 | $1.454M | 0.1% | $0.66 | $1.06 | — | COM | 01626L105 |
| — | LAVA THERAPEUTICS NV | 840,593 | $1.328M | 0.1% | $1.58 | $1.58 | — | SHS | N51517105 |
| — | NEKTAR THERAPEUTICS | 2,348,109 | $1.327M | 0.1% | $0.57 | $0.77 | — | COM | 640268108 |
| ARE | ALEXANDRIA REAL ESTATE EQ IN | 10,000 | $1.268M | 0.1% | $126.77 * | $95.66 | 0.0% | COM | 015271109 |
| — | PRECISION BIOSCIENCES INC | 3,400,000 | $1.241M | 0.1% | $0.36 | $0.36 | — | COM | 74019P108 |
| MASS | 908 DEVICES INC | 100,000 | $1.122M | 0.1% | $11.22 * | $8.04 | -15.0% | COM | 65443P102 |
| VNDA | VANDA PHARMACEUTICALS INC | 248,190 | $1.047M | 0.1% | $4.22 * | $4.03 | 0.0% | COM | 921659108 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 246,895 | $948K | 0.1% | $3.84 * | $2.97 | 0.0% | COM | 00509G209 |
| TSPH | TUSIMPLE HLDGS INC | 1,000,000 | $878K | 0.1% | $0.88 | $0.88 | — | CL A | 90089L108 |
| GOSS | GOSSAMER BIO INC | 838,600 | $765K | 0.1% | $0.91 * | $1.15 | -35.9% | COM | 38341P102 |
| ATYR | ATYR PHARMA INC | 471,134 | $664K | 0.1% | $1.41 * | $2.95 | -56.6% | COM NEW | 002120202 |
| SYRS | SYROS PHARMACEUTICALS INC | 85,031 | $662K | 0.1% | $7.79 * | $3.43 | 0.0% | COM NEW | 87184Q206 |
| EGRX | EAGLE PHARMACEUTICALS INC | 118,857 | $622K | 0.1% | $5.23 * | $32.45 | -69.6% | COM | 269796108 |
| STIM | NEURONETICS INC | 200,000 | $580K | 0.1% | $2.90 * | $2.43 | -35.0% | COM | 64131A105 |
| STEL | STELLAR BANCORP INC | 20,000 | $557K | 0.1% | $27.84 * | $25.71 | -6.6% | COM | 858927106 |
| — | NEXTCURE INC | 467,922 | $533K | 0.0% | $1.14 | $1.43 | — | COM | 65343E108 |
| MOLN | MOLECULAR PARTNERS AG | 100,000 | $418K | 0.0% | $4.18 | $5.03 | — | ADS | 60853G106 |
| TRVI | TREVI THERAPEUTICS INC | 300,000 | $402K | 0.0% | $1.34 * | $1.51 | 0.0% | COM | 89532M101 |
| XERS | XERIS BIOPHARMA HOLDINGS INC | 150,000 | $353K | 0.0% | $2.35 * | $2.29 | -19.4% | COM | 98422E103 |
| ERAS | ERASCA INC | 150,000 | $320K | 0.0% | $2.13 | $2.11 | 0.0% | COM | 29479A108 |
| — | KEZAR LIFE SCIENCES INC | 306,665 | $291K | 0.0% | $0.95 | $0.95 | — | COM | 49372L100 |
| EQ | EQUILLIUM INC | 400,000 | $289K | 0.0% | $0.72 * | $0.73 | -18.2% | COM | 29446K106 |
| — | CARTESIAN THERAPEUTICS INC | 400,000 | $276K | 0.0% | $0.69 | $1.12 | — | COM | 816212104 |
| WGS | GENEDX HOLDINGS CORP | 63,636 | $175K | 0.0% | $2.75 * | $7.91 | -70.6% | COM CL A | 81663L200 |
| TLPH | ACELRX PHARMACEUTICALS INC | 195,000 | $143K | 0.0% | $0.73 * | $2.81 | -77.3% | COM NEW | 00444T209 |