Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2015 (← Previous) (Next →)

Filing Date: Aug 14, 2015

Total Value: $2.249B (100.0% shares, 0.0% debt)

Holdings (45)

UTHR UNITED THERAPEUTICS CORP DEL 11.1%

Value $250M Shares 1,439,928 Est. Cost $77.14 Unrealized +133.2%

— ANACOR PHARMACEUTICALS INC 10.7%

Value $240M Shares 3,103,027 Est. Cost $23.70 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 10.1%

Value $227M Shares 1,660,092 Est. Cost $73.11 Unrealized +69.5%

— CLOVIS ONCOLOGY INC 9.4%

Value $211M Shares 2,401,117 Est. Cost $51.97 Unrealized —

— ABIOMED INC 8.0%

Value $180M Shares 2,742,305 Est. Cost $26.14 Unrealized —

— AMAG PHARMACEUTICALS INC 6.7%

Value $151M Shares 2,192,141 Est. Cost $28.67 Unrealized —

INSM INSMED INC 5.1%

Value $116M Shares 4,733,601 Est. Cost $14.79 Unrealized +53.5%

— THORATEC CORP 5.1%

Value $114M Shares 2,560,303 Est. Cost $40.89 Unrealized —

— KYTHERA BIOPHARMACEUTICALS I 4.3%

Value $97.17M Shares 1,290,292 Est. Cost $40.00 Unrealized —

— ENDO INTL PLC 3.1%

Value $68.87M Shares 864,604 Est. Cost $89.70 Unrealized —

— WRIGHT MED GROUP INC 2.4%

Value $54M Shares 2,056,251 Est. Cost $28.27 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.2%

Value $49.46M Shares 3,897,408 Est. Cost $8.39 Unrealized +28.6%

— KARYOPHARM THERAPEUTICS INC 2.1%

Value $47.12M Shares 1,731,530 Est. Cost $29.08 Unrealized —

PRTA PROTHENA CORP PLC 1.6%

Value $36.65M Shares 695,918 Est. Cost $22.18 Unrealized +77.9%

GILD GILEAD SCIENCES INC 1.6%

Value $35.06M Shares 299,500 Est. Cost $62.40 Unrealized +21.8%

— MOMENTA PHARMACEUTICALS INC 1.5%

Value $33.19M Shares 1,455,176 Est. Cost $14.44 Unrealized —

— SEQUENOM INC 1.4%

Value $30.47M Shares 10,023,842 Est. Cost $3.91 Unrealized —

— CELGENE CORP 1.3%

Value $30.35M Shares 262,200 Est. Cost $96.77 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.2%

Value $27.94M Shares 1,974,376 Est. Cost $3.07 Unrealized +291.2%

STAA STAAR SURGICAL CO 1.1%

Value $25.53M Shares 2,642,922 Est. Cost $8.11 Unrealized +14.3%

— CYBERONICS INC 1.1%

Value $24.5M Shares 412,000 Est. Cost $52.15 Unrealized —

— SHIRE PLC 1.1%

Value $23.74M Shares 98,300 Est. Cost $229.35 Unrealized —

— MEDIVATION INC 0.9%

Value $20.59M Shares 180,300 Est. Cost $86.62 Unrealized —

— ARIAD PHARMACEUTICALS INC 0.8%

Value $18.46M Shares 2,231,717 Est. Cost $6.82 Unrealized —

— HEARTWARE INTL INC 0.8%

Value $17.73M Shares 243,868 Est. Cost $87.77 Unrealized —

— ZELTIQ AESTHETICS INC 0.7%

Value $16.75M Shares 568,436 Est. Cost $26.16 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.7%

Value $16.62M Shares 5,176,319 Est. Cost $3.43 Unrealized —

ISRG INTUITIVE SURGICAL INC 0.7%

Value $15.67M Shares 32,350 Est. Cost $55.94 Unrealized 0.0%

— ALIMERA SCIENCES INC 0.6%

Value $13.89M Shares 3,013,793 Est. Cost $4.88 Unrealized —

EXAS EXACT SCIENCES CORP 0.5%

Value $11.68M Shares 392,676 Est. Cost $12.83 Unrealized +95.8%

— OREXIGEN THERAPEUTICS INC 0.4%

Value $9.56M Shares 1,931,324 Est. Cost $6.46 Unrealized —

— ACELRX PHARMACEUTICALS INC 0.4%

Value $9.056M Shares 2,135,739 Est. Cost $5.78 Unrealized —

— IDERA PHARMACEUTICALS INC 0.2%

Value $4.551M Shares 1,226,748 Est. Cost $3.71 Unrealized —

— XOMA CORP DEL 0.1%

Value $3.1M Shares 799,000 Est. Cost $4.07 Unrealized —

— HISTOGENICS CORP 0.1%

Value $2.936M Shares 454,545 Est. Cost $11.00 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $2.728M Shares 906,263 Est. Cost $2.64 Unrealized —

— BIOSPECIFICS TECHNOLOGIES CO 0.1%

Value $2.602M Shares 50,436 Est. Cost $34.45 Unrealized —

— INTREXON CORP 0.1%

Value $2.298M Shares 47,100 Est. Cost $28.82 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.1%

Value $1.741M Shares 27,757 Est. Cost $53.35 Unrealized +10.7%

— EPIZYME INC 0.1%

Value $1.47M Shares 61,265 Est. Cost $23.99 Unrealized —

— ALCOBRA LTD 0.0%

Value $1.024M Shares 156,588 Est. Cost $6.11 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.0%

Value $986K Shares 70,706 Est. Cost $13.95 Unrealized —

CYTK CYTOKINETICS INC 0.0%

Value $831K Shares 123,686 Est. Cost $6.71 Unrealized -2.3%

— MALLINCKRODT PUB LTD CO 0.0%

Value $422K Shares 3,588 Est. Cost $90.02 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value $150K Shares 191,600 Est. Cost $3.88 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,439,928	$250M	11.1%	$77.14	+133.2%	COM	91307C102
—	ANACOR PHARMACEUTICALS INC	3,103,027	$240M	10.7%	$23.70	—	COM	032420101
BMRN	BIOMARIN PHARMACEUTICAL INC	1,660,092	$227M	10.1%	$73.11	+69.5%	COM	09061G101
—	CLOVIS ONCOLOGY INC	2,401,117	$211M	9.4%	$51.97	—	COM	189464100
—	ABIOMED INC	2,742,305	$180M	8.0%	$26.14	—	COM	003654100
—	AMAG PHARMACEUTICALS INC	2,192,141	$151M	6.7%	$28.67	—	COM	00163U106
INSM	INSMED INC	4,733,601	$116M	5.1%	$14.79	+53.5%	COM PAR $.01	457669307
—	THORATEC CORP	2,560,303	$114M	5.1%	$40.89	—	COM NEW	885175307
—	KYTHERA BIOPHARMACEUTICALS I	1,290,292	$97.17M	4.3%	$40.00	—	COM	501570105
—	ENDO INTL PLC	864,604	$68.87M	3.1%	$89.70	—	SHS	G30401106
—	WRIGHT MED GROUP INC	2,056,251	$54M	2.4%	$28.27	—	COM	98235T107
VNDA	VANDA PHARMACEUTICALS INC	3,897,408	$49.46M	2.2%	$8.39	+28.6%	COM	921659108
—	KARYOPHARM THERAPEUTICS INC	1,731,530	$47.12M	2.1%	$29.08	—	COM	48576U106
PRTA	PROTHENA CORP PLC	695,918	$36.65M	1.6%	$22.18	+77.9%	SHS	G72800108
GILD	GILEAD SCIENCES INC	299,500	$35.06M	1.6%	$62.40	+21.8%	COM	375558103
—	MOMENTA PHARMACEUTICALS INC	1,455,176	$33.19M	1.5%	$14.44	—	COM	60877T100
—	SEQUENOM INC	10,023,842	$30.47M	1.4%	$3.91	—	COM NEW	817337405
—	CELGENE CORP	262,200	$30.35M	1.3%	$96.77	—	COM	151020104
FOLD	AMICUS THERAPEUTICS INC	1,974,376	$27.94M	1.2%	$3.07	+291.2%	COM	03152W109
STAA	STAAR SURGICAL CO	2,642,922	$25.53M	1.1%	$8.11	+14.3%	COM PAR $0.01	852312305
—	CYBERONICS INC	412,000	$24.5M	1.1%	$52.15	—	COM	23251P102
—	SHIRE PLC	98,300	$23.74M	1.1%	$229.35	—	SPONSORED ADR	82481R106
—	MEDIVATION INC	180,300	$20.59M	0.9%	$86.62	—	COM	58501N101
—	ARIAD PHARMACEUTICALS INC	2,231,717	$18.46M	0.8%	$6.82	—	COM	04033A100
—	HEARTWARE INTL INC	243,868	$17.73M	0.8%	$87.77	—	COM	422368100
—	ZELTIQ AESTHETICS INC	568,436	$16.75M	0.7%	$26.16	—	COM	98933Q108
—	RIGEL PHARMACEUTICALS INC	5,176,319	$16.62M	0.7%	$3.43	—	COM NEW	766559603
ISRG	INTUITIVE SURGICAL INC	32,350	$15.67M	0.7%	$55.94	0.0%	COM NEW	46120E602
—	ALIMERA SCIENCES INC	3,013,793	$13.89M	0.6%	$4.88	—	COM	016259103
EXAS	EXACT SCIENCES CORP	392,676	$11.68M	0.5%	$12.83	+95.8%	COM	30063P105
—	OREXIGEN THERAPEUTICS INC	1,931,324	$9.56M	0.4%	$6.46	—	COM	686164104
—	ACELRX PHARMACEUTICALS INC	2,135,739	$9.056M	0.4%	$5.78	—	COM	00444T100
—	IDERA PHARMACEUTICALS INC	1,226,748	$4.551M	0.2%	$3.71	—	COM NEW	45168K306
—	XOMA CORP DEL	799,000	$3.1M	0.1%	$4.07	—	COM	98419J107
—	HISTOGENICS CORP	454,545	$2.936M	0.1%	$11.00	—	COM	43358V109
—	SUNESIS PHARMACEUTICALS INC	906,263	$2.728M	0.1%	$2.64	—	COM NEW	867328601
—	BIOSPECIFICS TECHNOLOGIES CO	50,436	$2.602M	0.1%	$34.45	—	COM	090931106
—	INTREXON CORP	47,100	$2.298M	0.1%	$28.82	—	COM	46122T102
ALGN	ALIGN TECHNOLOGY INC	27,757	$1.741M	0.1%	$53.35	+10.7%	COM	016255101
—	EPIZYME INC	61,265	$1.47M	0.1%	$23.99	—	COM	29428V104
—	ALCOBRA LTD	156,588	$1.024M	0.0%	$6.11	—	SHS	M2239P109
—	DICERNA PHARMACEUTICALS INC	70,706	$986K	0.0%	$13.95	—	COM	253031108
CYTK	CYTOKINETICS INC	123,686	$831K	0.0%	$6.71	-2.3%	COM NEW	23282W605
—	MALLINCKRODT PUB LTD CO	3,588	$422K	0.0%	$90.02	—	SHS	G5785G107
—	SOPHIRIS BIO INC	191,600	$150K	0.0%	$3.88	—	COM NEW	83578Q209