Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2015 (← Previous) (Next →)

Filing Date: May 15, 2015

Total Value: $2.023B (100.0% shares, 0.0% debt)

Holdings (46)

UTHR UNITED THERAPEUTICS CORP DEL 12.2%

Value $247M Shares 1,429,928 Est. Cost $77.14 Unrealized +97.6%

BMRN BIOMARIN PHARMACEUTICAL INC 10.2%

Value $206M Shares 1,649,792 Est. Cost $73.11 Unrealized +44.9%

— ANACOR PHARMACEUTICALS INC 9.3%

Value $189M Shares 3,259,045 Est. Cost $23.70 Unrealized —

— ABIOMED INC 8.8%

Value $177M Shares 2,473,624 Est. Cost $21.84 Unrealized —

— CLOVIS ONCOLOGY INC 7.8%

Value $158M Shares 2,121,857 Est. Cost $47.24 Unrealized —

— AMAG PHARMACEUTICALS INC 5.9%

Value $120M Shares 2,187,041 Est. Cost $28.67 Unrealized —

— THORATEC CORP 5.3%

Value $106M Shares 2,538,203 Est. Cost $40.89 Unrealized —

INSM INSMED INC 4.8%

Value $96.71M Shares 4,649,448 Est. Cost $14.64 Unrealized +20.3%

— ENDO INTL PLC 3.8%

Value $77.16M Shares 860,204 Est. Cost $89.70 Unrealized —

— KYTHERA BIOPHARMACEUTICALS I 3.4%

Value $69.34M Shares 1,382,722 Est. Cost $40.00 Unrealized —

— WRIGHT MED GROUP INC 2.6%

Value $52.87M Shares 2,049,251 Est. Cost $28.27 Unrealized —

— SEQUENOM INC 1.9%

Value $39.41M Shares 9,977,642 Est. Cost $3.91 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 1.7%

Value $35.37M Shares 3,803,408 Est. Cost $8.33 Unrealized +35.7%

— KARYOPHARM THERAPEUTICS INC 1.4%

Value $29.11M Shares 951,032 Est. Cost $30.61 Unrealized —

— CELGENE CORP 1.4%

Value $28.75M Shares 249,400 Est. Cost $95.80 Unrealized —

GILD GILEAD SCIENCES INC 1.4%

Value $28.56M Shares 291,000 Est. Cost $62.00 Unrealized +13.8%

— CELLADON CORP 1.4%

Value $27.37M Shares 1,445,100 Est. Cost $12.12 Unrealized —

— CYBERONICS INC 1.3%

Value $26.75M Shares 412,000 Est. Cost $52.15 Unrealized —

PRTA PROTHENA CORP PLC 1.3%

Value $26.54M Shares 695,918 Est. Cost $22.18 Unrealized +15.6%

— SHIRE PLC 1.1%

Value $22.73M Shares 95,000 Est. Cost $228.93 Unrealized —

— MEDIVATION INC 1.1%

Value $22.16M Shares 171,700 Est. Cost $85.24 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.1%

Value $22.12M Shares 1,455,176 Est. Cost $14.44 Unrealized —

— HEARTWARE INTL INC 1.1%

Value $21.4M Shares 243,868 Est. Cost $87.77 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.1%

Value $21.29M Shares 1,956,376 Est. Cost $3.07 Unrealized +186.8%

STAA STAAR SURGICAL CO 1.0%

Value $19.64M Shares 2,642,922 Est. Cost $8.11 Unrealized -9.9%

— RIGEL PHARMACEUTICALS INC 0.9%

Value $18.48M Shares 5,176,319 Est. Cost $3.43 Unrealized —

— ARIAD PHARMACEUTICALS INC 0.9%

Value $18.39M Shares 2,231,717 Est. Cost $6.82 Unrealized —

— ZELTIQ AESTHETICS INC 0.9%

Value $17.52M Shares 568,436 Est. Cost $26.16 Unrealized —

— INTUITIVE SURGICAL INC 0.8%

Value $16.34M Shares 32,350 Est. Cost $447.59 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.7%

Value $15.17M Shares 282,057 Est. Cost $53.35 Unrealized +6.8%

— OREXIGEN THERAPEUTICS INC 0.7%

Value $15.12M Shares 1,931,324 Est. Cost $6.46 Unrealized —

— ALIMERA SCIENCES INC 0.7%

Value $15.1M Shares 3,013,793 Est. Cost $4.88 Unrealized —

EXAS EXACT SCIENCES CORP 0.4%

Value $8.647M Shares 392,676 Est. Cost $12.83 Unrealized +97.7%

— ACELRX PHARMACEUTICALS INC 0.4%

Value $8.244M Shares 2,135,739 Est. Cost $5.78 Unrealized —

— HISTOGENICS CORP 0.2%

Value $4.541M Shares 454,545 Est. Cost $11.00 Unrealized —

— IDERA PHARMACEUTICALS INC 0.2%

Value $4.342M Shares 1,170,248 Est. Cost $3.71 Unrealized —

— XOMA CORP DEL 0.1%

Value $2.892M Shares 794,500 Est. Cost $4.07 Unrealized —

— INTREXON CORP 0.1%

Value $2.137M Shares 47,100 Est. Cost $28.82 Unrealized —

— BIOSPECIFICS TECHNOLOGIES CO 0.1%

Value $1.975M Shares 50,436 Est. Cost $34.45 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $1.478M Shares 603,400 Est. Cost $2.45 Unrealized —

— QLT INC 0.1%

Value $1.235M Shares 315,906 Est. Cost $4.40 Unrealized —

— SALIX PHARMACEUTICALS INC 0.0%

Value $916K Shares 5,300 Est. Cost $114.94 Unrealized —

CYTK CYTOKINETICS INC 0.0%

Value $839K Shares 123,686 Est. Cost $6.71 Unrealized +11.2%

— MALLINCKRODT PUB LTD CO 0.0%

Value $454K Shares 3,588 Est. Cost $90.02 Unrealized —

— ALCOBRA LTD 0.0%

Value $412K Shares 73,188 Est. Cost $5.63 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value $111K Shares 191,600 Est. Cost $3.88 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
UTHR	UNITED THERAPEUTICS CORP DEL	1,429,928	$247M	12.2%	$77.14	+97.6%	COM	91307C102
BMRN	BIOMARIN PHARMACEUTICAL INC	1,649,792	$206M	10.2%	$73.11	+44.9%	COM	09061G101
—	ANACOR PHARMACEUTICALS INC	3,259,045	$189M	9.3%	$23.70	—	COM	032420101
—	ABIOMED INC	2,473,624	$177M	8.8%	$21.84	—	COM	003654100
—	CLOVIS ONCOLOGY INC	2,121,857	$158M	7.8%	$47.24	—	COM	189464100
—	AMAG PHARMACEUTICALS INC	2,187,041	$120M	5.9%	$28.67	—	COM	00163U106
—	THORATEC CORP	2,538,203	$106M	5.3%	$40.89	—	COM NEW	885175307
INSM	INSMED INC	4,649,448	$96.71M	4.8%	$14.64	+20.3%	COM PAR $.01	457669307
—	ENDO INTL PLC	860,204	$77.16M	3.8%	$89.70	—	SHS	G30401106
—	KYTHERA BIOPHARMACEUTICALS I	1,382,722	$69.34M	3.4%	$40.00	—	COM	501570105
—	WRIGHT MED GROUP INC	2,049,251	$52.87M	2.6%	$28.27	—	COM	98235T107
—	SEQUENOM INC	9,977,642	$39.41M	1.9%	$3.91	—	COM NEW	817337405
VNDA	VANDA PHARMACEUTICALS INC	3,803,408	$35.37M	1.7%	$8.33	+35.7%	COM	921659108
—	KARYOPHARM THERAPEUTICS INC	951,032	$29.11M	1.4%	$30.61	—	COM	48576U106
—	CELGENE CORP	249,400	$28.75M	1.4%	$95.80	—	COM	151020104
GILD	GILEAD SCIENCES INC	291,000	$28.56M	1.4%	$62.00	+13.8%	COM	375558103
—	CELLADON CORP	1,445,100	$27.37M	1.4%	$12.12	—	COM	15117E107
—	CYBERONICS INC	412,000	$26.75M	1.3%	$52.15	—	COM	23251P102
PRTA	PROTHENA CORP PLC	695,918	$26.54M	1.3%	$22.18	+15.6%	SHS	G72800108
—	SHIRE PLC	95,000	$22.73M	1.1%	$228.93	—	SPONSORED ADR	82481R106
—	MEDIVATION INC	171,700	$22.16M	1.1%	$85.24	—	COM	58501N101
—	MOMENTA PHARMACEUTICALS INC	1,455,176	$22.12M	1.1%	$14.44	—	COM	60877T100
—	HEARTWARE INTL INC	243,868	$21.4M	1.1%	$87.77	—	COM	422368100
FOLD	AMICUS THERAPEUTICS INC	1,956,376	$21.29M	1.1%	$3.07	+186.8%	COM	03152W109
STAA	STAAR SURGICAL CO	2,642,922	$19.64M	1.0%	$8.11	-9.9%	COM PAR $0.01	852312305
—	RIGEL PHARMACEUTICALS INC	5,176,319	$18.48M	0.9%	$3.43	—	COM NEW	766559603
—	ARIAD PHARMACEUTICALS INC	2,231,717	$18.39M	0.9%	$6.82	—	COM	04033A100
—	ZELTIQ AESTHETICS INC	568,436	$17.52M	0.9%	$26.16	—	COM	98933Q108
—	INTUITIVE SURGICAL INC	32,350	$16.34M	0.8%	$447.59	—	COM NEW	46120e602
ALGN	ALIGN TECHNOLOGY INC	282,057	$15.17M	0.7%	$53.35	+6.8%	COM	016255101
—	OREXIGEN THERAPEUTICS INC	1,931,324	$15.12M	0.7%	$6.46	—	COM	686164104
—	ALIMERA SCIENCES INC	3,013,793	$15.1M	0.7%	$4.88	—	COM	016259103
EXAS	EXACT SCIENCES CORP	392,676	$8.647M	0.4%	$12.83	+97.7%	COM	30063P105
—	ACELRX PHARMACEUTICALS INC	2,135,739	$8.244M	0.4%	$5.78	—	COM	00444T100
—	HISTOGENICS CORP	454,545	$4.541M	0.2%	$11.00	—	COM	43358V109
—	IDERA PHARMACEUTICALS INC	1,170,248	$4.342M	0.2%	$3.71	—	COM NEW	45168K306
—	XOMA CORP DEL	794,500	$2.892M	0.1%	$4.07	—	COM	98419J107
—	INTREXON CORP	47,100	$2.137M	0.1%	$28.82	—	COM	46122T102
—	BIOSPECIFICS TECHNOLOGIES CO	50,436	$1.975M	0.1%	$34.45	—	COM	090931106
—	SUNESIS PHARMACEUTICALS INC	603,400	$1.478M	0.1%	$2.45	—	COM NEW	867328601
—	QLT INC	315,906	$1.235M	0.1%	$4.40	—	COM	746927102
—	SALIX PHARMACEUTICALS INC	5,300	$916K	0.0%	$114.94	—	COM	795435106
CYTK	CYTOKINETICS INC	123,686	$839K	0.0%	$6.71	+11.2%	COM NEW	23282W605
—	MALLINCKRODT PUB LTD CO	3,588	$454K	0.0%	$90.02	—	SHS	G5785G107
—	ALCOBRA LTD	73,188	$412K	0.0%	$5.63	—	SHS	M2239P109
—	SOPHIRIS BIO INC	191,600	$111K	0.0%	$3.88	—	COM NEW	83578Q209