Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2015 (← Previous) (Next →)

Filing Date: Feb 16, 2016

Total Value: $1.797B (100.0% shares, 0.0% debt)

Holdings (43)

— ABIOMED INC 14.5%

Value $261M Shares 2,889,505 Est. Cost $29.48 Unrealized —

— ANACOR PHARMACEUTICALS INC 13.8%

Value $247M Shares 2,187,242 Est. Cost $23.70 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 13.2%

Value $238M Shares 1,518,654 Est. Cost $81.75 Unrealized +78.1%

BMRN BIOMARIN PHARMACEUTICAL INC 7.8%

Value $140M Shares 1,336,847 Est. Cost $73.11 Unrealized +42.7%

— CLOVIS ONCOLOGY INC 6.9%

Value $124M Shares 3,547,719 Est. Cost $57.85 Unrealized —

INSM INSMED INC 4.8%

Value $86.95M Shares 4,790,800 Est. Cost $14.79 Unrealized +19.1%

— AMAG PHARMACEUTICALS INC 4.8%

Value $85.61M Shares 2,835,792 Est. Cost $30.99 Unrealized —

— WRIGHT MED GROUP N V 2.9%

Value $51.56M Shares 2,132,157 Est. Cost $24.18 Unrealized —

— ENDO INTL PLC 2.7%

Value $49.05M Shares 801,230 Est. Cost $89.70 Unrealized —

PRTA PROTHENA CORP PLC 2.6%

Value $47.37M Shares 695,518 Est. Cost $22.18 Unrealized +171.9%

— EPIZYME INC 2.4%

Value $42.63M Shares 2,660,979 Est. Cost $13.76 Unrealized —

— KARYOPHARM THERAPEUTICS INC 2.3%

Value $41.24M Shares 3,112,645 Est. Cost $20.94 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.1%

Value $37.53M Shares 4,030,908 Est. Cost $8.48 Unrealized +17.7%

— CEMPRA INC 2.0%

Value $36.6M Shares 1,175,733 Est. Cost $31.13 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.9%

Value $34.45M Shares 3,551,173 Est. Cost $5.71 Unrealized +57.8%

— CELGENE CORP 1.8%

Value $32.43M Shares 270,800 Est. Cost $97.13 Unrealized —

GILD GILEAD SCIENCES INC 1.7%

Value $30.65M Shares 302,900 Est. Cost $63.23 Unrealized +15.3%

— MEDIVATION INC 1.4%

Value $24.65M Shares 509,862 Est. Cost $58.10 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.2%

Value $21.8M Shares 1,468,776 Est. Cost $14.44 Unrealized —

— SHIRE PLC 1.2%

Value $21.46M Shares 104,700 Est. Cost $227.87 Unrealized —

STAA STAAR SURGICAL CO 1.1%

Value $19.04M Shares 2,666,722 Est. Cost $8.11 Unrealized -0.1%

— SEQUENOM INC 0.9%

Value $16.44M Shares 10,023,842 Est. Cost $3.91 Unrealized —

— ZELTIQ AESTHETICS INC 0.9%

Value $16.37M Shares 573,636 Est. Cost $26.16 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.9%

Value $15.88M Shares 5,239,119 Est. Cost $3.43 Unrealized —

— ARIAD PHARMACEUTICALS INC 0.8%

Value $14.11M Shares 2,257,217 Est. Cost $6.81 Unrealized —

— HEARTWARE INTL INC 0.7%

Value $12.4M Shares 246,068 Est. Cost $87.77 Unrealized —

— ALIMERA SCIENCES INC 0.4%

Value $7.293M Shares 3,013,793 Est. Cost $4.88 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.3%

Value $6.26M Shares 6,974,854 Est. Cost $1.05 Unrealized —

— AIMMUNE THERAPEUTICS INC 0.3%

Value $6.007M Shares 325,599 Est. Cost $25.32 Unrealized —

— ACELRX PHARMACEUTICALS INC 0.3%

Value $5.488M Shares 1,425,439 Est. Cost $5.78 Unrealized —

— IDERA PHARMACEUTICALS INC 0.2%

Value $3.886M Shares 1,257,748 Est. Cost $3.70 Unrealized —

EXAS EXACT SCIENCES CORP 0.2%

Value $3.658M Shares 396,276 Est. Cost $12.83 Unrealized -27.5%

— DICERNA PHARMACEUTICALS INC 0.2%

Value $3.18M Shares 267,890 Est. Cost $9.72 Unrealized —

— OREXIGEN THERAPEUTICS INC 0.2%

Value $2.878M Shares 1,673,024 Est. Cost $6.46 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.1%

Value $1.828M Shares 27,757 Est. Cost $53.35 Unrealized +20.3%

— ALCOBRA LTD 0.1%

Value $1.596M Shares 254,188 Est. Cost $6.09 Unrealized —

— HISTOGENICS CORP 0.1%

Value $1.591M Shares 454,545 Est. Cost $11.00 Unrealized —

— INTREXON CORP 0.1%

Value $1.42M Shares 47,100 Est. Cost $28.82 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $1.294M Shares 123,686 Est. Cost $6.71 Unrealized +46.1%

— SOPHIRIS BIO INC 0.0%

Value $879K Shares 494,000 Est. Cost $2.60 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.0%

Value $451K Shares 59,017 Est. Cost $8.34 Unrealized —

— ZOGENIX INC 0.0%

Value $422K Shares 28,600 Est. Cost $13.52 Unrealized —

QURE UNIQURE NV 0.0%

Value $338K Shares 20,453 Est. Cost $26.34 Unrealized -29.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ABIOMED INC	2,889,505	$261M	14.5%	$29.48	—	COM	003654100
—	ANACOR PHARMACEUTICALS INC	2,187,242	$247M	13.8%	$23.70	—	COM	032420101
UTHR	UNITED THERAPEUTICS CORP DEL	1,518,654	$238M	13.2%	$81.75	+78.1%	COM	91307C102
BMRN	BIOMARIN PHARMACEUTICAL INC	1,336,847	$140M	7.8%	$73.11	+42.7%	COM	09061G101
—	CLOVIS ONCOLOGY INC	3,547,719	$124M	6.9%	$57.85	—	COM	189464100
INSM	INSMED INC	4,790,800	$86.95M	4.8%	$14.79	+19.1%	COM PAR $.01	457669307
—	AMAG PHARMACEUTICALS INC	2,835,792	$85.61M	4.8%	$30.99	—	COM	00163U106
—	WRIGHT MED GROUP N V	2,132,157	$51.56M	2.9%	$24.18	—	ORD SHS 0.03 PAR	N96617118
—	ENDO INTL PLC	801,230	$49.05M	2.7%	$89.70	—	SHS	G30401106
PRTA	PROTHENA CORP PLC	695,518	$47.37M	2.6%	$22.18	+171.9%	SHS	G72800108
—	EPIZYME INC	2,660,979	$42.63M	2.4%	$13.76	—	COM	29428V104
—	KARYOPHARM THERAPEUTICS INC	3,112,645	$41.24M	2.3%	$20.94	—	COM	48576U106
VNDA	VANDA PHARMACEUTICALS INC	4,030,908	$37.53M	2.1%	$8.48	+17.7%	COM	921659108
—	CEMPRA INC	1,175,733	$36.6M	2.0%	$31.13	—	COM	15130J109
FOLD	AMICUS THERAPEUTICS INC	3,551,173	$34.45M	1.9%	$5.71	+57.8%	COM	03152W109
—	CELGENE CORP	270,800	$32.43M	1.8%	$97.13	—	COM	151020104
GILD	GILEAD SCIENCES INC	302,900	$30.65M	1.7%	$63.23	+15.3%	COM	375558103
—	MEDIVATION INC	509,862	$24.65M	1.4%	$58.10	—	COM	58501N101
—	MOMENTA PHARMACEUTICALS INC	1,468,776	$21.8M	1.2%	$14.44	—	COM	60877T100
—	SHIRE PLC	104,700	$21.46M	1.2%	$227.87	—	SPONSORED ADR	82481R106
STAA	STAAR SURGICAL CO	2,666,722	$19.04M	1.1%	$8.11	-0.1%	COM PAR $0.01	852312305
—	SEQUENOM INC	10,023,842	$16.44M	0.9%	$3.91	—	COM NEW	817337405
—	ZELTIQ AESTHETICS INC	573,636	$16.37M	0.9%	$26.16	—	COM	98933Q108
—	RIGEL PHARMACEUTICALS INC	5,239,119	$15.88M	0.9%	$3.43	—	COM NEW	766559603
—	ARIAD PHARMACEUTICALS INC	2,257,217	$14.11M	0.8%	$6.81	—	COM	04033A100
—	HEARTWARE INTL INC	246,068	$12.4M	0.7%	$87.77	—	COM	422368100
—	ALIMERA SCIENCES INC	3,013,793	$7.293M	0.4%	$4.88	—	COM	016259103
—	SUNESIS PHARMACEUTICALS INC	6,974,854	$6.26M	0.3%	$1.05	—	COM NEW	867328601
—	AIMMUNE THERAPEUTICS INC	325,599	$6.007M	0.3%	$25.32	—	COM	00900T107
—	ACELRX PHARMACEUTICALS INC	1,425,439	$5.488M	0.3%	$5.78	—	COM	00444T100
—	IDERA PHARMACEUTICALS INC	1,257,748	$3.886M	0.2%	$3.70	—	COM NEW	45168K306
EXAS	EXACT SCIENCES CORP	396,276	$3.658M	0.2%	$12.83	-27.5%	COM	30063P105
—	DICERNA PHARMACEUTICALS INC	267,890	$3.18M	0.2%	$9.72	—	COM	253031108
—	OREXIGEN THERAPEUTICS INC	1,673,024	$2.878M	0.2%	$6.46	—	COM	686164104
ALGN	ALIGN TECHNOLOGY INC	27,757	$1.828M	0.1%	$53.35	+20.3%	COM	016255101
—	ALCOBRA LTD	254,188	$1.596M	0.1%	$6.09	—	SHS	M2239P109
—	HISTOGENICS CORP	454,545	$1.591M	0.1%	$11.00	—	COM	43358V109
—	INTREXON CORP	47,100	$1.42M	0.1%	$28.82	—	COM	46122T102
CYTK	CYTOKINETICS INC	123,686	$1.294M	0.1%	$6.71	+46.1%	COM NEW	23282W605
—	SOPHIRIS BIO INC	494,000	$879K	0.0%	$2.60	—	COM NEW	83578Q209
—	MARINUS PHARMACEUTICALS INC	59,017	$451K	0.0%	$8.34	—	COM	56854Q101
—	ZOGENIX INC	28,600	$422K	0.0%	$13.52	—	COM NEW	98978L204
QURE	UNIQURE NV	20,453	$338K	0.0%	$26.34	-29.7%	SHS	N90064101