Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q1 2016 (← Previous) (Next →)

Filing Date: May 16, 2016

Total Value ($000): $1,288,268 (100.0% shares, 0.0% debt)

Holdings (44)

— ABIOMED INC 17.1%

Value ($000) $220,524 Shares 2,325,959 Est. Cost $29.48 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 13.2%

Value ($000) $170,004 Shares 1,525,654 Est. Cost $81.75 Unrealized +54.8%

— ANACOR PHARMACEUTICALS INC 9.2%

Value ($000) $118,608 Shares 2,219,042 Est. Cost $24.12 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 8.6%

Value ($000) $110,552 Shares 1,340,347 Est. Cost $73.11 Unrealized +11.3%

— AMAG PHARMACEUTICALS INC 5.3%

Value ($000) $68,005 Shares 2,906,194 Est. Cost $30.80 Unrealized —

— CLOVIS ONCOLOGY INC 5.2%

Value ($000) $66,458 Shares 3,461,365 Est. Cost $57.85 Unrealized —

INSM INSMED INC 4.7%

Value ($000) $60,699 Shares 4,790,800 Est. Cost $14.79 Unrealized -11.1%

— WRIGHT MED GROUP N V 2.8%

Value ($000) $36,370 Shares 2,190,957 Est. Cost $23.98 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.6%

Value ($000) $33,698 Shares 4,030,908 Est. Cost $8.48 Unrealized -3.2%

— EPIZYME INC 2.5%

Value ($000) $32,184 Shares 2,655,479 Est. Cost $13.76 Unrealized —

FOLD AMICUS THERAPEUTICS INC 2.3%

Value ($000) $30,007 Shares 3,551,173 Est. Cost $5.71 Unrealized +24.0%

PRTA PROTHENA CORP PLC 2.2%

Value ($000) $28,628 Shares 695,518 Est. Cost $22.18 Unrealized +76.4%

GILD GILEAD SCIENCES INC 2.2%

Value ($000) $27,824 Shares 302,900 Est. Cost $63.23 Unrealized +0.4%

— KARYOPHARM THERAPEUTICS INC 2.1%

Value ($000) $27,635 Shares 3,098,145 Est. Cost $20.94 Unrealized —

— CELGENE CORP 2.1%

Value ($000) $27,104 Shares 270,800 Est. Cost $97.13 Unrealized —

— MEDIVATION INC 1.9%

Value ($000) $24,161 Shares 525,462 Est. Cost $57.74 Unrealized —

— ENDO INTL PLC 1.8%

Value ($000) $23,326 Shares 828,630 Est. Cost $87.66 Unrealized —

— CEMPRA INC 1.7%

Value ($000) $21,301 Shares 1,215,833 Est. Cost $30.68 Unrealized —

STAA STAAR SURGICAL CO 1.5%

Value ($000) $19,523 Shares 2,641,875 Est. Cost $8.11 Unrealized -16.5%

— SHIRE PLC 1.4%

Value ($000) $18,239 Shares 106,100 Est. Cost $227.14 Unrealized —

— ZELTIQ AESTHETICS INC 1.2%

Value ($000) $15,580 Shares 573,636 Est. Cost $26.16 Unrealized —

— ARIAD PHARMACEUTICALS INC 1.1%

Value ($000) $14,367 Shares 2,248,317 Est. Cost $6.81 Unrealized —

— SEQUENOM INC 1.1%

Value ($000) $14,134 Shares 10,023,842 Est. Cost $3.91 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.1%

Value ($000) $13,571 Shares 1,468,776 Est. Cost $14.44 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 1.1%

Value ($000) $13,563 Shares 485,100 Est. Cost $21.84 Unrealized 0.0%

— RIGEL PHARMACEUTICALS INC 0.8%

Value ($000) $10,880 Shares 5,230,919 Est. Cost $3.43 Unrealized —

— HEARTWARE INTL INC 0.6%

Value ($000) $7,914 Shares 251,868 Est. Cost $86.47 Unrealized —

— ALIMERA SCIENCES INC 0.4%

Value ($000) $5,274 Shares 3,013,793 Est. Cost $4.88 Unrealized —

— AIMMUNE THERAPEUTICS INC 0.3%

Value ($000) $4,415 Shares 325,599 Est. Cost $25.32 Unrealized —

— ACELRX PHARMACEUTICALS INC 0.3%

Value ($000) $4,390 Shares 1,425,439 Est. Cost $5.78 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.3%

Value ($000) $3,766 Shares 6,974,854 Est. Cost $1.05 Unrealized —

EXAS EXACT SCIENCES CORP 0.2%

Value ($000) $2,671 Shares 396,276 Est. Cost $12.83 Unrealized -50.1%

— IDERA PHARMACEUTICALS INC 0.2%

Value ($000) $2,490 Shares 1,257,748 Est. Cost $3.70 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.2%

Value ($000) $2,018 Shares 27,757 Est. Cost $53.35 Unrealized +22.7%

— INTREXON CORP 0.1%

Value ($000) $1,596 Shares 47,100 Est. Cost $28.82 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.1%

Value ($000) $1,436 Shares 267,890 Est. Cost $9.72 Unrealized —

— HISTOGENICS CORP 0.1%

Value ($000) $1,041 Shares 454,545 Est. Cost $11.00 Unrealized —

— ALCOBRA LTD 0.1%

Value ($000) $963 Shares 254,188 Est. Cost $6.09 Unrealized —

— OREXIGEN THERAPEUTICS INC 0.1%

Value ($000) $941 Shares 1,673,024 Est. Cost $6.46 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value ($000) $872 Shares 123,686 Est. Cost $6.71 Unrealized +8.8%

— SOPHIRIS BIO INC 0.1%

Value ($000) $711 Shares 494,000 Est. Cost $2.60 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $318 Shares 59,017 Est. Cost $8.34 Unrealized —

— ZOGENIX INC 0.0%

Value ($000) $264 Shares 28,600 Est. Cost $13.52 Unrealized —

QURE UNIQURE NV 0.0%

Value ($000) $243 Shares 20,453 Est. Cost $26.34 Unrealized -43.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	ABIOMED INC	2,325,959	$220,524	17.1%	$29.48	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP DEL	1,525,654	$170,004	13.2%	$81.75	+54.8%	COM	91307C102
—	ANACOR PHARMACEUTICALS INC	2,219,042	$118,608	9.2%	$24.12	—	COM	032420101
BMRN	BIOMARIN PHARMACEUTICAL INC	1,340,347	$110,552	8.6%	$73.11	+11.3%	COM	09061G101
—	AMAG PHARMACEUTICALS INC	2,906,194	$68,005	5.3%	$30.80	—	COM	00163U106
—	CLOVIS ONCOLOGY INC	3,461,365	$66,458	5.2%	$57.85	—	COM	189464100
INSM	INSMED INC	4,790,800	$60,699	4.7%	$14.79	-11.1%	COM PAR $.01	457669307
—	WRIGHT MED GROUP N V	2,190,957	$36,370	2.8%	$23.98	—	ORD SHS 0.03 PAR	N96617118
VNDA	VANDA PHARMACEUTICALS INC	4,030,908	$33,698	2.6%	$8.48	-3.2%	COM	921659108
—	EPIZYME INC	2,655,479	$32,184	2.5%	$13.76	—	COM	29428V104
FOLD	AMICUS THERAPEUTICS INC	3,551,173	$30,007	2.3%	$5.71	+24.0%	COM	03152W109
PRTA	PROTHENA CORP PLC	695,518	$28,628	2.2%	$22.18	+76.4%	SHS	G72800108
GILD	GILEAD SCIENCES INC	302,900	$27,824	2.2%	$63.23	+0.4%	COM	375558103
—	KARYOPHARM THERAPEUTICS INC	3,098,145	$27,635	2.1%	$20.94	—	COM	48576U106
—	CELGENE CORP	270,800	$27,104	2.1%	$97.13	—	COM	151020104
—	MEDIVATION INC	525,462	$24,161	1.9%	$57.74	—	COM	58501N101
—	ENDO INTL PLC	828,630	$23,326	1.8%	$87.66	—	SHS	G30401106
—	CEMPRA INC	1,215,833	$21,301	1.7%	$30.68	—	COM	15130J109
STAA	STAAR SURGICAL CO	2,641,875	$19,523	1.5%	$8.11	-16.5%	COM PAR $0.01	852312305
—	SHIRE PLC	106,100	$18,239	1.4%	$227.14	—	SPONSORED ADR	82481R106
—	ZELTIQ AESTHETICS INC	573,636	$15,580	1.2%	$26.16	—	COM	98933Q108
—	ARIAD PHARMACEUTICALS INC	2,248,317	$14,367	1.1%	$6.81	—	COM	04033A100
—	SEQUENOM INC	10,023,842	$14,134	1.1%	$3.91	—	COM NEW	817337405
—	MOMENTA PHARMACEUTICALS INC	1,468,776	$13,571	1.1%	$14.44	—	COM	60877T100
ACAD	ACADIA PHARMACEUTICALS INC	485,100	$13,563	1.1%	$21.84	0.0%	COM	004225108
—	RIGEL PHARMACEUTICALS INC	5,230,919	$10,880	0.8%	$3.43	—	COM NEW	766559603
—	HEARTWARE INTL INC	251,868	$7,914	0.6%	$86.47	—	COM	422368100
—	ALIMERA SCIENCES INC	3,013,793	$5,274	0.4%	$4.88	—	COM	016259103
—	AIMMUNE THERAPEUTICS INC	325,599	$4,415	0.3%	$25.32	—	COM	00900T107
—	ACELRX PHARMACEUTICALS INC	1,425,439	$4,390	0.3%	$5.78	—	COM	00444T100
—	SUNESIS PHARMACEUTICALS INC	6,974,854	$3,766	0.3%	$1.05	—	COM NEW	867328601
EXAS	EXACT SCIENCES CORP	396,276	$2,671	0.2%	$12.83	-50.1%	COM	30063P105
—	IDERA PHARMACEUTICALS INC	1,257,748	$2,490	0.2%	$3.70	—	COM NEW	45168K306
ALGN	ALIGN TECHNOLOGY INC	27,757	$2,018	0.2%	$53.35	+22.7%	COM	016255101
—	INTREXON CORP	47,100	$1,596	0.1%	$28.82	—	COM	46122T102
—	DICERNA PHARMACEUTICALS INC	267,890	$1,436	0.1%	$9.72	—	COM	253031108
—	HISTOGENICS CORP	454,545	$1,041	0.1%	$11.00	—	COM	43358V109
—	ALCOBRA LTD	254,188	$963	0.1%	$6.09	—	SHS	M2239P109
—	OREXIGEN THERAPEUTICS INC	1,673,024	$941	0.1%	$6.46	—	COM	686164104
CYTK	CYTOKINETICS INC	123,686	$872	0.1%	$6.71	+8.8%	COM NEW	23282W605
—	SOPHIRIS BIO INC	494,000	$711	0.1%	$2.60	—	COM NEW	83578Q209
—	MARINUS PHARMACEUTICALS INC	59,017	$318	0.0%	$8.34	—	COM	56854Q101
—	ZOGENIX INC	28,600	$264	0.0%	$13.52	—	COM NEW	98978L204
QURE	UNIQURE NV	20,453	$243	0.0%	$26.34	-43.9%	SHS	N90064101