Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2016 (← Previous) (Next →)

Filing Date: Aug 16, 2016

Total Value: $1.324B (100.0% shares, 0.0% debt)

Holdings (45)

— ABIOMED INC 17.1%

Value $226M Shares 2,066,919 Est. Cost $29.48 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 13.8%

Value $182M Shares 1,718,658 Est. Cost $85.10 Unrealized +31.1%

BMRN BIOMARIN PHARMACEUTICAL INC 10.2%

Value $135M Shares 1,737,399 Est. Cost $75.83 Unrealized +12.1%

— AMAG PHARMACEUTICALS INC 5.9%

Value $78.3M Shares 3,273,220 Est. Cost $30.03 Unrealized —

— CLOVIS ONCOLOGY INC 3.9%

Value $52.19M Shares 3,804,088 Est. Cost $53.87 Unrealized —

INSM INSMED INC 3.8%

Value $49.84M Shares 5,054,713 Est. Cost $14.63 Unrealized -20.2%

VNDA VANDA PHARMACEUTICALS INC 3.6%

Value $47.28M Shares 4,225,608 Est. Cost $8.54 Unrealized +13.4%

ACAD ACADIA PHARMACEUTICALS INC 3.5%

Value $46.67M Shares 1,437,730 Est. Cost $29.54 Unrealized +13.3%

— CEMPRA INC 3.5%

Value $45.97M Shares 2,787,542 Est. Cost $22.68 Unrealized —

— WRIGHT MED GROUP N V 3.2%

Value $41.83M Shares 2,408,393 Est. Cost $23.38 Unrealized —

— ALEXION PHARMACEUTICALS INC 3.0%

Value $39.63M Shares 339,400 Est. Cost $116.76 Unrealized —

— ZELTIQ AESTHETICS INC 2.9%

Value $38.02M Shares 1,391,079 Est. Cost $26.85 Unrealized —

— EPIZYME INC 2.1%

Value $27.77M Shares 2,711,381 Est. Cost $13.69 Unrealized —

— CELGENE CORP 2.1%

Value $27.58M Shares 279,600 Est. Cost $97.18 Unrealized —

PRTA PROTHENA CORP PLC 2.1%

Value $27.57M Shares 788,618 Est. Cost $24.71 Unrealized +76.3%

GILD GILEAD SCIENCES INC 2.0%

Value $26.56M Shares 318,400 Est. Cost $63.20 Unrealized -0.7%

— SHIRE PLC 1.7%

Value $21.96M Shares 119,300 Est. Cost $222.37 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.7%

Value $21.89M Shares 4,009,375 Est. Cost $5.86 Unrealized +19.4%

— KARYOPHARM THERAPEUTICS INC 1.6%

Value $21.07M Shares 3,139,433 Est. Cost $20.75 Unrealized —

— ARIAD PHARMACEUTICALS INC 1.4%

Value $18.73M Shares 2,535,117 Est. Cost $6.88 Unrealized —

STAA STAAR SURGICAL CO 1.3%

Value $17.67M Shares 3,207,210 Est. Cost $7.82 Unrealized -17.4%

— MOMENTA PHARMACEUTICALS INC 1.3%

Value $17.59M Shares 1,629,076 Est. Cost $14.08 Unrealized —

— MEDIVATION INC 1.2%

Value $16.52M Shares 273,983 Est. Cost $57.74 Unrealized —

— HEARTWARE INTL INC 1.2%

Value $15.77M Shares 272,986 Est. Cost $84.25 Unrealized —

— ENDO INTL PLC 1.1%

Value $14.39M Shares 923,230 Est. Cost $80.28 Unrealized —

— SAGE THERAPEUTICS INC 1.0%

Value $12.59M Shares 417,878 Est. Cost $30.13 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.9%

Value $12.01M Shares 5,386,534 Est. Cost $3.39 Unrealized —

— SEQUENOM INC 0.7%

Value $9.432M Shares 10,322,377 Est. Cost $3.82 Unrealized —

EXAS EXACT SCIENCES CORP 0.4%

Value $4.854M Shares 396,276 Est. Cost $12.83 Unrealized -41.3%

— ACELRX PHARMACEUTICALS INC 0.3%

Value $3.834M Shares 1,425,439 Est. Cost $5.78 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.3%

Value $3.82M Shares 6,974,854 Est. Cost $1.05 Unrealized —

— ALIMERA SCIENCES INC 0.3%

Value $3.707M Shares 3,013,793 Est. Cost $4.88 Unrealized —

— AIMMUNE THERAPEUTICS INC 0.3%

Value $3.523M Shares 325,599 Est. Cost $25.32 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.2%

Value $2.929M Shares 36,357 Est. Cost $58.82 Unrealized +30.0%

— IDERA PHARMACEUTICALS INC 0.1%

Value $1.924M Shares 1,257,748 Est. Cost $3.70 Unrealized —

— ALCOBRA LTD 0.1%

Value $1.225M Shares 272,788 Est. Cost $5.98 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value $1.174M Shares 123,686 Est. Cost $6.71 Unrealized +22.2%

— INTREXON CORP 0.1%

Value $1.159M Shares 47,100 Est. Cost $28.82 Unrealized —

— SOPHIRIS BIO INC 0.1%

Value $1.062M Shares 494,000 Est. Cost $2.60 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.1%

Value $804K Shares 267,890 Est. Cost $9.72 Unrealized —

— HISTOGENICS CORP 0.1%

Value $777K Shares 454,545 Est. Cost $11.00 Unrealized —

— OREXIGEN THERAPEUTICS INC 0.1%

Value $719K Shares 1,673,024 Est. Cost $6.46 Unrealized —

— ZOGENIX INC 0.0%

Value $237K Shares 29,500 Est. Cost $13.36 Unrealized —

QURE UNIQURE NV 0.0%

Value $151K Shares 20,453 Est. Cost $26.34 Unrealized -54.6%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $81,000 Shares 63,517 Est. Cost $7.84 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ABIOMED INC	2,066,919	$226M	17.1%	$29.48	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP DEL	1,718,658	$182M	13.8%	$85.10	+31.1%	COM	91307C102
BMRN	BIOMARIN PHARMACEUTICAL INC	1,737,399	$135M	10.2%	$75.83	+12.1%	COM	09061G101
—	AMAG PHARMACEUTICALS INC	3,273,220	$78.3M	5.9%	$30.03	—	COM	00163U106
—	CLOVIS ONCOLOGY INC	3,804,088	$52.19M	3.9%	$53.87	—	COM	189464100
INSM	INSMED INC	5,054,713	$49.84M	3.8%	$14.63	-20.2%	COM PAR $.01	457669307
VNDA	VANDA PHARMACEUTICALS INC	4,225,608	$47.28M	3.6%	$8.54	+13.4%	COM	921659108
ACAD	ACADIA PHARMACEUTICALS INC	1,437,730	$46.67M	3.5%	$29.54	+13.3%	COM	004225108
—	CEMPRA INC	2,787,542	$45.97M	3.5%	$22.68	—	COM	15130J109
—	WRIGHT MED GROUP N V	2,408,393	$41.83M	3.2%	$23.38	—	ORD SHS 0.03 PAR	N96617118
—	ALEXION PHARMACEUTICALS INC	339,400	$39.63M	3.0%	$116.76	—	COM	015351109
—	ZELTIQ AESTHETICS INC	1,391,079	$38.02M	2.9%	$26.85	—	COM	98933Q108
—	EPIZYME INC	2,711,381	$27.77M	2.1%	$13.69	—	COM	29428V104
—	CELGENE CORP	279,600	$27.58M	2.1%	$97.18	—	COM	151020104
PRTA	PROTHENA CORP PLC	788,618	$27.57M	2.1%	$24.71	+76.3%	SHS	G72800108
GILD	GILEAD SCIENCES INC	318,400	$26.56M	2.0%	$63.20	-0.7%	COM	375558103
—	SHIRE PLC	119,300	$21.96M	1.7%	$222.37	—	SPONSORED ADR	82481R106
FOLD	AMICUS THERAPEUTICS INC	4,009,375	$21.89M	1.7%	$5.86	+19.4%	COM	03152W109
—	KARYOPHARM THERAPEUTICS INC	3,139,433	$21.07M	1.6%	$20.75	—	COM	48576U106
—	ARIAD PHARMACEUTICALS INC	2,535,117	$18.73M	1.4%	$6.88	—	COM	04033A100
STAA	STAAR SURGICAL CO	3,207,210	$17.67M	1.3%	$7.82	-17.4%	COM PAR $0.01	852312305
—	MOMENTA PHARMACEUTICALS INC	1,629,076	$17.59M	1.3%	$14.08	—	COM	60877T100
—	MEDIVATION INC	273,983	$16.52M	1.2%	$57.74	—	COM	58501N101
—	HEARTWARE INTL INC	272,986	$15.77M	1.2%	$84.25	—	COM	422368100
—	ENDO INTL PLC	923,230	$14.39M	1.1%	$80.28	—	SHS	G30401106
—	SAGE THERAPEUTICS INC	417,878	$12.59M	1.0%	$30.13	—	COM	78667J108
—	RIGEL PHARMACEUTICALS INC	5,386,534	$12.01M	0.9%	$3.39	—	COM NEW	766559603
—	SEQUENOM INC	10,322,377	$9.432M	0.7%	$3.82	—	COM NEW	817337405
EXAS	EXACT SCIENCES CORP	396,276	$4.854M	0.4%	$12.83	-41.3%	COM	30063P105
—	ACELRX PHARMACEUTICALS INC	1,425,439	$3.834M	0.3%	$5.78	—	COM	00444T100
—	SUNESIS PHARMACEUTICALS INC	6,974,854	$3.82M	0.3%	$1.05	—	COM NEW	867328601
—	ALIMERA SCIENCES INC	3,013,793	$3.707M	0.3%	$4.88	—	COM	016259103
—	AIMMUNE THERAPEUTICS INC	325,599	$3.523M	0.3%	$25.32	—	COM	00900T107
ALGN	ALIGN TECHNOLOGY INC	36,357	$2.929M	0.2%	$58.82	+30.0%	COM	016255101
—	IDERA PHARMACEUTICALS INC	1,257,748	$1.924M	0.1%	$3.70	—	COM NEW	45168K306
—	ALCOBRA LTD	272,788	$1.225M	0.1%	$5.98	—	SHS	M2239P109
CYTK	CYTOKINETICS INC	123,686	$1.174M	0.1%	$6.71	+22.2%	COM NEW	23282W605
—	INTREXON CORP	47,100	$1.159M	0.1%	$28.82	—	COM	46122T102
—	SOPHIRIS BIO INC	494,000	$1.062M	0.1%	$2.60	—	COM NEW	83578Q209
—	DICERNA PHARMACEUTICALS INC	267,890	$804K	0.1%	$9.72	—	COM	253031108
—	HISTOGENICS CORP	454,545	$777K	0.1%	$11.00	—	COM	43358V109
—	OREXIGEN THERAPEUTICS INC	1,673,024	$719K	0.1%	$6.46	—	COM	686164104
—	ZOGENIX INC	29,500	$237K	0.0%	$13.36	—	COM NEW	98978L204
QURE	UNIQURE NV	20,453	$151K	0.0%	$26.34	-54.6%	SHS	N90064101
—	MARINUS PHARMACEUTICALS INC	63,517	$81,000	0.0%	$7.84	—	COM	56854Q101