Opaleye Management Inc. Quant / Systematic

Location: Boston, MA

CIK: 0001595855 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value: $449M (97.6% shares, 2.4% debt)

Holdings (45)

HROW HARROW HEALTH INC 23.4%

Value $105M Shares 3,955,000 Est. Cost $6.33 Unrealized +372.7%

ETON ETON PHARMACEUTICALS INC 8.2%

Value $37.02M Shares 2,852,070 Est. Cost $5.71 Unrealized +164.6%

SNWV SANUWAVE HEALTH INC 7.7%

Value $34.38M Shares 972,002 Est. Cost $28.49 Unrealized 0.0%

LQDA LIQUIDIA CORPORATION 7.4%

Value $33.34M Shares 2,260,000 Est. Cost $11.06 Unrealized +31.9%

RYTM RHYTHM PHARMACEUTICALS INC 5.8%

Value $25.96M Shares 490,000 Est. Cost $12.73 Unrealized +335.8%

CDXS CODEXIS INC 5.7%

Value $25.55M Shares 9,500,000 Est. Cost $2.96 Unrealized +30.9%

IMNM IMMUNOME INC 5.3%

Value $23.89M Shares 3,550,000 Est. Cost $12.21 Unrealized -21.4%

TGTX TG THERAPEUTICS INC 4.7%

Value $21.1M Shares 535,000 Est. Cost $13.67 Unrealized +146.2%

ARVN ARVINAS INC 3.1%

Value $13.86M Shares 1,975,000 Est. Cost $24.80 Unrealized -36.8%

OCUL OCULAR THERAPEUTIX INC 2.6%

Value $11.69M Shares 1,595,000 Est. Cost $5.10 Unrealized +50.8%

EWTX EDGEWISE THERAPEUTICS INC 1.9%

Value $8.69M Shares 395,000 Est. Cost $10.13 Unrealized +159.1%

TARA PROTARA THERAPEUTICS INC 1.6%

Value $7.37M Shares 1,730,000 Est. Cost $27.06 Unrealized -83.5%

DNA GINKGO BIOWORKS HOLDINGS 1.5%

Value $6.811M Shares 1,195,000 Est. Cost $9.56 Unrealized +6.5%

— GOSSAMER BIO INC 1.4%

Value $6.319M Shares 11,500,000 Est. Cost $0.43 Unrealized —

ANIK ANIKA THERAPEUTICS INC 1.3%

Value $5.937M Shares 395,000 Est. Cost $16.64 Unrealized 0.0%

PTGX PROTAGONIST THERAPEUTICS INC 1.1%

Value $5.078M Shares 105,000 Est. Cost $17.50 Unrealized +139.5%

XOMA XOMA CORP DEL 1.1%

Value $5.043M Shares 253,043 Est. Cost $11.42 Unrealized +110.9%

TRVI TREVI THERAPEUTICS INC 1.1%

Value $5.001M Shares 795,000 Est. Cost $2.06 Unrealized +131.9%

PVLA PALVELLA THERAPEUTICS INC 1.1%

Value $4.824M Shares 172,357 Est. Cost $19.27 Unrealized 0.0%

GOSS GOSSAMER BIO INC 1.1%

Value $4.716M Shares 4,287,415 Est. Cost $1.01 Unrealized +14.7%

ANAB ANAPTYS BIO INC 1.0%

Value $4.665M Shares 250,933 Est. Cost $16.68 Unrealized 0.0%

— KARYOPHARM THERAPEUTICS INC 1.0%

Value $4.557M Shares 6,000,000 Est. Cost $0.62 Unrealized —

IRON DISC MEDICINE INC 0.9%

Value $4.219M Shares 85,000 Est. Cost $55.60 Unrealized 0.0%

LRMR LARIMAR THERAPEUTICS INC 0.9%

Value $4.115M Shares 1,914,077 Est. Cost $3.16 Unrealized 0.0%

CGON CG ONCOLOGY INC 0.9%

Value $4.016M Shares 163,988 Est. Cost $28.13 Unrealized 0.0%

— ACELYRIN INC 0.9%

Value $3.989M Shares 1,615,000 Est. Cost $15.96 Unrealized —

RCEL AVITA MEDICAL INC 0.8%

Value $3.582M Shares 440,000 Est. Cost $9.34 Unrealized 0.0%

— ESSA PHARMA INC 0.8%

Value $3.492M Shares 2,209,998 Est. Cost $1.79 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.7%

Value $3.156M Shares 1,985,000 Est. Cost $3.33 Unrealized -35.2%

— CARGO THERAPEUTICS INC 0.6%

Value $2.713M Shares 666,503 Est. Cost $15.86 Unrealized —

ZYME ZYMEWORKS INC 0.5%

Value $2.084M Shares 175,000 Est. Cost $13.64 Unrealized 0.0%

— BIODESIX INC 0.4%

Value $2.016M Shares 3,225,000 Est. Cost $2.17 Unrealized —

STOK STOKE THERAPEUTICS INC 0.4%

Value $1.995M Shares 300,000 Est. Cost $9.57 Unrealized -2.6%

MBX MBX BIOSCIENCES INC 0.4%

Value $1.845M Shares 250,000 Est. Cost $10.57 Unrealized 0.0%

— OPTINOSE INC 0.4%

Value $1.77M Shares 193,039 Est. Cost $9.17 Unrealized —

IRD OPUS GENETICS INC 0.3%

Value $1.546M Shares 1,175,000 Est. Cost $1.12 Unrealized 0.0%

IBIO IBIO INC 0.3%

Value $1.508M Shares 375,000 Est. Cost $1.26 Unrealized +209.2%

KNSA KINIKSA PHARMACEUTICALS INTL 0.3%

Value $1.388M Shares 62,501 Est. Cost $20.58 Unrealized 0.0%

NRIX NURIX THERAPEUTICS INC 0.3%

Value $1.366M Shares 115,000 Est. Cost $12.50 Unrealized +33.8%

RZLT REZOLUTE INC 0.3%

Value $1.349M Shares 465,000 Est. Cost $4.59 Unrealized -5.1%

SGMO SANGAMO THERAPEUTICS INC 0.2%

Value $692K Shares 1,055,000 Est. Cost $1.06 Unrealized 0.0%

PEPG PEPGEN INC 0.1%

Value $590K Shares 420,000 Est. Cost $4.62 Unrealized -55.4%

DERM JOURNEY MEDICAL CORP 0.1%

Value $409K Shares 69,323 Est. Cost $4.92 Unrealized 0.0%

VTYX VENTYX BIOSCIENCES INC 0.0%

Value $219K Shares 190,000 Est. Cost $2.27 Unrealized -24.2%

ADGM ADAGIO MED HLDGS INC 0.0%

Value $92,106 Shares 110,571 Est. Cost $4.76 Unrealized -77.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,955,000	$105M	23.4%	$6.33	+372.7%	COM	415858109
ETON	ETON PHARMACEUTICALS INC	2,852,070	$37.02M	8.2%	$5.71	+164.6%	COM	29772L108
SNWV	SANUWAVE HEALTH INC	972,002	$34.38M	7.7%	$28.49	0.0%	COM	80303D305
LQDA	LIQUIDIA CORPORATION	2,260,000	$33.34M	7.4%	$11.06	+31.9%	COM NEW	53635D202
RYTM	RHYTHM PHARMACEUTICALS INC	490,000	$25.96M	5.8%	$12.73	+335.8%	COM	76243J105
CDXS	CODEXIS INC	9,500,000	$25.55M	5.7%	$2.96	+30.9%	COM	192005106
IMNM	IMMUNOME INC	3,550,000	$23.89M	5.3%	$12.21	-21.4%	COM	45257U108
TGTX	TG THERAPEUTICS INC	535,000	$21.1M	4.7%	$13.67	+146.2%	COM	88322Q108
ARVN	ARVINAS INC	1,975,000	$13.86M	3.1%	$24.80	-36.8%	COM	04335A105
OCUL	OCULAR THERAPEUTIX INC	1,595,000	$11.69M	2.6%	$5.10	+50.8%	COM	67576A100
EWTX	EDGEWISE THERAPEUTICS INC	395,000	$8.69M	1.9%	$10.13	+159.1%	COM	28036F105
TARA	PROTARA THERAPEUTICS INC	1,730,000	$7.37M	1.6%	$27.06	-83.5%	COM STK	74365U107
DNA	GINKGO BIOWORKS HOLDINGS	1,195,000	$6.811M	1.5%	$9.56	+6.5%	Class A New	37611X209
—	GOSSAMER BIO INC	11,500,000	$6.319M	1.4%	$0.43	—	NOTE 5.000% 6/0	38341PAA0
ANIK	ANIKA THERAPEUTICS INC	395,000	$5.937M	1.3%	$16.64	0.0%	COM	035255108
PTGX	PROTAGONIST THERAPEUTICS INC	105,000	$5.078M	1.1%	$17.50	+139.5%	COM	74366E102
XOMA	XOMA CORP DEL	253,043	$5.043M	1.1%	$11.42	+110.9%	COM NEW	98419J206
TRVI	TREVI THERAPEUTICS INC	795,000	$5.001M	1.1%	$2.06	+131.9%	COM	89532M101
PVLA	PALVELLA THERAPEUTICS INC	172,357	$4.824M	1.1%	$19.27	0.0%	COM	697947109
GOSS	GOSSAMER BIO INC	4,287,415	$4.716M	1.1%	$1.01	+14.7%	COM	38341P102
ANAB	ANAPTYS BIO INC	250,933	$4.665M	1.0%	$16.68	0.0%	COM	032724106
—	KARYOPHARM THERAPEUTICS INC	6,000,000	$4.557M	1.0%	$0.62	—	NOTE 3.000%10/1	48576UAA4
IRON	DISC MEDICINE INC	85,000	$4.219M	0.9%	$55.60	0.0%	COM	254604101
LRMR	LARIMAR THERAPEUTICS INC	1,914,077	$4.115M	0.9%	$3.16	0.0%	COM	517125100
CGON	CG ONCOLOGY INC	163,988	$4.016M	0.9%	$28.13	0.0%	COM	156944100
—	ACELYRIN INC	1,615,000	$3.989M	0.9%	$15.96	—	COM	00445A100
RCEL	AVITA MEDICAL INC	440,000	$3.582M	0.8%	$9.34	0.0%	COM	05380C102
—	ESSA PHARMA INC	2,209,998	$3.492M	0.8%	$1.79	—	COM NEW	29668H708
ZNTL	ZENTALIS PHARMACEUTICALS INC	1,985,000	$3.156M	0.7%	$3.33	-35.2%	COM	98943L107
—	CARGO THERAPEUTICS INC	666,503	$2.713M	0.6%	$15.86	—	COM	14179K101
ZYME	ZYMEWORKS INC	175,000	$2.084M	0.5%	$13.64	0.0%	COM	98985Y108
—	BIODESIX INC	3,225,000	$2.016M	0.4%	$2.17	—	COM	09075X108
STOK	STOKE THERAPEUTICS INC	300,000	$1.995M	0.4%	$9.57	-2.6%	COM	86150R107
MBX	MBX BIOSCIENCES INC	250,000	$1.845M	0.4%	$10.57	0.0%	COM	55287L101
—	OPTINOSE INC	193,039	$1.77M	0.4%	$9.17	—	COM NEW	68404V209
IRD	OPUS GENETICS INC	1,175,000	$1.546M	0.3%	$1.12	0.0%	COM	67577R102
IBIO	IBIO INC	375,000	$1.508M	0.3%	$1.26	+209.2%	COM NEW	451033708
KNSA	KINIKSA PHARMACEUTICALS INTL	62,501	$1.388M	0.3%	$20.58	0.0%	ORD SHRS CL A	G52694109
NRIX	NURIX THERAPEUTICS INC	115,000	$1.366M	0.3%	$12.50	+33.8%	COM	67080M103
RZLT	REZOLUTE INC	465,000	$1.349M	0.3%	$4.59	-5.1%	COM NEW	76200L309
SGMO	SANGAMO THERAPEUTICS INC	1,055,000	$692K	0.2%	$1.06	0.0%	COM	800677106
PEPG	PEPGEN INC	420,000	$590K	0.1%	$4.62	-55.4%	COM	713317105
DERM	JOURNEY MEDICAL CORP	69,323	$409K	0.1%	$4.92	0.0%	COM	48115J109
VTYX	VENTYX BIOSCIENCES INC	190,000	$219K	0.0%	$2.27	-24.2%	COM	92332V107
ADGM	ADAGIO MED HLDGS INC	110,571	$92,106	0.0%	$4.76	-77.7%	COM	00534B100