Avidity Partners Management LP Quant / Systematic

Location: Dallas, TX

CIK: 0001791827 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 13, 2026

Total Value: $347M (100.0% shares, 0.0% debt)

Holdings (39)

DNTH DIANTHUS THERAPEUTICS INC 25.0%

Value $86.71M Shares 2,104,184 Est. Cost $21.50 Unrealized +80.3%

CGON CG ONCOLOGY INC 17.6%

Value $61.15M Shares 1,472,699 Est. Cost $33.90 Unrealized +22.1%

JBIO JADE BIOSCIENCES INC 6.2%

Value $21.61M Shares 1,400,708 Est. Cost $29.10 Unrealized -59.7%

ORKA ORUKA THERAPEUTICS INC 5.8%

Value $20.02M Shares 660,424 Est. Cost $25.47 Unrealized +9.4%

TEVA TEVA PHARMACEUTICAL INDS LTD 3.8%

Value $13.02M Shares 417,300 Est. Cost $15.79 Unrealized —

BSX BOSTON SCIENTIFIC CORP 3.1%

Value $10.92M Shares 114,500 Est. Cost $49.10 Unrealized +99.7%

MDT MEDTRONIC PLC 3.0%

Value $10.34M Shares 107,600 Est. Cost $91.27 Unrealized +6.4%

CATX PERSPECTIVE THERAPEUTICS INC 2.5%

Value $8.83M Shares 3,210,733 Est. Cost $9.77 Unrealized -70.8%

ALNY ALNYLAM PHARMACEUTICALS INC 2.4%

Value $8.351M Shares 21,000 Est. Cost $442.56 Unrealized 0.0%

RGEN REPLIGEN CORP 2.4%

Value $8.242M Shares 50,300 Est. Cost $143.02 Unrealized +9.5%

CNTX CONTEXT THERAPEUTICS INC 2.3%

Value $8.092M Shares 5,504,855 Est. Cost $1.57 Unrealized -25.6%

MCK MCKESSON CORP 2.3%

Value $7.809M Shares 9,520 Est. Cost $747.44 Unrealized +9.1%

ICLR ICON PLC 1.7%

Value $6.031M Shares 33,100 Est. Cost $178.08 Unrealized 0.0%

A AGILENT TECHNOLOGIES INC 1.6%

Value $5.647M Shares 41,500 Est. Cost $143.72 Unrealized 0.0%

PFE PFIZER INC 1.5%

Value $5.07M Shares 203,600 Est. Cost $24.14 Unrealized +3.7%

CNC CENTENE CORP DEL 1.4%

Value $4.913M Shares 119,400 Est. Cost $37.43 Unrealized 0.0%

KVUE KENVUE INC 1.2%

Value $4.016M Shares 232,800 Est. Cost $20.06 Unrealized -19.0%

DHR DANAHER CORPORATION 1.1%

Value $3.892M Shares 17,000 Est. Cost $205.28 Unrealized +6.9%

TMO THERMO FISHER SCIENTIFIC INC 1.1%

Value $3.882M Shares 6,700 Est. Cost $475.70 Unrealized +18.8%

NVO NOVO-NORDISK A S 1.0%

Value $3.424M Shares 67,300 Est. Cost $50.88 Unrealized —

PHAT PHATHOM PHARMACEUTICALS INC 1.0%

Value $3.419M Shares 206,076 Est. Cost $16.93 Unrealized -15.6%

EHC ENCOMPASS HEALTH CORP 1.0%

Value $3.354M Shares 31,600 Est. Cost $113.68 Unrealized +1.8%

CI THE CIGNA GROUP 0.9%

Value $3.193M Shares 11,600 Est. Cost $293.19 Unrealized -4.8%

COR CENCORA INC 0.9%

Value $3.175M Shares 9,400 Est. Cost $249.56 Unrealized +36.5%

INSM INSMED INC 0.9%

Value $3.081M Shares 17,700 Est. Cost $94.59 Unrealized +92.9%

WAT WATERS CORP 0.9%

Value $3.077M Shares 8,100 Est. Cost $367.96 Unrealized 0.0%

ACAD ACADIA PHARMACEUTICALS INC 0.8%

Value $2.855M Shares 106,900 Est. Cost $23.65 Unrealized +1.0%

GMAB GENMAB A/S 0.8%

Value $2.834M Shares 92,000 Est. Cost $20.66 Unrealized —

NTRA NATERA INC 0.8%

Value $2.703M Shares 11,800 Est. Cost $95.53 Unrealized +118.3%

IMUX IMMUNIC INC 0.7%

Value $2.508M Shares 4,699,411 Est. Cost $1.22 Unrealized -40.0%

ACHC ACADIA HEALTHCARE COMPANY IN 0.7%

Value $2.398M Shares 169,000 Est. Cost $18.92 Unrealized 0.0%

ITGR INTEGER HLDGS CORP 0.7%

Value $2.337M Shares 29,800 Est. Cost $79.69 Unrealized 0.0%

ELVN ENLIVEN THERAPEUTICS INC 0.6%

Value $2.161M Shares 140,300 Est. Cost $20.27 Unrealized -1.7%

PVLA PALVELLA THERAPEUTICS INC NE 0.6%

Value $2.02M Shares 19,300 Est. Cost $85.31 Unrealized 0.0%

HQY HEALTHEQUITY INC 0.4%

Value $1.548M Shares 16,900 Est. Cost $101.38 Unrealized -5.6%

SCYX SCYNEXIS INC 0.4%

Value $1.316M Shares 2,081,660 Est. Cost $1.57 Unrealized -56.7%

IQV IQVIA HLDGS INC 0.3%

Value $992K Shares 4,400 Est. Cost $217.58 Unrealized 0.0%

KPTI KARYOPHARM THERAPEUTICS INC 0.3%

Value $990K Shares 134,566 Est. Cost $8.54 Unrealized -28.4%

CORT CORCEPT THERAPEUTICS INC 0.2%

Value $766K Shares 22,000 Est. Cost $78.55 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
DNTH	DIANTHUS THERAPEUTICS INC	2,104,184	$86.71M	25.0%	$21.50	+80.3%	COM	252828108
CGON	CG ONCOLOGY INC	1,472,699	$61.15M	17.6%	$33.90	+22.1%	COM	156944100
JBIO	JADE BIOSCIENCES INC	1,400,708	$21.61M	6.2%	$29.10	-59.7%	COM NEW	008064206
ORKA	ORUKA THERAPEUTICS INC	660,424	$20.02M	5.8%	$25.47	+9.4%	COM	687604108
TEVA	TEVA PHARMACEUTICAL INDS LTD	417,300	$13.02M	3.8%	$15.79	—	SPONSORED ADS	881624209
BSX	BOSTON SCIENTIFIC CORP	114,500	$10.92M	3.1%	$49.10	+99.7%	COM	101137107
MDT	MEDTRONIC PLC	107,600	$10.34M	3.0%	$91.27	+6.4%	SHS	G5960L103
CATX	PERSPECTIVE THERAPEUTICS INC	3,210,733	$8.83M	2.5%	$9.77	-70.8%	COM NEW	46489V302
ALNY	ALNYLAM PHARMACEUTICALS INC	21,000	$8.351M	2.4%	$442.56	0.0%	COM	02043Q107
RGEN	REPLIGEN CORP	50,300	$8.242M	2.4%	$143.02	+9.5%	COM	759916109
CNTX	CONTEXT THERAPEUTICS INC	5,504,855	$8.092M	2.3%	$1.57	-25.6%	COM	21077P108
MCK	MCKESSON CORP	9,520	$7.809M	2.3%	$747.44	+9.1%	COM	58155Q103
ICLR	ICON PLC	33,100	$6.031M	1.7%	$178.08	0.0%	SHS	G4705A100
A	AGILENT TECHNOLOGIES INC	41,500	$5.647M	1.6%	$143.72	0.0%	COM	00846U101
PFE	PFIZER INC	203,600	$5.07M	1.5%	$24.14	+3.7%	COM	717081103
CNC	CENTENE CORP DEL	119,400	$4.913M	1.4%	$37.43	0.0%	COM	15135B101
KVUE	KENVUE INC	232,800	$4.016M	1.2%	$20.06	-19.0%	COM	49177J102
DHR	DANAHER CORPORATION	17,000	$3.892M	1.1%	$205.28	+6.9%	COM	235851102
TMO	THERMO FISHER SCIENTIFIC INC	6,700	$3.882M	1.1%	$475.70	+18.8%	COM	883556102
NVO	NOVO-NORDISK A S	67,300	$3.424M	1.0%	$50.88	—	ADR	670100205
PHAT	PHATHOM PHARMACEUTICALS INC	206,076	$3.419M	1.0%	$16.93	-15.6%	COM	71722W107
EHC	ENCOMPASS HEALTH CORP	31,600	$3.354M	1.0%	$113.68	+1.8%	COM	29261A100
CI	THE CIGNA GROUP	11,600	$3.193M	0.9%	$293.19	-4.8%	COM	125523100
COR	CENCORA INC	9,400	$3.175M	0.9%	$249.56	+36.5%	COM	03073E105
INSM	INSMED INC	17,700	$3.081M	0.9%	$94.59	+92.9%	COM PAR $.01	457669307
WAT	WATERS CORP	8,100	$3.077M	0.9%	$367.96	0.0%	COM	941848103
ACAD	ACADIA PHARMACEUTICALS INC	106,900	$2.855M	0.8%	$23.65	+1.0%	COM	004225108
GMAB	GENMAB A/S	92,000	$2.834M	0.8%	$20.66	—	SPONSORED ADS	372303206
NTRA	NATERA INC	11,800	$2.703M	0.8%	$95.53	+118.3%	COM	632307104
IMUX	IMMUNIC INC	4,699,411	$2.508M	0.7%	$1.22	-40.0%	COM	4525EP101
ACHC	ACADIA HEALTHCARE COMPANY IN	169,000	$2.398M	0.7%	$18.92	0.0%	COM	00404A109
ITGR	INTEGER HLDGS CORP	29,800	$2.337M	0.7%	$79.69	0.0%	COM	45826H109
ELVN	ENLIVEN THERAPEUTICS INC	140,300	$2.161M	0.6%	$20.27	-1.7%	COM	29337E102
PVLA	PALVELLA THERAPEUTICS INC NE	19,300	$2.02M	0.6%	$85.31	0.0%	COM	697947109
HQY	HEALTHEQUITY INC	16,900	$1.548M	0.4%	$101.38	-5.6%	COM	42226A107
SCYX	SCYNEXIS INC	2,081,660	$1.316M	0.4%	$1.57	-56.7%	COM NEW	811292200
IQV	IQVIA HLDGS INC	4,400	$992K	0.3%	$217.58	0.0%	COM	46266C105
KPTI	KARYOPHARM THERAPEUTICS INC	134,566	$990K	0.3%	$8.54	-28.4%	COM NEW	48576U205
CORT	CORCEPT THERAPEUTICS INC	22,000	$766K	0.2%	$78.55	0.0%	COM	218352102