Avidity Partners Management LP Quant / Systematic

CIK: 0001791827 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $439,395 (100.0% shares, 0.0% debt)

Holdings (43)

DNTH DIANTHUS THERAPEUTICS INC 28.7%

Value ($000) $126,085 Shares 3,204,184 Est. Cost $21.50 Unrealized +18.9%

CGON CG ONCOLOGY INC 14.7%

Value ($000) $64,484 Shares 1,600,899 Est. Cost $33.90 Unrealized -14.2%

MDT MEDTRONIC PLC 4.1%

Value ($000) $18,153 Shares 190,600 Est. Cost $91.27 Unrealized 0.0%

BSX BOSTON SCIENTIFIC CORP 3.7%

Value ($000) $16,041 Shares 164,300 Est. Cost $49.10 Unrealized +110.9%

ORKA ORUKA THERAPEUTICS INC 2.9%

Value ($000) $12,700 Shares 660,424 Est. Cost $25.47 Unrealized -41.8%

BMY BRISTOL-MYERS SQUIBB CO 2.6%

Value ($000) $11,618 Shares 257,600 Est. Cost $45.51 Unrealized 0.0%

NTRA NATERA INC 2.6%

Value ($000) $11,332 Shares 70,400 Est. Cost $95.53 Unrealized +65.6%

DHR DANAHER CORPORATION 2.5%

Value ($000) $10,845 Shares 54,700 Est. Cost $205.28 Unrealized -3.4%

TEVA TEVA PHARMACEUTICAL INDS LTD 2.3%

Value ($000) $10,302 Shares 510,000 Est. Cost $15.79 Unrealized —

CATX PERSPECTIVE THERAPEUTICS INC 2.3%

Value ($000) $10,270 Shares 2,994,033 Est. Cost $10.27 Unrealized -64.5%

JBIO JADE BIOSCIENCES INC 2.2%

Value ($000) $9,728 Shares 1,127,186 Est. Cost $33.31 Unrealized -75.5%

PFE PFIZER INC 2.1%

Value ($000) $9,336 Shares 366,400 Est. Cost $24.14 Unrealized 0.0%

TMO THERMO FISHER SCIENTIFIC INC 2.1%

Value ($000) $9,167 Shares 18,900 Est. Cost $475.70 Unrealized -2.3%

CNTX CONTEXT THERAPEUTICS INC 2.0%

Value ($000) $8,702 Shares 8,981,855 Est. Cost $1.57 Unrealized -48.4%

GMAB GENMAB A/S 1.7%

Value ($000) $7,609 Shares 248,100 Est. Cost $20.66 Unrealized —

— METSERA INC 1.7%

Value ($000) $7,352 Shares 140,500 Est. Cost $52.33 Unrealized —

UNH UNITEDHEALTH GROUP INC 1.4%

Value ($000) $6,146 Shares 17,800 Est. Cost $548.30 Unrealized -45.5%

ARVN ARVINAS INC 1.4%

Value ($000) $5,950 Shares 698,363 Est. Cost $21.58 Unrealized -64.9%

COR CENCORA INC 1.4%

Value ($000) $5,938 Shares 19,000 Est. Cost $249.56 Unrealized +17.6%

EHC ENCOMPASS HEALTH CORP 1.2%

Value ($000) $5,322 Shares 41,900 Est. Cost $113.68 Unrealized +4.4%

JNJ JOHNSON & JOHNSON 1.1%

Value ($000) $4,969 Shares 26,800 Est. Cost $169.51 Unrealized 0.0%

CI THE CIGNA GROUP 1.1%

Value ($000) $4,785 Shares 16,600 Est. Cost $293.19 Unrealized 0.0%

ABBV ABBVIE INC 1.0%

Value ($000) $4,584 Shares 19,800 Est. Cost $201.95 Unrealized 0.0%

MCK MCKESSON CORP 1.0%

Value ($000) $4,481 Shares 5,800 Est. Cost $703.74 Unrealized -0.1%

CARL CARLSMED INC 1.0%

Value ($000) $4,310 Shares 321,912 Est. Cost $13.67 Unrealized 0.0%

KVUE KENVUE INC 1.0%

Value ($000) $4,304 Shares 265,200 Est. Cost $20.06 Unrealized 0.0%

IMUX IMMUNIC INC 0.9%

Value ($000) $4,143 Shares 4,699,411 Est. Cost $1.22 Unrealized -27.7%

ARQT ARCUTIS BIOTHERAPEUTICS INC 0.9%

Value ($000) $4,041 Shares 214,400 Est. Cost $14.02 Unrealized +12.5%

EXAS EXACT SCIENCES CORP 0.9%

Value ($000) $4,027 Shares 73,600 Est. Cost $55.79 Unrealized -10.4%

PHAT PHATHOM PHARMACEUTICALS INC 0.8%

Value ($000) $3,602 Shares 306,000 Est. Cost $16.93 Unrealized -39.0%

RGEN REPLIGEN CORP 0.7%

Value ($000) $3,115 Shares 23,300 Est. Cost $127.25 Unrealized -4.5%

ACAD ACADIA PHARMACEUTICALS INC 0.7%

Value ($000) $3,073 Shares 144,000 Est. Cost $23.65 Unrealized 0.0%

ASND ASCENDIS PHARMA A/S 0.7%

Value ($000) $2,883 Shares 14,500 Est. Cost $198.81 Unrealized —

ELVN ENLIVEN THERAPEUTICS INC 0.7%

Value ($000) $2,872 Shares 140,300 Est. Cost $20.27 Unrealized -0.5%

BEAM BEAM THERAPEUTICS INC 0.6%

Value ($000) $2,718 Shares 112,000 Est. Cost $26.20 Unrealized -24.1%

SCYX SCYNEXIS INC 0.6%

Value ($000) $2,580 Shares 3,350,528 Est. Cost $1.57 Unrealized -46.1%

HQY HEALTHEQUITY INC 0.5%

Value ($000) $2,398 Shares 25,300 Est. Cost $101.38 Unrealized -7.2%

WVE WAVE LIFE SCIENCES LTD 0.5%

Value ($000) $2,178 Shares 297,500 Est. Cost $8.09 Unrealized 0.0%

XENE XENON PHARMACEUTICALS INC 0.5%

Value ($000) $2,144 Shares 53,400 Est. Cost $37.48 Unrealized -6.0%

— AKERO THERAPEUTICS INC 0.4%

Value ($000) $1,923 Shares 40,500 Est. Cost $42.50 Unrealized —

INSM INSMED INC 0.4%

Value ($000) $1,671 Shares 11,600 Est. Cost $48.37 Unrealized +153.3%

KPTI KARYOPHARM THERAPEUTICS INC 0.2%

Value ($000) $880 Shares 134,566 Est. Cost $8.54 Unrealized -37.0%

IMRX IMMUNEERING CORP 0.1%

Value ($000) $636 Shares 90,900 Est. Cost $5.19 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
DNTH	DIANTHUS THERAPEUTICS INC	3,204,184	$126,085	28.7%	$21.50	+18.9%	COM	252828108
CGON	CG ONCOLOGY INC	1,600,899	$64,484	14.7%	$33.90	-14.2%	COM	156944100
MDT	MEDTRONIC PLC	190,600	$18,153	4.1%	$91.27	0.0%	SHS	G5960L103
BSX	BOSTON SCIENTIFIC CORP	164,300	$16,041	3.7%	$49.10	+110.9%	COM	101137107
ORKA	ORUKA THERAPEUTICS INC	660,424	$12,700	2.9%	$25.47	-41.8%	COM	687604108
BMY	BRISTOL-MYERS SQUIBB CO	257,600	$11,618	2.6%	$45.51	0.0%	COM	110122108
NTRA	NATERA INC	70,400	$11,332	2.6%	$95.53	+65.6%	COM	632307104
DHR	DANAHER CORPORATION	54,700	$10,845	2.5%	$205.28	-3.4%	COM	235851102
TEVA	TEVA PHARMACEUTICAL INDS LTD	510,000	$10,302	2.3%	$15.79	—	SPONSORED ADS	881624209
CATX	PERSPECTIVE THERAPEUTICS INC	2,994,033	$10,270	2.3%	$10.27	-64.5%	COM NEW	46489V302
JBIO	JADE BIOSCIENCES INC	1,127,186	$9,728	2.2%	$33.31	-75.5%	COM NEW	008064206
PFE	PFIZER INC	366,400	$9,336	2.1%	$24.14	0.0%	COM	717081103
TMO	THERMO FISHER SCIENTIFIC INC	18,900	$9,167	2.1%	$475.70	-2.3%	COM	883556102
CNTX	CONTEXT THERAPEUTICS INC	8,981,855	$8,702	2.0%	$1.57	-48.4%	COM	21077P108
GMAB	GENMAB A/S	248,100	$7,609	1.7%	$20.66	—	SPONSORED ADS	372303206
—	METSERA INC	140,500	$7,352	1.7%	$52.33	—	COM	59267L107
UNH	UNITEDHEALTH GROUP INC	17,800	$6,146	1.4%	$548.30	-45.5%	COM	91324P102
ARVN	ARVINAS INC	698,363	$5,950	1.4%	$21.58	-64.9%	COM	04335A105
COR	CENCORA INC	19,000	$5,938	1.4%	$249.56	+17.6%	COM	03073E105
EHC	ENCOMPASS HEALTH CORP	41,900	$5,322	1.2%	$113.68	+4.4%	COM	29261A100
JNJ	JOHNSON & JOHNSON	26,800	$4,969	1.1%	$169.51	0.0%	COM	478160104
CI	THE CIGNA GROUP	16,600	$4,785	1.1%	$293.19	0.0%	COM	125523100
ABBV	ABBVIE INC	19,800	$4,584	1.0%	$201.95	0.0%	COM	00287Y109
MCK	MCKESSON CORP	5,800	$4,481	1.0%	$703.74	-0.1%	COM	58155Q103
CARL	CARLSMED INC	321,912	$4,310	1.0%	$13.67	0.0%	COM	14280C105
KVUE	KENVUE INC	265,200	$4,304	1.0%	$20.06	0.0%	COM	49177J102
IMUX	IMMUNIC INC	4,699,411	$4,143	0.9%	$1.22	-27.7%	COM	4525EP101
ARQT	ARCUTIS BIOTHERAPEUTICS INC	214,400	$4,041	0.9%	$14.02	+12.5%	COM	03969K108
EXAS	EXACT SCIENCES CORP	73,600	$4,027	0.9%	$55.79	-10.4%	COM	30063P105
PHAT	PHATHOM PHARMACEUTICALS INC	306,000	$3,602	0.8%	$16.93	-39.0%	COM	71722W107
RGEN	REPLIGEN CORP	23,300	$3,115	0.7%	$127.25	-4.5%	COM	759916109
ACAD	ACADIA PHARMACEUTICALS INC	144,000	$3,073	0.7%	$23.65	0.0%	COM	004225108
ASND	ASCENDIS PHARMA A/S	14,500	$2,883	0.7%	$198.81	—	SPONSORED ADR	04351P101
ELVN	ENLIVEN THERAPEUTICS INC	140,300	$2,872	0.7%	$20.27	-0.5%	COM	29337E102
BEAM	BEAM THERAPEUTICS INC	112,000	$2,718	0.6%	$26.20	-24.1%	COM	07373V105
SCYX	SCYNEXIS INC	3,350,528	$2,580	0.6%	$1.57	-46.1%	COM NEW	811292200
HQY	HEALTHEQUITY INC	25,300	$2,398	0.5%	$101.38	-7.2%	COM	42226A107
WVE	WAVE LIFE SCIENCES LTD	297,500	$2,178	0.5%	$8.09	0.0%	SHS	Y95308105
XENE	XENON PHARMACEUTICALS INC	53,400	$2,144	0.5%	$37.48	-6.0%	COM	98420N105
—	AKERO THERAPEUTICS INC	40,500	$1,923	0.4%	$42.50	—	COM	00973Y108
INSM	INSMED INC	11,600	$1,671	0.4%	$48.37	+153.3%	COM PAR $.01	457669307
KPTI	KARYOPHARM THERAPEUTICS INC	134,566	$880	0.2%	$8.54	-37.0%	COM NEW	48576U205
IMRX	IMMUNEERING CORP	90,900	$636	0.1%	$5.19	0.0%	CLASS A COM	45254E107