| venBio Partners LLC | 9,699,925 | $10,961 |
| Redmile Group, LLC | 3,264,718 | $3,689 |
| MILLENNIUM MANAGEMENT LLC | 3,204,619 | $3,621 |
| Almitas Capital LLC | 2,536,891 | $2,867 |
| VANGUARD GROUP INC | 1,630,940 | $1,843 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,422,882 | $1,608 |
| ACADIAN ASSET MANAGEMENT LLC | 1,374,273 | $2 |
| UBS Group AG | 865,991 | $979 |
| TWO SIGMA ADVISERS, LP | 710,400 | $803 |
| TWO SIGMA INVESTMENTS, LP | 640,205 | $723 |
| BANK OF AMERICA CORP /DE/ | 531,845 | $601 |
| BANK OF MONTREAL /CAN/ | 474,781 | $537 |
| BlackRock, Inc. | 450,430 | $509 |
| RENAISSANCE TECHNOLOGIES LLC | 423,099 | $478 |
| GEODE CAPITAL MANAGEMENT, LLC | 353,696 | $400 |
| JANE STREET GROUP, LLC | 185,961 | $210 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,027 | $171 |
| NORTHERN TRUST CORP | 149,097 | $168 |
| STATE STREET CORP | 124,228 | $140 |
| Seven Fleet Capital Management LP | 117,817 | $133 |
| BANK OF NOVA SCOTIA | 105,858 | $120 |
| GSA CAPITAL PARTNERS LLP | 92,654 | $0 |
| IEQ CAPITAL, LLC | 92,233 | $104 |
| MORGAN STANLEY | 83,757 | $95 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 76,072 | $86 |
| CITADEL ADVISORS LLC | 56,732 | $64 |
| NAN FUNG TRINITY (HK) LTD | 41,950 | $47 |
| DekaBank Deutsche Girozentrale | 41,000 | $1 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 37,992 | $41 |
| Callan Family Office, LLC | 28,308 | $32 |
| MARSHALL WACE, LLP | 26,376 | $30 |
| HC Advisors, LLC | 23,900 | $27 |
| Point72 Asset Management, L.P. | 20,217 | $23 |
| JSF Financial, LLC | 17,500 | $20 |
| GOLDMAN SACHS GROUP INC | 17,262 | $20 |
| NINE MASTS CAPITAL Ltd | 15,475 | $17 |
| MONETA GROUP INVESTMENT ADVISORS LLC | 15,196 | $17 |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,102 | $17 |
| Virtu Financial LLC | 13,702 | $0 |
| Lido Advisors, LLC | 13,220 | $24 |
| FMR LLC | 12,986 | $15 |
| Abel Hall, LLC | 12,598 | $14 |
| BARCLAYS PLC | 10,515 | $12 |
| HSBC HOLDINGS PLC | 10,105 | $12 |
| SIMPLEX TRADING, LLC | 3,553 | $4 |
| Tower Research Capital LLC (TRC) | 3,142 | $4 |
| Torren Management, LLC | 1,632 | $2 |
| NISA INVESTMENT ADVISORS, LLC | 1,106 | $1 |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | $1 |
| ROYAL BANK OF CANADA | 963 | $1 |
| GROUP ONE TRADING, L.P. | 518 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 480 | $1 |
| SBI Securities Co., Ltd. | 412 | $0 |
| PNC Financial Services Group, Inc. | 100 | $0 |
| JPMORGAN CHASE & CO | 99 | $0 |
| CWM, LLC | 96 | $0 |
| Optiver Holding B.V. | 27 | $0 |