| Pfizer Inc | 22,032,040 | $30,184 |
| TPG GP A, LLC | 18,716,306 | $25,641 |
| BlackRock, Inc. | 17,676,029 | $24,216 |
| CITADEL ADVISORS LLC | 12,111,420 | $16,593 |
| VANGUARD GROUP INC | 9,251,609 | $12,675 |
| PRIMECAP MANAGEMENT CO/CA/ | 8,139,840 | $11,152 |
| Patient Square Capital LP | 4,963,756 | $6,800 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,932,910 | $5,389 |
| Frazier Life Sciences Management, L.P. | 3,868,750 | $5,300 |
| Woodline Partners LP | 3,500,499 | $4,796 |
| TWO SIGMA INVESTMENTS, LP | 3,423,441 | $4,690 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,209,275 | $4 |
| Wildcat Capital Management, LLC | 2,920,787 | $4,001 |
| TWO SIGMA ADVISERS, LP | 2,890,200 | $3,960 |
| STATE STREET CORP | 2,761,400 | $3,783 |
| Kalehua Capital Management LLC | 2,546,129 | $3,488 |
| Candriam S.C.A. | 2,305,644 | $3,159 |
| GOLDMAN SACHS GROUP INC | 2,289,458 | $3,137 |
| RENAISSANCE TECHNOLOGIES LLC | 2,187,084 | $2,996 |
| JANE STREET GROUP, LLC | 2,160,383 | $2,960 |
| abrdn plc | 2,086,332 | $2,858 |
| MILLENNIUM MANAGEMENT LLC | 1,841,307 | $2,523 |
| FMR LLC | 1,445,761 | $1,981 |
| AQR CAPITAL MANAGEMENT LLC | 1,429,247 | $1,958 |
| UBS Group AG | 1,389,593 | $1,904 |
| DAFNA Capital Management LLC | 1,380,118 | $1,891 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,355,809 | $1,857 |
| D. E. Shaw & Co., Inc. | 1,282,971 | $1,758 |
| NORTHERN TRUST CORP | 1,198,467 | $1,642 |
| BANK OF AMERICA CORP /DE/ | 1,007,328 | $1,380 |
| ACADIAN ASSET MANAGEMENT LLC | 995,141 | $1 |
| JPMORGAN CHASE & CO | 979,112 | $1,341 |
| DIMENSIONAL FUND ADVISORS LP | 957,816 | $1,312 |
| BNP PARIBAS ARBITRAGE, SA | 900,424 | $1,234 |
| Raiffeisen Bank International AG | 900,000 | $1,179 |
| MORGAN STANLEY | 703,138 | $963 |
| BARCLAYS PLC | 642,687 | $880 |
| GSA CAPITAL PARTNERS LLP | 613,998 | $1 |
| Invesco Ltd. | 609,807 | $835 |
| CITIGROUP INC | 591,952 | $811 |
| Man Group plc | 526,106 | $721 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 484,622 | $638 |
| XTX Topco Ltd | 476,307 | $653 |
| IEQ CAPITAL, LLC | 435,267 | $596 |
| TD Asset Management Inc | 414,074 | $567 |
| Bank of New York Mellon Corp | 405,843 | $556 |
| ALLIANCEBERNSTEIN L.P. | 296,498 | $406 |
| MARSHALL WACE, LLP | 285,561 | $391 |
| Quadrature Capital Ltd | 274,416 | $376 |
| Creative Planning | 273,384 | $375 |
| Nuveen, LLC | 272,007 | $373 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 250,000 | $343 |
| RHUMBLINE ADVISERS | 203,006 | $278 |
| WELLS FARGO & COMPANY/MN | 200,276 | $274 |
| ALGERT GLOBAL LLC | 196,400 | $0 |
| Harold Davidson & Associates Inc. | 194,753 | $267 |
| ZACKS INVESTMENT MANAGEMENT | 192,731 | $264 |
| Virtus Investment Advisers, LLC | 176,178 | $241 |
| LPL Financial LLC | 170,750 | $234 |
| OpenArc Corporate Advisory, LLC | 162,984 | $223 |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP | 161,597 | $221 |
| Graham Capital Management, L.P. | 148,671 | $204 |
| HSBC HOLDINGS PLC | 148,136 | $199 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 146,779 | $201 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 138,900 | $188 |
| DEUTSCHE BANK AG\ | 131,086 | $180 |
| Squarepoint Ops LLC | 104,656 | $143 |
| Point72 Asset Management, L.P. | 103,740 | $142 |
| NWI MANAGEMENT LP | 100,000 | $0 |
| Cerity Partners LLC | 97,909 | $134 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,253 | $125 |
| INTECH INVESTMENT MANAGEMENT LLC | 86,637 | $119 |
| R Squared Ltd | 86,215 | $118 |
| HRT FINANCIAL LP | 72,751 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,451 | $98 |
| TUDOR INVESTMENT CORP ET AL | 71,008 | $97 |
| Brevan Howard Capital Management LP | 70,429 | $96 |
| Vanguard Personalized Indexing Management, LLC | 67,788 | $93 |
| CWM, LLC | 62,738 | $0 |
| Vontobel Holding Ltd. | 62,080 | $85 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 55,583 | $78 |
| CAPTRUST FINANCIAL ADVISORS | 53,101 | $73 |
| Aquatic Capital Management LLC | 51,894 | $71 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 50,951 | $0 |
| Navalign, LLC | 49,398 | $68 |
| ROYAL BANK OF CANADA | 48,794 | $67 |
| SEI INVESTMENTS CO | 48,320 | $66 |
| Headlands Technologies LLC | 46,778 | $64 |
| Police & Firemen's Retirement System of New Jersey | 46,557 | $64 |
| Caitong International Asset Management Co., Ltd | 44,334 | $61 |
| Virtu Financial LLC | 42,351 | $0 |
| OSAIC HOLDINGS, INC. | 40,466 | $55 |
| Russell Investments Group, Ltd. | 40,041 | $55 |
| Connor, Clark & Lunn Investment Management Ltd. | 39,781 | $55 |
| CHOREO, LLC | 38,849 | $51 |
| CANADA PENSION PLAN INVESTMENT BOARD | 38,200 | $52 |
| ProShare Advisors LLC | 38,034 | $52 |
| China Universal Asset Management Co., Ltd. | 36,620 | $50 |
| Mariner, LLC | 36,493 | $49 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 35,970 | $44 |
| 70 other institutions | 650,000 | $827 |