Ticker: ACLX CUSIP: 03940C100 Class: Common Stock
Note: Option positions (PUT/CALL) are excluded.
| Institution | Shares | Value ($000) |
|---|---|---|
| Catalio Capital Management, LP | 156,109 | $10,178 |
| CLOUGH CAPITAL PARTNERS L P | 129,780 | $8,462 |
| Hood River Capital Management LLC | 335,500 | $21,875 |
| XTX Topco Ltd | 72,583 | $4,732 |
| Hudson Bay Capital Management LP | 400,942 | $26,141 |
| Shay Capital LLC | 11,400 | $743 |
| J. Goldman & Co LP | 31,219 | $2,035 |
| Candriam S.C.A. | 96,420 | $6,287 |
| Harbour Capital Advisors, LLC | 3,825 | $242 |
| Headlands Technologies LLC | 7,320 | $477 |
| Marks Group Wealth Management, Inc | 4,524 | $295 |
| TWINBEECH CAPITAL LP | 6,949 | $453 |
| Fisher Asset Management, LLC | 322,855 | $21,050 |
| ASPIRIANT, LLC | 7,910 | $516 |
| Qube Research & Technologies Ltd | 97,906 | $6,383 |
| Trexquant Investment LP | 14,915 | $972 |
| abrdn plc | 60,364 | $3,936 |
| TUDOR INVESTMENT CORP ET AL | 46,029 | $3,001 |
| Squarepoint Ops LLC | 49,875 | $3,252 |
| D. E. Shaw & Co., Inc. | 25,165 | $1,641 |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| STEMPOINT CAPITAL LP | 11,376 | 332,860 | +321,484 (+2826.0%) |
| Vestal Point Capital, LP | 1,250,000 | 2,925,000 | +1,675,000 (+134.0%) |
| Paradigm Biocapital Advisors LP | 4,649,016 | 5,724,016 | +1,075,000 (+23.1%) |
| Affinity Asset Advisors, LLC | 500,000 | 523,725 | +23,725 (+4.7%) |
| Rhenman & Partners Asset Management AB | 65,250 | 133,500 | +68,250 (+104.6%) |
| HealthInvest Partners AB | 25,732 | 41,717 | +15,985 (+62.1%) |
| Integral Health Asset Management, LLC | 150,000 | 200,000 | +50,000 (+33.3%) |
| Woodline Partners LP | 241,389 | 737,824 | +496,435 (+205.7%) |
| ExodusPoint Capital Management, LP | 9,446 | 217,424 | +207,978 (+2201.8%) |
| PROFUND ADVISORS LLC | 10,785 | 25,740 | +14,955 (+138.7%) |
| Brevan Howard Capital Management LP | 3,805 | 60,178 | +56,373 (+1481.6%) |
| Virtus Investment Advisers, LLC | 1,711 | 3,701 | +1,990 (+116.3%) |
| BAMCO INC /NY/ | 550,236 | 609,697 | +59,461 (+10.8%) |
| TEMA ETFS LLC | 36,809 | 39,314 | +2,505 (+6.8%) |
| Y-Intercept (Hong Kong) Ltd | 15,508 | 24,538 | +9,030 (+58.2%) |
| CITADEL ADVISORS LLC | 1,021,453 | 1,500,223 | +478,770 (+46.9%) |
| AlphaQuest LLC | 240 | 3,796 | +3,556 (+1481.7%) |
| JPMORGAN CHASE & CO | 882,503 | 1,454,477 | +571,974 (+64.8%) |
| STATE STREET CORP | 1,526,027 | 1,998,503 | +472,476 (+31.0%) |
| TD Asset Management Inc | 232,708 | 300,856 | +68,148 (+29.3%) |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| AJU IB Investment Co., Ltd. | 1,047,557 | 223,486 | -824,071 (-78.7%) |
| PERCEPTIVE ADVISORS LLC | 2,468,353 | 1,466,071 | -1,002,282 (-40.6%) |
| RA CAPITAL MANAGEMENT, L.P. | 3,036,527 | 1,267,156 | -1,769,371 (-58.3%) |
| HighVista Strategies LLC | 96,177 | 75,002 | -21,175 (-22.0%) |
| Logos Global Management LP | 165,000 | 115,000 | -50,000 (-30.3%) |
| Parkman Healthcare Partners LLC | 149,848 | 128,111 | -21,737 (-14.5%) |
| Samsara BioCapital, LLC | 81,165 | 60,873 | -20,292 (-25.0%) |
| Soleus Capital Management, L.P. | 100,000 | 30,000 | -70,000 (-70.0%) |
| Schonfeld Strategic Advisors LLC | 500,315 | 99,131 | -401,184 (-80.2%) |
| Rock Springs Capital Management LP | 178,982 | 169,859 | -9,123 (-5.1%) |
| T. Rowe Price Investment Management, Inc. | 6,352,356 | 5,653,523 | -698,833 (-11.0%) |
| Pier Capital, LLC | 60,215 | 59,063 | -1,152 (-1.9%) |
| FMR LLC | 5,761,317 | 3,563,728 | -2,197,589 (-38.1%) |
| Pictet Asset Management Holding SA | 420,805 | 342,612 | -78,193 (-18.6%) |
| Voya Investment Management LLC | 247,408 | 168,680 | -78,728 (-31.8%) |
| VICTORY CAPITAL MANAGEMENT INC | 172,049 | 54,872 | -117,177 (-68.1%) |
| DEUTSCHE BANK AG\ | 399,319 | 233,592 | -165,727 (-41.5%) |
| JANUS HENDERSON GROUP PLC | 1,013,921 | 919,578 | -94,343 (-9.3%) |
| Caption Management, LLC | 12,600 | 1,825 | -10,775 (-85.5%) |
| BNP PARIBAS ARBITRAGE, SA | 68,833 | 3,605 | -65,228 (-94.8%) |
| Institution | Prev Shares | Prev Value ($000) |
|---|---|---|
| PATHWAY CAPITAL MANAGEMENT, LP | 51,051 | $4,191 |
| Cormorant Asset Management, LP | 775,000 | $63,628 |
| First Turn Management, LLC | 313,733 | $25,757 |
| Blue Owl Capital Holdings LP | 26,823 | $2,202 |
| SECTOR GAMMA AS | 32,009 | $2,628 |
| Monaco Asset Management SAM | 78,589 | $6,452 |
| Nicholas Investment Partners, LP | 58,894 | $4,835 |
| DARK FOREST CAPITAL MANAGEMENT LP | 36,794 | $3,021 |
| BAKER BROS. ADVISORS LP | 166,825 | $13,696 |
| SummitTX Capital, L.P. | 25,448 | $2,089 |
| Cinctive Capital Management LP | 13,626 | $1,119 |
| Quarry LP | 3,376 | $277 |
| Lighthouse Investment Partners, LLC | 10,500 | $862 |
| Jain Global LLC | 50,011 | $4,106 |
| Capital World Investors | 783,011 | $64,285 |
| ALPS ADVISORS INC | 25,188 | $2,068 |
| BALYASNY ASSET MANAGEMENT L.P. | 48,691 | $3,998 |
| Aquatic Capital Management LLC | 5,232 | $430 |
| Jefferies Financial Group Inc. | 10,500 | $862 |
| FRED ALGER MANAGEMENT, LLC | 11,895 | $977 |