| GILEAD SCIENCES, INC. | 6,720,803 | $438,196 |
| Paradigm Biocapital Advisors LP | 5,724,016 | $373,206 |
| T. Rowe Price Investment Management, Inc. | 5,653,523 | $369 |
| VANGUARD GROUP INC | 4,081,519 | $266,115 |
| FMR LLC | 3,563,728 | $232,355 |
| BlackRock, Inc. | 3,548,787 | $231,381 |
| NEA Management Company, LLC | 3,045,262 | $198,551 |
| Vestal Point Capital, LP | 2,925,000 | $190,710 |
| SR ONE CAPITAL MANAGEMENT, LP | 2,346,630 | $153,000 |
| STATE STREET CORP | 1,998,503 | $130,302 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,610,801 | $105 |
| CITADEL ADVISORS LLC | 1,500,223 | $97,815 |
| PERCEPTIVE ADVISORS LLC | 1,466,071 | $95,588 |
| JPMORGAN CHASE & CO | 1,454,477 | $94,832 |
| RA CAPITAL MANAGEMENT, L.P. | 1,267,156 | $82,619 |
| GEODE CAPITAL MANAGEMENT, LLC | 958,057 | $62,479 |
| JANUS HENDERSON GROUP PLC | 919,578 | $59,958 |
| Woodline Partners LP | 737,824 | $48,106 |
| GOLDMAN SACHS GROUP INC | 668,480 | $43,585 |
| BAMCO INC /NY/ | 609,697 | $39,752 |
| Affinity Asset Advisors, LLC | 523,725 | $34,147 |
| MORGAN STANLEY | 518,404 | $33,800 |
| LORD, ABBETT & CO. LLC | 449,634 | $29 |
| BANK OF AMERICA CORP /DE/ | 427,769 | $27,891 |
| AMERICAN CENTURY COMPANIES INC | 419,080 | $27,324 |
| Hudson Bay Capital Management LP | 400,942 | $26,141 |
| Pictet Asset Management Holding SA | 342,612 | $22,338 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 339,813 | $22,156 |
| Hood River Capital Management LLC | 335,500 | $21,875 |
| STEMPOINT CAPITAL LP | 332,860 | $21,702 |
| Fisher Asset Management, LLC | 322,855 | $21,050 |
| NORTHERN TRUST CORP | 321,793 | $20,981 |
| UBS Group AG | 316,612 | $20,643 |
| TD Asset Management Inc | 300,856 | $19,616 |
| DEUTSCHE BANK AG\ | 233,592 | $15,230 |
| AJU IB Investment Co., Ltd. | 223,486 | $14,571 |
| ExodusPoint Capital Management, LP | 217,424 | $14,176 |
| WELLINGTON MANAGEMENT GROUP LLP | 214,776 | $14,003 |
| Integral Health Asset Management, LLC | 200,000 | $13,040 |
| BARCLAYS PLC | 196,772 | $12,830 |
| Rock Springs Capital Management LP | 169,859 | $11,075 |
| Voya Investment Management LLC | 168,680 | $10,998 |
| UBS ASSET MANAGEMENT AMERICAS INC | 161,035 | $10,499 |
| CITIGROUP INC | 156,519 | $10,205 |
| Catalio Capital Management, LP | 156,109 | $10,178 |
| Rhenman & Partners Asset Management AB | 133,500 | $8,704 |
| Russell Investments Group, Ltd. | 130,520 | $8,510 |
| CLOUGH CAPITAL PARTNERS L P | 129,780 | $8,462 |
| Parkman Healthcare Partners LLC | 128,111 | $8,353 |
| Bank of New York Mellon Corp | 123,171 | $8,031 |
| RAYMOND JAMES FINANCIAL INC | 122,346 | $7,788 |
| Logos Global Management LP | 115,000 | $7,498 |
| Schonfeld Strategic Advisors LLC | 99,131 | $6,463 |
| Qube Research & Technologies Ltd | 97,906 | $6,383 |
| Candriam S.C.A. | 96,420 | $6,287 |
| Nuveen, LLC | 81,944 | $5,343 |
| HighVista Strategies LLC | 75,002 | $4,890 |
| XTX Topco Ltd | 72,583 | $4,732 |
| Rafferty Asset Management, LLC | 69,515 | $4,532 |
| AMERIPRISE FINANCIAL INC | 69,156 | $4,509 |
| Samsara BioCapital, LLC | 60,873 | $3,969 |
| abrdn plc | 60,364 | $3,936 |
| Brevan Howard Capital Management LP | 60,178 | $3,924 |
| Pier Capital, LLC | 59,063 | $3,851 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,251 | $3,669 |
| VICTORY CAPITAL MANAGEMENT INC | 54,872 | $3,578 |
| Swiss National Bank | 54,700 | $3,566 |
| JANE STREET GROUP, LLC | 54,670 | $3,564 |
| WELLS FARGO & COMPANY/MN | 54,260 | $3,538 |
| Susquehanna Portfolio Strategies, LLC | 50,938 | $3,321 |
| Squarepoint Ops LLC | 49,875 | $3,252 |
| TUDOR INVESTMENT CORP ET AL | 46,029 | $3,001 |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 45,480 | $2,965 |
| RHUMBLINE ADVISERS | 44,352 | $2,892 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 42,478 | $2,702 |
| HealthInvest Partners AB | 41,717 | $2,720 |
| ALLIANCEBERNSTEIN L.P. | 40,791 | $2,660 |
| Invesco Ltd. | 40,372 | $2,632 |
| NEOS Investment Management LLC | 39,904 | $2,602 |
| TEMA ETFS LLC | 39,314 | $2,563 |
| ADAR1 Capital Management, LLC | 31,484 | $2,053 |
| J. Goldman & Co LP | 31,219 | $2,035 |
| DekaBank Deutsche Girozentrale | 30,000 | $2 |
| Soleus Capital Management, L.P. | 30,000 | $1,956 |
| Legal & General Group Plc | 29,565 | $1,928 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,115 | $1,768 |
| CONGRESS ASSET MANAGEMENT CO /MA | 25,999 | $1,695 |
| PROFUND ADVISORS LLC | 25,740 | $1,678 |
| D. E. Shaw & Co., Inc. | 25,165 | $1,641 |
| Y-Intercept (Hong Kong) Ltd | 24,538 | $1,600 |
| HARBOR CAPITAL ADVISORS, INC. | 24,121 | $2 |
| Erste Asset Management GmbH | 21,000 | $1,368 |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,918 | $1,364 |
| FIRST TRUST ADVISORS LP | 20,896 | $1,362 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,002 | $1,298 |
| MetLife Investment Management, LLC | 19,344 | $1,261 |
| STRS OHIO | 16,869 | $1,100 |
| PRUDENTIAL FINANCIAL INC | 16,720 | $1,090 |
| NORGES BANK | 16,707 | $1,089 |
| SEI INVESTMENTS CO | 15,668 | $1,022 |
| 116 other institutions | 420,237 | $25,354 |