BLACK DIAMOND THERAPEUTICS I

Institution	Shares	Value ($000)
Verdad Advisers, LP	96,286	$234
AlphaCentric Advisors LLC	53,625	$130
OXFORD ASSET MANAGEMENT LLP	114,383	$278
WINTON GROUP Ltd	421,280	$1,024
683 Capital Management, LLC	247,958	$603
Round Rock Advisors, LLC	79,539	$193
J. Goldman & Co LP	270,000	$656
SHERBROOKE PARK ADVISERS LLC	12,052	$29
RB Capital Management, LLC	35,000	$85
HCR Wealth Advisors	27,000	$66
MACKENZIE FINANCIAL CORP	352,454	$876
CITADEL ADVISORS LLC	425,459	$1,034
Point72 Asset Management, L.P.	196,741	$478
CANADA PENSION PLAN INVESTMENT BOARD	203,100	$494
Lighthouse Investment Partners, LLC	31,200	$76
SUSQUEHANNA INTERNATIONAL GROUP, LLP	104,724	$254
Jump Financial, LLC	39,026	$95
Stokes Family Office, LLC	11,077	$27
China Universal Asset Management Co., Ltd.	9,284	$23
Tower Research Capital LLC (TRC)	8,396	$20

Increased Positions (36)

State of Wyoming

Value ($000) $171 (+85.7%) Shares 70,343 (+189.6%)

nVerses Capital, LLC

Value ($000) $26 (+39.3%) Shares 10,722 (+149.3%)

AWM Investment Company, Inc.

Value ($000) $1,519 (-33.2%) Shares 625,000 (+4.2%)

GSA CAPITAL PARTNERS LLP

Value ($000) $1 (+28.4%) Shares 245,721 (+100.2%)

TWO SIGMA SECURITIES, LLC

Value ($000) $99 (+77.8%) Shares 40,538 (+177.4%)

Connor, Clark & Lunn Investment Management Ltd.

Value ($000) $1,591 (+218.9%) Shares 654,699 (+397.4%)

RITHOLTZ WEALTH MANAGEMENT

Value ($000) $554 (+44.0%) Shares 227,870 (+124.5%)

O'SHAUGHNESSY ASSET MANAGEMENT, LLC

Value ($000) $861 (+59.6%) Shares 354,454 (+148.8%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $421 (+13.0%) Shares 173,300 (+76.3%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $2,308 (+1.6%) Shares 949,735 (+58.4%)

D. E. Shaw & Co., Inc.

Value ($000) $1,594 (+192.7%) Shares 655,772 (+356.5%)

JANE STREET GROUP, LLC

Value ($000) $2,337 (+159.9%) Shares 961,776 (+305.3%)

OMERS ADMINISTRATION Corp

Value ($000) $338 (+709.6%) Shares 138,900 (+1162.7%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $2,083 (+20.6%) Shares 857,015 (+88.0%)

Graham Capital Management, L.P.

Value ($000) $210 (+52.0%) Shares 86,556 (+137.0%)

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

Value ($000) $2,528 (-25.6%) Shares 1,040,468 (+16.0%)

Qube Research & Technologies Ltd

Value ($000) $412 (+39.0%) Shares 169,618 (+116.7%)

Bank of New York Mellon Corp

Value ($000) $522 (+9.5%) Shares 214,671 (+70.8%)

FMR LLC

Value ($000) $1,315 (-23.5%) Shares 541,154 (+19.3%)

Man Group plc

Value ($000) $316 (+6.4%) Shares 130,033 (+66.0%)

Institution	Prev Shares	Curr Shares	Change
State of Wyoming	24,292	70,343	+46,051 (+189.6%)
nVerses Capital, LLC	4,300	10,722	+6,422 (+149.3%)
AWM Investment Company, Inc.	600,000	625,000	+25,000 (+4.2%)
GSA CAPITAL PARTNERS LLP	122,758	245,721	+122,963 (+100.2%)
TWO SIGMA SECURITIES, LLC	14,616	40,538	+25,922 (+177.4%)
Connor, Clark & Lunn Investment Management Ltd.	131,635	654,699	+523,064 (+397.4%)
RITHOLTZ WEALTH MANAGEMENT	101,479	227,870	+126,391 (+124.5%)
O'SHAUGHNESSY ASSET MANAGEMENT, LLC	142,439	354,454	+212,015 (+148.8%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	98,300	173,300	+75,000 (+76.3%)
RENAISSANCE TECHNOLOGIES LLC	599,400	949,735	+350,335 (+58.4%)
D. E. Shaw & Co., Inc.	143,643	655,772	+512,129 (+356.5%)
JANE STREET GROUP, LLC	237,273	961,776	+724,503 (+305.3%)
OMERS ADMINISTRATION Corp	11,000	138,900	+127,900 (+1162.7%)
DIMENSIONAL FUND ADVISORS LP	455,870	857,015	+401,145 (+88.0%)
Graham Capital Management, L.P.	36,521	86,556	+50,035 (+137.0%)
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	896,853	1,040,468	+143,615 (+16.0%)
Qube Research & Technologies Ltd	78,266	169,618	+91,352 (+116.7%)
Bank of New York Mellon Corp	125,672	214,671	+88,999 (+70.8%)
FMR LLC	453,558	541,154	+87,596 (+19.3%)
Man Group plc	78,326	130,033	+51,707 (+66.0%)

Decreased Positions (25)

Vestal Point Capital, LP

Value ($000) $2,114 (-89.9%) Shares 870,000 (-84.3%)

T. Rowe Price Investment Management, Inc.

Value ($000) $6 (-86.1%) Shares 2,332,222 (-78.3%)

XTX Topco Ltd

Value ($000) $291 (-64.5%) Shares 119,679 (-44.6%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $721 (-77.6%) Shares 296,556 (-65.1%)

UBS Group AG

Value ($000) $626 (-73.7%) Shares 257,633 (-59.0%)

Susquehanna Portfolio Strategies, LLC

Value ($000) $386 (-51.7%) Shares 158,984 (-24.7%)

MARSHALL WACE, LLP

Value ($000) $2,698 (-45.2%) Shares 1,110,088 (-14.6%)

BlackRock, Inc.

Value ($000) $2,158 (-44.6%) Shares 888,260 (-13.6%)

GOLDMAN SACHS GROUP INC

Value ($000) $791 (-53.5%) Shares 325,327 (-27.5%)

LPL Financial LLC

Value ($000) $90 (-65.7%) Shares 36,990 (-46.6%)

NORTHERN TRUST CORP

Value ($000) $1,149 (-37.9%) Shares 472,702 (-3.1%)

DLK Investment Management, LLC

Value ($000) $44 (-42.2%) Shares 18,200 (-9.9%)

WEBSTER BANK, N. A.

Value ($000) $5 (-78.6%) Shares 2,000 (-66.7%)

RAYMOND JAMES FINANCIAL INC

Value ($000) $33 (-49.8%) Shares 13,468 (-21.8%)

BARCLAYS PLC

Value ($000) $182 (-46.5%) Shares 74,810 (-4.3%)

GROUP ONE TRADING, L.P.

Value ($000) $4 (-76.3%) Shares 1,618 (-63.1%)

Squarepoint Ops LLC

Value ($000) $36 (-44.9%) Shares 14,752 (-14.1%)

Jefferies Financial Group Inc.

Value ($000) $53 (-39.1%) Shares 21,660 (-5.0%)

PRUDENTIAL FINANCIAL INC

Value ($000) $31 (-37.1%) Shares 12,850 (-1.9%)

FEDERATED HERMES, INC.

Value ($000) $12 (-38.2%) Shares 4,992 (-3.6%)

Institution	Prev Shares	Curr Shares	Change
Vestal Point Capital, LP	5,550,000	870,000	-4,680,000 (-84.3%)
T. Rowe Price Investment Management, Inc.	10,744,107	2,332,222	-8,411,885 (-78.3%)
XTX Topco Ltd	216,195	119,679	-96,516 (-44.6%)
MILLENNIUM MANAGEMENT LLC	850,331	296,556	-553,775 (-65.1%)
UBS Group AG	628,416	257,633	-370,783 (-59.0%)
Susquehanna Portfolio Strategies, LLC	211,082	158,984	-52,098 (-24.7%)
MARSHALL WACE, LLP	1,299,208	1,110,088	-189,120 (-14.6%)
BlackRock, Inc.	1,028,092	888,260	-139,832 (-13.6%)
GOLDMAN SACHS GROUP INC	449,018	325,327	-123,691 (-27.5%)
LPL Financial LLC	69,240	36,990	-32,250 (-46.6%)
NORTHERN TRUST CORP	488,064	472,702	-15,362 (-3.1%)
DLK Investment Management, LLC	20,200	18,200	-2,000 (-9.9%)
WEBSTER BANK, N. A.	6,000	2,000	-4,000 (-66.7%)
RAYMOND JAMES FINANCIAL INC	17,215	13,468	-3,747 (-21.8%)
BARCLAYS PLC	78,151	74,810	-3,341 (-4.3%)
GROUP ONE TRADING, L.P.	4,385	1,618	-2,767 (-63.1%)
Squarepoint Ops LLC	17,181	14,752	-2,429 (-14.1%)
Jefferies Financial Group Inc.	22,800	21,660	-1,140 (-5.0%)
PRUDENTIAL FINANCIAL INC	13,100	12,850	-250 (-1.9%)
FEDERATED HERMES, INC.	5,179	4,992	-187 (-3.6%)

Exited Positions (12)

TANG CAPITAL MANAGEMENT LLC

Value ($000) $7,846 Shares 2,070,209

DAFNA Capital Management LLC

Value ($000) $1,164 Shares 307,070

BROWN WEALTH MANAGEMENT, LLC

Value ($000) $79 Shares 20,932

Catalyst Funds Management Pty Ltd

Value ($000) $105 Shares 27,800

AQR CAPITAL MANAGEMENT LLC

Value ($000) $68 Shares 18,026

Quadrature Capital Ltd

Value ($000) $43 Shares 11,366

Rise Advisors, LLC

Value ($000) $2 Shares 646

Global Retirement Partners, LLC

Value ($000) $2 Shares 540

Cambridge Investment Research Advisors, Inc.

Value ($000) $0 Shares 64,521

Advisory Services Network, LLC

Value ($000) $0 Shares 67

Virtu Financial LLC

Value ($000) $0 Shares 10,415

NewEdge Advisors, LLC

Value ($000) $0 Shares 17

Institution	Prev Shares	Prev Value ($000)
TANG CAPITAL MANAGEMENT LLC	2,070,209	$7,846
DAFNA Capital Management LLC	307,070	$1,164
BROWN WEALTH MANAGEMENT, LLC	20,932	$79
Catalyst Funds Management Pty Ltd	27,800	$105
AQR CAPITAL MANAGEMENT LLC	18,026	$68
Quadrature Capital Ltd	11,366	$43
Rise Advisors, LLC	646	$2
Global Retirement Partners, LLC	540	$2
Cambridge Investment Research Advisors, Inc.	64,521	$0
Advisory Services Network, LLC	67	$0
Virtu Financial LLC	10,415	$0
NewEdge Advisors, LLC	17	$0