| Frazier Life Sciences Management, L.P. | 22,729,436 | $84,554 |
| VR Adviser, LLC | 17,857,083 | $66,428 |
| BlackRock, Inc. | 15,597,330 | $58,022 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,502,004 | $53,947 |
| Paradigm Biocapital Advisors LP | 14,159,095 | $52,672 |
| Logos Global Management LP | 13,000,000 | $48,360 |
| VANGUARD GROUP INC | 12,812,156 | $47,661 |
| ARCH Venture Management, LLC | 11,055,554 | $41,127 |
| Vivo Capital, LLC | 9,273,428 | $34,497 |
| Siren, L.L.C. | 8,757,249 | $32,577 |
| STATE STREET CORP | 6,174,642 | $22,970 |
| 5AM Venture Management, LLC | 5,405,404 | $20,108 |
| GEODE CAPITAL MANAGEMENT, LLC | 4,926,335 | $18,330 |
| T. Rowe Price Investment Management, Inc. | 4,786,825 | $18 |
| Affinity Asset Advisors, LLC | 3,900,000 | $14,508 |
| Spruce Street Capital LP | 3,889,632 | $14,469 |
| GOLDMAN SACHS GROUP INC | 3,331,418 | $12,393 |
| a16z Capital Management, L.L.C. | 2,862,500 | $10,649 |
| MILLENNIUM MANAGEMENT LLC | 2,237,951 | $8,325 |
| Soleus Capital Management, L.P. | 2,162,162 | $8,043 |
| Woodline Partners LP | 1,930,642 | $7,182 |
| DIMENSIONAL FUND ADVISORS LP | 1,775,685 | $6,602 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,673,404 | $6,225 |
| BANK OF AMERICA CORP /DE/ | 1,611,850 | $5,996 |
| ExodusPoint Capital Management, LP | 1,490,967 | $5,546 |
| NORTHERN TRUST CORP | 1,331,508 | $4,953 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,317,584 | $4,901 |
| JPMORGAN CHASE & CO | 1,153,090 | $4,289 |
| CITADEL ADVISORS LLC | 1,030,345 | $3,833 |
| Rock Springs Capital Management LP | 951,710 | $3,540 |
| JANE STREET GROUP, LLC | 912,519 | $3,395 |
| TANG CAPITAL MANAGEMENT LLC | 900,000 | $3,348 |
| RENAISSANCE TECHNOLOGIES LLC | 850,100 | $3,162 |
| MORGAN STANLEY | 810,385 | $3,015 |
| Ikarian Capital, LLC | 735,396 | $2,736 |
| AQR CAPITAL MANAGEMENT LLC | 669,876 | $2,492 |
| Bank of New York Mellon Corp | 546,776 | $2,034 |
| WELLINGTON MANAGEMENT GROUP LLP | 543,196 | $2,021 |
| HRT FINANCIAL LP | 536,909 | $2 |
| FMR LLC | 521,455 | $1,940 |
| Nuveen, LLC | 424,713 | $1,580 |
| BARCLAYS PLC | 402,796 | $1,498 |
| Creative Planning | 381,695 | $1,420 |
| SIMPLEX TRADING, LLC | 346,072 | $1,287 |
| Invesco Ltd. | 329,795 | $1,227 |
| Squarepoint Ops LLC | 258,275 | $961 |
| DAFNA Capital Management LLC | 254,436 | $947 |
| TD Asset Management Inc | 229,840 | $855 |
| WELLS FARGO & COMPANY/MN | 220,132 | $819 |
| ALLIANCEBERNSTEIN L.P. | 208,810 | $777 |
| D. E. Shaw & Co., Inc. | 201,938 | $751 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199,788 | $743 |
| RHUMBLINE ADVISERS | 189,012 | $703 |
| BOOTHBAY FUND MANAGEMENT, LLC | 188,467 | $701 |
| UBS Group AG | 170,531 | $634 |
| AMERICAN CENTURY COMPANIES INC | 165,359 | $615 |
| Hudson Bay Capital Management LP | 158,020 | $588 |
| RTW INVESTMENTS, LP | 146,651 | $546 |
| Palumbo Wealth Management LLC | 139,385 | $519 |
| Rafferty Asset Management, LLC | 131,019 | $487 |
| DEUTSCHE BANK AG\ | 121,977 | $454 |
| PANAGORA ASSET MANAGEMENT INC | 118,218 | $440 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 103,503 | $0 |
| BALYASNY ASSET MANAGEMENT L.P. | 98,073 | $365 |
| CITIGROUP INC | 95,770 | $356 |
| INTECH INVESTMENT MANAGEMENT LLC | 90,720 | $337 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88,232 | $327 |
| MetLife Investment Management, LLC | 80,368 | $299 |
| Cresset Asset Management, LLC | 79,913 | $297 |
| Virtus Investment Advisers, LLC | 73,896 | $275 |
| Scientech Research LLC | 72,203 | $269 |
| MARSHALL WACE, LLP | 61,960 | $230 |
| Cerity Partners LLC | 61,536 | $229 |
| IEQ CAPITAL, LLC | 60,346 | $224 |
| Susquehanna Portfolio Strategies, LLC | 59,087 | $220 |
| NEW YORK STATE COMMON RETIREMENT FUND | 55,559 | $207 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 54,769 | $204 |
| TUDOR INVESTMENT CORP ET AL | 53,436 | $199 |
| Brevan Howard Capital Management LP | 52,731 | $196 |
| PROFUND ADVISORS LLC | 50,605 | $188 |
| SG Americas Securities, LLC | 48,677 | $0 |
| China Universal Asset Management Co., Ltd. | 46,231 | $172 |
| ProShare Advisors LLC | 44,216 | $164 |
| Police & Firemen's Retirement System of New Jersey | 44,030 | $164 |
| Jain Global LLC | 42,336 | $157 |
| TWO SIGMA INVESTMENTS, LP | 38,024 | $141 |
| BAILARD, INC. | 35,238 | $131 |
| Vanguard Personalized Indexing Management, LLC | 34,659 | $129 |
| CWM, LLC | 33,605 | $0 |
| Voya Investment Management LLC | 33,187 | $123 |
| BNP PARIBAS ARBITRAGE, SA | 32,486 | $121 |
| EP Wealth Advisors, LLC | 30,000 | $112 |
| Y-Intercept (Hong Kong) Ltd | 24,311 | $90 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22,505 | $82 |
| AXQ CAPITAL, LP | 20,459 | $76 |
| VICTORY CAPITAL MANAGEMENT INC | 18,391 | $68 |
| CAPTRUST FINANCIAL ADVISORS | 17,606 | $65 |
| QUADRANT CAPITAL GROUP LLC | 17,546 | $65 |
| SEI INVESTMENTS CO | 16,682 | $62 |
| Abel Hall, LLC | 15,682 | $58 |
| 53 other institutions | 341,883 | $1,239 |