| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | $154,418 |
| JANUS HENDERSON GROUP PLC | 5,350,453 | $73,850 |
| BlackRock, Inc. | 4,080,200 | $56,307 |
| STATE STREET CORP | 3,853,951 | $53,185 |
| FMR LLC | 3,512,384 | $48,471 |
| VANGUARD GROUP INC | 2,906,386 | $40,108 |
| Prosight Management, LP | 2,392,523 | $33,017 |
| ORBIMED ADVISORS LLC | 1,954,426 | $26,971 |
| TCG Crossover Management, LLC | 1,789,617 | $24,697 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,610,186 | $22,221 |
| Alyeska Investment Group, L.P. | 1,301,089 | $17,955 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,113,582 | $15,371 |
| CITADEL ADVISORS LLC | 1,104,144 | $15,237 |
| GOLDMAN SACHS GROUP INC | 1,073,656 | $14,816 |
| Woodline Partners LP | 1,027,221 | $14,176 |
| Logos Global Management LP | 1,000,000 | $13,800 |
| Point72 Asset Management, L.P. | 961,819 | $13,273 |
| READYSTATE ASSET MANAGEMENT LP | 885,895 | $12,225 |
| BALYASNY ASSET MANAGEMENT L.P. | 885,551 | $12,221 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 744,466 | $10 |
| BANK OF AMERICA CORP /DE/ | 738,330 | $10,189 |
| Cormorant Asset Management, LP | 650,000 | $8,970 |
| MORGAN STANLEY | 618,385 | $8,534 |
| UBS Group AG | 590,060 | $8,143 |
| JANE STREET GROUP, LLC | 540,233 | $7,455 |
| TWO SIGMA INVESTMENTS, LP | 471,009 | $6,500 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | $5,520 |
| Squarepoint Ops LLC | 390,952 | $5,395 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 390,506 | $5,389 |
| FRANKLIN RESOURCES INC | 385,301 | $5,317 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 376,496 | $5,196 |
| University of Wisconsin Foundation | 362,000 | $4,996 |
| Rock Springs Capital Management LP | 358,798 | $4,951 |
| NORTHERN TRUST CORP | 340,406 | $4,698 |
| Walleye Capital LLC | 323,017 | $4,458 |
| MILLENNIUM MANAGEMENT LLC | 289,808 | $3,999 |
| Caption Management, LLC | 272,500 | $3,761 |
| Pictet Asset Management Holding SA | 272,251 | $3,757 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 267,051 | $3,693 |
| ADAR1 Capital Management, LLC | 245,452 | $3,387 |
| Rhenman & Partners Asset Management AB | 225,377 | $3,110 |
| DIMENSIONAL FUND ADVISORS LP | 224,294 | $3,095 |
| BARCLAYS PLC | 221,233 | $3,053 |
| Qube Research & Technologies Ltd | 216,005 | $2,981 |
| ALGERT GLOBAL LLC | 183,367 | $3 |
| Rafferty Asset Management, LLC | 175,248 | $2,418 |
| JPMORGAN CHASE & CO | 170,509 | $2,353 |
| Trexquant Investment LP | 170,484 | $2,353 |
| ExodusPoint Capital Management, LP | 161,548 | $2,229 |
| XTX Topco Ltd | 161,427 | $2,228 |
| SPHERA FUNDS MANAGEMENT LTD. | 157,840 | $2,178 |
| Bank of New York Mellon Corp | 122,066 | $1,685 |
| Hudson Bay Capital Management LP | 110,000 | $1,518 |
| TWO SIGMA ADVISERS, LP | 104,100 | $1,437 |
| Blue Owl Capital Holdings LP | 100,000 | $1,380 |
| Jump Financial, LLC | 96,684 | $1,334 |
| Nuveen, LLC | 96,416 | $1,331 |
| Deep Track Capital, LP | 89,589 | $1,236 |
| SG Americas Securities, LLC | 79,817 | $1 |
| TUDOR INVESTMENT CORP ET AL | 79,158 | $1,092 |
| Swiss National Bank | 77,100 | $1,064 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 76,601 | $1,057 |
| UBS ASSET MANAGEMENT AMERICAS INC | 75,498 | $1,042 |
| Man Group plc | 64,512 | $890 |
| PROFUND ADVISORS LLC | 64,022 | $884 |
| HRT FINANCIAL LP | 63,544 | $1 |
| TWINBEECH CAPITAL LP | 58,810 | $812 |
| DARK FOREST CAPITAL MANAGEMENT LP | 57,363 | $792 |
| CONGRESS ASSET MANAGEMENT CO /MA | 57,342 | $791 |
| Headlands Technologies LLC | 56,497 | $780 |
| Aquatic Capital Management LLC | 52,421 | $723 |
| RHUMBLINE ADVISERS | 52,361 | $723 |
| DekaBank Deutsche Girozentrale | 49,500 | $2 |
| WELLS FARGO & COMPANY/MN | 47,919 | $661 |
| Raiffeisen Bank International AG | 46,000 | $636 |
| Schonfeld Strategic Advisors LLC | 45,453 | $627 |
| Legal & General Group Plc | 43,467 | $600 |
| Freestone Grove Partners LP | 41,806 | $577 |
| HighVista Strategies LLC | 41,443 | $572 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 38,875 | $1 |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,487 | $531 |
| NEOS Investment Management LLC | 37,647 | $520 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,320 | $515 |
| TEMA ETFS LLC | 37,092 | $512 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36,555 | $505 |
| ALLIANCEBERNSTEIN L.P. | 35,590 | $491 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,237 | $486 |
| Quadrature Capital Ltd | 33,002 | $455 |
| D. E. Shaw & Co., Inc. | 32,707 | $451 |
| DEUTSCHE BANK AG\ | 32,170 | $444 |
| WINTON GROUP Ltd | 31,800 | $439 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,148 | $416 |
| Invesco Ltd. | 28,322 | $391 |
| Atom Investors LP | 27,942 | $386 |
| AMERICAN CENTURY COMPANIES INC | 27,691 | $382 |
| Rangeley Capital, LLC | 25,414 | $351 |
| Lester Murray Antman dba SimplyRich | 24,315 | $0 |
| CITIGROUP INC | 24,218 | $334 |
| Quantinno Capital Management LP | 24,218 | $334 |
| MetLife Investment Management, LLC | 23,876 | $329 |
| 75 other institutions | 505,787 | $6,668 |