KODIAK SCIENCES INC

Institution	Shares	Value ($000)
BRAIDWELL LP	2,072,788	$57,955
SPHERA FUNDS MANAGEMENT LTD.	175,500	$4,907
RTW INVESTMENTS, LP	1,487,933	$41,603
Atom Investors LP	207,495	$5,802
Harvest Investment Services, LLC	61,983	$1,733
Scientech Research LLC	10,329	$289
Virtus Investment Advisers, LLC	11,173	$312
Dynamic Technology Lab Private Ltd	13,560	$379
Artia Global Partners LP	17,019	$476
Artisan Partners Limited Partnership	836,506	$23,389
Jain Global LLC	284,899	$7,966
Aster Capital Management (DIFC) Ltd	4,253	$119
Y-Intercept (Hong Kong) Ltd	37,965	$1,062
JANUS HENDERSON GROUP PLC	1,000,000	$27,950
J. Goldman & Co LP	28,949	$809
PROFUND ADVISORS LLC	22,092	$618
China Universal Asset Management Co., Ltd.	8,644	$242
Rafferty Asset Management, LLC	59,520	$1,664
INTECH INVESTMENT MANAGEMENT LLC	13,939	$390
Brevan Howard Capital Management LP	17,207	$481

Increased Positions (49)

Boxer Capital Management, LLC

Value ($000) $31,763 (+158.7%) Shares 1,136,000 (+51.5%)

BAKER BROS. ADVISORS LP

Value ($000) $556,940 (+96.5%) Shares 19,919,186 (+15.1%)

SILVERARC CAPITAL MANAGEMENT, LLC

Value ($000) $28,606 (+74.7%) Shares 1,023,122 (+2.3%)

Ikarian Capital, LLC

Value ($000) $20,125 (+197.1%) Shares 719,787 (+73.9%)

TCG Crossover Management, LLC

Value ($000) $40,417 (+115.5%) Shares 1,445,538 (+26.2%)

PERCEPTIVE ADVISORS LLC

Value ($000) $23,735 (+128.5%) Shares 848,900 (+33.8%)

FOX RUN MANAGEMENT, L.L.C.

Value ($000) $823 (+303.3%) Shares 29,419 (+136.1%)

Soleus Capital Management, L.P.

Value ($000) $1,678 (+421.7%) Shares 60,000 (+205.4%)

Trexquant Investment LP

Value ($000) $5,327 (+588.6%) Shares 190,505 (+303.1%)

BOOTHBAY FUND MANAGEMENT, LLC

Value ($000) $4,843 (+154.1%) Shares 173,221 (+48.8%)

Campbell & CO Investment Adviser LLC

Value ($000) $1,213 (+148.5%) Shares 43,369 (+45.5%)

BALYASNY ASSET MANAGEMENT L.P.

Value ($000) $7,361 (+2816.4%) Shares 263,278 (+1607.5%)

GOLDMAN SACHS GROUP INC

Value ($000) $36,433 (+581.1%) Shares 1,303,030 (+298.8%)

STATE STREET CORP

Value ($000) $48,427 (+255.4%) Shares 1,732,015 (+108.1%)

Invesco Ltd.

Value ($000) $15,520 (+846.4%) Shares 555,073 (+454.1%)

BlackRock, Inc.

Value ($000) $110,571 (+128.8%) Shares 3,954,603 (+33.9%)

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $13,247 (+591.3%) Shares 473,796 (+304.7%)

CITADEL ADVISORS LLC

Value ($000) $8,122 (+991.5%) Shares 290,479 (+539.0%)

VANGUARD GROUP INC

Value ($000) $64,683 (+102.6%) Shares 2,313,395 (+18.6%)

OSAIC HOLDINGS, INC.

Value ($000) $2,332 (+1453.6%) Shares 83,421 (+726.0%)

Institution	Prev Shares	Curr Shares	Change
Boxer Capital Management, LLC	750,000	1,136,000	+386,000 (+51.5%)
BAKER BROS. ADVISORS LP	17,310,490	19,919,186	+2,608,696 (+15.1%)
SILVERARC CAPITAL MANAGEMENT, LLC	1,000,000	1,023,122	+23,122 (+2.3%)
Ikarian Capital, LLC	413,841	719,787	+305,946 (+73.9%)
TCG Crossover Management, LLC	1,145,538	1,445,538	+300,000 (+26.2%)
PERCEPTIVE ADVISORS LLC	634,577	848,900	+214,323 (+33.8%)
FOX RUN MANAGEMENT, L.L.C.	12,458	29,419	+16,961 (+136.1%)
Soleus Capital Management, L.P.	19,644	60,000	+40,356 (+205.4%)
Trexquant Investment LP	47,255	190,505	+143,250 (+303.1%)
BOOTHBAY FUND MANAGEMENT, LLC	116,435	173,221	+56,786 (+48.8%)
Campbell & CO Investment Adviser LLC	29,804	43,369	+13,565 (+45.5%)
BALYASNY ASSET MANAGEMENT L.P.	15,419	263,278	+247,859 (+1607.5%)
GOLDMAN SACHS GROUP INC	326,776	1,303,030	+976,254 (+298.8%)
STATE STREET CORP	832,443	1,732,015	+899,572 (+108.1%)
Invesco Ltd.	100,179	555,073	+454,894 (+454.1%)
BlackRock, Inc.	2,952,381	3,954,603	+1,002,222 (+33.9%)
WELLINGTON MANAGEMENT GROUP LLP	117,059	473,796	+356,737 (+304.7%)
CITADEL ADVISORS LLC	45,455	290,479	+245,024 (+539.0%)
VANGUARD GROUP INC	1,950,292	2,313,395	+363,103 (+18.6%)
OSAIC HOLDINGS, INC.	10,099	83,421	+73,322 (+726.0%)

Decreased Positions (39)

BOONE CAPITAL MANAGEMENT LLC

Value ($000) $14,087 (+20.2%) Shares 503,830 (-29.6%)

Bruce & Co., Inc.

Value ($000) $4,613 (+0.9%) Shares 165,000 (-40.9%)

RIA Advisory Group LLC

Value ($000) $3,173 (+17.1%) Shares 113,473 (-31.5%)

Brooklyn Investment Group

Value ($000) $306 (+43.8%) Shares 10,627 (-81.5%)

Point72 Asset Management, L.P.

Value ($000) $60,587 (+30.5%) Shares 2,166,929 (-23.6%)

ADAGE CAPITAL PARTNERS GP, L.L.C.

Value ($000) $21,949 (+0.4%) Shares 785,000 (-41.2%)

Headlands Technologies LLC

Value ($000) $455 (-6.5%) Shares 16,278 (-45.3%)

BRIDGEWAY CAPITAL MANAGEMENT, LLC

Value ($000) $1,208 (+2.2%) Shares 43,200 (-40.2%)

TWO SIGMA ADVISERS, LP

Value ($000) $2,883 (-15.9%) Shares 103,100 (-50.8%)

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $10,060 (+33.2%) Shares 359,800 (-22.0%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $1,445 (-36.2%) Shares 51,671 (-62.6%)

D. E. Shaw & Co., Inc.

Value ($000) $8,965 (+19.6%) Shares 320,647 (-30.0%)

JACOBS LEVY EQUITY MANAGEMENT, INC

Value ($000) $3,557 (+31.5%) Shares 127,230 (-23.0%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $9,156 (+8.0%) Shares 327,482 (-36.8%)

ROYAL BANK OF CANADA

Value ($000) $245 (-92.6%) Shares 8,745 (-95.6%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $1,695 (-33.3%) Shares 60,621 (-61.0%)

SUSQUEHANNA INTERNATIONAL GROUP, LLP

Value ($000) $1,027 (-63.4%) Shares 36,722 (-78.6%)

BANK OF AMERICA CORP /DE/

Value ($000) $5,499 (+8.7%) Shares 196,689 (-36.4%)

AMERICAN CENTURY COMPANIES INC

Value ($000) $239 (-81.3%) Shares 8,553 (-89.1%)

ACADIAN ASSET MANAGEMENT LLC

Value ($000) $20 (+25.0%) Shares 709,818 (-26.8%)

Institution	Prev Shares	Curr Shares	Change
BOONE CAPITAL MANAGEMENT LLC	715,877	503,830	-212,047 (-29.6%)
Bruce & Co., Inc.	279,308	165,000	-114,308 (-40.9%)
RIA Advisory Group LLC	165,534	113,473	-52,061 (-31.5%)
Brooklyn Investment Group	57,539	10,627	-46,912 (-81.5%)
Point72 Asset Management, L.P.	2,837,116	2,166,929	-670,187 (-23.6%)
ADAGE CAPITAL PARTNERS GP, L.L.C.	1,335,000	785,000	-550,000 (-41.2%)
Headlands Technologies LLC	29,736	16,278	-13,458 (-45.3%)
BRIDGEWAY CAPITAL MANAGEMENT, LLC	72,200	43,200	-29,000 (-40.2%)
TWO SIGMA ADVISERS, LP	209,400	103,100	-106,300 (-50.8%)
RENAISSANCE TECHNOLOGIES LLC	461,300	359,800	-101,500 (-22.0%)
TWO SIGMA INVESTMENTS, LP	138,261	51,671	-86,590 (-62.6%)
D. E. Shaw & Co., Inc.	457,856	320,647	-137,209 (-30.0%)
JACOBS LEVY EQUITY MANAGEMENT, INC	165,220	127,230	-37,990 (-23.0%)
DIMENSIONAL FUND ADVISORS LP	518,000	327,482	-190,518 (-36.8%)
ROYAL BANK OF CANADA	200,894	8,745	-192,149 (-95.6%)
MILLENNIUM MANAGEMENT LLC	155,255	60,621	-94,634 (-61.0%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP	171,404	36,722	-134,682 (-78.6%)
BANK OF AMERICA CORP /DE/	309,071	196,689	-112,382 (-36.4%)
AMERICAN CENTURY COMPANIES INC	78,178	8,553	-69,625 (-89.1%)
ACADIAN ASSET MANAGEMENT LLC	969,906	709,818	-260,088 (-26.8%)

Exited Positions (13)

Vestal Point Capital, LP

Value ($000) $4,093 Shares 250,000

Nantahala Capital Management, LLC

Value ($000) $4,762 Shares 290,884

TANG CAPITAL MANAGEMENT LLC

Value ($000) $1,637 Shares 100,000

GSA CAPITAL PARTNERS LLP

Value ($000) $1 Shares 87,697

XTX Topco Ltd

Value ($000) $411 Shares 25,078

FRED ALGER MANAGEMENT, LLC

Value ($000) $2,264 Shares 138,303

JANE STREET GROUP, LLC

Value ($000) $2,073 Shares 126,613

Virtu Financial LLC

Value ($000) $0 Shares 24,082

Rise Advisors, LLC

Value ($000) $6 Shares 356

Caitong International Asset Management Co., Ltd

Value ($000) $5 Shares 283

Ameritas Advisory Services, LLC

Value ($000) $8 Shares 500

Optiver Holding B.V.

Value ($000) $8 Shares 507

SRS Capital Advisors, Inc.

Value ($000) $4 Shares 230

Institution	Prev Shares	Prev Value ($000)
Vestal Point Capital, LP	250,000	$4,093
Nantahala Capital Management, LLC	290,884	$4,762
TANG CAPITAL MANAGEMENT LLC	100,000	$1,637
GSA CAPITAL PARTNERS LLP	87,697	$1
XTX Topco Ltd	25,078	$411
FRED ALGER MANAGEMENT, LLC	138,303	$2,264
JANE STREET GROUP, LLC	126,613	$2,073
Virtu Financial LLC	24,082	$0
Rise Advisors, LLC	356	$6
Caitong International Asset Management Co., Ltd	283	$5
Ameritas Advisory Services, LLC	500	$8
Optiver Holding B.V.	507	$8
SRS Capital Advisors, Inc.	230	$4