| BAKER BROS. ADVISORS LP | 19,919,186 | $556,940 |
| BlackRock, Inc. | 3,954,603 | $110,571 |
| VANGUARD GROUP INC | 2,313,395 | $64,683 |
| Point72 Asset Management, L.P. | 2,166,929 | $60,587 |
| BRAIDWELL LP | 2,072,788 | $57,955 |
| STATE STREET CORP | 1,732,015 | $48,427 |
| RTW INVESTMENTS, LP | 1,487,933 | $41,603 |
| TCG Crossover Management, LLC | 1,445,538 | $40,417 |
| GOLDMAN SACHS GROUP INC | 1,303,030 | $36,433 |
| ICONIQ Capital, LLC | 1,266,563 | $35,413 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,170,179 | $33 |
| Boxer Capital Management, LLC | 1,136,000 | $31,763 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,023,122 | $28,606 |
| JANUS HENDERSON GROUP PLC | 1,000,000 | $27,950 |
| GEODE CAPITAL MANAGEMENT, LLC | 897,692 | $25,105 |
| PERCEPTIVE ADVISORS LLC | 848,900 | $23,735 |
| Artisan Partners Limited Partnership | 836,506 | $23,389 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 785,000 | $21,949 |
| Ikarian Capital, LLC | 719,787 | $20,125 |
| ACADIAN ASSET MANAGEMENT LLC | 709,818 | $20 |
| MORGAN STANLEY | 699,772 | $19,566 |
| Board of Trustees of The Leland Stanford Junior University | 691,767 | $19,342 |
| Invesco Ltd. | 555,073 | $15,520 |
| BOONE CAPITAL MANAGEMENT LLC | 503,830 | $14,087 |
| WELLINGTON MANAGEMENT GROUP LLP | 473,796 | $13,247 |
| RENAISSANCE TECHNOLOGIES LLC | 359,800 | $10,060 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 340,657 | $9,525 |
| NORTHERN TRUST CORP | 333,668 | $9,329 |
| DIMENSIONAL FUND ADVISORS LP | 327,482 | $9,156 |
| D. E. Shaw & Co., Inc. | 320,647 | $8,965 |
| Squadron Capital Management LLC | 291,710 | $8,156 |
| CITADEL ADVISORS LLC | 290,479 | $8,122 |
| Jain Global LLC | 284,899 | $7,966 |
| BALYASNY ASSET MANAGEMENT L.P. | 263,278 | $7,361 |
| FEDERATED HERMES, INC. | 244,231 | $6,829 |
| Atom Investors LP | 207,495 | $5,802 |
| FMR LLC | 199,190 | $5,569 |
| BANK OF AMERICA CORP /DE/ | 196,689 | $5,499 |
| Trexquant Investment LP | 190,505 | $5,327 |
| PANAGORA ASSET MANAGEMENT INC | 180,718 | $5,053 |
| SPHERA FUNDS MANAGEMENT LTD. | 175,500 | $4,907 |
| BOOTHBAY FUND MANAGEMENT, LLC | 173,221 | $4,843 |
| UBS Group AG | 168,562 | $4,713 |
| Bruce & Co., Inc. | 165,000 | $4,613 |
| TD Asset Management Inc | 133,918 | $3,744 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 127,230 | $3,557 |
| BARCLAYS PLC | 124,334 | $3,476 |
| RIA Advisory Group LLC | 113,473 | $3,173 |
| TWO SIGMA ADVISERS, LP | 103,100 | $2,883 |
| Bank of New York Mellon Corp | 102,713 | $2,872 |
| WELLS FARGO & COMPANY/MN | 92,143 | $2,576 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 91,508 | $2,558 |
| OSAIC HOLDINGS, INC. | 83,421 | $2,332 |
| PRUDENTIAL FINANCIAL INC | 78,320 | $2,190 |
| Nuveen, LLC | 73,044 | $2,042 |
| NEW YORK STATE COMMON RETIREMENT FUND | 67,260 | $1,881 |
| Harvest Investment Services, LLC | 61,983 | $1,733 |
| MILLENNIUM MANAGEMENT LLC | 60,621 | $1,695 |
| Soleus Capital Management, L.P. | 60,000 | $1,678 |
| Rafferty Asset Management, LLC | 59,520 | $1,664 |
| AQR CAPITAL MANAGEMENT LLC | 57,693 | $1,613 |
| TWO SIGMA INVESTMENTS, LP | 51,671 | $1,445 |
| NORGES BANK | 50,000 | $1,398 |
| VICTORY CAPITAL MANAGEMENT INC | 44,047 | $1,232 |
| Campbell & CO Investment Adviser LLC | 43,369 | $1,213 |
| RHUMBLINE ADVISERS | 43,244 | $1,209 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 43,200 | $1,208 |
| POLEN CAPITAL MANAGEMENT LLC | 41,340 | $1,156 |
| Y-Intercept (Hong Kong) Ltd | 37,965 | $1,062 |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,775 | $1,028 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,722 | $1,027 |
| DEUTSCHE BANK AG\ | 35,317 | $987 |
| ALLIANCEBERNSTEIN L.P. | 35,180 | $984 |
| Russell Investments Group, Ltd. | 31,717 | $887 |
| FOX RUN MANAGEMENT, L.L.C. | 29,419 | $823 |
| J. Goldman & Co LP | 28,949 | $809 |
| Aries Wealth Management | 25,000 | $699 |
| SG Americas Securities, LLC | 24,125 | $1 |
| PROFUND ADVISORS LLC | 22,092 | $618 |
| SEI INVESTMENTS CO | 20,664 | $578 |
| AMERIPRISE FINANCIAL INC | 19,896 | $556 |
| FRANKLIN RESOURCES INC | 19,529 | $546 |
| MetLife Investment Management, LLC | 19,427 | $543 |
| PSP Research LLC | 19,418 | $543 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,666 | $522 |
| LPL Financial LLC | 18,399 | $514 |
| JPMORGAN CHASE & CO | 17,905 | $501 |
| Brevan Howard Capital Management LP | 17,207 | $481 |
| Artia Global Partners LP | 17,019 | $476 |
| CITIGROUP INC | 16,617 | $465 |
| Cerity Partners LLC | 16,446 | $460 |
| Headlands Technologies LLC | 16,278 | $455 |
| Continuum Advisory, LLC | 14,852 | $415 |
| Vanguard Personalized Indexing Management, LLC | 14,809 | $414 |
| INTECH INVESTMENT MANAGEMENT LLC | 13,939 | $390 |
| Dynamic Technology Lab Private Ltd | 13,560 | $379 |
| T. Rowe Price Investment Management, Inc. | 13,201 | $0 |
| Jefferies Financial Group Inc. | 13,134 | $367 |
| Virtus Investment Advisers, LLC | 11,173 | $312 |
| Creative Planning | 10,787 | $302 |
| 56 other institutions | 190,175 | $4,662 |