| Frazier Life Sciences Management, L.P. | 12,466,489 | $206,819 |
| Medicxi Ventures Management (Jersey) Ltd | 7,464,572 | $123,837 |
| Invesco Ltd. | 3,920,446 | $65,040 |
| BlackRock, Inc. | 3,555,548 | $58,987 |
| Carlyle Group Inc. | 3,496,808 | $57,977 |
| VANGUARD GROUP INC | 3,177,211 | $52,710 |
| Ensign Peak Advisors, Inc | 2,352,020 | $39,020 |
| MILLENNIUM MANAGEMENT LLC | 2,082,180 | $34,543 |
| NEA Management Company, LLC | 1,960,169 | $32,519 |
| 683 Capital Management, LLC | 1,785,000 | $29,613 |
| Catalys Pacific, LLC | 1,429,014 | $23,707 |
| WASATCH ADVISORS LP | 1,331,669 | $22,092 |
| GW&K Investment Management, LLC | 1,306,678 | $22 |
| STATE STREET CORP | 1,149,536 | $19,071 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,073,434 | $17,811 |
| Propel Bio Management, LLC | 740,918 | $12,292 |
| Catalio Capital Management, LP | 698,996 | $11,596 |
| Divisadero Street Capital Management, LP | 662,312 | $10,988 |
| MOORE CAPITAL MANAGEMENT, LP | 600,000 | $9,954 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 549,171 | $9,111 |
| SummitTX Capital, L.P. | 517,820 | $8,591 |
| StepStone Group LP | 422,085 | $4,968 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 397,910 | $6,601 |
| NEXT CENTURY GROWTH INVESTORS LLC | 393,774 | $6,533 |
| GOLDMAN SACHS GROUP INC | 392,045 | $6,504 |
| JANE STREET GROUP, LLC | 384,770 | $6,383 |
| NORTHERN TRUST CORP | 356,466 | $5,914 |
| Simplify Asset Management Inc. | 321,935 | $5,341 |
| CITADEL ADVISORS LLC | 311,315 | $5,165 |
| UBS Group AG | 304,383 | $5,050 |
| JPMORGAN CHASE & CO | 296,684 | $4,922 |
| Brevan Howard Capital Management LP | 276,989 | $4,595 |
| Susquehanna Portfolio Strategies, LLC | 267,962 | $4,445 |
| D. E. Shaw & Co., Inc. | 261,068 | $4,331 |
| BANK OF AMERICA CORP /DE/ | 258,996 | $4,297 |
| BALYASNY ASSET MANAGEMENT L.P. | 207,085 | $3,436 |
| Avidity Partners Management LP | 206,076 | $3,419 |
| NewEdge Advisors, LLC | 200,823 | $3,160 |
| Birchview Capital, LP | 195,000 | $3,235 |
| Woodline Partners LP | 187,291 | $3,107 |
| AMERIPRISE FINANCIAL INC | 185,744 | $3,081 |
| CAXTON ASSOCIATES LLP | 181,968 | $3,019 |
| HUSSMAN STRATEGIC ADVISORS, INC. | 147,000 | $2,439 |
| GILDER GAGNON HOWE & CO LLC | 145,174 | $2,408 |
| Trexquant Investment LP | 136,824 | $2,270 |
| WELLINGTON MANAGEMENT GROUP LLP | 134,546 | $2,232 |
| Bank of New York Mellon Corp | 122,967 | $2,040 |
| MORGAN STANLEY | 117,781 | $1,954 |
| Campbell & CO Investment Adviser LLC | 115,284 | $1,913 |
| Hennion & Walsh Asset Management, Inc. | 114,981 | $1,908 |
| Nuveen, LLC | 108,846 | $1,806 |
| GROUP ONE TRADING, L.P. | 103,684 | $1,720 |
| VARCOV Co. | 86,759 | $1,439 |
| BARCLAYS PLC | 84,859 | $1,408 |
| Swiss National Bank | 84,000 | $1,394 |
| GSA CAPITAL PARTNERS LLP | 82,624 | $1 |
| Creative Planning | 80,766 | $1,340 |
| WELLS FARGO & COMPANY/MN | 68,016 | $1,128 |
| Penn Mutual Asset Management, LLC | 62,802 | $1,042 |
| DARK FOREST CAPITAL MANAGEMENT LP | 62,248 | $1,033 |
| TWO SIGMA INVESTMENTS, LP | 57,783 | $959 |
| AQR CAPITAL MANAGEMENT LLC | 54,448 | $903 |
| RHUMBLINE ADVISERS | 52,093 | $864 |
| STIFEL FINANCIAL CORP | 51,661 | $857 |
| Stratos Wealth Partners, LTD. | 50,300 | $834 |
| ALLIANCEBERNSTEIN L.P. | 49,390 | $819 |
| Virtus Investment Advisers, LLC | 46,937 | $779 |
| Engineers Gate Manager LP | 44,258 | $734 |
| ADAR1 Capital Management, LLC | 42,900 | $712 |
| Southeast Asset Advisors Inc. | 42,874 | $711 |
| NEW YORK STATE COMMON RETIREMENT FUND | 41,756 | $693 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,143 | $666 |
| XTX Topco Ltd | 39,400 | $654 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,071 | $1 |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 34,700 | $576 |
| Legal & General Group Plc | 34,249 | $568 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 33,425 | $445 |
| DEUTSCHE BANK AG\ | 33,380 | $554 |
| Schonfeld Strategic Advisors LLC | 30,944 | $513 |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,940 | $513 |
| UBS ASSET MANAGEMENT AMERICAS INC | 30,631 | $508 |
| Y-Intercept (Hong Kong) Ltd | 30,488 | $506 |
| Occidental Asset Management, LLC | 29,919 | $496 |
| TUDOR INVESTMENT CORP ET AL | 28,554 | $474 |
| CITIGROUP INC | 28,459 | $472 |
| AlphaQuest LLC | 28,250 | $469 |
| HRT FINANCIAL LP | 27,010 | $0 |
| MetLife Investment Management, LLC | 25,845 | $429 |
| RAYMOND JAMES FINANCIAL INC | 24,390 | $405 |
| Kera Capital Partners, Inc. | 24,255 | $332 |
| ROYAL BANK OF CANADA | 22,554 | $374 |
| ExodusPoint Capital Management, LP | 22,401 | $372 |
| ACADIAN ASSET MANAGEMENT LLC | 22,185 | $0 |
| Summit Financial Wealth Advisors, LLC | 22,143 | $367 |
| Jain Global LLC | 21,737 | $361 |
| JANUS HENDERSON GROUP PLC | 21,500 | $357 |
| FOX RUN MANAGEMENT, L.L.C. | 20,487 | $340 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,890 | $330 |
| INSPIRION WEALTH ADVISORS, LLC | 19,814 | $329 |
| INTECH INVESTMENT MANAGEMENT LLC | 19,051 | $316 |
| 72 other institutions | 432,460 | $6,445 |