SEPTERNA INC

Institution	Shares	Value ($000)
First Light Asset Management, LLC	620,811	$17,308
HighVista Strategies LLC	78,682	$2,194
Numerai GP LLC	45,866	$1,279
Virtus Investment Advisers, LLC	10,457	$292
Dynamic Technology Lab Private Ltd	10,810	$301
Caitong International Asset Management Co., Ltd	3,170	$88
XTX Topco Ltd	23,315	$650
PRIMECAP MANAGEMENT CO/CA/	546,100	$15,225
China Universal Asset Management Co., Ltd.	10,296	$287
Atom Investors LP	9,791	$273
Baader Bank Aktiengesellschaft	10,000	$279
Trexquant Investment LP	44,005	$1,227
MARSHALL WACE, LLP	226,901	$6,326
ExodusPoint Capital Management, LP	37,867	$1,056
FEDERATED HERMES, INC.	78,905	$2,200
Graham Capital Management, L.P.	8,971	$250
INTECH INVESTMENT MANAGEMENT LLC	13,283	$370
CITADEL ADVISORS LLC	75,945	$2,117
ALGERT GLOBAL LLC	34,944	$1
Jump Financial, LLC	8,399	$234

Increased Positions (27)

Soleus Capital Management, L.P.

Value ($000) $10,688 (+3011.8%) Shares 383,368 (+1999.5%)

Woodline Partners LP

Value ($000) $10,742 (+102.1%) Shares 385,310 (+36.4%)

GOLDMAN SACHS GROUP INC

Value ($000) $75,698 (+176.6%) Shares 2,715,129 (+86.6%)

BlackRock, Inc.

Value ($000) $50,221 (+82.9%) Shares 1,801,328 (+23.4%)

JACOBS LEVY EQUITY MANAGEMENT, INC

Value ($000) $1,711 (+154.2%) Shares 61,370 (+71.5%)

STATE STREET CORP

Value ($000) $15,056 (+91.1%) Shares 540,028 (+28.9%)

JPMORGAN CHASE & CO

Value ($000) $1,905 (+1059.5%) Shares 68,338 (+682.3%)

MORGAN STANLEY

Value ($000) $2,899 (+183.0%) Shares 103,985 (+90.9%)

AMERICAN CENTURY COMPANIES INC

Value ($000) $1,413 (+197.2%) Shares 50,689 (+100.5%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $15,971 (+55.6%) Shares 572,734 (+5.0%)

Russell Investments Group, Ltd.

Value ($000) $427 (+1096.9%) Shares 15,310 (+707.5%)

UBS Group AG

Value ($000) $1,919 (+72.7%) Shares 68,817 (+16.5%)

CITIGROUP INC

Value ($000) $267 (+5590.9%) Shares 9,561 (+3739.8%)

WELLS FARGO & COMPANY/MN

Value ($000) $740 (+95.2%) Shares 26,529 (+31.7%)

TWO SIGMA ADVISERS, LP

Value ($000) $717 (+84.0%) Shares 25,700 (+24.2%)

Bank of New York Mellon Corp

Value ($000) $1,543 (+58.8%) Shares 55,332 (+7.2%)

NEW YORK STATE COMMON RETIREMENT FUND

Value ($000) $156 (+186.2%) Shares 5,600 (+93.1%)

Tower Research Capital LLC (TRC)

Value ($000) $60 (+233.2%) Shares 2,156 (+124.8%)

Nuveen, LLC

Value ($000) $719 (+59.6%) Shares 25,798 (+7.7%)

BNP PARIBAS ARBITRAGE, SA

Value ($000) $152 (+94.4%) Shares 5,449 (+31.1%)

Institution	Prev Shares	Curr Shares	Change
Soleus Capital Management, L.P.	18,260	383,368	+365,108 (+1999.5%)
Woodline Partners LP	282,585	385,310	+102,725 (+36.4%)
GOLDMAN SACHS GROUP INC	1,454,720	2,715,129	+1,260,409 (+86.6%)
BlackRock, Inc.	1,459,795	1,801,328	+341,533 (+23.4%)
JACOBS LEVY EQUITY MANAGEMENT, INC	35,778	61,370	+25,592 (+71.5%)
STATE STREET CORP	418,960	540,028	+121,068 (+28.9%)
JPMORGAN CHASE & CO	8,736	68,338	+59,602 (+682.3%)
MORGAN STANLEY	54,458	103,985	+49,527 (+90.9%)
AMERICAN CENTURY COMPANIES INC	25,283	50,689	+25,406 (+100.5%)
GEODE CAPITAL MANAGEMENT, LLC	545,701	572,734	+27,033 (+5.0%)
Russell Investments Group, Ltd.	1,896	15,310	+13,414 (+707.5%)
UBS Group AG	59,046	68,817	+9,771 (+16.5%)
CITIGROUP INC	249	9,561	+9,312 (+3739.8%)
WELLS FARGO & COMPANY/MN	20,147	26,529	+6,382 (+31.7%)
TWO SIGMA ADVISERS, LP	20,700	25,700	+5,000 (+24.2%)
Bank of New York Mellon Corp	51,631	55,332	+3,701 (+7.2%)
NEW YORK STATE COMMON RETIREMENT FUND	2,900	5,600	+2,700 (+93.1%)
Tower Research Capital LLC (TRC)	959	2,156	+1,197 (+124.8%)
Nuveen, LLC	23,961	25,798	+1,837 (+7.7%)
BNP PARIBAS ARBITRAGE, SA	4,155	5,449	+1,294 (+31.1%)

Decreased Positions (26)

BVF INC/IL

Value ($000) $47,975 (-36.5%) Shares 1,720,782 (-57.1%)

Rangeley Capital, LLC

Value ($000) $1,835 (+10.8%) Shares 65,800 (-25.2%)

Siren, L.L.C.

Value ($000) $55,760 (+34.6%) Shares 2,000,000 (-9.2%)

ADAR1 Capital Management, LLC

Value ($000) $32,274 (+45.8%) Shares 1,157,611 (-1.6%)

Logos Global Management LP

Value ($000) $657 (-58.2%) Shares 23,548 (-71.8%)

DRIEHAUS CAPITAL MANAGEMENT LLC

Value ($000) $134,088 (+44.9%) Shares 4,809,470 (-2.2%)

PERCEPTIVE ADVISORS LLC

Value ($000) $12,077 (+18.6%) Shares 433,160 (-20.0%)

Longaeva Partners L.P.

Value ($000) $1,391 (+29.6%) Shares 49,902 (-12.6%)

PharVision Advisers, LLC

Value ($000) $299 (+33.4%) Shares 10,739 (-10.0%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $2,996 (-58.5%) Shares 107,463 (-72.0%)

Quarry LP

Value ($000) $20 (-38.2%) Shares 724 (-58.3%)

Covestor Ltd

Value ($000) $0 (-20.6%) Shares 1,941 (-46.4%)

Invesco Ltd.

Value ($000) $4,517 (+35.6%) Shares 162,014 (-8.5%)

BANK OF AMERICA CORP /DE/

Value ($000) $1,048 (+8.2%) Shares 37,594 (-27.0%)

NORTHERN TRUST CORP

Value ($000) $4,299 (+36.6%) Shares 154,196 (-7.9%)

ALLIANCEBERNSTEIN L.P.

Value ($000) $546 (+31.5%) Shares 19,600 (-11.3%)

RHUMBLINE ADVISERS

Value ($000) $737 (+41.9%) Shares 26,419 (-4.3%)

GROUP ONE TRADING, L.P.

Value ($000) $26 (-17.2%) Shares 944 (-44.1%)

ROYAL BANK OF CANADA

Value ($000) $18 (-10.0%) Shares 628 (-42.0%)

Sterling Capital Management LLC

Value ($000) $34 (+23.8%) Shares 1,232 (-16.5%)

Institution	Prev Shares	Curr Shares	Change
BVF INC/IL	4,015,790	1,720,782	-2,295,008 (-57.1%)
Rangeley Capital, LLC	88,000	65,800	-22,200 (-25.2%)
Siren, L.L.C.	2,202,514	2,000,000	-202,514 (-9.2%)
ADAR1 Capital Management, LLC	1,176,491	1,157,611	-18,880 (-1.6%)
Logos Global Management LP	83,548	23,548	-60,000 (-71.8%)
DRIEHAUS CAPITAL MANAGEMENT LLC	4,919,896	4,809,470	-110,426 (-2.2%)
PERCEPTIVE ADVISORS LLC	541,450	433,160	-108,290 (-20.0%)
Longaeva Partners L.P.	57,064	49,902	-7,162 (-12.6%)
PharVision Advisers, LLC	11,932	10,739	-1,193 (-10.0%)
MILLENNIUM MANAGEMENT LLC	384,200	107,463	-276,737 (-72.0%)
Quarry LP	1,736	724	-1,012 (-58.3%)
Covestor Ltd	3,620	1,941	-1,679 (-46.4%)
Invesco Ltd.	177,070	162,014	-15,056 (-8.5%)
BANK OF AMERICA CORP /DE/	51,495	37,594	-13,901 (-27.0%)
NORTHERN TRUST CORP	167,345	154,196	-13,149 (-7.9%)
ALLIANCEBERNSTEIN L.P.	22,100	19,600	-2,500 (-11.3%)
RHUMBLINE ADVISERS	27,604	26,419	-1,185 (-4.3%)
GROUP ONE TRADING, L.P.	1,689	944	-745 (-44.1%)
ROYAL BANK OF CANADA	1,083	628	-455 (-42.0%)
Sterling Capital Management LLC	1,475	1,232	-243 (-16.5%)

Exited Positions (5)

Checkpoint Capital L.P.

Value ($000) $5,326 Shares 283,158

Sio Capital Management, LLC

Value ($000) $3,559 Shares 189,199

Walleye Capital LLC

Value ($000) $1,511 Shares 80,341

Verition Fund Management LLC

Value ($000) $379 Shares 20,131

NATIONAL BANK OF CANADA /FI/

Value ($000) $0 Shares 8

Institution	Prev Shares	Prev Value ($000)
Checkpoint Capital L.P.	283,158	$5,326
Sio Capital Management, LLC	189,199	$3,559
Walleye Capital LLC	80,341	$1,511
Verition Fund Management LLC	20,131	$379
NATIONAL BANK OF CANADA /FI/	8	$0