| Ikarian Capital, LLC | 967,600 | $11,795 |
| MORGAN STANLEY | 596,376 | $7,270 |
| PERCEPTIVE ADVISORS LLC | 439,142 | $5,353 |
| Siren, L.L.C. | 427,141 | $5,207 |
| Point72 Asset Management, L.P. | 423,415 | $5,161 |
| RTW INVESTMENTS, LP | 378,346 | $4,612 |
| BOOTHBAY FUND MANAGEMENT, LLC | 352,206 | $4,293 |
| BVF INC/IL | 339,549 | $4,139 |
| MILLENNIUM MANAGEMENT LLC | 302,473 | $3,687 |
| MARSHALL WACE, LLP | 298,153 | $3,634 |
| VANGUARD GROUP INC | 255,664 | $3,117 |
| DIADEMA PARTNERS LP | 243,170 | $2,964 |
| Vivo Capital, LLC | 208,333 | $2,540 |
| SPHERA FUNDS MANAGEMENT LTD. | 190,111 | $2,317 |
| Integral Health Asset Management, LLC | 167,000 | $2,036 |
| JANUS HENDERSON GROUP PLC | 166,666 | $2,019 |
| Woodline Partners LP | 143,481 | $1,749 |
| FMR LLC | 141,100 | $1,720 |
| CITADEL ADVISORS LLC | 129,528 | $1,579 |
| RENAISSANCE TECHNOLOGIES LLC | 125,579 | $1,531 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 83,333 | $1,016 |
| Velan Capital Investment Management LP | 83,333 | $1,016 |
| Persistent Asset Partners Ltd | 65,272 | $796 |
| ADAR1 Capital Management, LLC | 63,673 | $776 |
| GEODE CAPITAL MANAGEMENT, LLC | 55,699 | $679 |
| Vestal Point Capital, LP | 53,439 | $651 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 44,900 | $547 |
| Artia Global Partners LP | 42,080 | $513 |
| TWO SIGMA INVESTMENTS, LP | 33,470 | $408 |
| GOLDMAN SACHS GROUP INC | 22,409 | $273 |
| Quadrature Capital Ltd | 20,648 | $252 |
| BlackRock, Inc. | 16,714 | $204 |
| BNP PARIBAS ARBITRAGE, SA | 15,296 | $186 |
| TWO SIGMA ADVISERS, LP | 13,178 | $161 |
| Corient Private Wealth LLC | 12,388 | $151 |
| Stonepine Capital Management, LLC | 11,884 | $145 |
| LETKO, BROSSEAU & ASSOCIATES INC | 10,650 | $130 |
| BANK OF AMERICA CORP /DE/ | 3,780 | $46 |
| JPMORGAN CHASE & CO | 902 | $11 |
| UBS Group AG | 676 | $8 |
| Tower Research Capital LLC (TRC) | 199 | $2 |
| JONES FINANCIAL COMPANIES LLLP | 1 | $0 |
| CITIGROUP INC | 1 | $0 |
| Allworth Financial LP | 1 | $0 |
| Union Bancaire Privee, UBP SA | 1 | $0 |
| Physician Wealth Advisors, Inc. | 1 | $0 |
| Rockefeller Capital Management L.P. | 1 | $0 |