| JANUS HENDERSON GROUP PLC | 10,511,166 | $401,716 |
| FMR LLC | 9,617,863 | $367,499 |
| BlackRock, Inc. | 7,869,352 | $300,688 |
| VANGUARD GROUP INC | 6,309,229 | $241,076 |
| STATE STREET CORP | 4,756,666 | $181,752 |
| PERCEPTIVE ADVISORS LLC | 4,278,180 | $163,469 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 3,773,564 | $144,188 |
| ARMISTICE CAPITAL, LLC | 3,763,891 | $143,818 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,927,000 | $111,841 |
| RENAISSANCE TECHNOLOGIES LLC | 2,246,779 | $85,849 |
| Rock Springs Capital Management LP | 2,210,322 | $84,456 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,143,495 | $81,915 |
| GOLDMAN SACHS GROUP INC | 1,868,212 | $71,384 |
| BANK OF AMERICA CORP /DE/ | 1,850,355 | $70,702 |
| Stephens Investment Management Group LLC | 1,721,623 | $65,783 |
| EMERALD ADVISERS, LLC | 1,594,184 | $60,914 |
| MORGAN STANLEY | 1,415,897 | $54,101 |
| Eversept Partners, LP | 1,174,968 | $44,896 |
| TWO SIGMA INVESTMENTS, LP | 1,156,807 | $44,202 |
| D. E. Shaw & Co., Inc. | 1,094,556 | $41,823 |
| Nuveen, LLC | 993,613 | $37,966 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 948,459 | $36,241 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 901,404 | $34,443 |
| DEUTSCHE BANK AG\ | 881,680 | $33,689 |
| Fiera Capital Corp | 874,053 | $33,398 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 867,622 | $33,152 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 808,189 | $30,881 |
| Ensign Peak Advisors, Inc | 805,215 | $30,767 |
| WELLINGTON MANAGEMENT GROUP LLP | 798,984 | $30,529 |
| NORTHERN TRUST CORP | 761,473 | $29,096 |
| TWO SIGMA ADVISERS, LP | 725,500 | $27,721 |
| TANG CAPITAL MANAGEMENT LLC | 700,000 | $26,747 |
| BNP PARIBAS ARBITRAGE, SA | 665,795 | $25,440 |
| Connor, Clark & Lunn Investment Management Ltd. | 623,390 | $23,820 |
| PANAGORA ASSET MANAGEMENT INC | 587,354 | $22,443 |
| Legal & General Group Plc | 536,925 | $20,516 |
| Pictet Asset Management Holding SA | 534,614 | $20,778 |
| abrdn plc | 518,357 | $19,806 |
| Kynam Capital Management, LP | 517,884 | $19,788 |
| Invesco Ltd. | 474,075 | $18,114 |
| Candriam S.C.A. | 468,556 | $17,904 |
| UBS Group AG | 422,619 | $16,148 |
| Assenagon Asset Management S.A. | 417,742 | $15,962 |
| Qube Research & Technologies Ltd | 406,221 | $15,522 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 394,844 | $15 |
| JANE STREET GROUP, LLC | 392,273 | $14,989 |
| BARCLAYS PLC | 369,530 | $14,120 |
| AQR CAPITAL MANAGEMENT LLC | 352,717 | $13,477 |
| FIRST TRUST ADVISORS LP | 341,724 | $13,057 |
| JPMORGAN CHASE & CO | 321,615 | $12,289 |
| Squarepoint Ops LLC | 319,658 | $12,214 |
| Affinity Asset Advisors, LLC | 300,000 | $11,463 |
| Russell Investments Group, Ltd. | 285,311 | $10,902 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 268,926 | $10,276 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 268,045 | $10,242 |
| JENNISON ASSOCIATES LLC | 256,335 | $9,795 |
| NEW YORK STATE COMMON RETIREMENT FUND | 249,557 | $9,536 |
| Frazier Life Sciences Management, L.P. | 241,592 | $9,231 |
| LOOMIS SAYLES & CO L P | 238,924 | $9,129 |
| Impax Asset Management Group plc | 225,000 | $8,597 |
| Bank of New York Mellon Corp | 219,996 | $8,406 |
| PRUDENTIAL FINANCIAL INC | 219,745 | $8,396 |
| NEUBERGER BERMAN GROUP LLC | 218,027 | $8,331 |
| MARSHALL WACE, LLP | 217,171 | $8,298 |
| UBS ASSET MANAGEMENT AMERICAS INC | 215,951 | $8,251 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 202,222 | $7,727 |
| APIS CAPITAL ADVISORS, LLC | 186,002 | $7,107 |
| Knott David M Jr | 186,000 | $7,107 |
| Hillsdale Investment Management Inc. | 177,220 | $6,772 |
| Point72 Asset Management, L.P. | 173,383 | $6,625 |
| Rafferty Asset Management, LLC | 169,208 | $6,465 |
| F/M Investments LLC | 168,416 | $6,435 |
| Swiss National Bank | 167,100 | $6,385 |
| Woodline Partners LP | 164,264 | $6,277 |
| WELLS FARGO & COMPANY/MN | 158,834 | $6,069 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 158,709 | $6,064 |
| Voya Investment Management LLC | 155,895 | $5,957 |
| ALGERT GLOBAL LLC | 149,938 | $6 |
| PDT Partners, LLC | 148,721 | $5,683 |
| GW&K Investment Management, LLC | 141,180 | $5 |
| Lisanti Capital Growth, LLC | 138,482 | $5,291 |
| Palisades Investment Partners, LLC | 137,768 | $5,264 |
| Engineers Gate Manager LP | 136,608 | $5,220 |
| MILLENNIUM MANAGEMENT LLC | 136,065 | $5,199 |
| LORD, ABBETT & CO. LLC | 135,822 | $5 |
| SEI INVESTMENTS CO | 133,595 | $5,105 |
| ALLIANCEBERNSTEIN L.P. | 125,069 | $4,779 |
| Palo Alto Investors LP | 110,719 | $4,231 |
| Elmind Capital, LP | 110,000 | $4,203 |
| RHUMBLINE ADVISERS | 109,767 | $4,194 |
| EAM Investors, LLC | 109,404 | $4,180 |
| Voleon Capital Management LP | 102,553 | $3,919 |
| Hennion & Walsh Asset Management, Inc. | 99,229 | $3,792 |
| FRED ALGER MANAGEMENT, LLC | 94,832 | $3,624 |
| FRANKLIN RESOURCES INC | 93,702 | $3,580 |
| RICE HALL JAMES & ASSOCIATES, LLC | 91,536 | $3,498 |
| KVP Capital Advisors, LP | 91,000 | $3,477 |
| Exome Asset Management LLC | 89,052 | $3,403 |
| Parkman Healthcare Partners LLC | 86,297 | $3,297 |
| Penserra Capital Management LLC | 79,747 | $3 |
| 174 other institutions | 2,888,892 | $103,786 |