TREVI THERAPEUTICS INC

Institution	Shares	Value ($000)
SUPERSTRING CAPITAL MANAGEMENT LP	148,292	$1,857
EMERALD MUTUAL FUND ADVISERS TRUST	1,272,373	$15,930
EMERALD ADVISERS, LLC	1,892,276	$23,691
HighVista Strategies LLC	106,159	$1,329
AlphaCentric Advisors LLC	22,667	$284
FRONTIER CAPITAL MANAGEMENT CO LLC	1,108,468	$13,878
WEXFORD CAPITAL LP	82,034	$1,027
F/M Investments LLC	241,483	$3,023
FOX RUN MANAGEMENT, L.L.C.	31,346	$392
XTX Topco Ltd	83,818	$1,049
Abel Hall, LLC	10,191	$128
DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD.	20,000	$250
Erste Asset Management GmbH	90,000	$1,154
Caitong International Asset Management Co., Ltd	4,022	$50
AMERIPRISE FINANCIAL INC	324,172	$4,059
Hudson Bay Capital Management LP	75,000	$939
D. E. Shaw & Co., Inc.	141,312	$1,769
TUDOR INVESTMENT CORP ET AL	68,481	$857
Verition Fund Management LLC	32,119	$402
Allianz Asset Management GmbH	52,800	$661

Increased Positions (73)

NAN FUNG TRINITY (HK) LTD

Value ($000) $11,486 (+1301.5%) Shares 917,450 (+924.2%)

Soleus Capital Management, L.P.

Value ($000) $11,268 (+4825.9%) Shares 900,000 (+3500.0%)

EVENTIDE ASSET MANAGEMENT, LLC

Value ($000) $32,831 (+159.8%) Shares 2,622,306 (+89.8%)

STEMPOINT CAPITAL LP

Value ($000) $5,002 (+55.9%) Shares 399,557 (+13.9%)

Persistent Asset Partners Ltd

Value ($000) $574 (+218.5%) Shares 45,830 (+132.8%)

Woodline Partners LP

Value ($000) $12,524 (+1264.8%) Shares 1,000,282 (+897.5%)

BIT Capital GmbH

Value ($000) $1,628 (+2539.6%) Shares 130,000 (+1829.1%)

Campbell & CO Investment Adviser LLC

Value ($000) $890 (+290.9%) Shares 71,097 (+185.7%)

Pictet Asset Management Holding SA

Value ($000) $19,181 (+18518.5%) Shares 1,532,013 (+13507.0%)

DIADEMA PARTNERS LP

Value ($000) $1,217 (+54.9%) Shares 97,184 (+13.2%)

AXQ CAPITAL, LP

Value ($000) $278 (+95.7%) Shares 22,204 (+43.0%)

FMR LLC

Value ($000) $81,380 (+169.5%) Shares 6,500,009 (+97.0%)

NBC SECURITIES, INC.

Value ($000) $213 (+1063.1%) Shares 17,000 (+750.0%)

PANAGORA ASSET MANAGEMENT INC

Value ($000) $8,676 (+66.2%) Shares 693,001 (+21.5%)

Optimize Financial Inc

Value ($000) $770 (+38.8%) Shares 61,483 (+1.5%)

Voya Investment Management LLC

Value ($000) $2,832 (+1939.1%) Shares 226,215 (+1390.2%)

RAYMOND JAMES FINANCIAL INC

Value ($000) $22,122 (+71.3%) Shares 1,766,963 (+25.2%)

COMERICA BANK

Value ($000) $1,039 (+26691.2%) Shares 83,027 (+19481.8%)

BARCLAYS PLC

Value ($000) $7,295 (+2193.4%) Shares 582,653 (+511.8%)

VANGUARD GROUP INC

Value ($000) $80,562 (+51.1%) Shares 6,434,655 (+10.4%)

Institution	Prev Shares	Curr Shares	Change
NAN FUNG TRINITY (HK) LTD	89,575	917,450	+827,875 (+924.2%)
Soleus Capital Management, L.P.	25,000	900,000	+875,000 (+3500.0%)
EVENTIDE ASSET MANAGEMENT, LLC	1,381,324	2,622,306	+1,240,982 (+89.8%)
STEMPOINT CAPITAL LP	350,710	399,557	+48,847 (+13.9%)
Persistent Asset Partners Ltd	19,688	45,830	+26,142 (+132.8%)
Woodline Partners LP	100,282	1,000,282	+900,000 (+897.5%)
BIT Capital GmbH	6,739	130,000	+123,261 (+1829.1%)
Campbell & CO Investment Adviser LLC	24,885	71,097	+46,212 (+185.7%)
Pictet Asset Management Holding SA	11,259	1,532,013	+1,520,754 (+13507.0%)
DIADEMA PARTNERS LP	85,830	97,184	+11,354 (+13.2%)
AXQ CAPITAL, LP	15,524	22,204	+6,680 (+43.0%)
FMR LLC	3,299,891	6,500,009	+3,200,118 (+97.0%)
NBC SECURITIES, INC.	2,000	17,000	+15,000 (+750.0%)
PANAGORA ASSET MANAGEMENT INC	570,468	693,001	+122,533 (+21.5%)
Optimize Financial Inc	60,599	61,483	+884 (+1.5%)
Voya Investment Management LLC	15,180	226,215	+211,035 (+1390.2%)
RAYMOND JAMES FINANCIAL INC	1,411,037	1,766,963	+355,926 (+25.2%)
COMERICA BANK	424	83,027	+82,603 (+19481.8%)
BARCLAYS PLC	95,232	582,653	+487,421 (+511.8%)
VANGUARD GROUP INC	5,826,986	6,434,655	+607,669 (+10.4%)

Decreased Positions (46)

Affinity Asset Advisors, LLC

Value ($000) $26,920 (+5.1%) Shares 2,150,172 (-23.2%)

MPM BioImpact LLC

Value ($000) $41,154 (+32.0%) Shares 3,287,087 (-3.5%)

Logos Global Management LP

Value ($000) $19,406 (-3.6%) Shares 1,550,000 (-29.5%)

Rubric Capital Management LP

Value ($000) $47,160 (-39.6%) Shares 3,766,749 (-55.9%)

SPHERA FUNDS MANAGEMENT LTD.

Value ($000) $7,494 (+27.2%) Shares 598,534 (-7.1%)

SECTORAL ASSET MANAGEMENT INC

Value ($000) $1,055 (+8.8%) Shares 84,255 (-20.5%)

Siren, L.L.C.

Value ($000) $28,632 (+23.3%) Shares 2,286,867 (-9.9%)

SILVERARC CAPITAL MANAGEMENT, LLC

Value ($000) $6,776 (+25.8%) Shares 541,240 (-8.1%)

J. Goldman & Co LP

Value ($000) $5,563 (-23.3%) Shares 444,357 (-44.0%)

Opaleye Management Inc.

Value ($000) $4,321 (+21.1%) Shares 345,100 (-11.5%)

ORBIMED ADVISORS LLC

Value ($000) $39,948 (+32.0%) Shares 3,190,700 (-3.6%)

VIKING GLOBAL INVESTORS LP

Value ($000) $40,047 (-14.7%) Shares 3,198,644 (-37.6%)

PEREGRINE CAPITAL MANAGEMENT LLC

Value ($000) $6,356 (+12.0%) Shares 507,685 (-18.2%)

EAM Investors, LLC

Value ($000) $6,776 (+36.5%) Shares 541,242 (-1.5%)

DLD Asset Management, LP

Value ($000) $125 (-75.1%) Shares 10,000 (-81.8%)

CHAPIN DAVIS, INC.

Value ($000) $252 (-21.6%) Shares 20,100 (-42.7%)

Qube Research & Technologies Ltd

Value ($000) $283 (-95.3%) Shares 22,622 (-96.5%)

BALYASNY ASSET MANAGEMENT L.P.

Value ($000) $2,187 (-61.9%) Shares 174,641 (-72.1%)

ALLIANCEBERNSTEIN L.P.

Value ($000) $38,599 (-1.7%) Shares 3,082,986 (-28.2%)

MORGAN STANLEY

Value ($000) $13,150 (-66.6%) Shares 1,050,296 (-75.6%)

Institution	Prev Shares	Curr Shares	Change
Affinity Asset Advisors, LLC	2,800,000	2,150,172	-649,828 (-23.2%)
MPM BioImpact LLC	3,406,955	3,287,087	-119,868 (-3.5%)
Logos Global Management LP	2,200,000	1,550,000	-650,000 (-29.5%)
Rubric Capital Management LP	8,531,860	3,766,749	-4,765,111 (-55.9%)
SPHERA FUNDS MANAGEMENT LTD.	643,957	598,534	-45,423 (-7.1%)
SECTORAL ASSET MANAGEMENT INC	105,950	84,255	-21,695 (-20.5%)
Siren, L.L.C.	2,536,867	2,286,867	-250,000 (-9.9%)
SILVERARC CAPITAL MANAGEMENT, LLC	588,789	541,240	-47,549 (-8.1%)
J. Goldman & Co LP	792,806	444,357	-348,449 (-44.0%)
Opaleye Management Inc.	390,000	345,100	-44,900 (-11.5%)
ORBIMED ADVISORS LLC	3,308,400	3,190,700	-117,700 (-3.6%)
VIKING GLOBAL INVESTORS LP	5,128,875	3,198,644	-1,930,231 (-37.6%)
PEREGRINE CAPITAL MANAGEMENT LLC	620,464	507,685	-112,779 (-18.2%)
EAM Investors, LLC	549,479	541,242	-8,237 (-1.5%)
DLD Asset Management, LP	55,000	10,000	-45,000 (-81.8%)
CHAPIN DAVIS, INC.	35,100	20,100	-15,000 (-42.7%)
Qube Research & Technologies Ltd	651,679	22,622	-629,057 (-96.5%)
BALYASNY ASSET MANAGEMENT L.P.	626,462	174,641	-451,821 (-72.1%)
ALLIANCEBERNSTEIN L.P.	4,292,451	3,082,986	-1,209,465 (-28.2%)
MORGAN STANLEY	4,301,726	1,050,296	-3,251,430 (-75.6%)

Exited Positions (14)

Tejara Capital Ltd

Value ($000) $340 Shares 37,200

READYSTATE ASSET MANAGEMENT LP

Value ($000) $315 Shares 34,399

Graham Capital Management, L.P.

Value ($000) $449 Shares 49,043

GSA CAPITAL PARTNERS LLP

Value ($000) $0 Shares 43,506

RENAISSANCE TECHNOLOGIES LLC

Value ($000) $2,684 Shares 293,300

CANTOR FITZGERALD, L. P.

Value ($000) $465 Shares 50,861

ALPS ADVISORS INC

Value ($000) $533 Shares 58,292

KINGSWOOD WEALTH ADVISORS, LLC

Value ($000) $100 Shares 10,907

Engineers Gate Manager LP

Value ($000) $243 Shares 26,598

CAPSTONE INVESTMENT ADVISORS, LLC

Value ($000) $671 Shares 73,287

HSBC HOLDINGS PLC

Value ($000) $372 Shares 41,634

REAP Financial Group, LLC

Value ($000) $18 Shares 2,000

SBI Securities Co., Ltd.

Value ($000) $1 Shares 117

Clearstead Advisors, LLC

Value ($000) $0 Shares 39

Institution	Prev Shares	Prev Value ($000)
Tejara Capital Ltd	37,200	$340
READYSTATE ASSET MANAGEMENT LP	34,399	$315
Graham Capital Management, L.P.	49,043	$449
GSA CAPITAL PARTNERS LLP	43,506	$0
RENAISSANCE TECHNOLOGIES LLC	293,300	$2,684
CANTOR FITZGERALD, L. P.	50,861	$465
ALPS ADVISORS INC	58,292	$533
KINGSWOOD WEALTH ADVISORS, LLC	10,907	$100
Engineers Gate Manager LP	26,598	$243
CAPSTONE INVESTMENT ADVISORS, LLC	73,287	$671
HSBC HOLDINGS PLC	41,634	$372
REAP Financial Group, LLC	2,000	$18
SBI Securities Co., Ltd.	117	$1
Clearstead Advisors, LLC	39	$0