XBIOTECH INC

Institution	Prev Shares	Curr Shares	Change
BRIDGEWAY CAPITAL MANAGEMENT, LLC	59,547	89,547	+30,000 (+50.4%)
MORGAN STANLEY	121,453	163,419	+41,966 (+34.6%)
JANE STREET GROUP, LLC	55,767	69,738	+13,971 (+25.1%)
XTX Topco Ltd	15,056	21,703	+6,647 (+44.1%)
BNP PARIBAS ARBITRAGE, SA	20,610	26,864	+6,254 (+30.3%)
STATE STREET CORP	67,306	73,006	+5,700 (+8.5%)
Squarepoint Ops LLC	62,159	64,004	+1,845 (+3.0%)
FMR LLC	310	450	+140 (+45.2%)

Decreased Positions (15)

VANGUARD GROUP INC

Value ($000) $716 (-67.1%) Shares 299,556 (-63.4%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $324 (-70.8%) Shares 135,438 (-67.5%)

BARCLAYS PLC

Value ($000) $0 (-100.0%) Shares 1 (-100.0%)

BlackRock, Inc.

Value ($000) $690 (-14.2%) Shares 288,632 (-4.5%)

DIMENSIONAL FUND ADVISORS LP

Value ($000) $121 (-29.3%) Shares 50,695 (-21.2%)

BANK OF AMERICA CORP /DE/

Value ($000) $86 (-31.9%) Shares 35,895 (-24.3%)

Qube Research & Technologies Ltd

Value ($000) $49 (-38.9%) Shares 20,611 (-32.0%)

GOLDMAN SACHS GROUP INC

Value ($000) $40 (-39.5%) Shares 16,831 (-32.7%)

Connor, Clark & Lunn Investment Management Ltd.

Value ($000) $72 (-24.6%) Shares 30,229 (-16.1%)

NORTHERN TRUST CORP

Value ($000) $183 (-15.9%) Shares 76,439 (-6.4%)

ROYAL BANK OF CANADA

Value ($000) $0 (-100.0%) Shares 186 (-93.2%)

UBS Group AG

Value ($000) $12 (-29.9%) Shares 5,061 (-21.9%)

JPMORGAN CHASE & CO

Value ($000) $3 (-57.5%) Shares 1,128 (-52.6%)

SIMPLEX TRADING, LLC

Value ($000) $0 Shares 67 (-79.2%)

CWM, LLC

Value ($000) $0 Shares 23 (-81.9%)

Institution	Prev Shares	Curr Shares	Change
VANGUARD GROUP INC	819,239	299,556	-519,683 (-63.4%)
MILLENNIUM MANAGEMENT LLC	416,344	135,438	-280,906 (-67.5%)
BARCLAYS PLC	26,343	1	-26,342 (-100.0%)
BlackRock, Inc.	302,386	288,632	-13,754 (-4.5%)
DIMENSIONAL FUND ADVISORS LP	64,316	50,695	-13,621 (-21.2%)
BANK OF AMERICA CORP /DE/	47,389	35,895	-11,494 (-24.3%)
Qube Research & Technologies Ltd	30,317	20,611	-9,706 (-32.0%)
GOLDMAN SACHS GROUP INC	25,002	16,831	-8,171 (-32.7%)
Connor, Clark & Lunn Investment Management Ltd.	36,029	30,229	-5,800 (-16.1%)
NORTHERN TRUST CORP	81,624	76,439	-5,185 (-6.4%)
ROYAL BANK OF CANADA	2,755	186	-2,569 (-93.2%)
UBS Group AG	6,483	5,061	-1,422 (-21.9%)
JPMORGAN CHASE & CO	2,382	1,128	-1,254 (-52.6%)
SIMPLEX TRADING, LLC	322	67	-255 (-79.2%)
CWM, LLC	127	23	-104 (-81.9%)

Exited Positions (7)

CITADEL ADVISORS LLC

Value ($000) $114 Shares 42,816

HRT FINANCIAL LP

Value ($000) $0 Shares 26,156

SRS Capital Advisors, Inc.

Value ($000) $0 Shares 22

EverSource Wealth Advisors, LLC

Value ($000) $0 Shares 17

CITIGROUP INC

Value ($000) $0 Shares 12

True Wealth Design, LLC

Value ($000) $0 Shares 3

Sunbelt Securities, Inc.

Value ($000) $0 Shares 2

Institution	Prev Shares	Prev Value ($000)
CITADEL ADVISORS LLC	42,816	$114
HRT FINANCIAL LP	26,156	$0
SRS Capital Advisors, Inc.	22	$0
EverSource Wealth Advisors, LLC	17	$0
CITIGROUP INC	12	$0
True Wealth Design, LLC	3	$0
Sunbelt Securities, Inc.	2	$0