AC IMMUNE SA

Ticker: ACIU CUSIP: H00263105 Class: SHS

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (6)

Dauntless Investment Group, LLC
Value ($000) $363 Shares 115,677
Point72 Asset Management, L.P.
Value ($000) $1,208 Shares 384,845
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP
Value ($000) $1,179 Shares 375,623
MARSHALL WACE, LLP
Value ($000) $586 Shares 186,709
JANE STREET GROUP, LLC
Value ($000) $34 Shares 10,710
Leonteq Securities AG
Value ($000) $9 Shares 3,000

Increased Positions (16)

UBS Group AG
Value ($000) $610 (+1185.7%) Shares 194,349 (+1083.3%)
SUSQUEHANNA INTERNATIONAL GROUP, LLP
Value ($000) $464 (+634.4%) Shares 147,625 (+575.9%)
BlackRock, Inc.
Value ($000) $1,577 (+32.5%) Shares 502,169 (+21.9%)
TWO SIGMA INVESTMENTS, LP
Value ($000) $276 (+469.2%) Shares 87,884 (+423.9%)
CITADEL ADVISORS LLC
Value ($000) $223 (+284.4%) Shares 71,151 (+253.8%)
MILLENNIUM MANAGEMENT LLC
Value ($000) $2,931 (+13.4%) Shares 933,342 (+4.3%)
DIMENSIONAL FUND ADVISORS LP
Value ($000) $670 (+30.6%) Shares 213,464 (+20.5%)
BANK OF AMERICA CORP /DE/
Value ($000) $67 (+294.3%) Shares 21,471 (+262.9%)
GOLDMAN SACHS GROUP INC
Value ($000) $58 (+59.6%) Shares 18,555 (+46.9%)
Tower Research Capital LLC (TRC)
Value ($000) $19 (+102.7%) Shares 6,166 (+86.5%)
BARCLAYS PLC
Value ($000) $8 (+357.9%) Shares 2,701 (+451.2%)
MORGAN STANLEY
Value ($000) $296 (+11.4%) Shares 94,345 (+2.5%)
JPMORGAN CHASE & CO
Value ($000) $27 (+30.5%) Shares 8,721 (+20.1%)
Mirae Asset Global Investments Co., Ltd.
Value ($000) $15 (+36.6%) Shares 4,879 (+25.7%)
CITIGROUP INC
Value ($000) $9 (+57.6%) Shares 2,801 (+45.1%)
ACADIAN ASSET MANAGEMENT LLC
Value ($000) $1 (+22.2%) Shares 464,697 (+12.5%)

Decreased Positions (7)

RENAISSANCE TECHNOLOGIES LLC
Value ($000) $2,100 (-5.7%) Shares 668,867 (-13.2%)
Banque Cantonale Vaudoise
Value ($000) $25 (+47069.8%) Shares 7,892 (-57.2%)
China Universal Asset Management Co., Ltd.
Value ($000) $51 (+1.0%) Shares 16,362 (-7.0%)
ROYAL BANK OF CANADA
Value ($000) $2 (-60.0%) Shares 858 (-52.5%)
BNP PARIBAS ARBITRAGE, SA
Value ($000) $8 (-3.9%) Shares 2,480 (-11.5%)
GF FUND MANAGEMENT CO. LTD.
Value ($000) $6 (-0.8%) Shares 1,972 (-8.7%)
OSAIC HOLDINGS, INC.
Value ($000) $1 (-4.3%) Shares 221 (-12.0%)

Exited Positions (6)

Assenagon Asset Management S.A.
Value ($000) $549 Shares 189,892
DEUTSCHE BANK AG\
Value ($000) $732 Shares 253,375
TWO SIGMA ADVISERS, LP
Value ($000) $61 Shares 20,938
Private Advisor Group, LLC
Value ($000) $48 Shares 16,600
State of Tennessee, Department of Treasury
Value ($000) $15 Shares 5,126
SIMPLEX TRADING, LLC
Value ($000) $0 Shares 3,258