| BVF INC/IL | 19,822,436 | $62,242 |
| WELLS FARGO & COMPANY/MN | 1,006,289 | $3,160 |
| MILLENNIUM MANAGEMENT LLC | 933,342 | $2,931 |
| RENAISSANCE TECHNOLOGIES LLC | 668,867 | $2,100 |
| BlackRock, Inc. | 502,169 | $1,577 |
| ACADIAN ASSET MANAGEMENT LLC | 464,697 | $1 |
| Point72 Asset Management, L.P. | 384,845 | $1,208 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 375,623 | $1,179 |
| NORTHERN TRUST CORP | 281,953 | $885 |
| DIMENSIONAL FUND ADVISORS LP | 213,464 | $670 |
| UBS Group AG | 194,349 | $610 |
| MARSHALL WACE, LLP | 186,709 | $586 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,625 | $464 |
| Dauntless Investment Group, LLC | 115,677 | $363 |
| MORGAN STANLEY | 94,345 | $296 |
| TWO SIGMA INVESTMENTS, LP | 87,884 | $276 |
| CITADEL ADVISORS LLC | 71,151 | $223 |
| GEODE CAPITAL MANAGEMENT, LLC | 63,601 | $200 |
| BANK OF AMERICA CORP /DE/ | 21,471 | $67 |
| GOLDMAN SACHS GROUP INC | 18,555 | $58 |
| China Universal Asset Management Co., Ltd. | 16,362 | $51 |
| SEI INVESTMENTS CO | 15,884 | $50 |
| EFG International AG | 12,900 | $41 |
| JANE STREET GROUP, LLC | 10,710 | $34 |
| Quinn Opportunity Partners LLC | 10,100 | $32 |
| Silverberg Bernstein Capital Management LLC | 10,000 | $31 |
| JPMORGAN CHASE & CO | 8,721 | $27 |
| Banque Cantonale Vaudoise | 7,892 | $25 |
| Tower Research Capital LLC (TRC) | 6,166 | $19 |
| Mirae Asset Global Investments Co., Ltd. | 4,879 | $15 |
| Leonteq Securities AG | 3,000 | $9 |
| CITIGROUP INC | 2,801 | $9 |
| BARCLAYS PLC | 2,701 | $8 |
| BNP PARIBAS ARBITRAGE, SA | 2,480 | $8 |
| GF FUND MANAGEMENT CO. LTD. | 1,972 | $6 |
| Activest Wealth Management | 1,000 | $3 |
| Rockefeller Capital Management L.P. | 1,000 | $3 |
| ROYAL BANK OF CANADA | 858 | $2 |
| SBI Securities Co., Ltd. | 547 | $2 |
| OSAIC HOLDINGS, INC. | 221 | $1 |
| Strengthening Families & Communities, LLC | 200 | $1 |