Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2017 (← Previous) (Next →)
Filing Date: Nov 14, 2017
Total Value: $2.618B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| NBIX | NEUROCRINE BIOSCIENCES INC | 4,791,589 | $294M | 11.2% | $32.57 | +62.0% | COM | 64125C109 |
| FOLD | AMICUS THERAPEUTICS INC | 17,888,597 | $270M | 10.3% | $4.30 | +208.0% | COM | 03152W109 |
| ALNY | ALNYLAM PHARMACEUTICALS | 1,788,802 | $210M | 8.0% | $52.98 | +61.1% | COM | 02043Q107 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 4,264,066 | $132M | 5.1% | $27.65 | — | COM | 37890U108 |
| — | ZOGENIX INC | 3,670,357 | $129M | 4.9% | $13.82 | — | COM NEW | 98978L204 |
| PBYI | PUMA BIOTECHNOLOGY INC | 923,820 | $111M | 4.2% | $63.58 | +46.3% | COM | 74587V107 |
| — | LA JOLLA PHARMACEUTICAL CO | 2,157,011 | $75.02M | 2.9% | $22.99 | — | COM PAR.0001 2 | 503459604 |
| — | RETROPHIN INC | 2,686,204 | $66.86M | 2.6% | $14.79 | — | COM | 761299106 |
| — | AVEXIS INC | 671,181 | $64.92M | 2.5% | $75.86 | — | COM | 05366U100 |
| — | CORIUM INTL INC | 5,847,133 | $64.79M | 2.5% | $5.97 | — | COM | 21887L107 |
| — | ACCELERON PHARMA INC | 1,616,259 | $60.32M | 2.3% | $33.45 | — | COM | 00434H108 |
| — | TESARO INC | 388,651 | $50.17M | 1.9% | $77.17 | — | COM | 881569107 |
| RGNX | REGENXBIO INC | 1,441,186 | $47.49M | 1.8% | $19.99 | +12.6% | COM | 75901B107 |
| — | DOVA PHARMACEUTICALS INC | 1,754,015 | $42.59M | 1.6% | $22.34 | — | COM | 25985T102 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 4,726,114 | $36.63M | 1.4% | $6.36 | -0.4% | COM | 462260100 |
| — | NXSTAGE MEDICAL INC | 1,264,523 | $34.9M | 1.3% | $22.78 | — | COM | 67072V103 |
| ANAB | ANAPTYSBIO INC | 982,269 | $34.33M | 1.3% | $23.56 | +14.5% | COM | 032724106 |
| AKBA | AKEBIA THERAPEUTICS INC | 1,630,000 | $32.06M | 1.2% | $13.42 | +14.5% | COM | 00972D105 |
| XNCR | XENCOR INC | 1,293,095 | $29.64M | 1.1% | $11.62 | +91.0% | COM | 98401F105 |
| — | BLUEPRINT MEDICINES CORP | 424,661 | $29.59M | 1.1% | $31.50 | — | COM | 09627Y109 |
| ISRG | INTUITIVE SURGICAL INC | 25,195 | $26.35M | 1.0% | $98.40 | +10.7% | COM NEW | 46120E602 |
| — | VBI VACCINES INC | 6,565,843 | $25.28M | 1.0% | $3.25 | — | COM NEW | 91822J103 |
| CTMX | CYTOMX THERAPEUTICS INC | 1,390,381 | $25.26M | 1.0% | $12.53 | +24.5% | COM | 23284F105 |
| — | DBV TECHNOLOGIES S A | 576,419 | $24.46M | 0.9% | $34.37 | — | SPONSORED ADR | 23306J101 |
| HUM | HUMANA INC | 100,000 | $24.36M | 0.9% | $209.04 | +9.2% | COM | 444859102 |
| — | MYOKARDIA INC | 550,717 | $23.6M | 0.9% | $15.01 | — | COM | 62857M105 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $22.21M | 0.8% | $6.64 | -21.3% | COM | 01438T106 |
| — | AUDENTES THERAPEUTICS INC | 781,309 | $21.89M | 0.8% | $19.96 | — | COM | 05070R104 |
| — | SELECTA BIOSCIENCES INC | 1,162,325 | $21.21M | 0.8% | $18.64 | — | COM | 816212104 |
| VRTX | VERTEX PHARMACEUTICALS INC | 138,626 | $21.08M | 0.8% | $94.81 | +58.8% | COM | 92532F100 |
| GLPG | GALAPAGOS N V | 206,405 | $21M | 0.8% | $67.75 | — | SPON ADR | 36315X101 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 372,671 | $19.34M | 0.7% | $31.66 | +43.0% | COM | 450056106 |
| — | CYMABAY THERAPEUTICS INC | 2,350,882 | $18.95M | 0.7% | $8.06 | — | COM | 23257D103 |
| — | QUOTIENT TECHNOLOGY INC | 3,726,986 | $18.37M | 0.7% | $9.26 | — | COM | G73268107 |
| — | ALBIREO PHARMA INC | 845,000 | $17.7M | 0.7% | $20.60 | — | COM | 01345P106 |
| — | INVITAE CORP | 1,884,500 | $17.66M | 0.7% | $9.02 | — | COM | 46185L103 |
| — | KADMON HLDGS INC | 5,185,847 | $17.37M | 0.7% | $5.20 | — | COM | 48283N106 |
| — | AVADEL PHARMACEUTICALS PLC | 1,549,005 | $16.27M | 0.6% | $10.40 | — | SPONSORED ADR | 05337M104 |
| — | SPARK THERAPEUTICS INC | 180,000 | $16.05M | 0.6% | $89.16 | — | COM | 84652J103 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $15.85M | 0.6% | $3.40 | — | *W EXP 12/24/201 | 00289Y115 |
| — | ALLIQUA BIOMEDICAL INC | 4,233,951 | $15.46M | 0.6% | $0.64 | — | COM NEW | 019621200 |
| — | ASSEMBLY BIOSCIENCES INC | 441,833 | $15.43M | 0.6% | $7.21 | — | COM | 045396108 |
| EVH | EVOLENT HEALTH INC | 850,000 | $15.13M | 0.6% | $17.81 | +15.7% | CL A | 30050B101 |
| — | INTRA CELLULAR THERAPIES INC | 929,460 | $14.67M | 0.6% | $15.78 | — | COM | 46116X101 |
| — | ANTARES PHARMA INC | 4,353,897 | $14.11M | 0.5% | $2.62 | — | COM | 036642106 |
| WVE | WAVE LIFE SCIENCES LTD | 642,798 | $13.98M | 0.5% | $17.06 | +17.8% | SHS | Y95308105 |
| TFX | TELEFLEX INC | 55,200 | $13.36M | 0.5% | $207.38 | 0.0% | COM | 879369106 |
| — | SYNLOGIC INC | 686,352 | $13.05M | 0.5% | $19.01 | — | COM | 87166L100 |
| — | AVEO PHARMACEUTICALS INC | 3,415,116 | $12.55M | 0.5% | $1.03 | — | COM | 053588109 |
| — | BIOHAVEN PHARMACTL HLDG CO L | 306,134 | $11.44M | 0.4% | $32.53 | — | COM | G11196105 |
| ARGX | ARGENX SE | 450,000 | $10.1M | 0.4% | $21.21 | — | SPONSORED ADR | 04016X101 |
| QURE | UNIQURE NV | 1,040,119 | $9.985M | 0.4% | $18.17 | -55.7% | SHS | N90064101 |
| — | ABIOMED INC | 51,729 | $8.722M | 0.3% | $168.61 | — | COM | 003654100 |
| — | ATHENAHEALTH SHARES | 70,000 | $8.705M | 0.3% | $124.36 | — | COM | 04685W103 |
| — | MARINUS PHARMACEUTICALS | 1,452,700 | $8.527M | 0.3% | $5.87 | — | COM | 56854Q101 |
| URGN | UROGEN PHARMA LTD | 269,014 | $8.479M | 0.3% | $17.36 | +27.1% | COM | M96088105 |
| — | ANI PHARMACEUTICALS | 7,500,000 | $8.119M | 0.3% | $1.05 | — | NOTE 3.00% 12/0 | 00182CAA1 |
| — | OXFORD IMMUNOTEC GLOBAL PLC | 465,356 | $7.818M | 0.3% | $16.80 | — | ORD SHS | G6855A103 |
| ARDX | ARDELYX INC | 1,352,391 | $7.573M | 0.3% | $12.08 | -56.4% | COM | 039697107 |
| — | CAPITAL SR LIVING CORP | 560,173 | $7.031M | 0.3% | $19.31 | — | COM | 140475104 |
| EXAS | EXACT SCIENCES CORP | 135,444 | $6.382M | 0.2% | $25.16 | +60.0% | COM | 30063P105 |
| — | CLEMENTIA PHARMACEUTICALS IN | 352,250 | $6.291M | 0.2% | $17.86 | — | COM | 185575107 |
| — | FOAMIX PHARMACEUTICALS LTD | 1,117,324 | $6.201M | 0.2% | $7.58 | — | SHS | M46135105 |
| — | ZYMEWORKS INC | 730,768 | $5.832M | 0.2% | $8.35 | — | COM | 98985W102 |
| — | ACELRX PHARMACEUTICALS INC | 1,244,608 | $5.725M | 0.2% | $9.69 | — | COM | 00444T100 |
| — | SIERRA ONCOLOGY INC | 3,655,186 | $5.666M | 0.2% | $1.53 | — | COM | 82640U107 |
| HRTX | HERON THERAPEUTICS INC | 330,000 | $5.329M | 0.2% | $15.69 | 0.0% | COM | 427746102 |
| — | INTERCEPT PHARMACEUTICALS IN | 90,000 | $5.224M | 0.2% | $58.04 | — | COM | 45845P108 |
| — | CLEARSIDE BIOMEDICAL INC | 620,181 | $5.147M | 0.2% | $7.22 | — | COM | 185063104 |
| ZLAB | ZAI LAB LTD | 175,000 | $4.725M | 0.2% | $27.00 | — | ADR | 98887Q104 |
| — | ONCOMED PHARMACEUTICALS INC | 1,038,289 | $4.693M | 0.2% | $4.52 | — | COM | 68234X102 |
| — | VERSARTIS INC | 1,888,160 | $4.625M | 0.2% | $14.64 | — | COM | 92529L102 |
| — | NEWLINK GENETICS CORP | 450,000 | $4.581M | 0.2% | $10.18 | — | COM | 651511107 |
| MMSI | MERIT MEDICAL SYS INC | 100,000 | $4.235M | 0.2% | $40.30 | 0.0% | COM | 589889104 |
| — | MOLECULAR TEMPLATES INC | 724,133 | $4.231M | 0.2% | $5.84 | — | COM | 608550109 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,519,634 | $4.113M | 0.2% | $3.13 | — | COM | 64077P108 |
| — | INVACARE CORP | 200,000 | $3.95M | 0.2% | $19.75 | — | COM | 461203101 |
| — | GW PHARMACEUTICALS PLC | 36,763 | $3.731M | 0.1% | $101.49 | — | ADS | 36197T103 |
| — | NUCANA PLS | 200,000 | $3.674M | 0.1% | $18.37 | — | SPONSORED ADR | 67022C106 |
| — | HISTOGENICS CORP | 1,777,777 | $3.519M | 0.1% | $3.21 | — | COM | 43358V109 |
| RGEN | REPLIGEN INC | 87,400 | $3.349M | 0.1% | $41.91 | 0.0% | COM | 759916109 |
| GILD | GILEAD SCIENCES INC | 40,000 | $3.241M | 0.1% | $55.94 | 0.0% | COM | 375558103 |
| — | VERONA PHARMA PLC | 200,000 | $3.07M | 0.1% | $11.65 | — | SPONSORED ADR | 925050106 |
| — | CORBUS PHARMACEUTICALS HLDGS | 414,684 | $2.964M | 0.1% | $2.85 | — | COM | 21833P103 |
| — | DBV TECHNOLOGIES S A | 550,000 | $2.808M | 0.1% | $34.37 | — | Put | 23306J101 |
| — | PFENEX INC | 845,973 | $2.555M | 0.1% | $13.00 | — | COM | 717071104 |
| — | VIVEVE MEDICAL INC | 486,988 | $2.551M | 0.1% | $6.33 | — | COM NEW | 92852W204 |
| — | OCERA THERAPEUTICS INC | 2,038,880 | $2.324M | 0.1% | $1.31 | — | COM | 67552A108 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 100,000 | $2.315M | 0.1% | $52.98 | +61.1% | Call | 02043Q107 |
| — | MGC DIAGNOSTICS CORP | 252,327 | $2.261M | 0.1% | $8.55 | — | COM | 552768103 |
| ADMA | ADMA BIOLOGICS INC | 721,102 | $2.221M | 0.1% | $6.35 | -47.5% | COM | 000899104 |
| — | SERES THERAPEUTICS INC | 135,000 | $2.165M | 0.1% | $16.04 | — | COM | 81750R102 |
| — | ABEONA THERAPEUTICS INC | 116,900 | $1.993M | 0.1% | $4.32 | — | COM | 00289Y107 |
| — | DECIPHERA PHARMACEUTICALS IN | 102,500 | $1.946M | 0.1% | $18.99 | — | COM | 24344T101 |
| — | EIGER BIOPHARMACEUTICALS INC | 157,679 | $1.734M | 0.1% | $15.33 | — | COM | 28249U105 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $1.648M | 0.1% | $4.15 | — | COM NEW | 10501E201 |
| — | AFFIMED N V | 668,214 | $1.503M | 0.1% | $2.48 | — | COM | N01045108 |
| — | XENON PHARMACEUTICALS INC | 503,853 | $1.486M | 0.1% | $2.95 | — | COM | 9842ON105 |
| CSBR | CHAMPIONS ONCOLOGY INC | 386,540 | $1.418M | 0.1% | $5.93 | -48.4% | COM | 15870P307 |
| — | CURIS INC | 951,201 | $1.417M | 0.1% | $2.36 | — | COM | 231269101 |
| — | ZYNERBA PHARMACEUTICALS INC | 130,700 | $1.32M | 0.1% | $10.10 | — | COM | 98986X109 |
| OSUR | ORASURE TECHNOLOGIES INC | 54,729 | $1.231M | 0.0% | $10.91 | +84.4% | COM | 68554V108 |
| EXEL | EXELIXIS INC | 46,361 | $1.123M | 0.0% | $14.43 | +84.5% | COM | 30161Q104 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $1.11M | 0.0% | $14.53 | — | SHRS | N31738102 |
| LNTH | LANTHEUS HLDGS INC | 53,763 | $957K | 0.0% | $6.62 | +165.4% | COM | 516544103 |
| — | AZURRX BIOPHARMA INC | 227,272 | $907K | 0.0% | $4.74 | — | COM | 05502L105 |
| CNC | CENTENE CORP DEL | 7,726 | $748K | 0.0% | $33.47 | +28.6% | COM | 15135B101 |
| VYGR | VOYAGER THERAPEUTICS INC | 34,604 | $712K | 0.0% | $8.96 | — | COM | 92915B106 |
| RACE | FERRARI N V | 6,200 | $685K | 0.0% | $40.37 | +163.9% | COM | N3167Y103 |
| — | PROTEON THERAPEUTICS INC | 334,116 | $668K | 0.0% | $8.74 | — | COM | 74371L109 |
| INCY | INCYTE CORP | 5,619 | $656K | 0.0% | $84.26 | +50.2% | COM | 45337C102 |
| VNDA | VANDA PHARMACEUTICALS INC | 36,232 | $649K | 0.0% | $14.25 | +17.4% | COM | 921659108 |
| — | HESKA CORP | 7,300 | $643K | 0.0% | $104.53 | — | COM RESTRC NEW | 42805E306 |
| ALGN | ALIGN TECHNOLOGY INC | 3,448 | $642K | 0.0% | $171.20 | 0.0% | COM | 016255101 |
| — | KERYX BIOPHARMACEUTICALS INC | 83,386 | $592K | 0.0% | $7.10 | — | COM | 492515101 |
| ONC | BEIGENE LTD | 5,700 | $590K | 0.0% | $103.51 | — | SPONSORED ADR | 07725L102 |
| — | ATARA BIOTHERAPEUTICS INC | 35,106 | $581K | 0.0% | $16.55 | — | COM | 046513107 |
| — | PRA HEALTH SCIENCES INC | 7,427 | $566K | 0.0% | $76.21 | — | COM | 69354M108 |
| ESPR | ESPERION THERAPEUTICS INC NE | 10,769 | $540K | 0.0% | $48.22 | 0.0% | COM | 29664W105 |
| — | IMMUNOGEN INC | 70,126 | $536K | 0.0% | $7.64 | — | COM | 45253H101 |
| — | PARATEK PHARMACEUTICALS INC | 21,186 | $532K | 0.0% | $25.11 | — | COM | 699374302 |
| — | INOVALON HLDGS INC | 30,000 | $511K | 0.0% | $17.03 | — | COM CL A | 45781D101 |
| — | CUTERA INC | 11,981 | $495K | 0.0% | $20.68 | — | COM | 232109108 |
| TDOC | TELADOC INC | 14,641 | $485K | 0.0% | $32.78 | 0.0% | COM | 87918A105 |
| — | FIBROGEN INC | 8,593 | $462K | 0.0% | $53.76 | — | COM | 31572Q808 |
| — | ACHAOGEN INC | 27,551 | $439K | 0.0% | $24.72 | — | COM | 004449104 |
| — | NABRIVA THERAPEUTICS PLC | 52,570 | $431K | 0.0% | $8.20 | — | SHS | G63637105 |
| — | PORTOLA PHARMACEUTICALS INC | 7,870 | $425K | 0.0% | $39.19 | — | COM | 737010108 |
| — | PERNIX THERAPEUTICS HLDGS IN | 1,000,000 | $420K | 0.0% | $0.20 | — | DBCV 4.250% 4/0 | 71426VAK4 |
| — | ZOSANO PHARMA INC | 500,000 | $412K | 0.0% | $1.90 | — | COM | 98979H103 |
| MOH | MOLINA HEALTHCARE INC | 50,000 | $345K | 0.0% | $61.36 | +6.1% | Call | 60855R100 |
| — | INTERCEPT PHARMACEUTICALS IN | 250,000 | $283K | 0.0% | $58.04 | — | Call | 45845P108 |
| HCM | HUTCHISON CHINA MEDITECH LTD | 10,000 | $273K | 0.0% | $27.30 | — | SPONSORED ADR | 44842L103 |
| — | ACASTI PHARMA INC | 186,559 | $267K | 0.0% | $2.51 | — | CL A NEW | 00430K402 |
| — | SAGE THERAPEUTICS INC | 215,000 | $178K | 0.0% | — | — | Call | 78667J108 |
| — | SENSEONICS HOLDINGS INC | 50,000 | $160K | 0.0% | $3.20 | — | COM | 81727U105 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 420,000 | $45,000 | 0.0% | $52.98 | +61.1% | Put | 02043Q107 |
| INCY | INCYTE CORP | 100,000 | $35,000 | 0.0% | $84.26 | +50.2% | Call | 45337C102 |
| IONS | IONIS PHARMACEUTICALS INC | 60,000 | $24,000 | 0.0% | — | — | Call | 462222100 |