Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2017 (← Previous) (Next →)
Filing Date: Feb 14, 2018
Total Value: $3.017B (99.7% shares, 0.3% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| NBIX | NEUROCRINE BIOSCIENCES | 5,151,589 | $400M | 13.2% | $77.59 * | $35.06 | +94.6% | COM | 64125C109 |
| FOLD | AMICUS THERAPEUTICS INC | 17,888,597 | $257M | 8.5% | $14.39 * | $4.30 | +219.9% | COM | 03152W109 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 4,889,066 | $192M | 6.4% | $39.35 | $29.14 | — | COM | 37890U108 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 1,330,802 | $169M | 5.6% | $127.05 | $52.98 | +137.2% | COM | 02043Q107 |
| — | ZOGENIX INC | 3,970,357 | $161M | 5.3% | $40.50 | $15.83 | — | COM NEW | 98978L204 |
| — | LA JOLLA PHARMACEUTICAL CO | 3,388,611 | $109M | 3.6% | $32.18 | $26.33 | — | COM PAR $.0001 2 | 503459604 |
| — | BLUEPRINT MEDICINES CORP | 1,140,434 | $86M | 2.9% | $75.41 | $59.06 | — | COM | 09627Y109 |
| ANAB | ANAPTYSBIO INC | 756,387 | $76.18M | 2.5% | $100.72 * | $23.56 | +212.5% | COM | 032724106 |
| PBYI | PUMA BIOTECHNOLOGY INC | 703,820 | $69.57M | 2.3% | $98.85 * | $63.58 | +76.0% | COM | 74587V107 |
| — | ACCELERON PHARMA INC | 1,616,259 | $68.59M | 2.3% | $42.44 | $33.45 | — | COM | 00434H108 |
| — | RETROPHIN INC | 2,672,525 | $56.31M | 1.9% | $21.07 | $14.79 | — | COM | 761299106 |
| — | CORIUM INTL INC | 5,847,133 | $56.19M | 1.9% | $9.61 | $5.97 | — | COM | 21887L107 |
| — | AVEXIS INC | 480,141 | $53.14M | 1.8% | $110.67 | $75.86 | — | COM | 05366U100 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,490,381 | $52.57M | 1.7% | $21.11 | $16.15 | +28.4% | COM | 23284F105 |
| — | DOVA PHARMACEUTICALS INC | 1,809,015 | $52.1M | 1.7% | $28.80 | $22.54 | — | COM | 25985T102 |
| RGNX | REGENXBIO INC | 1,421,186 | $47.25M | 1.6% | $33.25 * | $19.99 | +50.7% | COM | 75901B107 |
| — | VBI VACCINES INC | 9,665,843 | $41.27M | 1.4% | $4.27 | $3.58 | — | COM NEW | 91822J103 |
| — | ABIOMED INC | 215,000 | $40.29M | 1.3% | $187.41 | $182.89 | — | COM | 003654100 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 4,776,114 | $38.21M | 1.3% | $8.00 | $6.37 | +26.0% | COM | 462260100 |
| MMSI | MERIT MED SYS INC | 874,013 | $37.76M | 1.3% | $43.20 * | $41.76 | +0.5% | COM | 589889104 |
| ARGX | ARGENX SE | 537,361 | $33.93M | 1.1% | $63.14 | $28.03 | — | SPONSORED ADR | 04016X101 |
| — | ALBIREO PHARMA INC | 1,320,000 | $33.79M | 1.1% | $25.60 | $22.40 | — | COM | 01345P106 |
| TFX | TELEFLEX INC | 125,900 | $31.33M | 1.0% | $248.82 * | $225.65 | +6.3% | COM | 879369106 |
| — | MYOKARDIA INC | 710,726 | $29.92M | 1.0% | $42.10 | $21.11 | — | COM | 62857M105 |
| — | QUOTIENT TECHNOLOGY INC | 6,033,020 | $29.68M | 1.0% | $4.92 | $7.60 | — | COM | G73268107 |
| AKBA | AKEBIA THERAPEUTICS INC | 1,987,400 | $29.55M | 1.0% | $14.87 * | $13.99 | +18.5% | COM | 00972D105 |
| XNCR | XENCOR INC | 1,313,095 | $28.78M | 1.0% | $21.92 | $11.77 | +84.2% | COM | 98401F105 |
| ISRG | INTUITIVE SURGICAL INC | 70,585 | $25.76M | 0.9% | $364.94 * | $115.60 | +8.3% | COM NEW | 46120E602 |
| — | CYMABAY THERAPEUTICS INC | 2,685,882 | $24.71M | 0.8% | $9.20 | $8.20 | — | COM | 23257D103 |
| — | AUDENTES THERAPEUTICS INC | 781,309 | $24.42M | 0.8% | $31.25 | $19.96 | — | COM | 05070R104 |
| — | ASSEMBLY BIOSCIENCES INC | 536,626 | $24.28M | 0.8% | $45.25 | $13.93 | — | COM | 045396108 |
| ZBH | ZIMMER BIOMET HLDGS INC | 200,000 | $24.13M | 0.8% | $120.67 * | $105.78 | 0.0% | COM | 98956P102 |
| — | DBV TECHNOLOGIES SA | 978,619 | $24.07M | 0.8% | $24.60 | $30.35 | — | SPONSORED ADR | 23306J101 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 427,371 | $23.95M | 0.8% | $56.05 * | $34.30 | +52.4% | COM | 450056106 |
| WVE | WAVE LIFE SCIENCES LTD | 662,798 | $23.26M | 0.8% | $35.10 * | $17.43 | +67.3% | SHS | Y95308105 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 745,135 | $21.65M | 0.7% | $29.06 * | $26.40 | 0.0% | COM | 76243J105 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $20.98M | 0.7% | $6.80 * | $6.64 | -0.7% | COM | 01438T106 |
| VRTX | VERTEX PHARMACEUTICALS INC | 138,626 | $20.77M | 0.7% | $149.86 | $94.81 | +56.2% | COM | 92532F100 |
| QURE | UNIQURE NV | 1,047,950 | $20.53M | 0.7% | $19.59 * | $18.17 | -16.2% | SHS | N90064101 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 8,374,015 | $19.76M | 0.7% | $2.36 | $2.96 | — | COM | 64077P108 |
| — | AVADEL PHARMACEUTICALS PLC | 2,391,841 | $19.61M | 0.7% | $8.20 | $9.62 | — | SPONSORED ADR | 05337M104 |
| GLPG | GALAPAGOS NV | 206,305 | $19.34M | 0.6% | $93.76 | $67.75 | — | SPON ADR | 36315X101 |
| HUM | HUMANA INC | 77,500 | $19.23M | 0.6% | $248.06 * | $209.04 | +10.3% | COM | 444859102 |
| — | KADMON HLDGS INC | 5,185,847 | $18.77M | 0.6% | $3.62 | $5.20 | — | COM | 48283N106 |
| — | SIERRA ONCOLOGY INC | 5,000,000 | $18.65M | 0.6% | $3.73 | $2.12 | — | COM | 82640U107 |
| — | INVITAE CORP | 2,004,500 | $18.2M | 0.6% | $9.08 | $9.03 | — | COM | 46185L103 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 188,893 | $17.34M | 0.6% | $91.79 * | $57.12 | 0.0% | COM | 558868105 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $14.61M | 0.5% | $11.60 | $3.40 | — | *W EXP 12/24/201 | 00289Y115 |
| — | REVANCE THERAPEUTICS INC | 400,000 | $14.3M | 0.5% | $35.75 | $35.75 | — | COM | 761330109 |
| ADMA | ADMA BIOLOGICS INC | 3,821,102 | $12.27M | 0.4% | $3.21 * | $3.47 | -19.3% | COM | 000899104 |
| — | ONCOMED PHARMACEUTICALS INC | 2,620,897 | $10.74M | 0.4% | $4.10 | $4.27 | — | COM | 68234X102 |
| — | TESARO INC | 129,372 | $10.72M | 0.4% | $82.87 | $77.17 | — | COM | 881569107 |
| CLLS | CELLECTIS SA | 350,000 | $10.2M | 0.3% | $29.15 | $29.15 | — | SPONSORED ADS | 15117K103 |
| — | CAPITAL SR LIVING CORP | 680,173 | $9.176M | 0.3% | $13.49 | $18.29 | — | COM | 140475104 |
| — | AGILE THERAPEUTICS INC | 3,380,000 | $9.092M | 0.3% | $2.69 | $2.69 | — | COM | 00847L100 |
| AMGN | AMGEN INC | 50,000 | $8.695M | 0.3% | $173.90 * | $138.21 | 0.0% | COM | 031162100 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $8.642M | 0.3% | $1.15 | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| — | AVEO PHARMACEUTICALS INC | 2,958,116 | $8.253M | 0.3% | $2.79 | $1.03 | — | COM | 053588109 |
| — | FLEXION THERAPEUTICS INC | 307,989 | $7.712M | 0.3% | $25.04 | $25.04 | — | COM | 33938J106 |
| CDNA | CAREDX INC | 1,040,676 | $7.639M | 0.3% | $7.34 * | $6.23 | 0.0% | COM | 14167L103 |
| REGN | REGENERON PHARMACEUTICALS | 20,000 | $7.519M | 0.2% | $375.95 * | $402.77 | 0.0% | COM | 75886F107 |
| — | ANTARES PHARMA INC | 3,745,662 | $7.454M | 0.2% | $1.99 | $2.62 | — | COM | 036642106 |
| — | MARINUS PHARMACEUTICALS INC | 907,732 | $7.407M | 0.2% | $8.16 | $5.87 | — | COM | 56854Q101 |
| URGN | UROGEN PHARMA LTD | 199,014 | $7.405M | 0.2% | $37.21 * | $17.36 | +105.1% | COM | M96088105 |
| — | MOLECULAR TEMPLATES INC | 724,133 | $7.255M | 0.2% | $10.02 | $5.84 | — | COM | 608550109 |
| — | BIOHAVEN PHARMACTL HLDG CO L | 261,134 | $7.045M | 0.2% | $26.98 | $32.53 | — | COM | G11196105 |
| — | OXFORD IMMUNOTEC GLOBAL PLC | 500,356 | $6.99M | 0.2% | $13.97 | $16.60 | — | ORD SHS | G6855A103 |
| — | FOAMIX PHARMACEUTICALS LTD | 1,117,324 | $6.715M | 0.2% | $6.01 | $7.58 | — | SHS | M46135105 |
| — | SYNLOGIC INC | 686,352 | $6.658M | 0.2% | $9.70 | $19.01 | — | COM | 87166L100 |
| — | ABLYNX NV | 250,000 | $6.248M | 0.2% | $24.99 | $24.99 | — | SPONSORED ADR | 00372Y105 |
| — | ENDOCYTE INC | 1,451,700 | $6.213M | 0.2% | $4.28 | $4.28 | — | COM | 29269A102 |
| — | SELECTA BIOSCIENCES INC | 632,712 | $6.206M | 0.2% | $9.81 | $18.64 | — | COM | 816212104 |
| — | ZYMEWORKS SHARES | 777,497 | $5.549M | 0.2% | $7.14 | $8.28 | — | COM | 98985W102 |
| GMED | GLOBUS MED INC | 113,100 | $4.648M | 0.2% | $41.10 * | $35.01 | 0.0% | CL A | 379577208 |
| — | CLEARSIDE BIOMEDICAL INC | 620,181 | $4.341M | 0.1% | $7.00 | $7.22 | — | COM | 185063104 |
| — | ODONATE THERAPEUTICS INC | 150,000 | $3.75M | 0.1% | $25.00 | $25.00 | — | COM | 676079106 |
| ZLAB | ZAI LAB LTD | 175,000 | $3.715M | 0.1% | $21.23 | $27.00 | — | ADR | 98887Q104 |
| — | NEWLINK GENETICS CORP | 450,000 | $3.65M | 0.1% | $8.11 | $10.18 | — | COM | 651511107 |
| — | HISTOGENICS CORP | 1,777,777 | $3.644M | 0.1% | $2.05 | $3.21 | — | COM | 43358V109 |
| QTRX | QUANTERIX CORP | 169,400 | $3.637M | 0.1% | $21.47 * | $19.52 | 0.0% | COM | 74766Q101 |
| — | INVACARE CORP | 200,000 | $3.37M | 0.1% | $16.85 | $19.75 | — | COM | 461203101 |
| — | VERSARTIS INC | 1,488,160 | $3.273M | 0.1% | $2.20 | $14.64 | — | COM | 92529L102 |
| — | NEOS THERAPEUTICS INC | 300,000 | $3.06M | 0.1% | $10.20 | $10.20 | — | COM | 64052L106 |
| — | ACHILLION PHARMACEUTICALS IN | 1,000,000 | $2.88M | 0.1% | $2.88 | $2.88 | — | COM | 00448Q201 |
| — | BLUEBIRD BIO INC | 14,400 | $2.565M | 0.1% | $178.13 | $178.13 | — | COM | 09609G100 |
| — | ALLENA PHARMACEUTICALS INC | 250,000 | $2.515M | 0.1% | $10.06 | $10.06 | — | COM | 018119107 |
| — | VERONA PHARMA PLC | 200,000 | $2.384M | 0.1% | $11.92 | $11.65 | — | SPONSORED ADR | 925050106 |
| — | DECIPHERA PHARMACEUTICALS IN | 102,500 | $2.324M | 0.1% | $22.67 | $18.99 | — | COM | 24344T101 |
| — | EIGER BIOPHARMACEUTICALS INC | 157,679 | $2.199M | 0.1% | $13.95 | $15.33 | — | COM | 28249U105 |
| — | ACER THERAPEUTICS INC | 150,000 | $2.091M | 0.1% | $13.94 | $13.94 | — | COM | 00444P108 |
| — | VICAL INC | 1,142,858 | $2.091M | 0.1% | $1.83 | $1.83 | — | COM NEW | 925602203 |
| — | STRONGBRIDGE BIOPHARMA PLC | 275,000 | $1.994M | 0.1% | $7.25 | $7.25 | — | SHS USD | G85347105 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $1.568M | 0.1% | $3.92 | $4.15 | — | COM NEW | 10501E201 |
| CSBR | CHAMPIONS ONCOLOGY INC | 386,540 | $1.499M | 0.0% | $3.88 * | $5.93 | -39.9% | COM NEW | 15870P307 |
| — | CORBUS PHARMACEUTICALS HLDGS | 200,000 | $1.42M | 0.0% | $7.10 | $2.85 | — | COM | 21833P103 |
| EXEL | EXELIXIS SHARES INC | 46,361 | $1.409M | 0.0% | $30.39 * | $14.43 | +84.4% | COM | 30161Q104 |
| — | PFENEX INC | 519,773 | $1.383M | 0.0% | $2.66 | $13.00 | — | COM | 717071104 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $1.106M | 0.0% | $17.84 | $14.53 | — | SHS | N31738102 |
| LNTH | LANTHEUS HLDGS INC | 53,763 | $1.099M | 0.0% | $20.44 | $6.62 | +207.5% | COM | 516544103 |
| — | VOCERA COMMUNICATIONS INC | 35,169 | $1.063M | 0.0% | $30.23 | $30.23 | — | COM | 92857F107 |
| — | ABEONA THERAPEUTICS INC | 59,662 | $946K | 0.0% | $15.86 | $4.32 | — | COM | 00289Y107 |
| — | AFFIMED NV | 668,214 | $869K | 0.0% | $1.30 | $2.48 | — | COM | N01045108 |
| — | AZURRX BIOPHARMA INC | 227,272 | $841K | 0.0% | $3.70 | $4.74 | — | COM | 05502L105 |
| — | IGNYTA INC | 30,211 | $807K | 0.0% | $26.71 | $26.71 | — | COM | 451731103 |
| ALGN | ALIGN TECHNOLOGY INC | 3,448 | $766K | 0.0% | $222.16 * | $171.20 | +32.7% | COM | 016255101 |
| — | ALLIQUA BIOMEDICAL INC | 423,394 | $766K | 0.0% | $1.81 | $1.81 | — | COM NEW | 019621309 |
| — | ARENA PHARMACEUTICALS INC | 21,978 | $747K | 0.0% | $33.99 | $33.99 | — | COM NEW | 040047607 |
| — | SUCAMPO PHARMACEUTICALS INC | 40,062 | $719K | 0.0% | $17.95 | $17.95 | — | CL A | 864909106 |
| ESPR | ESPERION THERAPEUTICS INC NE | 10,769 | $709K | 0.0% | $65.84 * | $48.22 | +11.7% | COM | 29664W105 |
| CNC | CENTENE CORP DEL | 6,699 | $676K | 0.0% | $100.91 * | $33.47 | +44.7% | COM | 15135B101 |
| — | CURIS INC | 951,201 | $666K | 0.0% | $0.70 | $2.36 | — | COM | 231269101 |
| RACE | FERRARI NV | 6,200 | $650K | 0.0% | $104.84 * | $40.37 | +175.4% | COM | N3167Y103 |
| — | PROTEON THERAPEUTICS INC | 334,116 | $635K | 0.0% | $1.90 | $8.74 | — | COM | 74371L109 |
| — | VALEANT PHARMACEUTICALS INTL | 30,092 | $625K | 0.0% | $20.77 | $20.77 | — | COM | 91911K102 |
| EVH | EVOLENT HEALTH INC | 50,000 | $615K | 0.0% | $12.30 * | $17.81 | -20.8% | CL A | 30050B101 |
| — | SPECTRUM PHARMACEUTICALS INC | 32,154 | $609K | 0.0% | $18.94 | $18.94 | — | COM | 84763A108 |
| XBI | SPDR S&P BIOTECH ETF SHS PUT 85 01/05/2018 | 600,000 | $579K | 0.0% | $0.96 | — | — | Put | 78464A870 |
| ONC | BEIGENE LTD | 5,700 | $557K | 0.0% | $97.72 | $103.51 | — | SPONSORED ADR | 07725L102 |
| — | CUTERA INC | 11,981 | $543K | 0.0% | $45.32 | $20.68 | — | COM | 232109108 |
| — | MIRATI THERAPEUTICS INC | 29,091 | $531K | 0.0% | $18.25 | $18.25 | — | COM | 60468T105 |
| VRAYQ | VIEWRAY INC | 50,000 | $463K | 0.0% | $9.26 * | $8.00 | 0.0% | COM | 92672L107 |
| — | PERNIX THERAPEUTICS HLDGS IN | 1,000,000 | $421K | 0.0% | $0.42 | $0.20 | — | DBCV 4.250% 4/0 | 71426VAK4 |
| HCM | HUTCHISON CHINA MEDITECH LTD | 10,000 | $394K | 0.0% | $39.40 | $27.30 | — | SPONSORED ADR | 44842L103 |
| — | KERYX BIOPHARMACEUTICALS INC | 83,386 | $388K | 0.0% | $4.65 | $7.10 | — | COM | 492515101 |
| — | PROGENICS PHARMACEUTICALS IN | 61,850 | $368K | 0.0% | $5.95 | $5.95 | — | COM | 743187106 |
| — | SENSEONICS HLDGS INC | 115,000 | $306K | 0.0% | $2.66 | $2.90 | — | COM | 81727U105 |
| — | CASI PHARMACEUTICALS INC | 83,682 | $272K | 0.0% | $3.25 | $3.25 | — | COM | 14757U109 |
| — | ZOSANO PHARMA CORP | 500,000 | $260K | 0.0% | $0.52 | $1.90 | — | COM | 98979H103 |
| — | ACASTI PHARMA INC | 186,559 | $176K | 0.0% | $0.94 | $2.51 | — | CL A NEW | 00430K402 |
| — | JUNO THERAPEUTICS INC | 300,000 | $93,000 | 0.0% | $0.31 | — | — | Call | 48205A109 |
| PBYI | PUMA BIOTECHNOLOGY INC | 100,000 | $55,000 | 0.0% | $0.55 * | $63.58 | +76.0% | Call | 74587V107 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $6,000 | 0.0% | $1.50 | $1.50 | — | COM | 14070B101 |