Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2018 (← Previous) (Next →)
Filing Date: May 15, 2018
Total Value: $3.57B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| NBIX | NEUROCRINE BIOSCIENCES INC | 4,761,989 | $395M | 11.1% | $35.06 | +140.9% | COM | 64125C109 |
| FOLD | AMICUS THERAPEUTICS INC | 20,024,424 | $301M | 8.4% | $5.46 | +178.7% | COM | 03152W109 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 4,989,066 | $241M | 6.7% | $29.53 | — | COM | 37890U108 |
| — | ZOGENIX INC | 3,970,357 | $159M | 4.5% | $15.83 | — | COM NEW | 98978L204 |
| ALNY | ALNYLAM PHARMACEUTICALS | 1,280,802 | $153M | 4.3% | $52.98 | +143.4% | COM | 02043Q107 |
| — | LA JOLLA PHARMACEUTICAL CO | 4,313,611 | $128M | 3.6% | $27.07 | — | COM PAR $.0001 2 | 503459604 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 6,162,202 | $104M | 2.9% | $8.35 | +81.5% | COM | 462260100 |
| — | ALEXION PHARMACEUTICALS INC | 873,450 | $97.36M | 2.7% | $111.46 | — | COM | 015351109 |
| — | ABIOMED INC | 332,449 | $96.74M | 2.7% | $221.08 | — | COM | 003654100 |
| — | BLUEPRINT MEDICINES CORP | 1,030,434 | $94.49M | 2.6% | $59.06 | — | COM | 09627Y109 |
| — | DOVA PHARMACEUTICALS INC | 2,780,977 | $75.42M | 2.1% | $24.14 | — | COM | 25985T102 |
| — | CORIUM INTERNATIONAL INC | 6,357,133 | $72.92M | 2.0% | $6.41 | — | COM | 21887L107 |
| — | RETROPHIN INC | 3,212,871 | $71.84M | 2.0% | $16.07 | — | COM | 761299106 |
| — | BIOHAVEN PHARMACEUTICAL HLDG CO L | 2,927,449 | $71.22M | 2.0% | $25.06 | — | COM | G11196105 |
| ASND | ASCENDIS PHARMA A S | 982,647 | $64.27M | 1.8% | $65.40 | — | SPONSORED ADR | 04351P101 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,208,812 | $62.84M | 1.8% | $16.15 | +76.7% | COM | 23284F105 |
| — | MENLO THERAPEUTICS INC | 1,598,958 | $60.09M | 1.7% | $37.58 | — | COM | 586858102 |
| — | ACCELERON PHARMA INC | 1,516,259 | $59.29M | 1.7% | $33.45 | — | COM | 00434H108 |
| — | ALBIREO PHARMA INC | 1,704,330 | $55.51M | 1.6% | $24.69 | — | COM | 01345P106 |
| — | DBV TECHNOLOGIES S A | 2,093,498 | $48.3M | 1.4% | $26.47 | — | SPONSORED ADR | 23306J101 |
| MMSI | MERIT MED SYS INC | 1,045,013 | $47.39M | 1.3% | $42.33 | +7.0% | COM | 589889104 |
| ARGX | ARGENX SE-ADR | 537,361 | $43.23M | 1.2% | $28.03 | — | COM | 04016X101 |
| — | MYOKARDIA INC | 834,679 | $40.73M | 1.1% | $25.22 | — | COM | 62857M105 |
| XNCR | XENCOR INC | 1,318,095 | $39.52M | 1.1% | $11.77 | +122.1% | COM | 98401F105 |
| — | AVEXIS INC | 276,400 | $34.16M | 1.0% | $75.86 | — | COM | 05366U100 |
| — | VBI VACCINES INC | 9,665,843 | $33.83M | 0.9% | $3.58 | — | COM NEW | 91822J103 |
| — | CYMABAY THERAPEUTICS INC | 2,802,821 | $33.74M | 0.9% | $8.36 | — | COM | 23257D103 |
| QURE | UNIQURE NV | 1,394,628 | $32.77M | 0.9% | $19.08 | +14.3% | COM | N90064101 |
| PBYI | PUMA BIOTECHNOLOGY INC | 442,179 | $30.09M | 0.8% | $63.58 | +17.8% | COM | 74587V107 |
| — | SOLID BIOSCIENCES INC | 3,927,222 | $29.45M | 0.8% | $7.50 | — | COM | 3422E1055 |
| — | QUOTIENT LTD | 6,033,020 | $28.41M | 0.8% | $7.60 | — | COM | G73268107 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 419,706 | $26.42M | 0.7% | $34.30 | +80.5% | COM | 450056106 |
| RGNX | REGENXBIO INC | 881,106 | $26.3M | 0.7% | $19.99 | +45.6% | COM | 75901B107 |
| VRTX | VERTEX PHARMACEUTICALS INC | 151,898 | $24.76M | 0.7% | $100.79 | +62.1% | COM | 92532F100 |
| ANAB | ANAPTYSBIO INC | 237,281 | $24.7M | 0.7% | $23.56 | +378.4% | COM | 032724106 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 8,574,015 | $24.09M | 0.7% | $2.95 | — | COM | 64077P108 |
| AKBA | AKEBIA THERAPEUTICS INC | 2,462,400 | $23.47M | 0.7% | $13.99 | -0.0% | COM | 00972D105 |
| — | ASSEMBLY BIOSCIENCES INC | 476,626 | $23.42M | 0.7% | $13.93 | — | COM | 045396108 |
| ALDX | ALDEYRA THERAPEUTICS INC | 3,085,458 | $23.14M | 0.6% | $6.64 | +14.4% | COM | 01438T106 |
| — | AUDENTES THERAPEUTICS INC | 756,215 | $22.72M | 0.6% | $19.96 | — | COM | 05070R104 |
| — | KADMON HLDGS INC | 5,165,746 | $21.95M | 0.6% | $5.20 | — | COM | 48283N106 |
| TDOC | TELADOC INC | 520,000 | $20.96M | 0.6% | $37.75 | 0.0% | COM | 87918A105 |
| GLPG | GALAPAGOS N V | 206,305 | $20.58M | 0.6% | $67.75 | — | SPON ADR | 36315X101 |
| AGIO | AGIO PHARMACEUTICALS INC | 250,000 | $20.45M | 0.6% | $77.29 | 0.0% | COM | 00847X104 |
| — | ABLYNX NV | 370,000 | $20.19M | 0.6% | $34.58 | — | SPONSORED ADR | 00372Y105 |
| — | ENDOCYTE INC | 2,201,700 | $20.01M | 0.6% | $5.92 | — | COM | 29269A102 |
| — | REVANCE THERAPEUTICS INC | 618,957 | $19.06M | 0.5% | $34.00 | — | COM | 761330109 |
| WVE | WAVE LIFE SCIENCES LTD | 462,798 | $18.56M | 0.5% | $17.43 | +141.2% | SHS | Y95308105 |
| ADMA | ADMA BIOLOGICS INC | 3,821,102 | $17.58M | 0.5% | $3.47 | +14.7% | COM | 000899104 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 142,522 | $16.64M | 0.5% | $57.12 | +116.1% | COM | 558868105 |
| HUM | HUMANA INC | 60,718 | $16.32M | 0.5% | $209.04 | +21.1% | COM | 444859102 |
| — | ADAMAS PHARMACEUTICALS INC | 630,000 | $15.06M | 0.4% | $23.90 | — | COM | 00548A106 |
| — | PORTOLA PHARMACEUTICALS INC | 440,000 | $14.37M | 0.4% | $32.66 | — | COM | 737010108 |
| — | ABEONA THERAPEUTICS INC | 998,162 | $14.18M | 0.4% | $13.62 | — | COM | 00289Y107 |
| — | MOTUS GI HLDGS INC | 2,810,542 | $12.59M | 0.4% | $4.48 | — | COM | 62014P108 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $11.97M | 0.3% | $3.40 | — | W EXP 12/24/201 | 00289Y115 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 592,286 | $11.79M | 0.3% | $26.40 | +0.6% | COM | 76243J105 |
| TFX | TELEFLEX INC | 40,900 | $10.43M | 0.3% | $225.65 | +11.3% | COM | 879369106 |
| — | SIERRA ONCOLOGY INC | 5,000,000 | $10.35M | 0.3% | $2.12 | — | COM | 82640U107 |
| CLLS | CELLECTIS S A | 300,000 | $9.453M | 0.3% | $29.15 | — | SPONSORED ADS | 15117K103 |
| — | AVADEL PHARMACEUTICALS PLC | 1,295,841 | $9.447M | 0.3% | $9.62 | — | SPONSORED ADR | 05337M104 |
| — | AGILE THERAPEUTICS INC | 3,530,000 | $9.072M | 0.3% | $2.68 | — | COM | 00847L100 |
| — | SYNLOGIC INC | 942,852 | $8.844M | 0.2% | $16.39 | — | COM | 87166L100 |
| — | INVITAE CORP | 1,851,100 | $8.7M | 0.2% | $9.03 | — | COM | 46185L103 |
| — | ONCOMED PHARMACEUTICALS INC | 2,620,897 | $8.334M | 0.2% | $4.27 | — | COM | 68234X102 |
| CDNA | CAREDX INC | 1,040,676 | $8.294M | 0.2% | $6.23 | -1.1% | COM | 14167L103 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $8.214M | 0.2% | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| PTCT | PTC THERAPEUTICS INC | 300,000 | $8.118M | 0.2% | $25.34 | 0.0% | COM | 69366J200 |
| — | ZYMEWORKS INC | 693,890 | $7.779M | 0.2% | $8.28 | — | COM | 98985W102 |
| — | CLEARSIDE BIOMEDICAL INC | 715,181 | $7.681M | 0.2% | $7.69 | — | COM | 185063104 |
| — | AVEO PHARMACEUTICALS INC | 2,458,116 | $7.129M | 0.2% | $1.03 | — | COM | 053588109 |
| INCY | INCYTE CORP | 1,510,000 | $6.946M | 0.2% | — | — | Call | 45337C102 |
| — | FLEXION THERAPEUTICS INC | 307,989 | $6.902M | 0.2% | $25.04 | — | COM | 33938J106 |
| — | ARENA PHARMACEUTICALS INC | 171,978 | $6.793M | 0.2% | $38.79 | — | COM NEW | 040047607 |
| ACAD | ACADIA PHARMACEUTICALS INC | 275,000 | $6.179M | 0.2% | $27.69 | 0.0% | COM | 004225108 |
| — | HISTOGENICS CORP | 2,203,277 | $6.059M | 0.2% | $3.12 | — | COM | 43358V109 |
| — | SELECTA BIOSCIENCES INC | 593,750 | $6.05M | 0.2% | $18.64 | — | COM | 816212104 |
| — | MOLECULAR TEMPLATES INC | 724,133 | $5.793M | 0.2% | $5.84 | — | COM | 608550109 |
| — | FOAMIX PHARMACEUTICALS LTD | 1,117,324 | $5.732M | 0.2% | $7.58 | — | COM | M46135105 |
| BIIB | BIOGEN INC | 20,000 | $5.476M | 0.2% | $310.41 | 0.0% | COM | 09062X103 |
| — | NUVECTRA CORP | 384,600 | $5.007M | 0.1% | $13.02 | — | COM | 67075N108 |
| ISRG | INTUITIVE SURGICAL INC | 10,000 | $4.128M | 0.1% | $115.60 | +20.7% | COM NEW | 46120E602 |
| — | ACHILLION PHARMACEUTICALS INC | 1,000,000 | $3.71M | 0.1% | $2.88 | — | COM | 00448Q201 |
| — | INVACARE CORP | 200,000 | $3.48M | 0.1% | $19.75 | — | COM | 461203101 |
| — | MARINUS PHARMACEUTICALS INC | 907,732 | $3.467M | 0.1% | $5.87 | — | COM | 56854Q101 |
| — | ATHENEX INC | 190,000 | $3.232M | 0.1% | $17.01 | — | COM | 04685N103 |
| — | ODONATE THERAPEUTICS INC | 150,000 | $3.177M | 0.1% | $25.00 | — | COM | 676079106 |
| — | ALLENA PHARMACEUTICALS INC | 250,000 | $2.755M | 0.1% | $10.06 | — | COM | 018119107 |
| ARWR | ARROWHEAD PHARMACEUTICALS INC | 365,445 | $2.635M | 0.1% | $6.16 | 0.0% | COM | 04280A100 |
| — | ADVAXIS INC | 1,500,000 | $2.535M | 0.1% | $1.69 | — | COM NEW | 007624208 |
| — | AKCEA THERAPEUTICS INC | 97,144 | $2.488M | 0.1% | $25.61 | — | COM | 00972L107 |
| — | STRONGBRIDGE BIOPHARMA PLC | 275,000 | $2.434M | 0.1% | $7.25 | — | SHS USD | G85347105 |
| INCY | INCYTE CORP | 100,000 | $2.23M | 0.1% | — | — | Put | 45337C102 |
| MCK | MCKESSON CORP | 15,000 | $2.113M | 0.1% | $146.42 | 0.0% | COM | 58155Q103 |
| — | VICAL INC | 1,142,858 | $1.657M | 0.0% | $1.83 | — | COM | 925602203 |
| PBYI | PUMA BIOTECHNOLOGY INC | 200,000 | $1.61M | 0.0% | $63.58 | +17.8% | Call | 74587V107 |
| — | EIGER BIOPHARMACEUTICALS INC | 157,679 | $1.553M | 0.0% | $15.33 | — | COM | 28249U105 |
| XBI | SPDR SERIES TRUST | 900,000 | $1.548M | 0.0% | — | — | Put | 78464A870 |
| — | INTRA CELLULAR THERAPIES INC | 70,000 | $1.474M | 0.0% | $21.06 | — | COM | 46116X101 |
| — | CATALYST BIOSCIENCES IINC | 55,000 | $1.419M | 0.0% | $25.80 | — | COM NEW | 14888D208 |
| CSBR | CHAMPIONS ONCOLOGY INC | 366,973 | $1.335M | 0.0% | $5.93 | -37.1% | COM NEW | 15870P307 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $1.272M | 0.0% | $14.53 | — | SHS | N31738102 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $1.26M | 0.0% | $4.15 | — | COM NEW | 10501E201 |
| — | VIVEVE MED INC | 334,894 | $1.226M | 0.0% | $3.66 | — | COM NEW | 92852W204 |
| — | PROGENICS PHARMACEUTICALS IN | 162,500 | $1.212M | 0.0% | $6.88 | — | COM | 743187106 |
| — | VERONA PHARMA PLC | 56,168 | $1.123M | 0.0% | $11.65 | — | SPONSORED ADS | 925050106 |
| — | DYNAVAX TECHNOLOGIES CORP | 55,713 | $1.106M | 0.0% | $19.85 | — | COM NEW | 268158201 |
| — | CAPITAL SR LIVING CORP | 100,173 | $1.077M | 0.0% | $18.29 | — | COM | 140475104 |
| ONC | BEIGENE LTD | 5,700 | $958K | 0.0% | $103.51 | — | SPONSORED | 07725L102 |
| — | MIRATI THERAPEUTICS INC | 29,091 | $893K | 0.0% | $18.25 | — | COM | 60468T105 |
| — | PROTEON THERAPEUTICS INC | 334,116 | $835K | 0.0% | $8.74 | — | COM | 74371L109 |
| — | ALLIQUA BIOMEDICAL INC | 423,394 | $821K | 0.0% | $1.81 | — | COM PAR | 019621309 |
| ESPR | ESPERION THERAPEUTICS INC NE | 10,769 | $779K | 0.0% | $48.22 | +52.3% | COM | 29664W105 |
| RACE | FERRARI N V | 6,200 | $747K | 0.0% | $40.37 | +200.4% | COM | N3167Y103 |
| ENTA | ENANTA PHARMACEUTICALS INC | 9,132 | $739K | 0.0% | $76.96 | 0.0% | COM | 29251M106 |
| — | AZURRX BIOPHARMA INC | 227,272 | $714K | 0.0% | $4.74 | — | COM | 05502L105 |
| — | ARRAY BIOPHARMA INC | 40,133 | $655K | 0.0% | $16.32 | — | COM | 04269X105 |
| — | NEKTAR THERAPEUTICS | 6,057 | $644K | 0.0% | $106.32 | — | COM | 640268108 |
| VRAYQ | VIEWRAY INC | 100,000 | $643K | 0.0% | $8.17 | +2.0% | COM | 92672L107 |
| — | CUTERA INC | 11,981 | $602K | 0.0% | $20.68 | — | COM | 232109108 |
| GERN | GERON CORP | 600,000 | $600K | 0.0% | — | — | Put | 374163103 |
| — | TABULA RASA HEALTHCARE INC | 14,663 | $569K | 0.0% | $38.81 | — | COM | 873379101 |
| SGMO | SANGAMO THERAPEUTICS INC | 25,000 | $475K | 0.0% | $21.38 | 0.0% | COM | 800677106 |
| — | ADVERUM BIOTECHNOLOGIES INC | 80,845 | $469K | 0.0% | $5.80 | — | COM | 00773U108 |
| — | PERNIX THERAPEUTICS HLDGS IN | 1,000,000 | $462K | 0.0% | $0.20 | — | DBVC 4.250% 4/0 | 71426VAK4 |
| — | VITAL THERAPIES INC | 150,000 | $454K | 0.0% | — | — | Put | 92847R104 |
| — | SENSEONICS HLDGS INC | 115,000 | $345K | 0.0% | $2.90 | — | COM | 81727U105 |
| REGN | REGENERON PHARMACEUTICALS | 50,000 | $335K | 0.0% | $402.77 | -14.1% | Call | 75886F107 |
| HCM | HUTCHISON CHINA MEDITECH LTD | 10,000 | $296K | 0.0% | $27.30 | — | SPONSORED ADR | 44842L103 |
| VCEL | VERICEL CORP | 27,211 | $271K | 0.0% | $8.27 | 0.0% | COM | 92346J108 |
| — | ACASTI PHARMA INC | 186,559 | $190K | 0.0% | $2.51 | — | COM | 00430K402 |
| — | SYNERGY PHARMACEUTICALS DEL | 100,000 | $183K | 0.0% | $1.83 | — | COM NEW | 871639308 |
| — | CASI PHARMACEUTICALS INC | 43,682 | $182K | 0.0% | $3.25 | — | COM | 14757U109 |
| — | PORTOLA PHARMACEUTICALS INC | 100,000 | $158K | 0.0% | $32.66 | — | Put | 737010108 |
| — | ONCOSEC MED INC | 50,000 | $94,000 | 0.0% | $1.88 | — | COM NEW | 68234L207 |
| BIIB | BIOGEN INC | 50,000 | $11,000 | 0.0% | $310.41 | 0.0% | Call | 09062X103 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $5,000 | 0.0% | $1.50 | — | COM | 14070B101 |