Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q2 2015 (← Previous) (Next →)
Filing Date: Aug 14, 2015
Total Value: $1.661B (99.1% shares, 0.9% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 14,439,444 | $204M | 12.3% | $3.01 | +298.8% | COM | 03152W109 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 3,284,467 | $157M | 9.4% | $13.82 | +206.8% | COM | 64125C109 |
| — | RETROPHIN INC | 2,820,875 | $91.65M | 5.5% | $13.90 | — | COM | 761299106 |
| SRPT | SAREPTA THERAPEUTICS INC | 2,809,528 | $85.49M | 5.1% | $30.34 | -32.6% | COM | 803607100 |
| — | TESARO INC | 835,359 | $49.11M | 3.0% | $37.04 | — | COM | 881569107 |
| — | DYAX CORP | 1,786,315 | $47.34M | 2.9% | $7.87 | — | COM | 26746E103 |
| — | NEVRO CORP | 798,959 | $42.94M | 2.6% | $47.65 | — | COM | 64157F103 |
| XNCR | XENCOR INC | 1,884,784 | $41.41M | 2.5% | $8.98 | +89.7% | COM | 98401F105 |
| XBI | STREETTRACKS SPDR BIOTEC ETF | 150,000 | $37.84M | 2.3% | — | — | Put | 78464A870 |
| — | RELYPSA INC | 1,139,142 | $37.69M | 2.3% | $27.90 | — | COM | 759531106 |
| — | IGNYTA INC | 1,967,600 | $29.69M | 1.8% | $15.09 | — | COM | 451731103 |
| — | ACELRX PHARMACEUTICALS INC | 6,574,060 | $27.87M | 1.7% | $9.69 | — | COM | 00444T100 |
| — | LION BIOTECHNOLOGIES INC | 2,759,593 | $25.3M | 1.5% | $9.29 | — | COM | 53619R102 |
| — | DERMA SCIENCES INC | 348,784 | $25M | 1.5% | $12.31 | — | COM PAR $.01 | 249827502 |
| GILD | GILEAD SCIENCES INC | 200,000 | $23.42M | 1.4% | $70.55 | +7.7% | Put | 375558103 |
| ANIP | ANI PHARMACEUTICALS INC | 327,157 | $20.3M | 1.2% | $45.00 | +32.2% | COM | 00182C103 |
| — | VERSARTIS INC | 1,321,400 | $20.11M | 1.2% | $20.54 | — | COM | 92529L102 |
| — | CEMPRA INC | 572,500 | $19.67M | 1.2% | $29.64 | — | COM | 15130J109 |
| — | PFENEX INC | 1,010,877 | $19.61M | 1.2% | $13.00 | — | COM | 717071104 |
| — | ZS PHARMA INC | 361,777 | $18.95M | 1.1% | $47.07 | — | COM | 98979G105 |
| EGRX | EAGLE PHARMACEUTICALS INC | 233,044 | $18.84M | 1.1% | $63.23 | +3.0% | COM | 269796108 |
| — | ALLERGAN PLC | 59,185 | $17.96M | 1.1% | $303.46 | — | SHS | G0177J108 |
| QURE | UNIQURE NV | 650,269 | $17.56M | 1.1% | $20.01 | +42.3% | SHS | N90064101 |
| — | ACADIA PHARMACEUTICALS INC | 410,240 | $17.18M | 1.0% | $41.88 | — | COM | 4225108 |
| — | CHINA BIOLOGIC PRODS INC | 147,604 | $17M | 1.0% | $92.08 | — | COM | 16938C106 |
| ESPR | ESPERION THERAPEUTICS INC | 200,000 | $16.35M | 1.0% | $30.61 | +219.8% | Call | 29664W105 |
| — | RADIUS HEALTH INC | 235,530 | $15.95M | 1.0% | $59.36 | — | COM NEW | 750469207 |
| — | CAPITAL SR LIVING CORP | 640,500 | $15.69M | 0.9% | $25.46 | — | COM | 140475104 |
| SRPT | Sarepta Therapeutics Inc | 500,000 | $15.21M | 0.9% | $30.34 | -32.6% | Call | 803607100 |
| — | ASSEMBLY BIOSCIENCES INC | 784,893 | $15.12M | 0.9% | $19.26 | — | COM | 45396108 |
| ZBH | ZIMMER BIOMET HLDGS INC | 135,193 | $14.77M | 0.9% | $91.02 | +11.5% | COM | 98956P102 |
| — | MYLAN N V | 215,133 | $14.6M | 0.9% | $67.66 | — | SHS EURO | N59465109 |
| HRTX | HERON THERAPEUTICS INC | 448,000 | $13.96M | 0.8% | $18.81 | 0.0% | COM | 427746102 |
| — | AFFIMED N V | 1,023,820 | $13.79M | 0.8% | $52.46 | — | COM | N01045108 |
| — | ONCOTHYREON INC | 3,346,897 | $12.52M | 0.8% | $3.20 | — | COM | 682324108 |
| — | BELLICUM PHARMACEUTICALS | 552,628 | $11.75M | 0.7% | $21.27 | — | COM | 79481107 |
| PBYI | PUMA BIOTECHNOLOGY INC | 100,000 | $11.68M | 0.7% | — | — | Call | 74587V107 |
| — | RECEPTOS INC | 60,969 | $11.59M | 0.7% | $49.28 | — | COM | 756207106 |
| — | BLUEPRINT MEDICINES CORP | 404,404 | $10.71M | 0.6% | $26.49 | — | COM | 09627Y109 |
| — | ANTHERA PHARMACEUTICALS INC | 1,202,156 | $10.36M | 0.6% | $3.66 | — | COM NEW | 03674U201 |
| — | ALLIQUA BIOMEDICAL INC | 1,921,951 | $10.13M | 0.6% | $5.29 | — | COM NEW | 19621200 |
| — | THORATEC CORP | 226,000 | $10.07M | 0.6% | $30.31 | — | COM NEW | 885175307 |
| — | SHIRE PLC | 40,000 | $9.66M | 0.6% | $233.15 | — | SPONSORED ADR | 82481R106 |
| SGMO | SANGAMO BIOSCIENCES INC | 800,000 | $8.872M | 0.5% | $19.28 | -33.1% | COM | 800677106 |
| — | ACCELERON PHARMA INC | 276,036 | $8.734M | 0.5% | $33.05 | — | COM | 00434H108 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,700,444 | $8.643M | 0.5% | $3.13 | — | COM | 64077P108 |
| — | QUOTIENT LTD | 562,436 | $8.577M | 0.5% | $13.65 | — | SHS | G73268107 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $8.488M | 0.5% | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| — | OTONOMY INC | 367,386 | $8.446M | 0.5% | $24.62 | — | COM | 68906L105 |
| CHRS | COHERUS BIOSCIENCES INC | 258,716 | $7.477M | 0.5% | $21.60 | +17.1% | COM | 19249H103 |
| BCRX | BIOCRYST PHARMACEUTICALS | 470,000 | $7.017M | 0.4% | $11.37 | 0.0% | COM | 09058V103 |
| — | SUPERNUS PHARMACEUTICALS INC | 2,187,000 | $7.008M | 0.4% | $2.28 | — | NOTE 7.500% 5/0 | 868459AB4 |
| INSM | INSMED INC | 285,812 | $6.98M | 0.4% | $15.42 | +47.2% | COM PAR $.01 | 457669307 |
| — | VBI VACCINES INC | 2,610,365 | $6.813M | 0.4% | $2.60 | — | COM | 91790E102 |
| ALDX | ALDEYRA THERAPEUTICS INC | 869,800 | $6.749M | 0.4% | $9.27 | -7.0% | COM | 01438T106 |
| CLLS | CELLECTIS S A | 181,500 | $6.549M | 0.4% | $36.07 | — | SPONSORED ADS | 15117K103 |
| — | TOKAI PHARMACEUTICALS INC | 485,338 | $6.455M | 0.4% | $14.80 | — | COM | 88907J107 |
| — | VITAL THERAPIES INC | 300,000 | $6.33M | 0.4% | — | — | Put | 92847R104 |
| — | LA JOLLA PHARMACEUTICAL CO | 252,915 | $6.199M | 0.4% | $10.80 | — | COM PAR $.0001 2 | 503459604 |
| — | TRANSENTERIX INC | 2,044,032 | $6.132M | 0.4% | $3.81 | — | COM NEW | 89366M201 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 493,600 | $5.953M | 0.4% | $11.62 | 0.0% | COM CL A | 46333X108 |
| — | FIVE PRIME THERAPEUTICS INC | 224,129 | $5.567M | 0.3% | $19.12 | — | COM | 33830X104 |
| ILMN | ILLUMINA INC | 25,000 | $5.459M | 0.3% | $194.52 | +0.4% | COM | 452327109 |
| — | PORTOLA PHARMACEUTICALS INC | 111,103 | $5.061M | 0.3% | $37.28 | — | COM | 737010108 |
| — | ARDELYX INC | 315,955 | $5.046M | 0.3% | $15.97 | — | COM | 39697107 |
| — | PROTEON THERAPEUTICS INC | 275,000 | $4.912M | 0.3% | $10.40 | — | COM | 74371L109 |
| — | ENDOLOGIX INC | 318,000 | $4.878M | 0.3% | $16.41 | — | COM | 29266S106 |
| — | TETRAPHASE PHARMACEUTICALS I | 100,000 | $4.744M | 0.3% | $39.71 | — | COM | 88165N105 |
| — | MINVERA NEUROSCIENCES | 810,537 | $4.701M | 0.3% | $5.00 | — | COM | 603380106 |
| — | APPLIED GENETIC TECHNOL CORP | 300,922 | $4.616M | 0.3% | $20.83 | — | COM | 03820J100 |
| HCA | HCA HOLDINGS INC | 50,563 | $4.587M | 0.3% | $49.74 | +49.7% | COM | 40412C101 |
| — | THORATEC CORP | 100,000 | $4.457M | 0.3% | $30.31 | — | Call | 885175307 |
| — | CIDARA THERAPEUTICS INC | 300,000 | $4.206M | 0.3% | $14.02 | — | COM | 171757107 |
| — | NEKTAR THERAPEUTICS | 335,000 | $4.191M | 0.3% | $12.51 | — | COM | 640268108 |
| — | RAPTOR PHARMACEUTICAL CORP | 264,204 | $4.172M | 0.3% | $10.87 | — | COM | 75382F106 |
| — | CELYAD SA | 75,000 | $3.902M | 0.2% | $52.03 | — | ADR | 151205200 |
| — | AXOVANT SCIENCES LTD | 190,000 | $3.872M | 0.2% | $20.38 | — | COM | G0750W104 |
| — | CIGNA CORPORATION | 21,970 | $3.559M | 0.2% | $156.68 | — | COM | 125509109 |
| CPRX | CATALYST PHARMACEUTICALS INC | 851,200 | $3.515M | 0.2% | $3.60 | +10.6% | COM | 14888U101 |
| — | RETROPHIN INC | 100,000 | $3.315M | 0.2% | $13.90 | — | Put | 761299106 |
| SSO | PROSHARES ULTRA S & P500 | 50,000 | $3.227M | 0.2% | $64.53 | — | Put | 74347R107 |
| — | NEURODERM LTD | 200,000 | $3.07M | 0.2% | $14.04 | — | ORD SHS | M74231107 |
| EVH | EVOLENT HEALTH INC | 152,800 | $2.98M | 0.2% | $18.64 | 0.0% | CL A | 30050B101 |
| — | WALGREENS BOOTS ALLIANCE INC | 35,292 | $2.98M | 0.2% | $79.69 | — | COM | 931427108 |
| MGNX | MACROGENICS INC | 76,208 | $2.894M | 0.2% | $26.16 | +25.6% | COM | 556099109 |
| — | MEDGENICS INC | 465,225 | $2.852M | 0.2% | $5.54 | — | COM NEW | 58436Q203 |
| — | IMMUNOMEDICS INC | 700,000 | $2.842M | 0.2% | $4.06 | — | Put | 452907108 |
| — | CORBUS PHARMACEUTICALS HOLDINGS INC | 870,000 | $2.679M | 0.2% | $3.08 | — | COM | 21833P103 |
| — | DERMIRA INC | 152,000 | $2.668M | 0.2% | $18.11 | — | COM | 24983L104 |
| XENE | XENON PHARMACEUTICALS INC | 225,000 | $2.594M | 0.2% | $14.68 | -5.8% | COM | 98420N105 |
| — | IMMUNOMEDICS INC | 600,000 | $2.436M | 0.1% | $4.06 | — | COM | 452907108 |
| — | ABEONA THERAPEUTICS INC | 470,000 | $2.378M | 0.1% | $5.06 | — | COM | 00289Y107 |
| — | INVITAE CORP | 299,583 | $2.306M | 0.1% | $12.69 | — | COM | 46185L103 |
| — | ISHARES TR | 87,000 | $2.27M | 0.1% | $28.48 | — | HDG MSCI GERMN | 46434V704 |
| — | POWERSHS DB US DOLLAR INDEX | 90,000 | $2.253M | 0.1% | $25.03 | — | DOLL INDX BULL | 73936D107 |
| — | ABEONA THERAPEUTICS INC | 1,250,000 | $2.25M | 0.1% | $1.80 | — | *W EXP 12/19/201 | 00289Y115 |
| — | CHAMPIONS ONCOLOGY | 4,471,180 | $2.235M | 0.1% | $0.71 | — | COM | 15870P109 |
| — | REGULUS THERAPEUTICS INC | 200,000 | $2.196M | 0.1% | — | — | Put | 75915K101 |
| — | VITAE PHARMACEUTICALS INC | 150,000 | $2.16M | 0.1% | $14.40 | — | COM | 92847N103 |
| — | SUNESIS PHARMACEUTICALS INC | 700,000 | $2.107M | 0.1% | $2.52 | — | COM NEW | 867328601 |
| — | SERES THERAPEUTICS INC | 50,000 | $2.075M | 0.1% | $41.50 | — | COM | 81750R102 |
| SSO | PROSHARES TR | 30,000 | $1.936M | 0.1% | $64.53 | — | PSHS ULT S&P 500 | 74347R107 |
| VCEL | VERICEL CORP | 528,697 | $1.887M | 0.1% | $2.85 | +20.3% | COM | 92346J108 |
| — | MGC DIAGNOSTICS CORP | 336,287 | $1.762M | 0.1% | $8.55 | — | COM | 552768103 |
| — | ARIAD PHARMACEUTICALS INC | 191,949 | $1.587M | 0.1% | $8.26 | — | COM | 04033A100 |
| INCY | INCYTE CORP | 15,000 | $1.563M | 0.1% | $89.61 | +15.5% | COM | 45337C102 |
| — | SCYNEXIS INC | 175,000 | $1.538M | 0.1% | $8.79 | — | COM | 811292101 |
| — | SAGE THERAPEUTICS INC | 20,000 | $1.46M | 0.1% | $31.50 | — | COM | 78667J108 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $1.444M | 0.1% | $4.45 | — | COM | 10501E201 |
| — | EPIZYME INC | 60,000 | $1.44M | 0.1% | $24.00 | — | COM | 29428V104 |
| — | AVINGER INC | 102,500 | $1.323M | 0.1% | $12.91 | — | COM | 53734109 |
| — | TRACON PHARMACEUTICALS INC | 100,000 | $1.294M | 0.1% | $14.04 | — | COM | 89237H100 |
| — | AETNA INC NEW | 10,086 | $1.286M | 0.1% | $116.60 | — | COM | 00817Y108 |
| — | GENVEC INC | 615,844 | $1.256M | 0.1% | $2.54 | — | COM NEW | 37246C307 |
| — | ARNO THERAPEUTICS INC | 2,034,721 | $1.221M | 0.1% | $0.58 | — | COM | 42564203 |
| — | PSIVIDA CORP | 315,000 | $1.187M | 0.1% | $4.11 | — | COM | 74440J101 |
| — | COGENTIX MED INC | 673,257 | $1.091M | 0.1% | $1.62 | — | COM | 19243A104 |
| GLPG | GALAPAGOS NV | 20,000 | $1.03M | 0.1% | $51.50 | — | SPON ADR | 36315X101 |
| — | IMPRIVATA INC | 60,000 | $982K | 0.1% | $14.39 | — | COM | 45323J103 |
| — | STEMLINE THERAPEUTICS INC | 79,245 | $933K | 0.1% | $14.47 | — | COM | 85858C107 |
| — | AQUINOX PHARMACEUTICALS INC | 130,000 | $902K | 0.1% | $12.73 | — | COM | 03842B101 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $901K | 0.1% | $14.53 | — | SHS | N31738102 |
| DHR | DANAHER CORP DEL | 10,000 | $856K | 0.1% | $34.86 | 0.0% | COM | 235851102 |
| — | GALMED PHARMACEUTICALS LTD | 75,000 | $755K | 0.0% | $11.47 | — | SHS | M47238106 |
| — | ACASTI PHARMA INC | 2,365,600 | $745K | 0.0% | $1.23 | — | CL A SHS | 00430K105 |
| — | DICERNA PHARMACEUTICALS INC | 50,000 | $698K | 0.0% | $13.96 | — | COM | 253031108 |
| — | ABIOMED INC | 10,000 | $657K | 0.0% | $65.70 | — | COM | 3654100 |
| — | TRILLIUM THERAPEUTICS INC | 30,000 | $655K | 0.0% | $21.83 | — | COM NEW | 89620X506 |
| — | CONATUS PHARMACEUTICALS INC | 100,000 | $515K | 0.0% | $5.15 | — | COM | 20600T108 |
| CNMD | CONMED CORP | 8,554 | $498K | 0.0% | $47.83 | 0.0% | COM | 207410101 |
| THC | TENET HEALTHCARE CORP | 8,500 | $492K | 0.0% | $55.41 | -7.8% | COM NEW | 88033G407 |
| — | BOVIE MEDICAL CORP | 172,700 | $482K | 0.0% | $2.39 | — | COM | 10211F100 |
| INFIQ | INFINITY PHARMACEUTICALS INC | 41,000 | $449K | 0.0% | $15.11 | -15.0% | COM | 45665G303 |
| — | JUNIPER PHARMACEUTICALS INC | 44,900 | $411K | 0.0% | $9.15 | — | COM | 48203L107 |
| — | ACHAOGEN INC | 60,000 | $362K | 0.0% | $6.03 | — | COM | 4449104 |
| — | OREXIGEN THERAPEUTICS INC | 70,600 | $350K | 0.0% | $4.96 | — | COM | 686164104 |
| — | KERYX BIOPHARMACEUTICALS INC | 34,380 | $343K | 0.0% | $12.73 | — | COM | 492515101 |
| PARNEUR | PARNELL PHARMACEUT HLDGS LTD | 68,800 | $341K | 0.0% | $5.72 | — | SHS | Q73622104 |
| SUPN | SUPERNUS PHARMACEUTICALS INC | 19,470 | $331K | 0.0% | $14.23 | 0.0% | COM | 868459108 |
| — | CAMBREX CORP | 7,331 | $322K | 0.0% | $21.59 | — | COM | 132011107 |
| — | INTERSECT ENT INC | 10,251 | $293K | 0.0% | $28.58 | — | COM | 46071F103 |
| — | INC RESH HLDGS INC | 7,261 | $291K | 0.0% | $40.08 | — | CL A | 45329R109 |
| GILD | GILEAD SCIENCES INC | 2,457 | $288K | 0.0% | $70.55 | +7.7% | COM | 375558103 |
| — | TRIPLE-S MGMT CORP | 10,605 | $272K | 0.0% | $20.57 | — | CL B | 896749108 |
| UHS | UNIVERSAL HLTH SVCS INC | 1,883 | $268K | 0.0% | $91.46 | +31.0% | CL B | 913903100 |
| PAHC | PHIBRO ANIMAL HEALTH CORP | 6,809 | $265K | 0.0% | $27.66 | +24.7% | CL A COM | 71742Q106 |
| — | MERGE HEALTHCARE INC | 55,015 | $264K | 0.0% | $2.88 | — | COM | 589499102 |
| CYH | COMMUNITY HEALTH SYS INC NEW | 3,978 | $250K | 0.0% | $44.86 | 0.0% | COM | 203668108 |
| — | HEALTH NET INC | 3,831 | $246K | 0.0% | $53.53 | — | COM | 42222G108 |
| LMAT | LEMAITRE VASCULAR INC | 19,838 | $239K | 0.0% | $8.87 | 0.0% | COM | 525558201 |
| — | GREATBATCH INC | 4,391 | $237K | 0.0% | $57.85 | — | COM | 39153L106 |
| — | ANTHEM INC | 1,436 | $236K | 0.0% | $164.35 | — | COM | 36752103 |
| MCK | MCKESSON CORP | 1,015 | $228K | 0.0% | $204.26 | +4.3% | COM | 58155Q103 |
| — | LHC GROUP INC | 5,917 | $226K | 0.0% | $31.17 | — | COM | 50187A107 |
| — | PHARMERICA CORP | 6,800 | $226K | 0.0% | $33.24 | — | COM | 71714F104 |
| ICLR | ICON PLC | 3,348 | $225K | 0.0% | $62.71 | +7.6% | SHS | G4705A100 |
| ENTA | ENANTA PHARMACEUTICALS INC | 4,956 | $223K | 0.0% | $38.90 | 0.0% | COM | 29251M106 |
| — | TARO PHARMACEUTICAL INDS LTD | 1,493 | $215K | 0.0% | $130.22 | — | SHS | M8737E108 |
| CAH | CARDINAL HEALTH INC | 2,574 | $215K | 0.0% | $63.64 | +2.9% | COM | 14149Y108 |
| — | SYNERGETICS USA INC | 44,266 | $208K | 0.0% | $5.03 | — | COM | 87160G107 |
| UNH | UNITEDHEALTH GROUP INC | 1,685 | $206K | 0.0% | $99.59 | 0.0% | COM | 91324P102 |
| MOH | MOLINA HEALTHCARE INC | 2,888 | $203K | 0.0% | $66.88 | 0.0% | COM | 60855R100 |
| — | MAGELLAN HEALTH INC | 2,900 | $203K | 0.0% | $70.69 | — | COM NEW | 559079207 |
| — | DIVERSICARE HEALTHCARE SVCS | 15,337 | $198K | 0.0% | $12.91 | — | COM | 255104101 |
| — | NEOTHETICS INC | 20,000 | $180K | 0.0% | $9.00 | — | COM | 64066G101 |
| ASND | ASCENDIS PHARMA A S | 10,000 | $176K | 0.0% | $17.40 | — | SPONSORED ADR | 04351P101 |
| — | CREDIT SUISSE NASSAU BRH | 4,000 | $162K | 0.0% | $40.50 | — | INVRS VIX STERM | 22542D795 |
| NVO | NOVO-NORDISK A S | 2,340 | $128K | 0.0% | $54.70 | — | ADR | 670100205 |
| — | NANOSPHERE INC | 35,379 | $115K | 0.0% | $3.25 | — | COM NEW | 63009F204 |
| — | DBV TECHNOLOGIES S A | 3,002 | $89,000 | 0.0% | $29.65 | — | SPONSORED ADR | 23306J101 |
| MYGN | MYRIAD GENETICS INC | 2,500 | $85,000 | 0.0% | $34.00 | 0.0% | COM | 62855J104 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $20,000 | 0.0% | $8.75 | — | COM | 14070B101 |
| PCRX | PACIRA PHARMACEUTICALS INC | 50 | $4,000 | 0.0% | $78.75 | 0.0% | COM | 695127100 |