Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	Seagen Inc.	46,913,769	$9.499B	51.7%	$195.69	—	COM	81181C104
INCY	Incyte Corporation	36,175,400	$2.614B	14.2%	$72.80	+7.5%	COM	45337C102
ONC	BeiGene, Ltd.	11,668,897	$2.515B	13.7%	$136.93	—	SPONSORED ADR	07725L102
ACAD	ACADIA Pharmaceuticals Inc.	41,938,486	$789M	4.3%	$18.86	+1.0%	COM	004225108
MDGL	Madrigal Pharmaceuticals, Inc.	1,545,113	$374M	2.0%	$104.60	+160.5%	COM	558868105
BMRN	BioMarin Pharmaceutical Inc.	3,810,248	$371M	2.0%	$81.02	+27.9%	COM	09061G101
IMCR	Immunocore Holdings plc	2,520,731	$125M	0.7%	$42.57	—	ADS	45258D105
RYTM	Rhythm Pharmaceuticals, Inc.	6,498,267	$116M	0.6%	$23.52	+6.8%	COM	76243J105
KOD	Kodiak Sciences Inc.	17,310,490	$107M	0.6%	$30.30	-76.9%	COM	50015M109
BCRX	BioCryst Pharmaceuticals, Inc.	12,710,818	$106M	0.6%	$6.35	+51.5%	COM	09058V103
ARGX	argenx SE	280,159	$104M	0.6%	$79.01	—	SPONSORED ADR	04016X101
—	Akero Therapeutics, Inc.	2,368,378	$90.61M	0.5%	$33.89	—	COM	00973Y108
KYMR	Kymera Therapeutics, Inc.	2,879,825	$85.33M	0.5%	$33.35	-3.3%	COM	501575104
REPL	Replimune Group, Inc.	4,578,280	$80.85M	0.4%	$19.30	+23.2%	COM	76029N106
ABCL	AbCellera Biologics Inc.	10,450,180	$78.79M	0.4%	$45.73	-80.1%	COM	00288U106
—	SpringWorks Therapeutics, Inc.	2,753,502	$70.88M	0.4%	$25.89	—	COM	85205L107
TRDA	Entrada Therapeutics, Inc.	4,865,819	$70.55M	0.4%	$16.96	—	COM	29384C108
BMEA	Biomea Fusion, Inc.	2,108,949	$65.4M	0.4%	$8.56	+45.1%	COM	09077A106
RVMD	Revolution Medicines, Inc.	2,691,493	$58.3M	0.3%	$26.29	-6.3%	COM	76155X100
PRLD	Prelude Therapeutics Inc.	10,123,824	$57.71M	0.3%	$28.24	-78.4%	COM	74065P101
—	Mirati Therapeutics, Inc.	1,409,784	$52.42M	0.3%	$22.85	—	COM	60468T105
—	FibroGen, Inc.	2,637,384	$49.21M	0.3%	$16.38	—	COM	31572Q808
CERS	Cerus Corporation	16,067,558	$47.72M	0.3%	$4.69	-35.8%	COM	157085101
—	IGM Biosciences, Inc.	3,156,656	$43.37M	0.2%	$17.75	—	COM	449585108
—	Aerovate Therapeutics, Inc.	1,963,479	$39.6M	0.2%	$21.15	—	COM	008064107
IMTX	Immatics N.V.	5,187,081	$35.79M	0.2%	$10.97	-25.4%	SHS	N44445109
ROIV	Roivant Sciences Ltd.	4,777,430	$35.26M	0.2%	$7.83	+5.1%	SHS	G76279101
NRIX	Nurix Therapeutics, Inc.	3,882,125	$34.47M	0.2%	$22.27	-53.2%	COM	67080M103
—	Chinook Therapeutics, Inc.	1,455,202	$33.69M	0.2%	$14.83	—	COM	16961L106
—	Kiniksa Pharmaceuticals, Ltd.	2,799,577	$30.12M	0.2%	$17.35	—	COM CL A	G5269C101
—	DICE Therapeutics, Inc.	1,035,786	$29.68M	0.2%	$31.65	—	COM	23345J104
XENE	Xenon Pharmaceuticals Inc.	751,639	$26.9M	0.1%	$13.09	+182.3%	COM	98420N105
—	2seventy bio, Inc.	2,497,526	$25.47M	0.1%	$18.72	—	COM	901384107
DNLI	Denali Therapeutics Inc.	1,088,738	$25.08M	0.1%	$27.40	+0.5%	COM	24823R105
—	DBV Technologies S.A.	14,614,264	$24.7M	0.1%	$19.06	—	SPONSORED ADR	23306J101
KRYS	Krystal Biotech, Inc.	302,716	$24.24M	0.1%	$34.45	+128.1%	COM	501147102
—	Verve Therapeutics, Inc.	1,416,530	$20.43M	0.1%	$60.25	—	COM	92539P101
RARE	Ultragenyx Pharmaceutical Inc.	470,974	$18.89M	0.1%	$115.41	-62.8%	COM	90400D108
BCYC	Bicycle Therapeutics plc	843,814	$17.95M	0.1%	$23.26	—	SPONSORED ADS	088786108
STOK	Stoke Therapeutics, Inc.	2,115,416	$17.62M	0.1%	$10.71	-15.8%	COM	86150R107
ANAB	AnaptysBio, Inc.	775,924	$16.88M	0.1%	$27.04	-10.1%	COM	032724106
RNAM	Avidity Biosciences, Inc.	1,004,051	$15.41M	0.1%	$18.93	+16.2%	COM	05370A108
—	Blueprint Medicines Corporation	333,665	$15.01M	0.1%	$44.99	—	COM	09627Y109
SPRY	ARS Pharmaceuticals, Inc.	2,006,451	$13.06M	0.1%	$6.49	+18.4%	COM	82835W108
PACB	Pacific Biosciences of California, Inc.	1,127,782	$13.06M	0.1%	$15.59	-36.2%	COM	69404D108
PRME	Prime Medicine, Inc.	1,028,466	$12.65M	0.1%	$18.06	-9.8%	COM	74168J101
HRTX	Heron Therapeutics, Inc.	8,131,678	$12.28M	0.1%	$17.29	-85.5%	COM	427746102
—	Invitae Corporation	8,881,104	$11.99M	0.1%	$24.10	—	COM	46185L103
IDYA	IDEAYA Biosciences, Inc.	832,769	$11.43M	0.1%	$12.99	+28.3%	COM	45166A102
CABA	Cabaletta Bio, Inc.	1,344,000	$11.11M	0.1%	$7.63	+22.6%	COM	12674W109
SMMT	Summit Therapeutics Inc.	6,304,705	$11.03M	0.1%	$2.44	+11.8%	COM	86627T108
ADAPY	Adaptimmune Therapeutics plc	9,830,877	$10.72M	0.1%	$5.77	—	SPONSORED ADR	00653A107
OPTEY	Opthea Limited	2,691,391	$10.63M	0.1%	$11.12	—	SPONSORED ADS	68386J208
—	Verastem, Inc.	25,521,447	$10.6M	0.1%	$2.39	—	COM	92337C104
FATE	Fate Therapeutics, Inc.	1,671,717	$9.529M	0.1%	$8.98	-32.8%	COM	31189P102
—	POINT Biopharma Global Inc.	1,169,103	$8.499M	0.0%	$7.73	—	COM	730541109
—	bluebird bio, Inc.	2,499,715	$7.949M	0.0%	$22.65	—	COM	09609G100
ALLO	Allogene Therapeutics, Inc.	1,576,901	$7.79M	0.0%	$6.41	0.0%	COM	019770106
—	Mersana Therapeutics, Inc.	1,886,115	$7.752M	0.0%	$4.11	—	COM	59045L106
WHWK	Aadi Bioscience, Inc.	989,928	$7.167M	0.0%	$13.14	-18.7%	COM	00032Q104
SERA	Sera Prognostics, Inc.	1,789,000	$6.852M	0.0%	$3.50	-25.0%	CLASS A COM	81749D107
GERN	Geron Corporation	3,061,224	$6.643M	0.0%	$2.84	0.0%	COM	374163103
SANA	Sana Biotechnology, Inc.	2,000,000	$6.54M	0.0%	$4.00	0.0%	SHS	799566104
—	Aravive, Inc.	3,261,224	$6.522M	0.0%	$1.32	—	COM	03890D108
MGNX	MacroGenics, Inc.	892,579	$6.4M	0.0%	$14.35	-58.0%	COM	556099109
ALEC	Alector, Inc.	964,851	$5.972M	0.0%	$12.71	-36.0%	COM	014442107
—	Athira Pharma, Inc.	2,350,355	$5.876M	0.0%	$8.27	—	COM	04746L104
INSM	Insmed Incorporated	343,000	$5.848M	0.0%	$19.59	-0.8%	COM PAR $.01	457669307
TCRX	TScan Therapeutics, Inc.	2,784,792	$5.848M	0.0%	$6.08	-61.0%	COM	89854M101
NTRA	Natera, Inc.	100,000	$5.552M	0.0%	$37.02	+29.6%	COM	632307104
CMPX	Compass Therapeutics, Inc.	1,557,630	$5.093M	0.0%	$3.99	-1.6%	COM	20454B104
—	Affimed N.V.	6,596,830	$4.919M	0.0%	$4.50	—	COM	N01045108
RLAY	Relay Therapeutics, Inc.	284,000	$4.677M	0.0%	$17.93	0.0%	COM	75943R102
—	Atreca, Inc.	3,532,760	$4.027M	0.0%	$18.84	—	CL A COM	04965G109
IPSC	Century Therapeutics, Inc.	1,149,340	$3.988M	0.0%	$9.79	-55.1%	COM	15673T100
—	Talis Biomedical Corporation	7,624,835	$3.736M	0.0%	$12.85	—	COM	87424L108
DSGN	Design Therapeutics, Inc.	626,884	$3.617M	0.0%	$31.14	-76.0%	COM	25056L103
—	Instil Bio, Inc.	5,273,789	$3.485M	0.0%	$18.68	—	COM	45783C101
XNCR	Xencor, Inc.	123,127	$3.434M	0.0%	$27.96	+10.2%	COM	98401F105
—	Vor Biopharma Inc.	633,848	$3.41M	0.0%	$4.75	—	COM	929033108
EWTX	Edgewise Therapeutics, Inc.	500,000	$3.335M	0.0%	$32.43	-71.4%	COM	28036F105
TNGX	Tango Therapeutics, Inc.	750,000	$2.962M	0.0%	$11.99	-51.6%	COM	87583X109
GLUE	Monte Rosa Therapeutics, Inc.	375,095	$2.922M	0.0%	$6.95	0.0%	COM	61225M102
—	Neoleukin Therapeutics, Inc.	3,821,740	$2.675M	0.0%	$3.87	—	COM	64049K104
VERA	Vera Therapeutics, Inc.	333,333	$2.587M	0.0%	$21.52	-64.1%	CL A	92337R101
—	HOOKIPA Pharma Inc.	3,475,535	$2.558M	0.0%	$2.72	—	COM	43906K100
—	Leap Therapeutics, Inc.	7,425,570	$2.525M	0.0%	$0.40	—	COM	52187K101
—	Achilles Therapeutics plc	2,591,366	$2.481M	0.0%	$16.55	—	SPONSORED ADS	00449L102
—	Atara Biotherapeutics, Inc.	744,186	$2.158M	0.0%	$7.79	—	COM	046513107
—	iTeos Therapeutics, Inc.	150,346	$2.046M	0.0%	$24.67	—	COM	46565G104
—	Veru Inc.	1,609,579	$1.867M	0.0%	$11.52	—	COM	92536C103
PCVX	Vaxcyte, Inc.	48,885	$1.832M	0.0%	$39.24	+8.1%	COM	92243G108
—	Aligos Therapeutics, Inc.	2,076,400	$1.815M	0.0%	$24.92	—	COM	01626L105
PMVP	PMV Pharmaceuticals, Inc.	322,024	$1.536M	0.0%	$14.45	-51.3%	COM	69353Y103
—	Praxis Precision Medicines, Inc.	1,879,915	$1.521M	0.0%	$2.34	—	COM	74006W108
NKTX	Nkarta, Inc.	400,000	$1.42M	0.0%	$13.12	-63.9%	COM	65487U108
KALA	Kala Pharmaceuticals, Inc.	76,813	$1.156M	0.0%	$7.92	+120.3%	COM	483119202
—	TCR2 Therapeutics Inc.	753,064	$1.13M	0.0%	$8.48	—	COM	87808K106
—	Aeglea BioTherapeutics, Inc.	3,410,106	$989K	0.0%	$7.84	—	COM	00773J103
TARA	Protara Therapeutics, Inc.	199,671	$625K	0.0%	$30.96	-89.3%	COM STK	74365U107
—	Genetron Holdings Limited	455,306	$478K	0.0%	$13.55	—	ADS	37186H100
FHTX	Foghorn Therapeutics Inc.	45,027	$279K	0.0%	$14.37	-54.5%	COM	344174107
—	Vincerx Pharma, Inc.	241,379	$251K	0.0%	$16.17	—	COM	92731L106
SRZNW	Surrozen, Inc.	833,333	$83,333	0.0%	$1.14	—	W EXP 8/11/2026	86889P117
—	Bellicum Pharmaceuticals, Inc.	249,123	$82,211	0.0%	$4.71	—	COM	079481404