Location: New York, NY
CIK: 0001263508 · Show all filings
Period: Q4 2022 (← Previous) (Next →)
Filing Date: Feb 14, 2023
Total Value: $16.65B (99.8% shares, 0.2% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | Seagen Inc. | 46,912,266 | $6.029B | 36.2% | $195.69 | — | COM | 81181C104 |
| INCY | Incyte Corporation | 36,154,971 | $2.904B | 17.4% | $72.80 | +5.1% | COM | 45337C102 |
| ONC | BeiGene, Ltd. | 11,668,897 | $2.566B | 15.4% | $136.93 | — | SPONSORED ADR | 07725L102 |
| BMRN | BioMarin Pharmaceutical Inc. | 7,620,494 | $789M | 4.7% | $81.02 | +15.9% | COM | 09061G101 |
| ACAD | ACADIA Pharmaceuticals Inc. | 41,923,486 | $667M | 4.0% | $18.86 | -17.1% | COM | 004225108 |
| ASND | Ascendis Pharma A/S | 4,954,855 | $605M | 3.6% | $75.49 | — | SPONSORED ADR | 04351P101 |
| MDGL | Madrigal Pharmaceuticals, Inc. | 1,545,113 | $448M | 2.7% | $104.60 | -6.5% | COM | 558868105 |
| RYTM | Rhythm Pharmaceuticals, Inc. | 6,354,608 | $185M | 1.1% | $23.48 | +9.4% | COM | 76243J105 |
| BCRX | BioCryst Pharmaceuticals, Inc. | 12,710,818 | $146M | 0.9% | $6.35 | +96.3% | COM | 09058V103 |
| IMCR | Immunocore Holdings plc | 2,520,731 | $144M | 0.9% | $42.57 | — | ADS | 45258D105 |
| — | Akero Therapeutics, Inc. | 2,368,378 | $130M | 0.8% | $33.89 | — | COM | 00973Y108 |
| REPL | Replimune Group, Inc. | 4,578,280 | $125M | 0.7% | $19.30 | +7.7% | COM | 76029N106 |
| KOD | Kodiak Sciences Inc. | 17,310,490 | $124M | 0.7% | $30.30 | -76.3% | COM | 50015M109 |
| — | Horizon Therapeutics Public Ltd Co | 969,727 | $110M | 0.7% | $77.79 | — | SHS | G46188101 |
| ARGX | argenx SE | 280,159 | $106M | 0.6% | $79.01 | — | SPONSORED ADR | 04016X101 |
| ABCL | AbCellera Biologics Inc. | 10,450,180 | $106M | 0.6% | $45.73 | -74.7% | COM | 00288U106 |
| KYMR | Kymera Therapeutics, Inc. | 2,879,825 | $71.88M | 0.4% | $33.35 | -20.1% | COM | 501575104 |
| — | Chinook Therapeutics, Inc. | 2,534,102 | $66.39M | 0.4% | $14.83 | — | COM | 16961L106 |
| TRDA | Entrada Therapeutics, Inc. | 4,865,819 | $65.79M | 0.4% | $16.96 | — | COM | 29384C108 |
| — | Mirati Therapeutics, Inc. | 1,409,784 | $63.88M | 0.4% | $22.85 | — | COM | 60468T105 |
| PRLD | Prelude Therapeutics Inc. | 10,123,824 | $61.15M | 0.4% | $28.24 | -77.3% | COM | 74065P101 |
| CERS | Cerus Corporation | 16,067,558 | $58.65M | 0.4% | $4.69 | -19.7% | COM | 157085101 |
| — | Aerovate Therapeutics, Inc. | 1,976,868 | $57.92M | 0.3% | $21.15 | — | COM | 008064107 |
| — | IGM Biosciences, Inc. | 3,156,102 | $53.69M | 0.3% | $17.75 | — | COM | 449585108 |
| IMTX | Immatics N.V. | 5,187,081 | $45.18M | 0.3% | $10.97 | -5.7% | SHS | N44445109 |
| NRIX | Nurix Therapeutics, Inc. | 3,882,125 | $42.63M | 0.3% | $22.27 | -45.8% | COM | 67080M103 |
| — | Kiniksa Pharmaceuticals, Ltd. | 2,799,577 | $41.94M | 0.3% | $17.35 | — | COM CL A | G5269C101 |
| — | SpringWorks Therapeutics, Inc. | 1,528,538 | $39.76M | 0.2% | $26.01 | — | COM | 85205L107 |
| IDYA | IDEAYA Biosciences, Inc. | 1,668,355 | $30.31M | 0.2% | $12.99 | +29.5% | COM | 45166A102 |
| DNLI | Denali Therapeutics Inc. | 1,088,738 | $30.28M | 0.2% | $27.40 | +8.6% | COM | 24823R105 |
| XENE | Xenon Pharmaceuticals Inc. | 751,639 | $29.64M | 0.2% | $13.09 | +178.3% | COM | 98420N105 |
| — | Verve Therapeutics, Inc. | 1,416,530 | $27.41M | 0.2% | $60.25 | — | COM | 92539P101 |
| — | DICE Therapeutics, Inc. | 862,207 | $26.9M | 0.2% | $32.26 | — | COM | 23345J104 |
| TVTX | Travere Therapeutics, Inc. | 1,225,255 | $25.77M | 0.2% | $22.33 | -5.1% | COM | 89422G107 |
| BCYC | Bicycle Therapeutics plc | 843,814 | $24.98M | 0.1% | $23.26 | — | SPONSORED ADS | 088786108 |
| ANAB | AnaptysBio, Inc. | 775,924 | $24.05M | 0.1% | $27.04 | +4.4% | COM | 032724106 |
| KRYS | Krystal Biotech, Inc. | 302,716 | $23.98M | 0.1% | $34.45 | +115.5% | COM | 501147102 |
| — | DBV Technologies S.A. | 14,614,264 | $22.36M | 0.1% | $19.06 | — | SPONSORED ADR | 23306J101 |
| — | FibroGen, Inc. | 1,375,211 | $22.03M | 0.1% | $14.28 | — | COM | 31572Q808 |
| RARE | Ultragenyx Pharmaceutical Inc. | 470,974 | $21.82M | 0.1% | $115.41 | -65.9% | COM | 90400D108 |
| HRTX | Heron Therapeutics, Inc. | 8,131,678 | $20.33M | 0.1% | $17.29 | -81.4% | COM | 427746102 |
| — | 2seventy bio, Inc. | 2,062,744 | $19.33M | 0.1% | $20.52 | — | COM | 901384107 |
| — | Insmed Incorporated | 23,500,000 | $19.23M | 0.1% | $1.10 | — | Note 0.75% 6/1/2028 | 457669AB5 |
| PRME | Prime Medicine, Inc. | 1,028,466 | $19.11M | 0.1% | $18.06 | 0.0% | COM | 74168J101 |
| BMEA | Biomea Fusion, Inc. | 2,104,559 | $17.74M | 0.1% | $8.56 | -0.4% | COM | 09077A106 |
| — | bluebird bio, Inc. | 2,499,715 | $17.3M | 0.1% | $22.65 | — | COM | 09609G100 |
| SPRY | ARS Pharmaceuticals, Inc. | 2,006,451 | $17.12M | 0.1% | $6.49 | 0.0% | COM | 82835W108 |
| — | Invitae Corporation | 8,402,035 | $15.63M | 0.1% | $25.40 | — | COM | 46185L103 |
| OPTEY | Opthea Limited | 2,691,391 | $14.43M | 0.1% | $11.12 | — | SPONSORED ADS | 68386J208 |
| ADAPY | Adaptimmune Therapeutics plc | 9,830,877 | $14.35M | 0.1% | $5.77 | — | SPONSORED ADR | 00653A107 |
| — | CymaBay Therapeutics, Inc. | 2,170,464 | $13.61M | 0.1% | $5.48 | — | COM | 23257D103 |
| ZYME | Zymeworks Inc. | 1,708,472 | $13.43M | 0.1% | $7.03 | 0.0% | COM | 98985Y108 |
| WHWK | Aadi Bioscience, Inc. | 989,928 | $12.7M | 0.1% | $13.14 | -0.6% | COM | 00032Q104 |
| CABA | Cabaletta Bio, Inc. | 1,344,000 | $12.43M | 0.1% | $7.63 | -52.3% | COM | 12674W109 |
| — | Verastem, Inc. | 26,988,898 | $10.86M | 0.1% | $2.39 | — | COM | 92337C104 |
| ALT | Altimmune, Inc. | 653,562 | $10.75M | 0.1% | $7.80 | +44.1% | COM | 02155H200 |
| STOK | Stoke Therapeutics, Inc. | 1,108,913 | $10.24M | 0.1% | $12.24 | -15.1% | COM | 86150R107 |
| — | CinCor Pharma, Inc. | 807,212 | $9.921M | 0.1% | $32.82 | — | COM | 17240Y109 |
| — | Vor Biopharma Inc. | 1,465,925 | $9.748M | 0.1% | $4.75 | — | COM | 929033108 |
| RNAM | Avidity Biosciences, Inc. | 434,782 | $9.648M | 0.1% | $14.91 | 0.0% | COM | 05370A108 |
| PACB | Pacific Biosciences of California, Inc. | 1,127,782 | $9.225M | 0.1% | $15.59 | -44.7% | COM | 69404D108 |
| — | POINT Biopharma Global Inc. | 1,169,103 | $8.523M | 0.1% | $7.73 | — | COM | 730541109 |
| — | Reata Pharmaceuticals, Inc. | 223,976 | $8.509M | 0.1% | $138.99 | — | CL A | 75615P103 |
| SMMT | Summit Therapeutics Inc. | 2,000,000 | $8.5M | 0.1% | $1.82 | 0.0% | COM | 86627T108 |
| — | Veru Inc. | 1,609,579 | $8.499M | 0.1% | $11.52 | — | COM | 92536C103 |
| — | Affimed N.V. | 6,596,830 | $8.18M | 0.0% | $4.50 | — | COM | N01045108 |
| — | Invitae Corporation | 10,300,000 | $8.058M | 0.0% | $1.64 | — | Note 2.0% 9/1/2024 | 46185LAB9 |
| CMPX | Compass Therapeutics, Inc. | 1,557,630 | $7.835M | 0.0% | $3.99 | 0.0% | COM | 20454B104 |
| DSGN | Design Therapeutics, Inc. | 692,131 | $7.101M | 0.0% | $31.14 | -56.5% | COM | 25056L103 |
| BHVN | Biohaven Ltd. | 476,190 | $6.61M | 0.0% | $14.12 | 0.0% | COM | G1110E107 |
| VERA | Vera Therapeutics, Inc. | 333,333 | $6.45M | 0.0% | $21.52 | -15.8% | CL A | 92337R101 |
| ALEC | Alector, Inc. | 681,991 | $6.295M | 0.0% | $14.60 | -40.3% | COM | 014442107 |
| MGNX | MacroGenics, Inc. | 892,579 | $5.989M | 0.0% | $14.35 | -61.8% | COM | 556099109 |
| — | Athira Pharma, Inc. | 1,879,836 | $5.959M | 0.0% | $9.71 | — | COM | 04746L104 |
| IPSC | Century Therapeutics, Inc. | 1,149,340 | $5.896M | 0.0% | $9.79 | -3.6% | COM | 15673T100 |
| ROIV | Roivant Sciences Ltd. | 716,653 | $5.726M | 0.0% | $5.56 | 0.0% | SHS | G76279101 |
| TNGX | Tango Therapeutics, Inc. | 750,000 | $5.438M | 0.0% | $11.99 | -41.3% | COM | 87583X109 |
| RVMD | Revolution Medicines, Inc. | 222,222 | $5.293M | 0.0% | $44.84 | -52.6% | COM | 76155X100 |
| EWTX | Edgewise Therapeutics, Inc. | 500,000 | $4.47M | 0.0% | $32.43 | -71.1% | COM | 28036F105 |
| — | Praxis Precision Medicines, Inc. | 1,830,315 | $4.356M | 0.0% | $2.38 | — | COM | 74006W108 |
| TCRX | TScan Therapeutics, Inc. | 2,784,792 | $4.316M | 0.0% | $6.08 | -59.7% | COM | 89854M101 |
| — | Aravive, Inc. | 3,261,224 | $4.305M | 0.0% | $1.32 | — | COM | 03890D108 |
| — | Cyteir Therapeutics, Inc. | 2,492,118 | $4.112M | 0.0% | $8.65 | — | COM | 23284P103 |
| NTRA | Natera, Inc. | 100,000 | $4.017M | 0.0% | $37.02 | +11.3% | COM | 632307104 |
| — | Talis Biomedical Corporation | 7,624,835 | $3.398M | 0.0% | $12.85 | — | COM | 87424L108 |
| — | Instil Bio, Inc. | 5,273,789 | $3.322M | 0.0% | $18.68 | — | COM | 45783C101 |
| XNCR | Xencor, Inc. | 123,127 | $3.206M | 0.0% | $27.96 | 0.0% | COM | 98401F105 |
| — | iTeos Therapeutics, Inc. | 150,346 | $2.936M | 0.0% | $24.67 | — | COM | 46565G104 |
| KALA | Kala Pharmaceuticals, Inc. | 76,813 | $2.93M | 0.0% | $7.92 | 0.0% | COM | 483119202 |
| — | Atreca, Inc. | 3,532,760 | $2.828M | 0.0% | $18.84 | — | CL A COM | 04965G109 |
| — | HOOKIPA Pharma Inc. | 3,475,535 | $2.815M | 0.0% | $2.72 | — | COM | 43906K100 |
| PMVP | PMV Pharmaceuticals, Inc. | 322,024 | $2.802M | 0.0% | $14.45 | -26.2% | COM | 69353Y103 |
| — | Atara Biotherapeutics, Inc. | 744,186 | $2.441M | 0.0% | $7.79 | — | COM | 046513107 |
| NKTX | Nkarta, Inc. | 400,000 | $2.396M | 0.0% | $13.12 | -23.1% | COM | 65487U108 |
| PCVX | Vaxcyte, Inc. | 48,885 | $2.344M | 0.0% | $39.24 | 0.0% | COM | 92243G108 |
| — | Achilles Therapeutics plc | 2,591,366 | $2.332M | 0.0% | $16.55 | — | SPONSORED ADS | 00449L102 |
| FATE | Fate Therapeutics, Inc. | 215,695 | $2.176M | 0.0% | $28.89 | -35.0% | COM | 31189P102 |
| — | Aligos Therapeutics, Inc. | 2,076,400 | $1.979M | 0.0% | $24.92 | — | COM | 01626L105 |
| — | Neoleukin Therapeutics, Inc. | 3,821,740 | $1.945M | 0.0% | $3.87 | — | COM | 64049K104 |
| — | Kronos Bio, Inc. | 1,198,151 | $1.941M | 0.0% | $3.35 | — | COM | 50107A104 |
| — | Aeglea BioTherapeutics, Inc. | 3,410,106 | $1.534M | 0.0% | $7.84 | — | COM | 00773J103 |
| — | TCR2 Therapeutics Inc. | 753,064 | $752K | 0.0% | $8.48 | — | COM | 87808K106 |
| TARA | Protara Therapeutics, Inc. | 199,671 | $535K | 0.0% | $30.96 | -89.8% | COM STK | 74365U107 |
| — | Genetron Holdings Limited | 455,306 | $510K | 0.0% | $13.55 | — | ADS | 37186H100 |
| — | Kezar Life Sciences, Inc. | 61,946 | $436K | 0.0% | $5.18 | — | COM | 49372L100 |
| INSM | Insmed Incorporated | 19,950 | $399K | 0.0% | $22.18 | -12.8% | COM PAR $.01 | 457669307 |
| FHTX | Foghorn Therapeutics Inc. | 45,027 | $287K | 0.0% | $14.37 | -47.5% | COM | 344174107 |
| SERA | Sera Prognostics, Inc. | 201,562 | $254K | 0.0% | $10.38 | -86.4% | CLASS A COM | 81749D107 |
| — | Leap Therapeutics, Inc. | 559,705 | $252K | 0.0% | $1.17 | — | COM | 52187K101 |
| — | Vincerx Pharma, Inc. | 241,379 | $246K | 0.0% | $16.17 | — | COM | 92731L106 |
| — | Bellicum Pharmaceuticals, Inc. | 249,123 | $179K | 0.0% | $4.71 | — | COM | 079481404 |
| SRZNW | Surrozen, Inc. | 833,333 | $45,917 | 0.0% | $1.14 | — | W EXP 8/11/2026 | 86889P117 |
| ATYR | aTyr Pharma, Inc. | 8,565 | $18,757 | 0.0% | $5.98 | -60.6% | COM | 002120202 |