Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2014 (← Previous) (Next →)

Filing Date: Aug 14, 2014

Total Value: $1.343B (100.0% shares, 0.0% debt)

Holdings (42)

— INTERMUNE INC 16.9%

Value $227M Shares 5,134,058 Est. Cost $19.48 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 8.0%

Value $107M Shares 1,213,828 Est. Cost $69.22 Unrealized +38.9%

— CYBERONICS INC 8.0%

Value $107M Shares 1,715,430 Est. Cost $52.15 Unrealized —

— CUBIST PHARMACEUTICALS INC 7.9%

Value $107M Shares 1,526,916 Est. Cost $57.96 Unrealized —

— AUXILIUM PHARMACEUTICALS INC 7.3%

Value $97.38M Shares 4,854,631 Est. Cost $17.45 Unrealized —

BMRN BIOMARIN PHARMACEUTICAL INC 4.2%

Value $56.96M Shares 915,587 Est. Cost $63.05 Unrealized -4.2%

— ABIOMED INC 4.1%

Value $55.5M Shares 2,207,489 Est. Cost $21.31 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.9%

Value $52.43M Shares 3,240,424 Est. Cost $7.72 Unrealized +72.6%

STAA STAAR SURGICAL CO 3.3%

Value $43.67M Shares 2,599,553 Est. Cost $8.10 Unrealized +103.2%

— SEQUENOM INC 2.8%

Value $37.97M Shares 9,810,442 Est. Cost $3.91 Unrealized —

— CLOVIS ONCOLOGY INC 2.8%

Value $37.9M Shares 915,321 Est. Cost $45.26 Unrealized —

— KYTHERA BIOPHARMACEUTICALS I 2.7%

Value $36.45M Shares 949,959 Est. Cost $38.49 Unrealized —

— AMAG PHARMACEUTICALS INC 2.5%

Value $33.45M Shares 1,614,536 Est. Cost $22.29 Unrealized —

— ANACOR PHARMACEUTICALS INC 2.2%

Value $29.46M Shares 1,661,612 Est. Cost $6.24 Unrealized —

— CELLADON CORP 1.8%

Value $23.52M Shares 1,468,300 Est. Cost $11.92 Unrealized —

— ALIMERA SCIENCES INC 1.6%

Value $21.74M Shares 3,634,984 Est. Cost $4.88 Unrealized —

— QUESTCOR PHARMACEUTICALS INC 1.5%

Value $20.25M Shares 218,995 Est. Cost $48.32 Unrealized —

— NPS PHARMACEUTICALS INC 1.5%

Value $20.14M Shares 609,300 Est. Cost $31.13 Unrealized —

INSM INSMED INC 1.4%

Value $19.22M Shares 962,101 Est. Cost $13.66 Unrealized +8.4%

— RIGEL PHARMACEUTICALS INC 1.4%

Value $18.8M Shares 5,180,101 Est. Cost $3.43 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.3%

Value $17.58M Shares 1,455,176 Est. Cost $14.44 Unrealized —

— SHIRE PLC 1.1%

Value $15M Shares 63,700 Est. Cost $233.03 Unrealized —

— ARIAD PHARMACEUTICALS INC 1.1%

Value $14.5M Shares 2,275,603 Est. Cost $6.82 Unrealized —

— CELGENE CORP 1.0%

Value $13.33M Shares 155,180 Est. Cost $87.10 Unrealized —

FOLD AMICUS THERAPEUTICS INC 1.0%

Value $13.27M Shares 3,971,576 Est. Cost $3.07 Unrealized -23.6%

EXAS EXACT SCIENCES CORP 1.0%

Value $13.24M Shares 777,676 Est. Cost $12.83 Unrealized +7.3%

GILD GILEAD SCIENCES INC 1.0%

Value $12.8M Shares 154,400 Est. Cost $54.09 Unrealized -0.0%

— ALLERGAN INC 0.9%

Value $12.51M Shares 73,900 Est. Cost $169.22 Unrealized —

PRTA PROTHENA CORP PLC 0.9%

Value $12.04M Shares 534,018 Est. Cost $22.48 Unrealized +11.2%

— OREXIGEN THERAPEUTICS INC 0.9%

Value $11.94M Shares 1,931,324 Est. Cost $6.46 Unrealized —

— QLT INC 0.9%

Value $11.66M Shares 1,887,208 Est. Cost $4.40 Unrealized —

ALGN ALIGN TECHNOLOGY INC 0.7%

Value $9.907M Shares 176,788 Est. Cost $52.19 Unrealized -0.3%

— MEDIVATION INC 0.7%

Value $9.473M Shares 122,900 Est. Cost $77.08 Unrealized —

— INTUITIVE SURGICAL INC 0.6%

Value $7.577M Shares 18,400 Est. Cost $411.79 Unrealized —

GERN GERON CORP 0.3%

Value $4.043M Shares 1,259,500 Est. Cost $2.85 Unrealized -26.8%

— REVANCE THERAPEUTICS INC 0.2%

Value $3.117M Shares 91,669 Est. Cost $31.50 Unrealized —

— XOMA CORP DEL 0.2%

Value $2.868M Shares 624,900 Est. Cost $4.20 Unrealized —

— AVEO PHARMACEUTICALS INC 0.2%

Value $2.197M Shares 1,200,800 Est. Cost $2.50 Unrealized —

— HYPERION THERAPEUTICS INC 0.1%

Value $1.636M Shares 62,700 Est. Cost $22.00 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value $656K Shares 292,900 Est. Cost $3.88 Unrealized —

CYTK CYTOKINETICS INC 0.0%

Value $591K Shares 123,686 Est. Cost $6.71 Unrealized -9.1%

— BIOSPECIFICS TECHNOLOGIES CO 0.0%

Value $302K Shares 11,184 Est. Cost $27.00 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	INTERMUNE INC	5,134,058	$227M	16.9%	$19.48	—	COM	45884X103
UTHR	UNITED THERAPEUTICS CORP DEL	1,213,828	$107M	8.0%	$69.22	+38.9%	COM	91307C102
—	CYBERONICS INC	1,715,430	$107M	8.0%	$52.15	—	COM	23251P102
—	CUBIST PHARMACEUTICALS INC	1,526,916	$107M	7.9%	$57.96	—	COM	229678107
—	AUXILIUM PHARMACEUTICALS INC	4,854,631	$97.38M	7.3%	$17.45	—	COM	05334D107
BMRN	BIOMARIN PHARMACEUTICAL INC	915,587	$56.96M	4.2%	$63.05	-4.2%	COM	09061G101
—	ABIOMED INC	2,207,489	$55.5M	4.1%	$21.31	—	COM	003654100
VNDA	VANDA PHARMACEUTICALS INC	3,240,424	$52.43M	3.9%	$7.72	+72.6%	COM	921659108
STAA	STAAR SURGICAL CO	2,599,553	$43.67M	3.3%	$8.10	+103.2%	COM PAR $0.01	852312305
—	SEQUENOM INC	9,810,442	$37.97M	2.8%	$3.91	—	COM NEW	817337405
—	CLOVIS ONCOLOGY INC	915,321	$37.9M	2.8%	$45.26	—	COM	189464100
—	KYTHERA BIOPHARMACEUTICALS I	949,959	$36.45M	2.7%	$38.49	—	COM	501570105
—	AMAG PHARMACEUTICALS INC	1,614,536	$33.45M	2.5%	$22.29	—	COM	00163U106
—	ANACOR PHARMACEUTICALS INC	1,661,612	$29.46M	2.2%	$6.24	—	COM	032420101
—	CELLADON CORP	1,468,300	$23.52M	1.8%	$11.92	—	COM	15117E107
—	ALIMERA SCIENCES INC	3,634,984	$21.74M	1.6%	$4.88	—	COM	016259103
—	QUESTCOR PHARMACEUTICALS INC	218,995	$20.25M	1.5%	$48.32	—	COM	74835Y101
—	NPS PHARMACEUTICALS INC	609,300	$20.14M	1.5%	$31.13	—	COM	62936P103
INSM	INSMED INC	962,101	$19.22M	1.4%	$13.66	+8.4%	COM PAR $.01	457669307
—	RIGEL PHARMACEUTICALS INC	5,180,101	$18.8M	1.4%	$3.43	—	COM NEW	766559603
—	MOMENTA PHARMACEUTICALS INC	1,455,176	$17.58M	1.3%	$14.44	—	COM	60877T100
—	SHIRE PLC	63,700	$15M	1.1%	$233.03	—	SPONSORED ADR	82481R106
—	ARIAD PHARMACEUTICALS INC	2,275,603	$14.5M	1.1%	$6.82	—	COM	04033A100
—	CELGENE CORP	155,180	$13.33M	1.0%	$87.10	—	COM	151020104
FOLD	AMICUS THERAPEUTICS INC	3,971,576	$13.27M	1.0%	$3.07	-23.6%	COM	03152W109
EXAS	EXACT SCIENCES CORP	777,676	$13.24M	1.0%	$12.83	+7.3%	COM	30063P105
GILD	GILEAD SCIENCES INC	154,400	$12.8M	1.0%	$54.09	-0.0%	COM	375558103
—	ALLERGAN INC	73,900	$12.51M	0.9%	$169.22	—	COM	018490102
PRTA	PROTHENA CORP PLC	534,018	$12.04M	0.9%	$22.48	+11.2%	SHS	G72800108
—	OREXIGEN THERAPEUTICS INC	1,931,324	$11.94M	0.9%	$6.46	—	COM	686164104
—	QLT INC	1,887,208	$11.66M	0.9%	$4.40	—	COM	746927102
ALGN	ALIGN TECHNOLOGY INC	176,788	$9.907M	0.7%	$52.19	-0.3%	COM	016255101
—	MEDIVATION INC	122,900	$9.473M	0.7%	$77.08	—	COM	58501N101
—	INTUITIVE SURGICAL INC	18,400	$7.577M	0.6%	$411.79	—	COM NEW	46120e602
GERN	GERON CORP	1,259,500	$4.043M	0.3%	$2.85	-26.8%	COM	374163103
—	REVANCE THERAPEUTICS INC	91,669	$3.117M	0.2%	$31.50	—	COM	761330109
—	XOMA CORP DEL	624,900	$2.868M	0.2%	$4.20	—	COM	98419J107
—	AVEO PHARMACEUTICALS INC	1,200,800	$2.197M	0.2%	$2.50	—	COM	053588109
—	HYPERION THERAPEUTICS INC	62,700	$1.636M	0.1%	$22.00	—	COM	44915N101
—	SOPHIRIS BIO INC	292,900	$656K	0.0%	$3.88	—	COM NEW	83578Q209
CYTK	CYTOKINETICS INC	123,686	$591K	0.0%	$6.71	-9.1%	COM NEW	23282W605
—	BIOSPECIFICS TECHNOLOGIES CO	11,184	$302K	0.0%	$27.00	—	COM	090931106